• Molecules and Cells
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• 제44권5호
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• pp.342-355
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• 2021

The microphthalmia-associated transcription factor family (MiT family) proteins are evolutionarily conserved transcription factors that perform many essential biological functions. In mammals, the MiT family consists of MITF (microphthalmia-associated transcription factor or melanocyte-inducing transcription factor), TFEB (transcription factor EB), TFE3 (transcription factor E3), and TFEC (transcription factor EC). These transcriptional factors belong to the basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. The best studied functions of MiT proteins include lysosome biogenesis and autophagy induction. In addition, they modulate cellular metabolism, mitochondria dynamics, and various stress responses. The control of nuclear localization via phosphorylation and dephosphorylation serves as the primary regulatory mechanism for MiT family proteins, and several kinases and phosphatases have been identified to directly determine the transcriptional activities of MiT proteins. In different immune cell types, each MiT family member is shown to play distinct or redundant roles and we expect that there is far more to learn about their functions and regulatory mechanisms in host defense and inflammatory responses.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2003년도 The Korea-Japan Plastics Processing Joint Seminar
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• pp.1-6
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• 2003

In injection molding of an optical disk, a toric lens, etc., their performance depends on the transcription preciseness of fine surface structure of a mold. However, transcription behavior has not been made clear yet, because transcription is made in very short time and the structure is very small. In this paper, transcription properties have been examined, by using V-grooves of various sizes. machined on mold surfaces, and the following results are obtained. (1) Transcription properties have been made clear experimentally and it was found that the mold temperature $T_D$ makes great influence on the transcription property and that compression applying time $t_c$ should be taken more than 2.0s for fine transcription. (2) A mechanical model of transcription process, in consideration with strain recovery due to viscoelastic property of polymer. is proposed. (3) Simulation results agree with experimental ones fairly well. It means that the transcription model is useful for estimation of transcription property in advance of an actual. injection molding.

• 대한의생명과학회지
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• 제29권3호
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• pp.103-108
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• 2023

Enhancers are cis-elements to regulate transcription of cell/tissue-specific genes in multicellular organisms. These elements locate in upstream or downstream regions of target genes and are found in a long distance up to 100 Kb in some cases. Transcription factors and coactivators bind to enhancers in a chromatin environment. Enhancers appear to facilitate the transcription of target genes by communicating with promoters and activating them. As transcription activation mechanism of enhancers, chromatin looping between enhancers and promoters, tracking of enhancer activity to promoters along the intervening regions, and movement of enhancers and promoters into transcription condensates have been suggested based on various molecular and cellular biology studies. These mechanisms are likely to act together rather than exclusive each other for gene transcription. Understanding of enhancer action mechanism may provide a way to regulate the transcription of cell/tissue-specific genes relating with aging or various diseases.

• 한국컴퓨터산업학회논문지
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• 제3권5호
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• pp.585-594
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• 2002

본 논문에서는 음성인식의 후처리를 위한 음가-표기 변환표의 생성과 구현에 관한 연구를 수행하였다. 음절 단위 음가를 인식하는 음성인식 시스템을 위한 후처리를 위하여 인식된 음가로 발음되는 표기 집합을 생성하는 표기 집합 생성기를 설계 구현하였다. 표준 발음법을 페트리넷으로 모델링하여 생성된 표기-음가 변환표를 기반으로 음가표기 변환표를 생성하였다. 음가-표기 변환표가 올바른 표기 집합을 생성함을 보이기 위하여 표기 집합 생성기를 설계 구현하고, 표준 발음법 예제와 발음법 사전에서 무작위로 추출된 단어에 대하여 실험한 결과 발성 이전의 표기가 포함된 올바른 표기 집합이 생성됨을 입증하였다.

• 한국지능시스템학회논문지
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• 제24권3호
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• pp.323-329
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• 2014

구어 연구에서는 음성 데이터를 문자로 옮기는 전사(Transcription)라는 과정이 필요하다. 전사 작업을 보조하는 프로그램을 전사도구라고 하는데, 발화 내용을 비롯하여, 발화 시간, 화자 정보 등의 많은 정보를 기록하는 다양한 기능을 제공한다. 이로 인하여 컴퓨터 사용에 익숙하지 않은 사용자는 숙지하는데 어려움이 있다. 또한 전사 도구는 국내에서 개발된 것이 거의 없어서 한국어 환경에 적합하지 않는 경우가 많다. 본 논문에서는 효율적인 한국어 전사를 지원하면서 비숙련자도 도구를 쉽고 빠르게 적응할 수 있는 전사 도구를 제안한다. 이를 위해 비숙련자를 위한 사용자 친화적인 인터페이스 환경을 제공한다. 또한 전사 과정에서 발생할 수 있는 실수를 최소화하기 위해 전사 지원 기능을 제공한다. 마지막으로 데이터 신뢰성을 위한 시스템 구조를 제공한다. 제안하는 도구에 대해 전사 경험의 유무에 따라 사용성 평가를 하였으며, 평가결과는 전체적으로 전사 속도 향상 및 전사 지원 기능이 편리한 것으로 나타났다.

• 음성과학
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• 제10권4호
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• pp.23-40
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• 2003

This paper examines transcription of sounds from a phonological perspective. It has found that most of transcriptions have been done on a segmental basis alone, without consideration of the whole phonological systems and levels, and without a full understanding of the nature of the linguistic and phonetic alphabets. In a word, sound transcriptions have not been done on the basis of the phonology of the language and the alphabet. This study shows a phonological model for transcribing foreign and native sounds, suggesting ways of improving some of the current transcription systems such as the Hangeul transcription of loan words and the romanization of Hangeul, as well as the phonetic transcription of English and other foreign languages.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 하계학술대회 논문집 D
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• pp.1812-1814
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• 1999

The effects of polarity of the polymer on transcription-aligned twisted nematic (TN)-liquid crystal display (LCD) on various the polyimide (PI) surfaces were investigated. The monodomain alignment of nematic (N)LC is obtained in cells fabricated by transcription alignment method on PI surface with medium polarity. The LC alignment using transcription alignment method is attributed to polarity of the polymer. The threshold voltage of transcription-aligned TN-LCD decreases with increasing the polarity of the polymer on three kinds of the PI surfaces. The threshold voltage of transcription-aligned TN-LCD on PI surface with high polarity is almost the same compared to rubbing-aligned TN-LCD. The response time of transcription-aligned TN-LCD decreases with the increasing the polarity of the polymer on all PI surfaces. The decay time of transcription-aligned TN-LCD is slow compared with the rubbing-aligned TN-LCD.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2006년도 춘계학술대회 논문집
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• pp.81-85
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• 2006

In this study, we have been examined nano Injection Molding process which can improve transcription of 100nm-level pattern. We changed the various parameter (temperature of injection mold, clamp force, temperature of nozzle) which can be influence for improving transcription. And we measured and analyzed shapes of 100nm-level pattern by Automic Force Microscope for proving transcription. We made the Blu-ray Disc sample for proving transcription. And we measured HF-Signal and jitter. As a result, when the temperature of mold is more than $120^{\circ}C$ and the clamp force is more than 10 ton, We reached over 95 percent of transcription compared with stamper pattern. And we reached in-spec. value for HF-Signal and Jitter. Then we reached over 95 percent of transcription compared with stamper pattern.

• BMB Reports
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• 제35권4호
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• pp.409-413
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• 2002

Thioltransferase, also known as glutaredoxin, is an enzyme that catalyzes the reduction of a variety of disulfide compounds. In Schizosaccharomyces pombe, two thioltransferases were reported and the cDNA of one of the thioltransferases (thioltransferase-1) was cloned. Using a Northern blot assay, we investigated the thioltransferase transcription in response to various stress conditions. When the culture was shifted to a high temperature, the thioltransferases transcription was not significantly changed compared to the unshifted $30^{\circ}C$ culture. Treatment of zinc chloride to exponentially-growing cells remarkably increased the thioltransferase transcription, whereas the treatment of mercury chloride greatly reduced the transcription. Treatment of hydrogen peroxide and cadmium chloride caused no significant effects on the transcription of the thioltransferase. These results suggest that the transcription of thioltransferase-1 in S. pombe is induced in response to metal stress that is caused by zinc chloride, but not in response to heat stress or oxidative stress that is caused by hydrogen peroxide.

• 생명과학회지
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• 제17권4호
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• pp.593-598
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• 2007

Amino acids of histone tail are covalently modified in eukaryotic cells. Lysine residues in histone H3 and H4 are methylated at three levels; mono-, di- or trimethylation. Methylation in histones is related with transcription of the genes in distinct pattern depending on lysine residues and methylated levels. Relation between transcription and methylation has been relatively well understood at three lysines H3K4, H3K9 and H3K36. H3K4 is methylated in active or potentially active chromatin and its methylation associates with active transcription. H3K9 is generally methylated in heterochromatin or repressed gene, but trimethylation of this lysine occur in actively transcribed genes also. Methylation at H3K36 generally correlates with active chromatin/transcription, but the correlation of its dimethylation with transcription is controversial. All together methylation patterns of individual lysine residues in histone relate with activation or repression of transcription and may provide distinctive roles in transcriptional regulation of the eukaryotic genes.