• Asian Pacific Journal of Cancer Prevention
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• v.15 no.13
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• pp.5249-5252
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• 2014

Nogo protein, encoded by gene reticulon-4 (RTN4), includes three major isoforms by different splicing, named Nogo-A Nogo-B and Nogo-C. Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. RTN4 single nucleotide polymorphisms (SNPs) can influence the efficiency of transcription and translation thus being related with an individual's predisposition to cancer. The CAA insertion/deletion polymorphism (rs34917480) within RTN4 3'-UTR has been reported to be associated with many cancer types. In order to investigate the relationship between this polymorphism and susceptibility to non-small cell lung cancer (NSCLC) in the Chinese population, we conducted the present case-control study including 411 NSCLC patients and 471 unrelated healthy controls. The genotype distributions were significantly different between cases and controls (p=0.014). We found that the del allele could significantly increase NSCLC risk (ins/ins vs ins/del: p=0.007, OR 1.46, 95%CI=1.11-1.93; dominant model: p=0.004, OR 1.47, 95%CI=1.13-1.92 and allele model: p=0.008, OR 1.35, 95%CI=1.08-1.67). This association was stronger in participants over 60 years old, males and smokers. We therefore conclude that the CAA insertion/deletion polymorphism (rs34917480) contributes to non-small cell lung cancer risk in Chinese population. Age, sex and environmental exposure are also related to carcinogenic effects of rs34917480.

• Journal of the Korea Society for Simulation
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• v.21 no.1
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• pp.55-68
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• 2012

Recently it is important to understand service supply chain because the economy moves from manufacturing to services. However, most of existing supply chain research focuses exclusively on the manufacturing sector. To overcome this situation, it needs to investigate and analyze service supply chain. Simulation is one of the most frequently used techniques for analysis and design of complex system. Service supply chain is complex and large systems that require an accurate designing phase. Especially, it is important to examine closely the dynamically interactive behavior of the different service supply chain components in order to predict the performance of the servcie supply chain. In this paper, we develop a conceptual model of service supply chain. Then, we present a new procedure to develop simulation model for the developed conceptual model of service supply chain, based on the UML analysis and design tools and on the ARENA simulation language. The two main characteristics of the proposed procedure are the definition of a systematic procedure to design service supply chain and of a set of rules for the conceptual model translation in an ARENA simulation language. The goal is to improve the knowledge on service supply chain management and support the simulation model development efficiency on service supply chain.

• Journal of the Korea Institute of Building Construction
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• v.10 no.2
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• pp.97-104
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• 2010

This study evaluated the energy efficiency of a windows system using built-in blinds, with regard to their insulation performance and their blocking of solar radiation. The study took advantage of the "Physibel Voltra" program as a physical simulation of heat transfer. To simulate the "Physibel Voltra" program, I practiced a mock-up test to determine heating quality and translation condition. I analyzed the propensity to annual energy consumption, the annual quantity of heat transfer, and the annual cooling and heating cost through a computer simulation for one general household in an apartment building. In the test, it was found that compared to a general windows system, a windows system with built-in blinds reduced the annual heat transfer by 10% in cooling states and by 11% in heating states when the blind was up. When the blind was down, the windows system with built-in blinds reduced the annual heat transfer by 25% in cooling states and 30% in heating states. When a windows system with built-in blinds is compared with a general windows system, the quantity of cooling and heating loads is reduced by 283.3kw in cooling states and 76.3kw in heating states. This leads to a reduction in the required cooling and heating energy of 359.6kw per house. It is thus judged that the use of a windows system with built-in blinds is advantageous in terms of reducing greenhouse gas emissions, because the annual TOE (tons of oil equivalent) per house is reduced by 0.078TOE, while $tCO_2$ is reduced by $0.16tCO_2$. In addition, compared with a general windows system, the cost of cooling and heating loads in the system reduces the annual cooling cost by 100,000won, and the annual heating cost by 50,000won. Ultimately, this means that cooling and heating loads are cut by 150,000won per year.

• 대한공업교육학회지
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• v.32 no.1
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• pp.134-152
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• 2007

This study deals with the development of computer program which can restrict students to access to the unallowable web sites during the Internet based class. Our suggested program can find the student's access list to the unallowable sites, display it on the teacher's computer screen. Through the limitation of the student's access, teacher can enhance the efficiency of class and fulfill his educational purpose for the class. The use of our results leads to the effective and safe utilization of the Internet as the teaching tools in the class. Meanwhile, the typical method is to turn off the LAN (Local Area Network) power in order to limit the student's access to the unallowable web sites. Our program has been developed on the Linux operating systems in the small network environment. The program includes following five functions: the translation function to change the domain name into the IP(Internet Protocol) address, the search function to find the active students' computers, the packet snoop to capture the ongoing packets and investigate their contents, the comparison function to compare the captured packet contents with the predefined access restriction IP address list, and the restriction function to limit the network access when the destination IP address is equal to the IP address in the access restriction list. Our program can capture all passing packets through the computer laboratory in real time and exactly. In addition, it provides teacher's computer screen with the all relation information of students' access to the unallowable sites. Thus, teacher can limit the student's unallowable access immediately. The proposed program can be applied to the small network of the elementary, junior and senior high school. Our research results make a contribution toward the effective class management and the efficient computer laboratory management. The related researches provides teacher with the packet observation and the access limitation for only one host, but our suggested program provides teacher with those for all active hosts.

• Reproductive and Developmental Biology
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• v.32 no.3
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• pp.153-158
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• 2008

Tissue-specific and temporal regulation of milk protein gene expression is advantageous when creating transgenic animal that produces foreign protein into milk. Gene expression, i.e. protein production, is regulated not only by promoter strength but also mRNA stability. Especially, poly A tail length by polyadenylation affects in vivo and in vitro mRNA stability and translation efficiency of the target gene. In the present study, nucleotide sequence of 3'-UTR was analyzed to evaluate the effects of mRNA stability on the target gene expression. Based on the poly A signal of 3' -untranslated region (UTR), nucleotide sequences of putative cytoplasmic polyadenylation elements (CPEs) and downstream elements (DSEs: U-rich, G-rich, GU-rich) were analyzed and used to construct 15 luciferase reporter vectors. Each vector was transfected to HC11 and porcine mammary gland cell (PMGC) and measured for dual luciferase expression levels after 48 hours of incubation. Luciferase expression was significantly higher in construct #6 (with CPE 2, 3 and DSE 1 of exon 9) and #11 (with CPE 2, 3 and DSE 1, 2 and 3 of exon 9) than construct #1 in the PMGC. These results suggest that expression of target genes in PMGC may be effectively expressed by using the construct #6 and #11 on production of transgenic pig.