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The Effects of Eucommiae Cortex Pharmacopuncture Injected at Sinsu($BL_{23}$) on Neuropathic Pain in Rats (신유(腎兪)($BL_{23}$) 두중약침(杜仲藥鍼)이 흰쥐의 신경병리성 동통모델에 미치는 영향)

  • Lee, Dong Geun;Lee, Ook Jae;Lee, Ju Hee;Lee, Sang Hyun;Lee, Jung Hun;Shin, Jeong Cheol;Kim, Jae Hong
    • Journal of Acupuncture Research
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    • v.30 no.4
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    • pp.69-78
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    • 2013
  • Objectives : The purpose of this study is to examine whether Eucommiae Cortex pharmacopuncture may affect to the neuropathic pain in a rat model. Methods : To produce the model of neuropathic pain, under isoflurane 2.5 % anesthesia, underwent tight ligation by 6.0 silk thread and transection of the tibial and sural nerves, leaving the common peroneal nerve intact. After neuropathic surgery, the author examined if the exhibited the behavioral sign of allodynia. The allodynia was assessed by stimulating the plantar with Dynamic Plantar Aesthesiometer. Three days after the neuropathic surgery, Eucommiae Cortex pharmacopuncture was injected at Sinsu($BL_{23}$) once every week for 6 weeks. After that, the author examined the withdrawal response of neuropathic rats' leg by Dynamic Plantar Aesthesiometer. And also the author examined Bax, Bcl-2, Bax/Bcl-2 ratio in the spinal cord of neuropathic rats and the change of WBC, RBC, HGB, HCT count in the blood of neuropathic rats. Results : 1. The Eucommiae Cortex pharmacopuncture decreased the withdrawal response of mechanical allodynia that assessed with Dynamic Plantar Aesthesiometer in EC2-$BL_{23}$ group as compared with control group. 2. The Eucommiae Cortex pharmacopuncture decreased Bax/Bcl-2 ratio in EC1-$BL_{23}$, EC2-$BL_{23}$ group. But The Eucommiae Cortex pharmacopuncture injected at Sinsu($BL_{23}$) didn't change Bax, Bcl-2 expression level in the all group. 3. The Eucommiae Cortex pharmacopuncture decreased WBC count in EC1-$BL_{23}$, EC2-$BL_{23}$ group. Conclusions : We have noticed that Eucommiae Cortex pharmacopuncture decreased mechanical allodynia in the model of neuropathic pain compared with the control group. Bax/Bcl-2 ratio in spinal cord of that group was also decreased compared with the control group. This study can be used as a basic resource on a study and a treatment of neuropathic pain.

Two Cases of Fractured and Embolized Implanted Central Venous Chemoports in Lung Cancer (폐암환자에서 발생한 피하매몰 중심정맥포트 골절 및 색전증 2예)

  • Ju, Jin Yung;Cho, Jae Yeong;Lim, Jung Hwan;Cho, Gye Jung;Chae, Dong Ryeol;Oh, In Jae;Kim, Kyu Sik;Kim, Yu Il;Lim, Sung Chul;Kim, Young Chul;Song, Sang Yoon;Na, Kook Ju;Kim, Yun Hyun;Kim, Jae Kyu
    • Tuberculosis and Respiratory Diseases
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    • v.63 no.5
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    • pp.449-453
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    • 2007
  • Totally implanted central venous access devices for chemotherapy (chemoport) are being used increasingly in lung cancer patients. Vascular catheters are associated with various complications including infection, thrombosis as well as spontaneous fractures and embolization of the catheter, which is known as 'pinch-off syndrome'. 'Pinch-off syndrome' refers to the compression of a subclavian central venous catheter between the clavicle and first rib resulting in an intermittent or permanent obstruction, which can lead to tears, transection, or embolization. We report two cases of fractured and embolized implanted subclavian venous catheters in which the fragments were removed percutaneously. A 62-year-old man presented with back pain with a duration of a few weeks. The chest radiograph revealed complete transsection and embolization of the catheter into the right atrium. In addition, a 47-year-old woman with a chemoport had a grade 3 pinch-off sign in a chest radiograph demonstrating complete transsection and embolization of the catheter into the pulmonary artery. Both cases were managed by retrieving the embolized distal fragment percutaneously and removing the proximal section of the catheter.

A taxonomic study on six section subgenus Vigena Nees of Carex L. (Cyperaceae) in Korea (한국산 괭이사초아속(subgen. Vignea Nees) 6절의 분류 형질에 관한 연구)

  • Oh, Yong Cha;Jo, Mi Jung
    • Korean Journal of Plant Taxonomy
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    • v.33 no.3
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    • pp.227-253
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    • 2003
  • Morphological characters of C. kobomugi, C. gibba, C. echinata. C. remotiuscula. C. maakii. C. curta, and C. loliacea of genus Carex were rexamined. The epidermal patterns of perigynium, achene and leaf were investigated using by a scanning electron microscope(SEM) and a light microscope(LM). Morphological characters. such as length and width of stem and leaf, sheath, bract, spike, scale, perigynium, beak of perigynium, length of spike peduncle, size, and frequency of stomatal complex of leaf, number of bract, shape of stem transection, scale and apex of scale, beak and base of perigynium, achene, epidermal cell and cell wall of perigynium, achene, leaf epidermal patterns (fundamental epidermal cell and cell wall, silica body, subsidiary cell), hair, papillae, prickle present/absent of perigynium and leaf were useful for the identification of observed seven taxa. Examined six taxa of section Macrocephalae, Gibbae, Stellulatae, Elongatae, Ovales, and Heleonates were distint from each other with respect of length and width stem, leaf, bract, perigynium, perigynium beak, lenght of spike peduncle, perigynium, and leaf. A key based on data was presented here.

A Study on Developing the TCP/IP Application Communication Protocol for the Standard Traffic Signal Controller (표준규격 교통신호제어기에서 TCP/IP 통신프로토콜 제정방안 연구)

  • Han, Won-Sub;Hyun, Cheol-Seung;Lee, Ho-Won;Joo, Doo-Hwan;Lee, Choul-Ki
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.8 no.5
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    • pp.71-84
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    • 2009
  • The communication between the center system and the local controller in the Traffic Signal Controller Specification has been specified by a communication line for the exclusive use and the analog modem serial protocol. Therefore, it can't be adapted in the ITS communication network of the TCP/IP protocol being constructed in the local city. The international and domestic ITS device's communication specification has adapted the DATEX-ASN data exchange technique based on the ethernet communication network. So, this study was performed by the purpose of developing the application communication protocol's standard draft based on the TCP/IP communication protocol for the traffic signal controller, to be able to constitute the traffic signal control system in the ITS communication network. The communication format for 23 items of control, status, and database request etc. which are specified in the standard traffic signal controller was developed by appling the DATEX-ASN data interface procedure and structure which are KS ISO X 14827 Part1, 2, ISO/ DIS 15784 Part-3. To test the developed protocol, the application program for the communication items was developed and according to the test result, the encoding and the decoding transection for all communication items was possible.

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Arthroscopic Reduction of Subluxed Medial Meniscus using Suture Anchor for Restoration of Hoop Stress - Technical Note - (버팀테응력 회복을 위한 아탈구된 내측 반월상 연골의 Suture anchor를 이용한 정복술 - 술기 보고 -)

  • Kim, Jaw-Hwa;Lee, Yoon-Seok;Kim, Chul;Han, Seung-Chul
    • Journal of the Korean Arthroscopy Society
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    • v.13 no.3
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    • pp.280-284
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    • 2009
  • Purpose: The authors introduce a new technique of arthroscopic reduction of subluxed medial meniscus using suture anchor for the restoration of hoop stress. Operative Technique: Anterolateral, anteromedial, and medial midpatellar arthroscopic portal are used. Arthroscope was inserted through anterolateral portal. Through the scope, we confirmed subluxation of medial meniscus. Transection of menisci including radial and root tear were excluded. We released the anterior horn of medial meniscus through anteromedial and burred the future insertion site of suture anchor. After inserting suture anchor through medial midpatellar portal, we used 90 degree suture hook and no.2 Nylon to retrieve the suture of inserted anchor. We tied the suture by sliding knot-tying method. Weight bearing was limited for 6 weeks postoperatively. Conclusion: Arthroscopic retightening of medial meniscus is less invasive, conserving and progressed method for subluxed meniscus.

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A taxanomic study on sections Foetidae, Arenariae, and Multiflorae of Carex L. in Korea(Cyperaceae) (한국산 사초속 진퍼리사초절, 까락사초절과 괭이사초절에 관한 분류학적 연구)

  • Oh, Yong Cha;Kim, Ji Hye
    • Korean Journal of Plant Taxonomy
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    • v.32 no.3
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    • pp.257-292
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    • 2002
  • Morphological characters of sections Foetidae(one taxon), Arenariae(one taxon) and Multiflorae(six taxa) of genus Carex(Cyperaceae) were reexamined. The epidermal patterns of perigynium, achene and leaf were investigated using by a scanning electron microscope(SEM) and a light microscope(LM). Morphological characters, such as length and width of stem, leaf, leaf sheath, bract, spike, scale, perigynium and beak of perigynium, length of spike peduncle, size and frequency of stomatal complex of leaf, number of bract, shape of stem transection, scale and apex of scale, beak and base of perigynuim, achene, epidermal cell and cell wall of perigynium, achene, leaf epidermal patterns(fundamental epidermal cell and cell wall, silica body, subsidiary cell), hair, papillae present/absent of perigynium, and leaf were useful for the identification of observed eight taxa. According to the current study, examined eight taxa of sections Foetidae, Arenariae and Multiflorae were distinct from each other with respect to length and width of stem, leaf, bract, perigynium, perigynium beak, length of spike peduncle, shape of bract, scale and apex of scale, perigynium, perigynium beak, hair presence/absence of perigynium and leaf. A key based on data was presented here.

A Prognostic Factor for Prolonged Mechanical Ventilator-Dependent Respiratory Failure after Cervical Spinal Cord Injury : Maximal Canal Compromise on Magnetic Resonance Imaging

  • Lee, Subum;Roh, Sung Woo;Jeon, Sang Ryong;Park, Jin Hoon;Kim, Kyoung-Tae;Lee, Young-Seok;Cho, Dae-Chul
    • Journal of Korean Neurosurgical Society
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    • v.64 no.5
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    • pp.791-798
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    • 2021
  • Objective : The period of mechanical ventilator (MV)-dependent respiratory failure after cervical spinal cord injury (CSCI) varies from patient to patient. This study aimed to identify predictors of MV at hospital discharge (MVDC) due to prolonged respiratory failure among patients with MV after CSCI. Methods : Two hundred forty-three patients with CSCI were admitted to our institution between May 2006 and April 2018. Their medical records and radiographic data were retrospectively reviewed. Level and completeness of injury were defined according to the American Spinal Injury Association (ASIA) standards. Respiratory failure was defined as the requirement for definitive airway and assistance of MV. We also evaluated magnetic resonance imaging characteristics of the cervical spine. These characteristics included : maximum canal compromise (MCC); intramedullary hematoma or cord transection; and integrity of the disco-ligamentous complex for assessment of the Subaxial Cervical Spine Injury Classification (SLIC) scoring. The inclusion criteria were patients with CSCI who underwent decompression surgery within 48 hours after trauma with respiratory failure during hospital stay. Patients with Glasgow coma scale 12 or lower, major fatal trauma of vital organs, or stroke caused by vertebral artery injury were excluded from the study. Results : Out of 243 patients with CSCI, 30 required MV during their hospital stay, and 27 met the inclusion criteria. Among them, 48.1% (13/27) of patients had MVDC with greater than 30 days MV or death caused by aspiration pneumonia. In total, 51.9% (14/27) of patients could be weaned from MV during 30 days or less of hospital stay (MV days : MVDC 38.23±20.79 vs. MV weaning, 13.57±8.40; p<0.001). Vital signs at hospital arrival, smoking, the American Society of Anesthesiologists classification, Associated injury with Injury Severity Score, SLIC score, and length of cord edema did not differ between the MVDC and MV weaning groups. The ASIA impairment scale, level of injury within C3 to C6, and MCC significantly affected MVDC. The MCC significantly correlated with MVDC, and the optimal cutoff value was 51.40%, with 76.9% sensitivity and 78.6% specificity. In multivariate logistic regression analysis, MCC >51.4% was a significant risk factor for MVDC (odds ratio, 7.574; p=0.039). Conclusion : As a method of predicting which patients would be able to undergo weaning from MV early, the MCC is a valid factor. If the MCC exceeds 51.4%, prognosis of respiratory function becomes poor and the probability of MVDC is increased.

Proteinases and their Inhibitors in Cartilage and Synovial Fluid Acquired from a Canine Osteoarthritic Model (개 퇴행성 관절염 모델을 이용한 연골과 활액 내 단백질 분해 효소와 억제제의 작용 연구)

  • Seo, Jae-Won;Lee, Hae-Beom;Kim, Nam-Soo;Lee, Young-Hoon;Kang, Hyung-Sub;Kim, In-Shik;Park, Sang-Youel
    • Journal of Veterinary Clinics
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    • v.26 no.2
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    • pp.144-149
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    • 2009
  • Chondrocytes and synovial fluid derived markers are used to monitor for osteoarthritis(OA). Specific inhibitors, known as tissue inhibitors of metalloproteinases(TIMP), regulate the proteolytic activity of matrix metalloproteinases(MMP). This study investigated whether MMP and TIMP levels were altered in synovial fluid and cartilage following the experimental induction of OA in canines. Twenty mature beagle dogs underwent a unilateral surgical transection of the cranial cruciate ligament and the medial collateral ligament as well as a medial meniscectomy. Matrix metalloproteinase-2 and MMP-9 levels were assayed using Western blot and TIMP-2 levels were measured with enzyme-linked immunosorbent assays four weeks after OA induction. Increased MMP-2 expression was observed in chondrocytes isolated from cartilage following OA induction, but MMP-9 expression decreased. Matrix metalloproteinase-2 and MMP-9 levels in synovial fluid from the OA induced joint significantly increased compared to those of the sham group. Tissue inhibitors of metalloproteinase-2 concentrations were higher in chondrocytes from the OA cartilage, yet TIMP-2 remained lower in the synovial fluid of OA. This suggests the elevated release of MMP-9 over MMP-2 into the synovial fluid following the cartilage degradation-related death of chondrocytes after OA. Osteoarthritis can be further deteriorated by increased MMP activity in the synovial fluid because TIMP-2 exist low concentration into the extracellular matrix. As a result, MMP activity, particularly MMP-9 activity, can be useful as a biomarker in diagnosing and monitoring the early stages of canine OA.