• Journal of Life Science
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• v.11 no.4
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• pp.362-370
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• 2001

Regulation of cell proliferation is a complex process involving the regulated expression and /or modification of discrete gene products. which control transition between different stages of the cycle. The purpose of this short review is to provide an overview of somatic cell cycle events and their controls. Cycline have appeared as major positive regulators in this network, because their association to the cyclin-dependent kinases(Cdks) allows the subsequent activation on the Cdk/cyclin complexes and their catalatic activity. In mammalian cells, early to mid G1 progression and late G1 progression leading to S phase entry are directed by D-type cyclins-Cdk4, 6 and cyclin E-Cdk 2 both of which can phosphorylate the retinoblastoma protein (pRB). pRB is a transcriptional repressor which, in its unphosphorylated state, binds to members of the E2F transcription factor family and blocks E2F-dependent transcription of genes controlling the G1 to S phase transition an subsequent DNA synthesis. Cyclin A is produced in late G1 and expressed during S and G2 phae, and expression of B-type cyclins is typically maximal during the G2 to M phase transition and it controls the passage through M phase. They primarily associate with the activate Cdk2, and Cdc2, respectively. On the other hand, the Cdk inhibitors negatively control the activity of C아/cyclin complex by coordinating internal and/or external signals and impending proliferation at several key checkpoints. These current and further findings will provide novel approaches to understanding and treating major diseases.

• Women's Health Nursing
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• v.17 no.3
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• pp.243-255
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• 2011

Purpose: This study was to provide understanding of the meaning of the transition experiences in pregnancy and childbirth among the married immigrant women. Methods: Data was collected through a face-to-face interview from 11 married immigrant women. Their conjugal lives were followed using the hermeneutics phenomenological method developed by van Manen: focusing on the meaning of lived experience. Results: The essential themes that were associated with the transition experiences of the participants' lives during pregnancy and childbirth were as follows: "entering a strange world filled with chaos and tension where they feel like outsiders", "being pregnant and giving birth in increasingly difficult times", "giving birth to a child, which strengthens them to persevere through painful life experiences", "receiving greater support from their families". Conclusion: It contributes a deeper understanding of the essence of the transition experiences of married immigrant women who undergo pregnancy and childbirth after immigration. On the basis of this understanding, this study would be likely to highlight the importance of establishing an appropriate health and medicare systems and the expert network of nursing care for immigrant wom.

• The Journal of Korean Academic Society of Nursing Education
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• v.25 no.1
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• pp.17-26
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• 2019

Purpose: This study was conducted to verify the validity and reliability of the modified Transition Shock Scale for use among nursing students. Methods: From March 8-April 3, 2018, 207 nursing students participated in this study and were asked to complete self-reported questionnaires, including transition shock, clinical stress, and adapting to clinical practicums. The IBM SPSS Win 18.0 and AMOS 18.0 programs were used for data analysis. Results: A confirmatory factor analysis supported good convergent and discriminant validities ($x^2/df=1.58$, TLI=.92, CFI=.95, RMSEA=.053, AVE=.51-.68, CR=.75-.68). Correlations among transition shock, clinical stress (r=.34, p<.001), and adapting to clinical practicums (r=-.54, p<.001) were significant. Cronbach's alpha for the overall scale was .85, and for the six subfactors it ranged from .65 to .75. Conclusion: The findings suggest that the 17-item transition shock questionnaire is an appropriate instrument for measuring nursing students' transition shock with good validity and reliability.

• Transactions of Materials Processing
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• v.13 no.5
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• pp.435-440
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• 2004

The temperature in hot forming of metallic materials, such as hot extrusion and hot forging, ranges from $300^{\circ}C$ to $900^{\circ}C$. Correspondingly, the die also exhibits high temperatures close to that of a work piece and its life is limited generally by high temperature fatigue. Thus, the analysis of high temperature fatigue would need the mechanical properties over the wide ranges of temperature. However, very few studies on the high temperature fatigue of brittle materials have been reported. Especially, the study on the fatigue behavior over such transition temperature regime is very rare. In this paper, the stress-strain curves and stress-life curves of a die steel such as STD61 are experimentally obtained. The wide ranges of temperature from $300^{\circ}C$ to $900^{\circ}C$ are considered in experiments and the transition temperature zone is carefully examined.

• Journal of Microbiology and Biotechnology
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• v.15 no.5
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• pp.965-970
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• 2005

In our previous study [14], we found that heat-shock exposure did not stimulate the neutral trehalase activity in Sacchromyces cerevisiae KNU5377, but did in ATCC24858. Consequently, the trehalose content in KNU5377 became 2.6 times higher than that in ATCC24858. Because trehalose has been shown to stabilize the structure and function of some macromolecules, the present work was focused to elucidate the relationship between trehalose content of these strains and thermal stabilities of whole cells, through differential scanning calorimetry (DSC), and to predict critical targets calculated from the hyperthermic cell killing rates. These analyses showed that the prominent DSC transition of both strains gave identical $T_m$ (transition temperature) values in exponentially growing cells, and that the $T_m$ values of critical targets was about $3^{\circ}C$ higher in KNU5377 than in ATCC24858. Both heat-shocked KNU5377 and ATCC24858 cells displayed similar shifts in their DSC transition profiles. On the other hand, the $T_m$ value of the critical target of KNU5377 was decreased by $2.1^{\circ}C$, which was still higher than ATCC24858 showing no changes. In view of these results, the intrinsic thermotolerance of KNU5377 did not appear to result from the stability of entire cellular components, but rather possibly from that of particular macromolecules, including critical targets, even though it should be investigated in more details. Although the trehalose levels in heat-shocked cells are significantly different, as described in our previous study [14], the overall pattern of thermal stabilities and their predicted critical targets in two heat-shocked strains seemed to be identical. These data suggest that the trehalose levels examined before and after heat shock of exponentially growing cells are not closely correlated with the stabilities of whole cells and/or critical targets in both yeast strains.

• Journal of the Korean housing association
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• v.16 no.5
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• pp.117-125
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• 2005

Since Mapo Apartment was introduced as a new urban housing type in the early sixties, apartment has been a typical urban housing in our country. In these days, according to various life-styles and new attitudes about the quality of life, apartment has been developed in various types like high rise residential complex and apartments with special themes. This study has been focused on the transition of modem urban housing in France. The origin of a word, apartment, has been defined and history of apartment in French urban life has been analyzed focusing on the common space and community facilities. Representative apartments in the 18th, 19th and 20th century were selected and comparatively analyzed. Especially in the 19th century, urban housing for working class had been a major concern among the communist and the bourgeoisie and has its own characteristics relative to each other. The characteristics shown in the apartment by the communist in France have been followed in the Korean apartments since 1960's, then the recent trends are rapidly changing in the housing market in Korea. Thus, the findings of this study can be very useful to understand the recent changes of diverse housing types in our society and also be very helpful to prospect our urban housing types in the future according to the changes of new lift styles.

• Journal of Families and Better Life
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• v.34 no.4
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• pp.51-75
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• 2016

This study focuses on the life experience of married women in their 30s to 40s who have experienced parental divorce. For a comprehensive understanding towards the women, this study takes a life history research approach. The participants of this research are 8 women who have experienced parental divorce and are now married with children. The data were gathered through in-depth interviews and were analyzed through the spiral of analysis, following the process of Wolcott's "description, analysis, and interpretation." The results of this study are as follows. First, participants experienced emotions such as fear, anger, and lack of affection. Second, parenting attitude and parental divorce had negative effects on the participants' formation and development of self concept and in turn, participants experienced anxiety and withdrawal from interpersonal relationships. Some had difficulties in concentrating on their schoolwork, which was caused by psychological effects from their instable home environments and some were negligent at school due to their parents' indifference or as an act of rebellion towards them. Third, although participants displayed interest towards the opposite sex, fear towards the opposite sex or unrealistic expectations led to difficulties in forming relationships. Participants also confessed that although they married so that they could escape their original family and form a new happy one, they experienced a rocky start at the beginning of their marriage. Fourth, parental divorce had a lifelong impact on children. Even after the children became adults, parental divorce affected each key stage of transition in life such as dating, choosing one's spouse, marriage, and child rearing. Fifth, participants displayed a strong attachment to life under the assumption that only they themselves can be depended on. This led to their strong commitments to a successful marriage without the possibility of divorce. In conclusion, parental divorce is not a transitory or incidental event. Rather, it becomes a part of the children's lives with lifelong implications.

• Journal of agriculture & life science
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• v.43 no.4
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• pp.15-20
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• 2009

The transition from pregnancy to lactation, commonly referred to as the "transition period" is characterized by dramatic changes in metabolic processes and their regulation in order to prepare the dairy cow for parturition and lactogenesis. An important adaptation to lactation is the increase in gluconeogenesis by the liver to meet the tremendous increase in demand of glucose for lactose synthesis, and the accumulation of lipid in adipose tissue during pregnancy, its mobilization that begins prior to lactation and the dramatic increase in plasma NEFA concentration early lactation. Epinephrine and insulin, the homeostatic regulators of metabolism are responsible for the adaptations of lipid and carbohydrate metabolism in support of milk production along with mobilization of body fat to meet overall energy demands because dry matter intake is insufficient to meet these demands during early lactation.

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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• 2004.11a
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• pp.73-80
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• 2004

The speed up of conventional lines feel strongly the necessity of it, for fully realizing a role of transportation system, for human life style is high, and increasing of time value. Especially curved lines zone have crucial effects on the speed of train. In this study, the extension method of transition curve is evaluated, based on the alignment of Jang-Hang line, investigated field conditions of the sections where the curves exist. The result of this research is very applicable to the condition where it is difficult to over-all alignment improvements.

• Journal of Ginseng Research
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• v.44 no.2
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• pp.300-307
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• 2020

Background: Emerging evidence suggests that endothelial-to-mesenchymal transition (EndMT) in endothelial dysfunction due to persistent inflammation is a key component and emerging concept in the pathogenesis of vascular diseases. Ginsenoside Rg3 (Rg3), an active compound from red ginseng, has been known to be important for vascular homeostasis. However, the effect of Rg3 on inflammation-induced EndMT has never been reported. Here, we hypothesize that Rg3 might reverse the inflammation-induced EndMT and serve as a novel therapeutic strategy for vascular diseases. Methods: EndMT was examined under an inflammatory condition mediated by the NOD1 agonist, γ-d-glutamyl-meso-diaminopimelic acid (iE-DAP), treatment in human umbilical vein endothelial cells. The expression of EndMT markers was determined by Western blot analysis, real-time polymerase chain reaction, and immunocytochemistry. The underlying mechanisms of Rg3-mediated EndMT regulation were investigated by modulating the microRNA expression. Results: The NOD1 agonist, iE-DAP, led to a fibroblast-like morphology change with a decrease in the expression of endothelial markers and an increase in the expression of the mesenchymal marker, namely EndMT. On the other hand, Rg3 markedly attenuated the iE-DAP-induced EndMT and preserved the endothelial phenotype. Mechanically, miR-139 was downregulated in cells with iE-DAP-induced EndMT and partly reversed in response to Rg3 via the regulation of NF-κB signaling, suggesting that the Rg3-miR-139-5p-NF-κB axis is a key mediator in iE-DAP-induced EndMT. Conclusion: These results suggest, for the first time, that Rg3 can be used to inhibit inflammation-induced EndMT and may be a novel therapeutic option against EndMT-associated vascular diseases.