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The Correlation of Sonographic Finding of Fatty Liver with Hematologic Examination and Body Fat Percentage (초음파상 지방간과 혈액학적 검사 및 체지방률과의 상관관계)

  • Cheon, Hae-Kyung;Lee, Tae-Yong;Kim, Young-Ran
    • Journal of radiological science and technology
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    • v.32 no.4
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    • pp.437-444
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    • 2009
  • Ultrasonography has been used as a basic examination of a medical check up for prevention and diagnostics of diseases. Even the person who has no particular subjective symptoms can have a variety of diseases. Especially fatty liver is found in many cases. In this study, we tested 3582 persons who are in between the ages of 15 to 81 and observed that 1390 persons had fatty liver while 2192 persons are normal. We classified the grade of fatty liver and compared their life styles with the results of liver function test and BMI. The results are as follows. Ratio of the subjects who had a fatty liver is 38.8%. Male and female ratio was 46.2% and 24.2%. On the correlation among the fatty liver, the body mass index and the body fat%, the average value of body mass index and body fat% were significantly higher in the group of the fatty liver than in those of the normal liver. The influence of the related factor and the correlation on the fatty liver was shown that it was more related with the order of age, body mass index, triglyceride, ALT, body fat%, sex, HDL-Cholesterol, LDL-Cholesterol, and GGT. The result of the ultrasonography carried out for the purpose of regular health check up indicates that even the 38.8% of those who was diagnosed as normal condition could have the fatty liver and have possibility of other diseases. Therefore, if there are any troubles related to liver function and lipid through hematologic examination or when practicing follow-up study with ultrasonography concerning the correlation relation between the body fat% and dietary preference, alcohol consumption and exercise, the ultrasonography is definitely useful for prevention and treatment of diseases.

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Clinical Efficacy of Belotecan (CKD-602), Newly Developed Camptothecin Analog, in the 2nd Line Treatment of Relapsed Small Cell Lung Cancer (재발된 소세포폐암환자에서 이차 약제로 사용되는 Belotecan (CKD-602)의 임상적 효용성)

  • Ban, Hee-Jung;Oh, In-Jae;Kim, Kyu-Sik;Ju, Jin-Yung;Kwon, Yong-Soo;Kim, Yu-Il;Lim, Sung-Chul;Kim, Young-Chul
    • Tuberculosis and Respiratory Diseases
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    • v.66 no.2
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    • pp.93-97
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    • 2009
  • Background: Belotecan (Camtobell, CKD-602, Chongkundang Pharm., Korea), a camptothecin derivative, has anticancer effects by inhibiting topoisomerase I such as topotecan. This study observed the response, survival and toxicity of belotecan monotherapy after the failure of etoposide and platinum (EP). Methods: Forty nine small cell lung cancer (SCLC) patients (M/F=41/8; age, 64.5${\pm}$7.6 (mean${\pm}$SD) years), who failed in their first line chemotherapy were enrolled in this study. Twenty one SCLC patients showed relapsed lung cancer more than 90 days after their priorEP chemotherapy (sensitive relapse group, SR) and 28 patients relapsed within 90 days (refractory relapse group, RR). Results: The response rate was 25%. Eleven patients showed partial responses and 5 patients could not be checked. The response rate of the SR and RR patients was similar. The relative dose intensity was lower in the responders (78${\pm}$15%) than non-responders (83${\pm}$13%, p=0.03). The median survival time (MST) was 10.3 months (290 days). The MST of the non-responders and responders was 186 days (95% CI; 67-305) and 401 days (95% CI; 234-568, p=0.07), respectively. The median progression free survival (MPFS) was similar in the SR (79 days) and RR (67 days) patients. Grade 3-4 neutropenia, anemia, and thrombocytopenia were observed in 59.6%, 12.8% and 23.4% of patients, respectively. Conclusion: The efficacy and survival were demonstrated in the second-line setting. However, a randomized comparative trial with topotecan will be needed.

Development of the Multi-Parametric Mapping Software Based on Functional Maps to Determine the Clinical Target Volumes (임상표적체적 결정을 위한 기능 영상 기반 생물학적 인자 맵핑 소프트웨어 개발)

  • Park, Ji-Yeon;Jung, Won-Gyun;Lee, Jeong-Woo;Lee, Kyoung-Nam;Ahn, Kook-Jin;Hong, Se-Mie;Juh, Ra-Hyeong;Choe, Bo-Young;Suh, Tae-Suk
    • Progress in Medical Physics
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    • v.21 no.2
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    • pp.153-164
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    • 2010
  • To determine the clinical target volumes considering vascularity and cellularity of tumors, the software was developed for mapping of the analyzed biological clinical target volumes on anatomical images using regional cerebral blood volume (rCBV) maps and apparent diffusion coefficient (ADC) maps. The program provides the functions for integrated registrations using mutual information, affine transform and non-rigid registration. The registration accuracy is evaluated by the calculation of the overlapped ratio of segmented bone regions and average distance difference of contours between reference and registered images. The performance of the developed software was tested using multimodal images of a patient who has the residual tumor of high grade gliomas. Registration accuracy of about 74% and average 2.3 mm distance difference were calculated by the evaluation method of bone segmentation and contour extraction. The registration accuracy can be improved as higher as 4% by the manual adjustment functions. Advanced MR images are analyzed using color maps for rCBV maps and quantitative calculation based on region of interest (ROI) for ADC maps. Then, multi-parameters on the same voxels are plotted on plane and constitute the multi-functional parametric maps of which x and y axis representing rCBV and ADC values. According to the distributions of functional parameters, tumor regions showing the higher vascularity and cellularity are categorized according to the criteria corresponding malignant gliomas. Determined volumes reflecting pathological and physiological characteristics of tumors are marked on anatomical images. By applying the multi-functional images, errors arising from using one type of image would be reduced and local regions representing higher probability as tumor cells would be determined for radiation treatment plan. Biological tumor characteristics can be expressed using image registration and multi-functional parametric maps in the developed software. The software can be considered to delineate clinical target volumes using advanced MR images with anatomical images.

The Effects of Dietary Herbal Plant Mixture on Growth Performance, Nutrient Digestibility, Serological Changes and Carcass Characteristics in Finishing Pigs (비육돈에 있어서 생약제 혼합물의 급여가 성장율, 영양소 소화율, 혈청학적 변화 및 도체특성에 미치는 영향)

  • 권오석;김인호;김지훈;홍종욱;민병준;이원백;손경승
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.4 no.4
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    • pp.334-340
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    • 2003
  • This study was conducted to evaluate the effects of dietary herbal extracts mixture on the growth rate. carcass traits and serological changes in finishing pigs. For the Exp 1, eighty Duroc(Yorkshir(Landrace pigs(81.58$\pm$3.20kg average initial body weight) were used in a 45 day experiment. Dietary treatments included 1) NC(negative control; antibiotics-free diet), 2) PC(positive control; NC diet added 0.1% of chlortetracycline), 3) NCM(NC diet added 0.1% of herbal plant mixture) and 4) PCM(PC diet added 0.1% of herbal plant mixture). Through the entire experimental period, ADG of pigs fed NCM and PCM diets was greater(P<0.08) than that of pigs fed NC diet. There was interaction of ADG(P<0.01) in pigs fed NC diet with herbal plant mixture compared to pigs fed PC diet with herbal plant mixture. ADFI and G/F tended to increase in PC and NCM treatments. However, there were not significantly differences among the treatments. Total protein of serum was improved by supplementation of the herbal plant mixture in NC diet(P<0.04). For the Exp 2. one hundred Duroc(Yorkshir(Landrace pigs(77.36$\pm$2.01kg average initial body weight) were used in a 28 day experiment. Dietary treatments included 1) NC(negative control; antibiotics-free diet), 2) PC(positive control; NC diet added 0.1% of chlortetracycline), 3) PM0.1(NC diet added 0.1% of herbal plant mixture) and 4) PM0.2(NC diet added 0.2% of herbal plant mixture). Through the entire experimental period, ADG tended to increase in PC treatment. However, there was not significantly difference among the treatments. Carcass weight in NC was higher than other treatments(P<0.06). Backfat thickness was higher in pigs fed PC than other treatments. However, there was not significantly difference among the treatments. A grade appearances of carcass tended to increase in pigs fed PM(P<0.09). In conclusion, the results of the experiments suggest that pigs fed PM could be a beneficial growth performance and serogical immunity for finishing pigs.

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Effect of Dietary Bacillus sp. Inoculated Feather Meal on the Performance and Carcass Characteristics in Finishing Pigs (Bacillus sp. 접종 우모분이 비육돈의 생산성과 도체특성에 미치는 영향)

  • Kim, J.H.
    • Journal of Animal Science and Technology
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    • v.47 no.4
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    • pp.525-536
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    • 2005
  • This study was carried out investigate the effect of replacing soybean meal with feather meal or Bacillus sp. inoculated feather meal in finisher pig diets on the performances, and amino acid composition and carcass characteristics of pork. One hundred fifty pigs were randomly allotted to five dietary treatments (① control, basal diet; ② BSM (bacillus sp. inoculated soybean meal) 10, 10% of soybean meal was replaced with bacillus sp. inoculated feather meal; ③ BSM 20, 20% of soybean meal was replaced with bacillus sp. inoculated feather meal; ④ CSM (conventional soybean meal) 10, 10% of soybean meal was replaced with conventional feather meal and ⑤ CSM 20, 20% of soybean meal was replaced with conventional feather meal) in a 70-days feeding trial. In overall period, body weight gain of BSM 20 (0.95kg) was higher (P<0.05) than those of CSM 10 (0.80kg) and CSM 20 (0.81kg), respectively. And feed conversion of BSM 20 (2.94) was lower (P<0.05) than that for other treatments (3.06-3.41). Carcass weight of BSM 10 (81.84kg) and BSM 20 (83.77kg) were greater (P<0.05) than those of CSM 10 (74.75kg) and CSM 20 (76.07kg), respectively. Proportion of grade A carcass in BSM 20 (35.03%) was higher compared to the control treatment (32.78%). CIE L* of meat color was lowest in the BSM 10 (45.56), and hightest (P<0.05) in the CSM 20 (59.96). In addition CIE a* of meat color of control (9.35) highest (P<0.05) than those of BSM 10 and BSM 20 were 7.56 and 7.42, respectively.

Effects of Fermented Feedstuff with Wet Brewer’s Grain and Soybean on Fattening Performance and Carcass Grade in hanwoo Steers (맥주박 발효사료 및 대두의 급여가 한우 거세우의 육성성적 및 도체등급에 미치는 영향)

  • Park, B.K.;Gil, J.M.;Kim, J.B.;Hong, B.J.;Ra, C.S.;Shin, J.S.
    • Journal of Animal Science and Technology
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    • v.45 no.3
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    • pp.397-408
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    • 2003
  • This study was conducted to examine the feeding effects of FFWBG (fermented feedstuff with wet brewer’s grain) and GS(grinding soybean) in Hanwoo steers. For this research, total twenty steers(average body weight : 455.7$\pm$25.9kg) were grouped into control(formula feed), T1(formula feed:FFWBG=60:40), T2(formula feed:GS=80:20), T3(formula feed:FFWBG:GS=50:40:10), and T4(formula feed: FFWBG:GS=40:40:20), each treatment was allocated to four steers. There was a tendency to be increased average daily gain in T1, T2, T3 and T4 compared with the control even though no statistical significance was found. The feed conversion of T1, T2, T3 and T4 were beneficially better than that of control(P<0.05; 8.25, 9.44, 6.69 and 7.71 vs 11.90, respectively). The blood urea nitrogen concentration of T4 was higher than that of control(P<0.05), but the creatinine concentration of T4 was lower than that of control(P<0.05). The glucose concentration of T1, T2, T3 and T4 were higher than that of control(P<0.05; 59.39, 62.44, 62.17 and 54.00 vs 51.00mg/$d\ell$, respectively). The back-fat thickness of T3 was thicker than that of control, T1, T2 and T4. The rib-eye area of T1, T3 and T4 was wider than that of control. Appearances percentage of ‘A’ ranked meat quantity were 66, 33, 75 and 33% in control, T1, T2 and T4, respectively.

A Study on the Physical Growth and Health Status in University Students (일부(一部) 대학생(大學生) 신체발육(身體發育) 및 건강상태(健康狀態)에 관(關)한 조사(調査))

  • Kwon, E-Hyock;Cha, Chul-Hwan
    • Journal of Preventive Medicine and Public Health
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    • v.1 no.1
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    • pp.67-78
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    • 1968
  • For the purpose of ascertaining the status of physical growth and health status of the University students, a intensive survey was conducted by the authors towards a total of 2,638(male; 2,228, female; 410) who passed the written entrance examination at the Seoul National University. The items included the measurements on physical growth, various physical indixes, visual acuity, tuberculosis and dental status. The findings and results can be summarized as follows: 1. Physical Growth No significant difference was found in the physical growth between classes(literature and science) and by ages. In males, the means of body height, body weight, chest-girth and sittingheight were $168.0{\pm}5.07cm,\;55.7{\pm}5.71kg,\;85.8{\pm}4.4cm\;and\;91.5{\pm}2.21cm$, respectively. In females, these were $157.4{\pm}4.57\;cm,\;00.4{\pm}5.75kg,\;80.3{\pm}4.51cm\;and\;86.1{\pm}3.30cm$, respectively. Basing on the above measurements several physical indixes were calculated as follows ; Relative body weight 33.15 in males and 32.02 in females. Relative chest-girth 51.07 and 51.01, relative sitting-height 54.46 and 54.70 $R\ddot{o}hrer$ index 1.00 and 1.02, Kaup index 1.97 and 2.04, Vervaeck index 83.63 and 83.03, and Pelidisi index 89.94 and 92.45. 2. Visual Acuity Among the students of science classes those of 0.8 and below in vision on left and right occupied 46.4% and 45.0%, those of 0.6 and below 39.1% and 41.2%, respectively. Among the students of literature classes those of 0.8 and below occupied 46.3% and 42.9%, and those of 0.6 and below occupied 41.4% and 39.0, respectively. In males those of 0.8 and below occupied 46.8% and 44.5% and 0.6 and below occupied 41.9% and 39.7%, while in females 0.8 and below occupied 43.9%, and 42.4%, and 0.6 and below occupied 38.3% and 37.3%, respectively. In males those of 0.8 and below in corrected vision occupied 12.1% and 10.3%, while in females 12.9% and 12.2%, respectively. More students of abnormal vision were found among science classes and the proportions of corrected vision were 38.9% and 37.4% in males, and 33.9% and 33.2% in females, respectively. 3. Tuberculosis Among the total, 55 students were diagnosed as tuberculosis, of whom 50 were minimal cases, 2 were moderately advanced cases and 3 were far advanced cases. 4. Dental Status Among the total, 81.2% were of decayed teeth, 20.8% filled, 9.5% missed, 5.0% extraction needed, 9.1% sunplatinum bridges, 3.3% golden bridges and 5.5% golden inlay. Regarding tartar on teeth moderate, heavy and light grades occupied 49.5%, 29.7% and 20.3%, respectively and 0.8% had none. 5. Comprehensive evaluation According to criteria 4 grades were applied to comprehensive evaluation as follows : A...excellent in physical status B...with some physical defects but no difficulties in study C...need treatment D...need treatiment and rest Out of the total, A grade occupied 21.6%, B 76.2% and C. and D 2.2.

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Effect of Non Breeding Season on Oocyte Recovery from Superovulated Korean Native Goats (재래산양의 비번식기에 과배란 처리에 의한 난자 회수와 단위발생란의 체외발달)

  • Yun, Yun Jin;Park, Hee Sung
    • Journal of Embryo Transfer
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    • v.28 no.1
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    • pp.19-24
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    • 2013
  • This study assesses of efficiency of oocyte recovery and in vitro development for during the non breeding season in goat. Thirty-four matured goats, maintained in a pen under natural day length and fed hay ad libitum, were pretreated with progestagen implanted CIDR for 10 days. Superovulation treatment of the goats received twice daily intramuscular injections of a total of 70 mg FSH for 3 days from Day 8 of CIDR. All the gonadotropin treated goats were injected with 10 mg $PGF_2{\alpha}$ on Day 8 and 400~600 IU hCG in the afternoon on Day 10. Oocytes were recovered by follicle aspiration or oviduct flushing at 35 to 40 h after hCG injection through mid-ventral incision. The in vivo matured oocytes were activated by ionomycin (5 min) and 6-DMAP (3.5~4 h). The activated oocytes were cultured in mSOF medium containing 0.8% BSA at $38.5^{\circ}C$ in an atmosphere of 5% $CO_2$, 5% $O_2$, 90% $N_2$ for 7~8 days. There was no significant difference in the mean number of CL and in vivo matured and follicular oocytes recovered. But, quality of I+II grade follicular oocytes was lower (p<0.05) in the prepubertal goat (25.0%) than the adults (52.4%). The same results were also observed in the cleavage and blastocyst rate of activated oocytes. The clavage and blastocyst rate from prepubertal derived oocytes were lower (p<0.05) in the prepubertal goat (54.5%, 23.3%) than the adult goat (86.8%, 46.6%). Considering overall these results, we suggest that maturation of donor goats is a major factor affecting recovered oocytes quality and in vitro development of activated goat oocytes. There was no significant difference in oocyte quality between seasonal treatments.

Comparison of Urinary Tract Infections Caused by Escherichia coli and Non-E.coli in Infants (대장균과 비대장균에 의한 영아 요로 감염의 비교)

  • Joung, Jin-Kyo;Choi, Cheol-Soon;Kim, Seong-Joon;Park, So-Hyun;Kim, Jong-Hyun;Koh, Dae-Kyun
    • Pediatric Infection and Vaccine
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    • v.16 no.2
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    • pp.162-166
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    • 2009
  • Purpose : Urinary tract infection (UTI) is one of the most common bacterial infectious disease in childhood. Renal scarring is an important complication of UTIs. Known risk factors for renal scarring are younger age, anatomic defects, delayed treatment, and causative pathogens other than Escherichia coli. The aim of this study was to compare the characteristics of clinical and laboratory features of UTI with E. coli to those with non-E. coli in infants. Methods : We reviewed the medical records of 1,120 infants under 12 months of age who had been admitted for UTIs between January 1998 and December 2007. All patients who were diagnosed with UTIs were divided into two groups (E. coli and non-E. coli UTIs). Results : Three hundred twenty-four of 1,120 cases met the inclusion criteria. The number of E. coli and non-E. coli UTIs was 273 (84.3%) and 51 (15.7%), respectively. As compared to the non-E. coli UTI group, the E. coli UTI group was younger (3.59 vs. 4.47 months, P =0.008), a longer duration of pyuria (3.96 vs. 3.06 days, P =0.01), higher peripheral white blood cell counts (13.89 vs. $12.13{\times}10^3/mm^3$, P =0.043), and lower rates of high degree (III-V) vesico-ureteral reflux (P =0.005). Conclusion : UTIs with E. coli might have more severe clinical features and a lower prevalence of high grade vesicoureteral reflux than UTIs with non-E. coli. However, no difference was noted in the clinical response to antibiotic therapy between the two groups.

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Correlation between Clinicomorphologic Findings and Clinical Outcome in Childhood $Henoch-Sch\"{o}nlein$ Purpura Nephritis (소아 $Henoch-Sch\"{o}nlein$ 자반병 신염의 임상양상 및 병리소견과 임상경과)

  • Huh Yun-Jung;Shin Jae-Il;Park Jee-Min;Jeong Hyeon-Joo;Lee Jae-Seung
    • Childhood Kidney Diseases
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    • v.7 no.1
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    • pp.30-37
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    • 2003
  • Purpose : $Henoch-Sch\"{o}nlein$ purpura(HSP) is usually a self-limited disease with a good eventual outcome. The prognosis of HSP is mainly determined by the renal involvement. In this study, We evaluated children with biopsy-proven $Henoch-Sch\"{o}nlein$ purpura nephritis about the clinical outcome correlated with renal manifestation and morphologic findings. Methods : The clinical features, initial laboratory and pathologic findings, and clinical out-come were evaluated in 60 children with biopsy-proven $Henoch-Sch\"{o}nlein$ purpura nephritis at Yonsei University Severance Hospital during the period from Jan. 1990 to Dec. 2002. Results : The ratio of male to female patients was 1.2:1. The interval between the onset of $Henoch-Sch\"{o}nlein$ purpura and renal manifestation was less than 3 months in 81% of the patients. Initial renal manifestation was microscopic hematuria in 100% of patients, isolated hematuria in 15%, acute nephritic syndrome in 7%, nephrotic syndrome In 22% of patients. Renal manifestation correlated with clinical outcome. Grade II and III were the most common in histologic grades of ISKDC. Renal pathologic finding correlated with clinical outcome. Conclusion : Renal manifestation and pathologic findings correlated with the clinical out-come. It is necessary to evaluate the correlation between pathologic findings and treatment.

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