• Journal of Life Science
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• v.31 no.5
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• pp.502-510
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• 2021

The objective of this study was to develop a novel ticagrelor-loaded self-nanoemulsifying drug delivery system with an enhanced solubility and dissolution rate. Numerous oils and surfactants were screened, then medium chain triglyceride (MCT) oil and the surfactants polyoxyethylene sorbitan monooleate (Tween 80) and Labrafil M1944CS were selected for the preparation of the ticagrelor-loaded self-nanoemulsifying drug delivery system. A pseudo-ternary phase diagram was constructed to detect the nanoemulsion region. Of the various formulations tested, the liquid SNEDDS, composed of MCT (oil), Tween 80 (surfactant), and Labrafil M1944CS (cosurfactant) at a weight ratio of 20/70/10 produced the smallest emulsion droplet size (around 20.56±0.70 nm). Then, particle size, polydispersity, and zeta potential were measured using drugs containing liquid SNEDDS. The selected ticagrelor-loaded liquid SNEDDS was spray-dried to convert it into a ticagrelor-loaded solid SNEDDS with a suitable inert carrier, such as silicon dioxide, calcium silicate, or magnesium aluminometasilicate. The solid SNEDDS was characterized by scanning electron microscopy, transmission electron microscopy, and in vitro dissolution studies. SEM, PXRD, and DSC results suggested that amorphous ticagrelor was present in the solid SNEDDS. Also, the solid SNEDDS significantly increased the dissolution rate of ticagrelor. In particular, the emulsion particle size and the polydispersity index of the solid SNEDDS using silicon dioxide (SS1) as a carrier was the smallest among the evaluated solid SNEDDS, and the flowability and compressibility result of the SS1 was the most suitable for the manufacturing of solid dosage forms. Therefore, solid SNEDDS using silicon dioxide (SS1) could be a potential nano-sized drug delivery system for the poorly water-soluble drug ticagrelor.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2002.11b
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• pp.210-215
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• 2002

MR(Magnetorheogical) fluid composed of fine iron powders dispersed in silicon oil is utilized to many smart structures and devices because of its significant rheological property change by the application of an external magnetic field. When we deal with the shock wave attenuation of warship structures, we should be able to characterize the high frequency behavior of MR fluids. So far, however, many efforts have been focused on the material characterization of MR fluids at low frequencies below 100Hz. In this paper, the MR fluid property characterization at high frequency region is performed. An experimental setup based on wave transmission technique is made and the storage modulus as well as the loss modulus of MR fluids are found from the measured data of speed sound and attenuation. Details of the experiment are addressed and the obtained storage and loss moduli are addressed at $50kHz{\sim}100kHz$.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7537-7542
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• 2013

Background: Terpinen-4-ol, a monoterpene, is found as the main component of essential oil extracts from many plants. In this study apoptotic and autophagic types of cell death induced by terpinen-4-ol and associated mechanisms were investigated in human leukemic HL-60 cells. Materials and Methods: The cytotoxicity of human leukemic U937 and HL-60 cells was determined by MTT assay. Cytochrome c release, expression of Bax, Bcl-2, Bcl-xl and cleaved Bid were determined by Western blotting. Cell morphology was examined under a transmission electron microscope. LC3-I/II, ATG5 and Beclin-1 levels were detected by immunoblotting. Results: Terpinen-4-ol exhibited cytotoxicity to human leukemic HL-60 but not U937 cells. The apoptotic response to terpinen-4-ol in HL-60 cells was due to induction of cytochrome c release from mitochondria and cleavage of Bid protein after the stimulation of caspase-8. There was a slightly decrease of Bcl-xl protein level. The characteristic cell morphology of autophagic cell death was demonstrated with multiple autophagosomes in the cytoplasm. At the molecular level, the results from Western blot analysis showed that terpinen-4-ol significantly induced accumulation of LC3-I/II, ATG5 and Beclin-1, regulatory proteins required for autophagy in mammalian cells. Conclusions: Terpinen-4-ol induced-human leukemic HL-60 cell death was via both autophagy and apoptosis.

• Proceedings of the SAREK Conference
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• 2009.06a
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• pp.321-324
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• 2009

The unpredicted worldwide oil price makes the energy efficiency technology be more importance than any other period. The small cogeneration system is one of the most representative technology among the energy efficiency technologies, and recently, the household cogeneration system has been the center object of attention because of the loss of power transmission and the reasonable energy consumption relative to the household (condensing) boiler producing heat only. A tiny, 1kW of electrical output, gas fueled internal combustion engine cogeneration system was investigated. The electrical efficiency and thermal efficiency of the system were measured. With the emission characteristics, the cogeneration system was analyzed. It was showed the gas engine cogeneration system produced the lowest NOx level compared any other cogeneration system due to the three-way catalyst.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.1195-1196
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• 2008

최근, 친환경 물질이면서 광유에 비하여 발화점이 높은 식물성절연유에 대한 관심이 고조되고 있으며 식물성절연유변압기의 사용이 미주 등 해외시장에서 급격하게 증가되고 있다. 본 연구에서는 송전급 식물성절연유변압기 개발을 위하여 액체절연 매질의 고전압 시험법을 검토하고 전극 간 이격 거리에 따른 절연파괴 시험을 통하여 식물성절연유의 절연성능을 평가하였다. Weibull 분포와 전계해석을 이용하여 2% 절연파괴전압을 산출하고 전계분포를 계산하여 기존의 변압기 절연매질인 광유와 비교하였다. 본 연구 결과는 향후 식물성 절연유변압기 제작에 필요한 설계 자료로 활용될 것이다.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.23 no.11
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• pp.52-60
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• 2009

High reliability is essential for power transformers, and their fault causes are reportedly more related to mechanical causes than electrical ones. The transformer soundness judgment currently depends only on the electrical insulation characteristic and the chemical test of the insulation oil, so that there are few fundamental measures against the frequent mechanical damages and failures in transformers. The mechanical soundness judgment techniques are conducted through processes that include structural analysis and vibration resistance treatment during the manufacturing process of each manufacturer, but the vibration is not tested during the design, manufacturing, and operating processes since there are no detailed technical standards and procedures on the vibration problem, which are important in terms of maintenance. Therefore, in this study, vibration phenomena were measured from the 32 power transformers in operation in the substations under the Daejeon Power Transmission District Office of the Korean Electric Power Corporation (KEPCO). The vibration was measured at 24 sections ($6{\times}4$) on one side, and only the maximum values were selected from the measured vibration values. This was because the maximum vibration values more significantly affect the soundness of the transformer than the average vibration values. The vibration classes were given considering the maximum vibration based on ISO 10016-1 (2001).

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.19 no.7
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• pp.60-66
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• 2020

In order to improve fatigue life of transmission gear carburizing is normally used. Carburizing is a very good process to achieve low cost and high performance. The machined gears are heated up to carburizing temperature and then cooled rapidly in an oil bath to produce high surface hardness. The gears may undergo excessive thermal distortion during heating and rapid cooling. In order to predict the distortion during heating and rapid cooling, a coupled thermo-mechanical simulation is needed. In the current research, the simulation of heating and cooling was performed. The results show that the thermal distortion and the residual stresses are well predicted by the coupled simulation. In addition, induction heating and rapid cooling simulation is carried out to predict the thermal distortion. The amount of distortion is compared. It is shown that induction heating is very effective to reduce thermal distortion.

• Proceedings of the KSME Conference
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• 2001.06a
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• pp.453-458
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• 2001

Pipelines have the highest capacity and are the safest and the least environmentally disruptive way for gas or oil transmission. Recently, failures due to corrosion defects have become of major concern in maintaining pipeline integrity. A number of solutions have been developed for the assessment of remaining strength of corroded pipelines. However, these solutions are known to be dependent on material properties and pipeline geometries. In this paper, a Fitness-For-Purpose type limit load solution for corroded gas pipelines made of the X65 steel is proposed. For this purpose, a series of burst tests with various types of corrosion defects are performed. Finite element simulations are carried out to derive an appropriate failure criterion. And then, further, extensive finite element analyses are performed to obtain the FFP type limit load solution for corroded X65 gas pipelines as a function of defect depth, length and pipeline geometry. And also, a window based computer program far the assessment of corrosion defect, which is named as COPAP(COrroded Pipeline Assessment Program) has been developed on the basis of proposed limit load solution.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2003.11a
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• pp.324-328
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• 2003

Water-lubricated frictional characteristics of stainless steel ball bearing is not well known compared to oil-lubricated frictional characteristics. Furthermore study on friction at high temperature is rare because bearing maintenance strategy for water-lubricated or chemicals-lubricated bearings of equipment is mostly based on change of failed bearings and parts. Ball bearings and ball screw are installed on the power transmission for a developing integral reactor and these are lubricated with high temperature and high pressure chemically-controlled pure water. Bearings and power transmitting mechanical elements for an atomic reactor needs high reliability. and high performance during estimated lifetime, and it should be verified. In this paper, experimental research results of frictional characteristics of water-lubricated ball bearing as a preliminary investigation.

• Journal of Biosystems Engineering
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• v.36 no.3
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• pp.171-179
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• 2011

Facing the current hikes of labor wage and high oil price, it is needed to have energy-saving machinery which also enables us precise farm operations. Thus, it was necessary to develop a safe machine which allows secure and pleasant works along orchard slopes. In this study, a lifting utility with balance-controlled platform was developed. The platform utility could maintain to level the workbench while driving along slopes. Even the machine body was driven at the tilt angle ranges of ${\pm}20^{\circ}$, the platform bench could be maintained within ${\pm}0.5^{\circ}$ of a gimbal angle. In addition, the machine lifted up to 2.0 m using an electric-hybrid driving mechanism with a low noise. A tandem hybrid power source was developed with a DC 72 V, 100 AH for the Deep-Cycle batteries, charged with 3.5 kW gasoline generator as an auxiliary power source. HST, which is one of the CVT's, was adopted as a transmission device, and a crawer track was used for the safety of the vehicle against tip-over. The maximum lifting height of platform was is 2,500 mm, and the maximum extendable width was 2,900 mm.