• Journal of Yeungnam Medical Science
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• 제21권2호
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• pp.143-150
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• 2004

A thromboembolic stroke is believed to be precipitated by a rupture of vulnerable atheromatous plaques. Until recently the assessment of a further risk of stroke in high-risk patients in whom atherosclerosis has presented with a transient ischaemic attack (TIA), has been confined to a quantitative assessment of the luminal patency of the internal carotid artery. These traditional stratification parameters are no longer believed to be the most accurate predictors of a thrombo-embolism. This is because the process of vessel wall remodeling can maintain a luminal patency, and consequently, quite large friable plaques may remain unidentified. Accordingly, there is a need for an improved risk assessment. The fibrous cap of a vulnerable plaque is thinner, and an intraplaque hemorrhage and inflammation can occur during the development of atherosclerotic plaque. Several imaging methods for identifying vulnerable plaques have been developed. Recently, high resolution magnetic resonance (MR) imaging has emerged as an accurate non-invasive tool that can characterize the carotid plaque components in vivo. A High resolution carotid magnetic resonance is capable of distinguishing an intact, thick fibrous cap from a thin and ruptured cap in carotid plaque. In addition, a plaque MR can identify the active inflammation and detect a hemorrhage. High resolution carotid MR imaging is a valuable noninvasive method for quantifying the plaque components and identifying vulnerable plaque.

• 대한바이러스학회지
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• 제29권1호
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• pp.33-38
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• 1999

Retroviral vector provide a highly efficient method for gene transfer into eukaryotic cells. This vector system can be divided into two components; the retroviral vector itself and the retroviral packaging cell line. The key improvement in the design of these two components are, focused on two aspects; the reduction of helper virus production and high titer-virus. We used PA317 for retrovirus packaging cell line, for its high producibility of viral titer. To test the ability of the vectors to generate high titer-virus, we have chosen four different retroviral vectors; LN, LNSX, LNCX and LXSN. To test easily the viral titer, we have made recombinant construction with CD4 and CD8, checked their viral titer and stained their surface expression. LXSN which contain SV40 early promoter in front of neo gene showed best results in viral transient transfection assay, dot blot assay and surface expression. In addition, recombinant containing CD8 generally showed much higher viral titration and surface expression than CD4.

• Nuclear Engineering and Technology
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• 제46권5호
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• pp.655-666
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• 2014

The CUPID code has been developed at KAERI for a transient, three-dimensional analysis of a two-phase flow in light water nuclear reactor components. It can provide both a component-scale and a CFD-scale simulation by using a porous media or an open media model for a two-phase flow. In this paper, recent advances in the CUPID code are presented in three sections. First, the domain decomposition parallel method implemented in the CUPID code is described with the parallel efficiency test for multiple processors. Then, the coupling of CUPID-MARS via heat structure is introduced, where CUPID has been coupled with a system-scale thermal-hydraulics code, MARS, through the heat structure. The coupled code has been applied to a multi-scale thermal-hydraulic analysis of a pool mixing test. Finally, CUPID-SG is developed for analyzing two-phase flows in PWR steam generators. Physical models and validation results of CUPID-SG are discussed.

• Nuclear Engineering and Technology
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• 제47권5호
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• pp.567-578
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• 2015

In a nuclear reactor containment, wall condensation forms with noncondensable gases and their accumulation near the condensate film leads to a significant reduction in heat transfer. In the framework of nuclear reactor safety, the film condensation in the presence of noncondensable gases is of high relevance with regards to safety concerns as it is closely associated with peak pressure predictions for containment integrity and the performance of components installed for containment cooling in accident conditions. In the present study, CUPID code, which has been developed by KAERI for the analysis of transient two-phase flows in nuclear reactor components, is improved for simulating film condensation in the presence of noncondensable gases. In order to evaluate the condensate heat transfer accurately in a large system using the two-fluid model, a mass diffusion model, a liquid film model, and a wall film condensation model were implemented into CUPID. For the condensation simulation, a wall function approach with a heat/mass transfer analogy was applied in order to save computational time without considerable refinement for the boundary layer. This paper presents the implemented wall film condensation model, and then introduces the simulation result using the improved CUPID for a conceptual condensation problem in a large system.

• 수면정신생리
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• 제8권1호
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• pp.67-71
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• 2001

Independent Component Analysis (ICA) is a blind source separation method using unsupervised learning and mutual information theory created in the late eighties and developed in the nineties. It has already succeeded in separating eye movement artifacts from human scalp EEG recording. Several characteristic sleep waves such as sleep spindle, K-complex, and positive occipital sharp transient of sleep (POSTS) can be recorded during sleep EEG recording. They are used as stage determining factors of sleep staging and might be reflections of unknown neural sources during sleep. We applied the ICA method to sleep EEG for sleep waves separation. Eighteen channel scalp longitudinal bipolar montage was used for the EEG recording. With the sampling rate of 256Hz, digital EEG data were converted into 18 by n matrix which was used as a original data matrix X. Independent source matrix U (18 by n) was obtained by independent component analysis method ($U=W{\timex}X$, where W is an 18 by 18 matrix obtained by ICA procedures). ICA was applied to the original EEG containing sleep spindle, K-complex, and POSTS. Among the 18 independent components, those containing characteristic shape of sleep waves could be identified. Each independent component was reconstructed into original montage by the product of inverse matrix of W (inv(W)) and U. The reconstructed EEG might be a separation of sleep waves without other components of original EEG matrix X. This result (might) demonstrates that characteristic sleep waves may be separated from original EEG of unknown mixed neural origins by the Independent Component Analysis (ICA) method.

• 한국에너지공학회:학술대회논문집
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• 한국에너지공학회 1999년도 춘계 학술발표회 논문집
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• pp.171-176
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• 1999

Nondestructive inspection and accompanying life analysis based on fracture mechanics were the major conventional methods for evaluating remaining life of critical high temperature components in power plants. By using these conventional methods, it has been difficult to perform in-service inspection for life prediction. Also, quantitative damage evaluation due to unexpected abrupt changes in operating temperature was almost impossible. Thus, many efforts have been made for evaluating remaining life during operation of the plants and predicting real-time life usage values based on the shape of structures, operating history, and material properties. In this study, a core software for on-line life monitoring system which carries out real-time life evaluation of a critical component in power boiler(high temperature steam headers) is developed. The software is capable of evaluating creep and fatigue life usage from the real-time stress data calculated by using temperature/stress transfer Green functions derived for the specific headers and by counting transient cycles. The major benefits of the developed software lie in determining future operating schedule, inspection interval, and replacement plan by monitoring real-time life usage based on prior operating history.

• 조명전기설비학회논문지
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• 제29권5호
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• pp.71-79
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• 2015

Recently, new Low Voltage DC (LVDC) power distribution systems have been constantly researched as uses of DC in end-user equipment are increased. As in conventional AC distribution system, High Impedance Fault (HIF) which may cause a failure of protective relay can occur in LVDC distribution system as well. It, however, is hard to be detected since change in magnitude of current due to the fault is too small to detect the fault by the protective relay using overcurrent element. In order to solve the problem, this paper presents an algorithm for detecting HIF using accumulated energy in LVDC distribution system. Wavelet Singular Value Decomposition (WSVD) is used to extract abnormal high frequency components from fault current and accumulated energy of high frequency components is considered as the element to detect the fault. LVDC distribution system including AC/DC and DC/DC converter is modeled to verify the proposed algorithm using ElectroMagnetic Transient Program (EMTP) software. Simulation results considering various conditions show that the proposed algorithm can be utilized to effectively detect HIF.

• 한국펄프종이공학회:학술대회논문집
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• 한국펄프종이공학회 2006년도 PAN PACIFIC CONFERENCE vol.2
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• pp.209-213
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• 2006

Relationship between printability and rheological properties of UV flexographic (flexo) inks were investigated. UV flexo suspensions of carbon black in liquid medium having various binding materials such as acylate pre-polymer, di/multi-functional monomer, and diluents, were used as sample inks. Inks were characterized on a rheometer in terms of steady and dynamic behaviors. To understand the rheological properties of UV flexo inks, we must determine the specific rheological properties of chemical and/or physical interactions of their components (pigments, functional monomers, and pre-polymers). In particular, we discussed the influence of multi-functional monomers and the relationship between the rheological properties and transient networks formed by carbon black. In this study, we investigated the interrelationships between rheological properties of UV flexo inks and chemical and/or physical interactions of their components. To investigate correlations between the printability and the rheological behaviors induced by interfacial interactions between ink compositions, we carried out rheological tests of UV ink suspensions. The results were compared with printing tests so as to find out the relationship between printability and rheological properties of ink.

• BMB Reports
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• 제54권3호
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• pp.157-163
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• 2021

The transient interactions between cellular components, particularly on membrane surfaces, are critical in the proper function of many biochemical reactions. For example, many signaling pathways involve dimerization, oligomerization, or other types of clustering of signaling proteins as a key step in the signaling cascade. However, it is often experimentally challenging to directly observe and characterize the molecular mechanisms such interactions-the greatest difficulty lies in the fact that living cells have an unknown number of background processes that may or may not participate in the molecular process of interest, and as a consequence, it is usually impossible to definitively correlate an observation to a well-defined cellular mechanism. One of the experimental methods that can quantitatively capture these interactions is through membrane reconstitution, whereby a lipid bilayer is fabricated to mimic the membrane environment, and the biological components of interest are systematically introduced, without unknown background processes. This configuration allows the extensive use of fluorescence techniques, particularly fluorescence fluctuation spectroscopy and single-molecule fluorescence microscopy. In this review, we describe how the equilibrium diffusion of two proteins, K-Ras4B and the PH domain of Bruton's tyrosine kinase (Btk), on fluid lipid membranes can be used to determine the kinetics of homodimerization reactions.

• 한국추진공학회지
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• 제13권5호
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• pp.57-63
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• 2009

본 논문에서는 항공기 POD용 환경조절장치의 개발을 위한 모델링 및 시뮬레이션에 관한 연구를 수행하였다. 먼저, 시스템 요구성능을 분석하여 ACM 방식의 환경조절장치를 구성하고 성능모사를 위한 모델링을 수행하였다. 다음으로 각 구성품의 개념설계를 위해 주요구성품의 성능변화에 따른 민감도를 분석하고 시스템 요구성능을 만족하는 설계점 성능을 결정하였다. 다양한 비행환경에서의 탈설계 성능 모사를 통해 전체 운용영역에서의 개념설계 타당성을 검토하고 천이 성능해석을 통해 동적 거동특성을 분석하였다.