• The Journal of the Acoustical Society of Korea
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• v.21 no.1
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• pp.56-61
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• 2002

In piezoelectric ultrasonic linear array transducers widely used for diagnosis, the cross talk caused by the structural cross-coupling between adjacent elements inside the transducer affects the probe performance in a significant manner. In this study, we constructed a finite element model of a piezoelectric ultrasonic transducer, and analyzed its cross talk level with respect to the shape of and materials inside the kerf, The results of this work can be utilized in optimal design of the transducers for medical diagonosis and treatment as well as W applications.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.841-844
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• 2002

The vertical impact crusher is the machine which could produce artifical sand similar to natural aggregates in the site of guarry and pits. FEM was used to analyse the stress and strength of the machine at high rotational speed. The test specimen was made from the same material as the shaft and tension tests were conducted. The shaft under extreme conditions was analysed to determine maximum stress level and its location from the results. The maximum level of stress and its location could be predicted.

• Proceedings of the Safety Management and Science Conference
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• 2004.05a
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• pp.211-220
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• 2004

The vertical impact crusher is the machine which could produce artifical sand similar to natural aggregates in the site of guarry and pits. FEM was used to analyse the stress and strength of the machine at high rotational speed. The test specimen was made from the same material as the shaft and tension tests were conducted. The Shaft under extreme conditions was analysed to determine maximum stress level and its location from the results. The maximum level of stress and its location could be predicted.

• Korea Journal of Hospital Management
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• v.22 no.4
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• pp.24-32
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• 2017

Purpose: This study is to provide basic data for establishing successful organization management strategies of organizations by understanding rank systems and duty types of dental hygienists who work in dental hospitals. Methodology/Approach: The study conducted a survey and an interview survey two times targeting the entire dental hospitals. The first survey secured the response results of 113 hospitals in the result that conducted the survey targeting 190 dental hospitals in the whole country except 24 ones including dental college hospitals, dental hospitals affiliated with medical colleges or general hospitals, military dental hospitals, and dental hospitals for the disabled among the 214 ones which were registered in the Health Insurance Review & Assessment Service as of December 2015. The second survey conducted the interview survey targeting persons in charge of personnel management by selecting 34 dental hospitals with rank systems of 4 rank systems and above. Finding: The dental hospital has found that dental hygienists-centered human resources were composed. The number of ranks has found that 1 to 6 levels are shown and level 3 is highest. Titles of staff levels have found that 32 places are highest in order of 'employees

• KOREAN JOURNAL OF CROP SCIENCE
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• v.48 no.1
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• pp.20-24
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• 2003

Proline is known as an osmotrotectant to enhance tolerance against both salt and dehydration stresses. A P5CS ($\Delta^1$-pyrroline-5-carboxylate synthetase) plays a major role in regulation of synthesis of proline. An overexpression of the mothbean P5CS gene in transgenic tobacco plant increased the levels of proline and osmotolerance. In an attempt to look for the possibility to use content of proline as well as a level of P5CS gene expression as molecular markers for salt tolerance, the amounts of proline and transcript levels of P5CS were measured as functions of either concentration of NaCl or length of treatment period among different species of zoysiagrass. Hybridzoysia showed the highest level of proline ($329\mu\textrm{g}$/g.f.w.) among five different species of zoysiagrass at 250 mM NaCl in 24 hours. The level of P5CS transcript was also the highest in the hybridzoysia at 250 mM NaCl in 24 hours. The transcriptions of P5CS gene were induced at the rates of 1.2, 1.2, 1.8, and 1.8, upon treatment of 250 mM NaCl in Z. japonica, Z. matrella, Z. sinica and hybridzoysia respectively. Based on a correlation between the level of P5CS transcript and the proline content among different species of zoysiagrass, a comparative structural analysis of the gene for P5CS from either Z. sinica or hybridzoysia may lead to an understanding of mechanism for salt tolerance shown differently among zoysiagrasses.

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.6
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• pp.816-822
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• 2015

The objective of this study was to evaluate the anticancer effects of gamma-irradiated apigenin against various human cancer cells. Structural changes were analyzed by high pressure liquid chromatography. Gamma-irradiated apigenin showed a new peak distinguished from the main peak of apigenin (non-irradiated). Cytotoxic effects in human normal cells (HS68) were not observed upon gamma-irradiated and non-irradiated apigenin treatment. However, gamma-irradiated apigenin treatment significantly increased cytotoxicity against non-small lung cancer cells. For apoptosis induction activity tested by Annexin V/PI staining, gamma-irradiated apigenin showed a stronger effect than non-irradiated apigenin, and the level of reactive oxygen species was apparently elevated by gamma-irradiated apigenin treatment. These results suggest that gamma irradiation could be an effective method for development of a new physiological compound from an original compound by inducing structural changes.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.7
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• pp.1049-1053
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• 1999

Chopped wheat straw (0.5-1.5 cm) was subjected to different treatment combinations in a $5{\times}4$ factorial arrangement involving the five levels of urea (0, 2, 3, 4 and 5%, w/w) and four levels of lime (0, 2, 4 and 6%, w/w) at 50% moisture and kept for 3 wk reaction period at about $35{^{\circ}C}$ in laboratory. Treated wheat straw samples were analyzed to study the associative effect of urea and lime on chemical composition, in sacco and in vitro digestibilities. Results showed that cell wall constituents (CWC) solubilized significantly (p<0.01) due to urea and lime treatment on one hand and substantially increase the crude protein (CP) on the other in wheat straw. The main effect on synergism of both chemicals was noticed on organic matter (OM), neutral detergent fibre (NDF), hemicellulose (HC), acid detergent lignin (ADL) and silica by solubilising their contents as a result of considerable increase in cell contents in treated wheat straw. The respective decreases were 5.45, 13.0, 37.23, 44.95 and 26.16% in different treatment combinations. The most interesting feature of the treatment was evident by increase in ash content on each level of lime application. CP content increase up to 12.78% due to urea treatment in comparison with untreated wheat straw (2.56%). The effect of solubilization of structural carbohydrates and increased crude protein due to synergistic effect of urea and lime were clearly seen on improved digestibility of OM and DM. The increase in ISOMD, ISDMD, and IVDMD were 21.67, 21.67, 16.24, and 17.5 units. The increase in digestibility were relative to additions of both chemicals and digestibility values increased with increasing levels of urea plus lime concentration in different treatment combination. The maximum improvement was noticed at 4% urea and 4% lime levels at 50% moisture for 3 wk reaction period in treated wheat straw.

• Structural Engineering and Mechanics
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• v.23 no.1
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• pp.43-61
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• 2006

An investigation of the effectiveness of the interface treatment when column concrete jacketing is performed is presented. Alternative methods of interface connection were used in order to investigate the performance of strengthened concrete columns. These connecting techniques involved roughening the surface of the original column, embedding steel dowels into the original column and a combination of these two techniques. The experimental program included three strengthened specimens, one original specimen (unstrengthened) and one as-built specimen (monolithic). The specimens represented half height full-scale old Greek Code (1950's) designed ground floor columns of a typical concrete frame building. The jackets of the strengthened specimens were constructed with shotcrete. All specimens were subjected to displacement controlled earthquake simulation loading. The seismic performance of the strengthened specimens is compared to both the original and the monolithic specimens. The comparison was performed in terms of strength, stiffness and hysteretic response. The results demonstrate the effectiveness of the strengthening methods and indicate that the proper construction of a jacket can improve the behaviour of the specimens up to a level comparable to monolithic behaviour. It was found that different methods of interface treatment could influence the failure mechanism and the crack patterns of the specimens. It was also found that the specimen that combined roughening with dowel placement performed the best and all strengthened columns were better at dissipating energy than the monolithic specimen.

• Journal of Chest Surgery
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• v.22 no.3
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• pp.402-415
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• 1989

Extracorporeal circulation leads to functional disorder and structural damage of organs, especially hematologic and pulmonary system, mainly by sequestration of neutrophils and deposition of macrophages at lung. Then, proteases are secreted, which insult vascular basement membrane of pulmonary capillary and alveolar septa of the lung. Among these, the most important protease at lung is elastase, because major component of lung is elastin. For prevention of lung injury, inactivators or antidotes to elastase should be necessary and Alpha 1-Proteinase Inhibitor is the elastase inactivator. Clinical experimental study was carried out to investigate the immediate postoperative change of serum Alpha 1-PI level following cardiopulmonary bypass for 20 heart cases [congenital 16 cases, acquired 4 cases] and 10 control [subtotal gastrectomy] cases. Also preliminary study was performed for 31 cases of open heart patients. The results were as follows: l. Immediate postoperative serum levels of Alpha 1-PI was significantly decreased at open heart surgery group [P< 0.005], but not decreased at control group. 2. There were no significant difference in change of serum Alpha 1-PI level between and membrane and bubble oxygenator group.Z 3. There were no significant difference in changes of serum Alpha 1-PI level between CHD and AHD. Alpha 1-PI is consumed at lung during cardiopulmonary bypass and increase after operation compensatedly and protect multiple organic damage especially lung. Therefore, Alpha 1-PI can be indicator for evaluation of prevention and treatment of pump-lung syndrome.

• Korean Journal of Biological Psychiatry
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• v.8 no.1
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• pp.3-19
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• 2001

Recent basic and clinical studies demonstrate a major role for neural plasticity in the etiology and treatment of depression and stress-related illness. The neural plasticity is reflected both in the birth of new cell in the adult brain(neurogenesis) and the death of genetically healthy cells(apoptosis) in the response to the individual's interaction with the environment. The neural plasticity includes adaptations of intracellular signal transduction pathway and gene expression, as well as alterations in neuronal morphology and cell survival. At the cellular level, repeated stress causes shortening and debranching of dendrite in the CA3 region of hippocampus and suppress neurogenesis of dentate gyrus granule neurons. At the molecular level, both form of structural remodeling appear to be mediated by glucocorticoid hormone working in concert with glutamate and N-methyl-D-aspartate(NMDA) receptor, along with transmitters such as serotonin and GABA-benzodiazepine system. In addition, the decreased expression and reduced level of brain-derived neurotrophic factor(BDNF) could contribute the atrophy and decreased function of stress-vulnerable hippocampal neurons. It is also suggested that atrophy and death of neurons in the hippocampus, as well as prefrontal cortex and possibly other regions, could contribute to the pathophysiology of depression. Antidepressant treatment could oppose these adverse cellular effects, which may be regarded as a loss of neural plasticity, by blocking or reversing the atrophy of hippocampal neurons and by increasing cell survival and function via up-regulation of cyclic adenosine monophosphate response element-binding proteins(CREB) and BDNF. In this article, the molecular and cellular mechanisms that underlie stress, depression, and action of antidepressant are precisely discussed.