• Title/Summary/Keyword: Transients

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Stoichiometry of $Ns^+/Ca^{2+}$ Exchange Quantified with Ion-selective Microelectrodes in Giant Excised Cardiac Membrane Patches

  • kang, Tong Mook;Hilgemann, Donald W.
    • Proceedings of the Korean Biophysical Society Conference
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    • 2003.06a
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    • pp.30-30
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    • 2003
  • Without a definitive resolution of stoichiometry of cardiac Na$^{+}$-Ca$^{2+}$exchange (NCX), we cannot proceed to any quantitative analysis of exchange function as well as cardiac excitation-contraction coupling. The stoichiometry of cardiac NCX, however, is presently in doubt because reversal potentials determined by various groups range between those expected for a 3-to-1 and a 4-to-1 flux coupling. For a new perspective on this problem, we have used ion-selective microelectrodes to quantify directly exchanger-mediated fluxes of $Ca^{2+}$and Na$^{+}$in giant membrane patches. $Ca^{2+}$- and Na$^{+}$-selective microelectrodes, fabricated from quartz capillaries, are placed inside of the patch pipettes to detect extracellular ion transients associated with exchange activity. Ion changes are monitored at various distances from the membrane, and the absolute ion fluxes through NCX are determined via simulations of ion diffusion and compared with standard ion fluxes (Ca$^{2+}$ fluxes mediated by $Ca^{2+}$ ionophore, and Na$^{+}$ fluxes through gramicidin channels and Na$^{+}$/K$^{+}$pumps). Both guinea pig myocytes and NCX1-expressing BHK cells were employed, and for both systems the calculated stoichiometries for inward and outward exchange currents range between 3.2- and 3.4-to-1. The coupling ratios do not change significantly when currents are varied by changing cytoplasmic [Ca$^{2+}$] or by adding cytoplasmic Na$^{+}$. The exchanger reversal potentials, measured in both systems under several ionic conditions, range from 3.1- to 3.3-to-1. Taken together, a clear discrepancy from a NCX stoichiometry of 3-to-1 was obtained. Further definitive experiments are required to acquire a fixed number, and the present working hypothesis is that NCX current has an extra current via ‘conduction mode’.ent via ‘conduction mode’.

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Effects of Alloying Elements(Cr, Mo, N) on Repassivation Characteristics of Stainless Steels Studied by the Abrading Electrode Technique and A.C Impedance Spectroscopy (마멸 전극 기법과 교류 임피던스법으로 연구한 스테인리스강의 합금원소(Cr, Mo, N)가 재부동태 특성에 미치는 영향)

  • Ham Dong-Ho;Kim Suk-Won;Lee Jae-Bong
    • Journal of the Korean Electrochemical Society
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    • v.3 no.4
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    • pp.211-218
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    • 2000
  • The effects of alloying elements, Cr, Mo, and N on repassivation characteristics of stainless steels were investigated by using the abrading electrode technique and a.c impedance spectroscopy. The role of alloying elements on the stability of passive film and their repassivation characteristics were examined using alloy steels such as Fe-Cr, Fe-Cr-Mo, 304, 304LN, 316, and 316LN. The electrochemical characteristics of the passive film were investigated by in-situ d.c. and a.c. electrochemical methods. Localized corrosion resistance is believed to have much to do with the stability and repassivation characteristics of the passive film. The effects of alloying elements on the current transients and repassivation kinetics were systematically examined by using the abrading electrode technique and a.c. impedance spectroscopy. The experimental results were analyzed in order to elucidate the relationship between passive film stability, repassivation characteristics, and alloying elements.

Cyclic Alternating Pattern : Implications for Insomnia (불면증에서 순환교대파형의 의미)

  • Cyn, Jae-Gong
    • Sleep Medicine and Psychophysiology
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    • v.17 no.2
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    • pp.75-84
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    • 2010
  • The cyclic alternating pattern (CAP) is a periodic EEG activity in NREM sleep, characterized by sequences of transient electrocortical events that are distinct from background EEG activities. A CAP cycle consists of two periodic EEG features, phase A and subsequent phase B whose durations are 2-60 s. At least two consecutive CAP cycles are required to define a CAP sequence. The CAP phase A is a phasic EEG event, such as delta bursts, vertex sharp transients, K-complex sequences, polyphasic bursts, K-alpha, intermittent alpha, and arousals. Phase B is repetitive periods of background EEG activity. The absence of CAP more than 60 seconds or an isolated phase A is classified as non-CAP. Phase A activities can be classified into three subtypes (A1, A2, and A3), based on the amounts of high-voltage slow waves (EEG synchrony) and low-amplitude fast rhythms (EEG desynchrony). CAP rate, the percentage of CAP durations in NREM sleep is considered to be a physiologic marker of the NREM sleep instability. In insomnia, the frequent discrepancy between self-reports and polysomnographic findings could be attributed to subtle abnormalities in the sleep tracing, which are overlooked by the conventional scoring methods. The conventional scoring scheme has superiority in analysis of macrostructure of sleep but shows limited power in finding arousals and transient EEG events that are major component of microstructure of sleep. But, it has recently been found that a significant correlation exists between CAP rate and the subjective estimates of the sleep quality in insomniacs and sleep-improving treatments often reduce the amount of CAP. Thus, the extension of conventional sleep measures with the new CAP variables, which appear to be the more sensitive to sleep disturbance, may improve our knowledge on the diagnosis and management of insomnia.

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Analysis on the Effect of LCR Filter to Mitigate Transient Overvoltage on the High Voltage Induction Motor Fed by Multi Level Inverter (멀티레벨 인버터 구동 고압유도전동기에시 발생하는 과도과전압 저감을 위한 LCR필터의 효과분석)

  • Kim, Jae-Chul;Kwon, Young-Mok
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.20 no.3
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    • pp.45-52
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    • 2006
  • In this paper, we analyze on the effect of LCR filter to mitigate transient overvoltage on the high voltage induction motor fed by H-bridge cascaded 7-level inverter. The switching surge voltage that it was occurred in inverter appears transient overvoltage at the motor input terminal. the transient overvoltage becomes the major cause to occur the insulation failure by serious voltage stress in the stator winding of high voltage induction motor. The effect of transient overvoltage appears more serious in high voltage induction motor than low voltage induction motor. We selected LCR filter for reduction of the transient overvoltage. Consequently, we demonstrated that the LCR filter connected to the invertor output terminals greatly reduces the transient voltage stress and ringing. The results of simulation show the suppression of transient overvoltage at the motor end of a long cable. using EMTP

Development of a Current-Type Electromagnetic Flowmeter to Obtain the Liquid Mean Velocity in Two-Phase Slug Flow (슬러그류 액상속도 측정용 전류형식 전자기유량계 개발)

  • Kang, Deok-Hong;Ahn, Yeh-Chan;Kim, Jong-Rok;Oh, Byung-Do;Kim, Moo-Hwan
    • Proceedings of the KSME Conference
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    • 2004.04a
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    • pp.1951-1956
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    • 2004
  • The transient nature and complex flow geometries of two-phase gas-liquid flows cause fundamental difficulties when measuring flow velocity using an electromagnetic flowmeter. Recently, a current-sensing flowmeter was introduced to obtain measurements with high temporal resolution (Ahn et $al.^{(1)}$). In this study, current-sensing flowmeter theory was applied to measure the fast velocity transients in slug flows. To do this, the velocity fields of axisymmetric gas-liquid slug flow in a vertical pipe were obtained using Volume-of-Fluid (VOF) method and the virtual potential distributions for the electrodes of finite size were also computed using the finite volume method for the simulated slug flow. The output signal prediction for slug flow was carried out from the velocity and virtual potential (or weight function) fields. The flowmeter was numerically calibrated to obtain the cross-sectional liquid mean velocity at an electrode plane from the predicted output signal. Two calibration parameters are required for this procedure: a flow pattern coefficient and a localization parameter. The flow pattern coefficient was defined by the ratio of the liquid resistance between the electrodes for two-phase flow with respect to that for single-phase flow, and the localization parameter was introduced to avoid errors in the flowmeter readings caused by liquid acceleration or deceleration around the electrodes. These parameters were also calculated from the computed velocity and virtual potential fields. The results can be used to obtain the liquid mean velocity from the slug flow signal measured by a current-sensing flowmeter.

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Fatigue Evaluation for the Socket Weld in Nuclear Power Plants

  • Choi, Young Hwan;Choi, Sun Yeong;Huh, Nam Soo
    • Corrosion Science and Technology
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    • v.3 no.5
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    • pp.216-221
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    • 2004
  • The operating experience showed that the fatigue is one of the major piping failure mechanisms in nuclear power plants (NPPs). The pressure and/or temperature loading transients, the vibration, and the mechanical cyclic loading during the plant operation may induce the fatigue failure in the nuclear piping. Recently, many fatigue piping failure occurred at the socket weld area have been widely reported. Many failure cases showed that the gap requirement between the pipe and fitting in the socket weld was not satisfied though the ASME Code Sec. III requires 1/16 inch gap in the socket weld. The ASME Code OM also limits the vibration level of the piping system, but some failure cases showed the limitation was not satisfied during the plant operation. In this paper, the fatigue behavior of the socket weld in the nuclear piping was estimated by using the three dimensional finite element method. The results are as follows. (1) The socket weld is susceptible to the vibration if the vibration levels exceed the requirement in the ASME Code OM. (2) The effect of the pressure or temperature transient load on the socket weld in NPPs is not significant because of the very low frequency of the transient during the plant lifetime operation. (3) 'No gap' is very risky to the socket weld integrity for the specific systems having the vibration condition to exceed the requirement in the ASME OM Code and/or the transient loading condition. (4) The reduction of the weld leg size from $1.09*t_1$ to $0.75*t_1$ can affect severely on the socket weld integrity.

An Analysis of the Transient's Social Behavior in the Radiological Emergency Planning Zone (방사선 비상계획구역에서의 일시거주자의 사회행동 특성 분석)

  • Bang, Sun-Young;Lee, Gab-Bock;Chung, Yang-Geun;Lee, Jae-Eun
    • Journal of Radiation Protection and Research
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    • v.32 no.2
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    • pp.71-78
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    • 2007
  • The purpose of this study is to analyze the social behavior, especially, the evacuation-related social behavior, of the transients in the radiological emergency planning zone(EPZ) of nuclear power plants. So, the meaning and kinds of the evacuation and the significance of the trip generation time(TGT) have been reviewed. The characteristics of the social behavior of the transient around Ulchin, Wolsong and Kori sites was analyzed through field surveys by using the questionnaire. The major findings of this research implications are as follows. First, for securing the safe evacuation, the alternatives to effectively provide the information on the evacuation warning may be prepared. Second, it is necessary to establish the education and training of transient's evacuation. Third, it is needed that the cause and background of the evacuation refusal are identified and the new response plan to secure transient's safety is prepared.

A Numerical Study of Flow Structure in Over-Expanded Rocket Nozzles

  • Yonezawa, Koichi;Yamashita, Yukinori;Tsujimoto, Yoshinobu;Watanabe, Yasuhide;Yokota, Kazuhiko
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • 2004.03a
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    • pp.165-172
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    • 2004
  • LE-7A is the main engine of the H-IIA launch vehicle. Under its development, the nozzle suffered from two troubles during startup and shutdown transients of the engine. One is a large side load, which damages the actuator of the nozzle, and the other is damage on regenerative cooling tubes due to high heat load. It has been considered that these problems are caused by a peculiar separation pattern called Restricted Shock Separation (RSS). RSS is observed in several rocket nozzles, for example, LE-7A nozzle, Vulcain nozzle and so on. Their contours are not conventional truncated perfect (TP) nozzle - LE-7A nozzle is a compressed truncated perfect (CTP) nozzle and Vulcain nozzle is a thrust optimized (TO) nozzle. Although it is believed that the occurrence of RSS is affected by the nozzle contour, the mechanisms are not clarified sufficiently yet. In the present paper, a parametric numerical study is carried out to investigate the mechanisms of the occurrence of RSS in CTP nozzles during startup transient. The results show that RSS is caused by the adverse pressure gradient downstream of the Mach disk. The adverse pressure gradient is caused by the interaction of the pressure wave and Mach disk. The method to avoid the occurrence of RSS is also examined. A small step inside the nozzle affects the position of the separation point and prevents RSS. The result shows that the possibility that RSS can be suppressed by controlling the position of the separation point.

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Sensitivity Analysis on PWR Reactivity Induced Accidents (가압경수로 반응도사고에 대한 민감도 분석)

  • Myung Hyun Kim;Un Chul Lee;Ki In Han
    • Nuclear Engineering and Technology
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    • v.14 no.3
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    • pp.122-137
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    • 1982
  • Analyzed is the sensitivity of reactor transient behavior to various reactor parameters during the reactivity induced accidents (RIA) of the Kori Unit 1. Included in the analysis is a partial spectrum of RIAs with relatively fast transients such as uncontrolled rod cluster control assembly bank withdrawl from a subcritical or low power startup condition and rod ejection accidents. The analysis can be performed generally in three steps: calculation of an average core power change, hot spot heat transfer calculation and DNBR (departure from nucleate boiling ratio) calculation. The computer codes used for the analysis are either developed based on the codes relevent to it. These codes are evaluated to be highly reliable. An extensive sensitivity analysis is performed to study the effects of various reactor design and operating parameters on the reactor transient behavior during the accidents. The assumptions and initial conditions used for the RIA analysis in the Kori Unit 1 FSAR (Final Safety Analysis Report) are reexamined, and the corresponding analysis results are reassessed, based on the sensitivity analysis results, to be conservative and reliable.

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Improving Accident Tolerance of Nuclear Fuel with Coated Mo-alloy Cladding

  • Cheng, Bo;Kim, Young-Jin;Chou, Peter
    • Nuclear Engineering and Technology
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    • v.48 no.1
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    • pp.16-25
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    • 2016
  • In severe loss of coolant accidents (LOCA), similar to those experienced at Fukushima Daiichi and Three Mile Island Unit 1, the zirconiumalloy fuel claddingmaterials are rapidlyheateddue to nuclear decay heating and rapid exothermic oxidation of zirconium with steam. This heating causes the cladding to rapidly react with steam, lose strength, burst or collapse, and generate large quantities of hydrogen gas. Although maintaining core cooling remains the highest priority in accident management, an accident tolerant fuel (ATF) design may extend coping and recovery time for operators to restore emergency power, and cooling, and achieve safe shutdown. An ATF is required to possess high resistance to steam oxidation to reduce hydrogen generation and sufficient mechanical strength to maintain fuel rod integrity and core coolability. The initiative undertaken by Electric Power Research Institute (EPRI) is to demonstrate the feasibility of developing an ATF cladding with capability to maintain its integrity in $1,200-1,500^{\circ}C$ steam for at least 24 hours. This ATF cladding utilizes thin-walled Mo-alloys coated with oxidation-resistant surface layers. The basic design consists of a thin-walled Mo alloy structural tube with a metallurgically bonded, oxidation-resistant outer layer. Two options are being investigated: a commercially available iron, chromium, and aluminum alloy with excellent high temperature oxidation resistance, and a Zr alloy with demonstratedcorrosionresistance.Asthese composite claddings will incorporate either no Zr, or thin Zr outer layers, hydrogen generation under severe LOCA conditions will be greatly reduced. Key technical challenges and uncertainties specific to Moalloy fuel cladding include: economic core design, industrial scale fabricability, radiation embrittlement, and corrosion and oxidation resistance during normal operation, transients, and severe accidents. Progress in each aspect has been made and key results are discussed in this document. In addition to assisting plants in meeting Light Water Reactor (LWR) challenges, accident-tolerant Mo-based cladding technologies are expected to be applicable for use in high-temperature helium and molten salt reactor designs, as well as nonnuclear high temperature applications.