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http://dx.doi.org/10.3746/jkfn.2015.44.6.816

Induction of Apoptosis by Gamma-Irradiated Apigenin in H1975 Human Non-Small Lung Cells  

Park, Jae-Nam (Advance Radiation Technology Institute, Korea Atomic Energy Research Institute)
Byun, Eui-Baek (Advance Radiation Technology Institute, Korea Atomic Energy Research Institute)
Kim, Jwa-Jin (Department of Anatomy, College of Medicine, Konyang University)
Jang, Beon-Su (Advance Radiation Technology Institute, Korea Atomic Energy Research Institute)
Park, Sang-Hyun (Advance Radiation Technology Institute, Korea Atomic Energy Research Institute)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.44, no.6, 2015 , pp. 816-822 More about this Journal
Abstract
The objective of this study was to evaluate the anticancer effects of gamma-irradiated apigenin against various human cancer cells. Structural changes were analyzed by high pressure liquid chromatography. Gamma-irradiated apigenin showed a new peak distinguished from the main peak of apigenin (non-irradiated). Cytotoxic effects in human normal cells (HS68) were not observed upon gamma-irradiated and non-irradiated apigenin treatment. However, gamma-irradiated apigenin treatment significantly increased cytotoxicity against non-small lung cancer cells. For apoptosis induction activity tested by Annexin V/PI staining, gamma-irradiated apigenin showed a stronger effect than non-irradiated apigenin, and the level of reactive oxygen species was apparently elevated by gamma-irradiated apigenin treatment. These results suggest that gamma irradiation could be an effective method for development of a new physiological compound from an original compound by inducing structural changes.
Keywords
gamma irradiation; apigenin; non-small cell lung cancer; apoptosis; reactive oxygen species;
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Times Cited By KSCI : 4  (Citation Analysis)
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