• The Korean Journal of Physiology and Pharmacology
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• 제22권2호
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• pp.183-192
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• 2018

Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, anxiety, depression, and amnesic symptoms that may involve the release of monoamines in the fear circuit. The present study measured several anxiety-related behavioral responses to examine the effects of berberine (BER) on symptoms of anxiety in rats after single prolonged stress (SPS) exposure, and to determine if BER reversed the dopamine (DA) dysfunction. Rats received BER (10, 20, or 30 mg/kg, intraperitoneally, once daily) for 14 days after SPS exposure. BER administration significantly increased the time spent in the open arms and reduced grooming behavior during the elevated plus maze test, and increased the time spent in the central zone and the number of central zone crossings in the open field test. BER restored neurochemical abnormalities and the SPS-induced decrease in DA tissue levels in the hippocampus and striatum. The increased DA concentration during BER treatment may partly be attributed to mRNA expression of tyrosine hydroxylase and the DA transporter in the hippocampus, while BER exerted no significant effects on vesicular monoamine transporter mRNA expression in the hippocampus of rats with PTSD. These results suggest that BER had anxiolytic-like effects on behavioral and biochemical measures associated with anxiety. These findings support a role for reduced anxiety altered DAergic transmission and reduced anxiety in rats with PTSD. Thus, BER may be a useful agent to treat or alleviate psychiatric disorders like those observed in patients with PTSD.

• 대한불안의학회지
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• 제9권2호
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• pp.106-112
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• 2013

Objective : Several reports have found abnormal levels of androgen in post-traumatic stress disorder (PTSD) patients. This abnormality in androgen is hypothesized to due to chronic psychological stress effects on the hypothalamic-pituitary-gonadal (HPG) system. The present study was conducted to estimate serum testosterone levels in PTSD patients in comparison with normal subjects. Methods : Seventy-five male Korean veterans of the Vietnam War volunteered for the study, of which eleven were excluded because of incomplete psychological assessment. To measure basal serum testosterone, blood samples were collected between 8.00 and 9.30 a.m. The clinician administered PTSD scale (CAPS), the structured clinical interview for DSM-IV (SCID), Hamilton Anxiety Rating Scale (HAM-A), Hamilton Rating Scale for Depression (HAM-D), Mini International Neuropsychiatric Interview Plus (Korean version of MINI-Plus), CES-K (Korean version of combat exposure scale). Results : The serum testosterone level of PTSD patients ($5.4{\pm}2.5ng/mL$) was higher than that of a control group ($3.1{\pm}1.7ng/mL$, p<0.001). Testosterone levels were significantly correlated with CAPS (r=.38, p<.01), HAM-A (r=.35, p<.01) and HAM-D (r=.28, p<.01) in all subjects. Conclusion : The results of the present study suggest that chronic psychological stress affects the HPG system.

• The Korean Journal of Physiology and Pharmacology
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• 제22권5호
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• pp.525-538
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• 2018

Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, and anxiety that may involve the release of monoamines in the fear circuit. The reported pharmacological properties of tetramethylpyrazine (TMP) include anti-cancer, anti-diabetic, anti-atherosclerotic, and neuropsychiatric activities. However, the anxiolytic-like effects of TMP and its mechanism of action in PTSD are unclear. This study measured several anxiety-related behavioral responses to examine the effects of TMP on symptoms of anxiety in rats after single prolonged stress (SPS) exposure by reversing the serotonin (5-HT) and hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Rats were given TMP (10, 20, or 40 mg/kg, i.p.) for 14 days after SPS exposure. Administration of TMP significantly reduced grooming behavior, increased the time spent and number of visits to the open arm in the elevated plus maze test, and significantly increased the number of central zone crossings in the open field test. TMP administration significantly reduced the freezing response to contextual fear conditioning and significantly restored the neurochemical abnormalities and the SPS-induced decrease in 5-HT tissue levels in the prefrontal cortex and hippocampus. The increased 5-HT concentration during TMP treatment might be partially attribute to the tryptophan and 5-hydroxyindoleacetic acid mRNA level expression in the hippocampus of rats with PTSD. These findings support a role for reducing the altered serotonergic transmission in rats with PTSD. TMP simultaneously attenuated the HPA axis dysfunction. Therefore, TMP may be useful for developing an agent for treating psychiatric disorders, such those observed in patients with PTSD.

• 한국화재소방학회논문지
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• 제34권3호
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• pp.126-133
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• 2020

본 연구는 소방공무원의 무조건적 자기수용과 자기노출이 외상 후 성장에 미치는 영향을 알아봄으로써 외상 후 스트레스 장애 등 병리적 결과에 머물지 않고 이전 수준을 뛰어넘는 외상 후 성장을 이룰 수 있는 프로그램 개발 등에 도움을 주고자 하였다. 이를 위해 무조건적 자기수용, 자기노출, 한국판 외상 후 성장 척도 등을 활용하였으며, 연구결과는 다음과 같다. 첫째, 소방공무원의 무조건적 자기수용, 자기노출이 외상 후 성장과 상관관계가 있음이 확인되었다. 둘째, 소방공무원의 무조건적 자기수용과 자기노출 변인 중 외상 후 성장에 미치는 상대적 영향력을 알아보기 위해 위계적 회귀분석을 실시한 결과, 무조건적 자기수용이 자기노출 보다 더 많은 영향을 주는 것으로 확인되었다. 본 연구결과를 토대로 소방공무원 외상 후 성장을 촉진시키는 프로그램 개발 방향 및 치료적 개입 전략 등을 제안하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.641-646
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• 2015

Breast cancer (BC) is potentially a traumatic stressor which may be associated with negative outcomes, such as post-traumatic stress disorder (PTSD) or positive changes, such as post-traumatic growth (PTG). This study aims to identify the core issues of BC related PTSD, PTG and psychological distress by interrogating the literature in BC survivors. We have also highlighted issues related to the assessment, diagnosis and clinical management of PTSD and PTG. The authors systematically reviewed studies published from 1985 to 2014 pertaining to PTSD, psychological distress and PTG in BC survivors with particular attention paid to incidence rates and causative factors. Multiple studies intimated that women with BC have evidence of PTSD at the initial stages of diagnosis, whereas PTG develops once patients undergo treatment. Early diagnosis and treatment of PTSD/PTG is paramount from literature review but the previously mentioned relationship between PTSD and PTG in BC patients could not be verified. It is evident from the literature that a small percentage of BC patients experience PTSD, while the majority experience PTG after BC diagnosis and treatment. Future research should include prospective studies focusing on high-risk patients, causative factors and the development of psychological interventions.

• 한국방재학회:학술대회논문집
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• 한국방재학회 2008년도 정기총회 및 학술발표대회
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• pp.381-384
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• 2008

The purpose of this study is to evaluate influence factors of secondary traumatic stress, burnout, and physical symptoms which were experienced by fire fighters. The questionnaire research was done for field service fire fighters who work in Korea. I analyzed 358 questionnaires and the questionnaires consisted of stress scale, work force, burden of physical symptoms, and self-control to stress. Through this study I will propose the solution for the posttraumatic stress disorder(PTSD) for the near future.

• 한국산업간호협회지
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• 제15권1호
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• pp.16-20
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• 2008

• 대한불안의학회:학술대회논문집
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• 대한불안의학회 2005년도 동계연수교육
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• pp.73-79
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• 2005

• 성인간호학회지
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• 제24권1호
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• pp.38-51
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• 2012

Purpose: In this study the literature of compassion fatigue in nurses was reviewed in order to analyze the trends of overall research for level of fatigue, symptoms, and factors. Methods: For this study, five databases were searched using the key words 'compassion fatigue', 'secondary traumatization', 'secondary traumatic stress', and 'vicarious traumatization'. Thirty-six papers were analyzed. Results: Most of the compassion fatigue research (86%) was conducted between 2006 and 2011 and the most frequent research approach was quantitative research with the ProQOL which was the most frequently used instrument in the studies. He research was conducted in pediatric, emergency & trauma, oncology, psychiatric, and hospice units with no consistent patterns of t compassion fatigue levels. Factors affecting compassion fatigue were personal factors such as age, education background, work-related factors such as caring for trauma patients, work hours, psychological factors such as work stress, burnout, and support/coping factors such as organizational support, and coping resources. Conclusion: Nurses' compassion fatigue varied from low to high by nursing specialties. Many factors affected the compassion fatigue of nurses. In the future there is a need for study on Korean nurses, and identification of groups at risk for compassion fatigue. Furthermore there is a need to develop management programs on compassion fatigue in nurses, stress reduction and wellbeing.

• Child Health Nursing Research
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• 제27권3호
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• pp.243-255
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• 2021

Purpose: This study aimed to develop and examine the effects of a psychosocial adaptation program for North Korean adolescent defectors. Methods: This quasi-experimental study was conducted with 28 North Korean adolescent defectors who were recruited through alternative schools. The experimental and control groups consisted of 14 participants each. A program was conducted across eight sessions, each lasting about 90-120 minutes. The data were analyzed using the x² test, t-test, paired t-test, and analysis of covariance. Results: No significant differences were observed in the score changes for psychosocial adaptation (t=0.25, p=.808), post-traumatic stress symptoms (t=0.32, p=.749), cultural adaptation stress (t=0.05, p=.957), and self-efficacy (t=0.35, p=.726) in either group before and after the intervention. No intergroup differences were observed for psychosocial adaptation (t=0.12, p=.902), post-traumatic stress symptoms (t=0.07, p=.946), cultural adaptation stress (t=0.01, p=.994), and self-efficacy (t=0.58, p=.570). Conclusion: These findings suggest that psychosocial adaptation, stress, and self-efficacy cannot be improved by a short-term intervention program alone. It was also determined that the cultural characteristics of the North Korean adolescent defectors were not sufficiently considered before implementing the program. Therefore, it is essential to provide an in-depth orientation for the participants before implementing the program.