• Korean Journal of Environment and Ecology
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• v.12 no.4
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• pp.398-405
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• 1999

This study was carried out to investigate exercise load of visitors and physical condition of stairway in the trail of Keumsan located in Hallyo-Haesang National Park. Total trail length of Keumsan is 2,126m, and the number of step-trail section are 15, and the total length of step-trail section is 1,000.4m. Average gradient of step-trail was 20~40%. But the gradient and length were 45.7% and 268.5m in the section 11, and 58.4% and 188.6m in the section 12. The greatest gradient was 67.8% in the section 13. During the climbing in trail, heart rate were 104~184beats/min.. And in the step-trail section 11, 12, and 13, IHR, ELI, and %HRmax were 166.5%, 89.1%, 92.9%, and 167.4%, 89.6%, 93.2%, and 157.8%, 84.5%, 89.9%, respectively.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4819-4822
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• 2013

Background: Lung cancer is the leading cause of cancer mortality in the world. Many factors can protect against or facilitate its development. A TNF family member TRAIL, has a complex physiological role beyond that of merely activating the apoptotic pathway in cancer cells. Vitamin D is converted to its active form locally in the lung, and is also thought to play an important role in lung health. Our goal was to investigate the possible clinical significance of serum sTRAIL and 1,25-dihydroxyvitamin D(3) levels in patients with non-small cell lung cancer (NSCLC). Materials and Methods: Totals of 18 consecutive adenocarcinoma and 22 squamous cell carcinoma patients with stage-IV non-small cell lung cancer referred to our institute were included in this study. There were 12 men and 6 women, with ages ranging from 38 to 97 (mean 60.5) years with adenocarcinoma, and 20 men and 2 women, with ages ranging from 46 to 80 (mean 65) years with squamous cell carcinoma. Serum levels of sTRAIL and 1,25-dihydroxyvitamin D(3) were measured in all samples at the time of diagnosis. Results: sTRAIL levels in NSCLC patients were higher than in the control group. Although there was no correlation between patient survival and sTRAIL levels, the highest sTRAIL levels were correlated with age and cigarette smoking in the adenocarcinoma patients. sTRAIL level in healthy individuals were correlated with serum 1,25-dihydroxyvitamin D(3). Conclusions: Serum sTRAIL concentrations were increased in NSCLC patients, and correlated with age and smoking history, but not with overall survival.

• Korean Journal of Veterinary Research
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• v.49 no.1
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• pp.1-8
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• 2009

The ubiquitin-proteasome mediated protein degradation pathway plays an important role in regulating both cell proliferation and cell death. Proteasome inhibitors are well known to induce apoptosis in various human cancer cell lines. We investigated the effect of combined treatment with proteasome inhibitor and TRAIL, and a possible mechanism of the enhancing apoptosis by the both treatment, on TRAIL-resistant non-small cell lung cancer. A549 cells were exposed to the N-Acetyl-Leu-Leu-Norleu-al (ALLN) as a proteasome inhibitor and then treated with recombinant TRAIL protein. In A549 cells under proteasome inhibition conditions by pretreatment with ALLN, TRAIL treatment significantly decreased cell viability compared to that ALLN and TRAIL alone treatment. Also, the both treatment induced cell damage through DNA fragmentation and p53 expression. In addition, the combined treatment of both markedly increased caspase-8 activation, especially the exposure for 2 h, and Bax expression and induced the dissipation of mitochondrial transmembrane potential in A549 cells. Taken together, these findings showed that proteasome inhibition by ALLN enhanced TRAIL-induced apoptosis via DNA degradation by activated P53 and mitochondrial transmembrane potential loss by caspase-8 activation and bax expression. Therefore, our results suggest that proteasome inhibitor may be used a very effectively chemotherapeutic agent for the tumor treatment, especially TRAIL-resistant tumor cell.

• Journal of Korean Society of Forest Science
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• v.94 no.6
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• pp.351-361
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• 2005

This study compared the results of Importance-Performance Analysis (IPA) on trail managerial conditions by trail section in Mudeung-Mountain Provincial Park. The study also examined the validity of using overall survey method (OSM: analyzing IPA from the data collected from all the trails without separating trails by section) by comparing the OSM results with those obtained from the survey by section. A total of 258 users who visited the Park was surveyed using questionnaire in the four designated trail sections during the September of 2000. The result of IPA showed that there are differences in twenty three attributes out of the 26 selected attributes (88.5%) among four trail sections. The overall IPA results obtained from the total of four trail sections were not the same with the IPA results from each trail section in twenty three attributes (88.5%) out of the 26 selected attributes. It suggests that we need to use a survey segmented by trail sections rather than a survey for overall trails to obtain better information for more efficient trail management.

• Korean Journal of Environment and Ecology
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• v.7 no.2
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• pp.241-251
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• 1994

Use impacts on environmental deteriorations were studied on the four major trails and a campsite of Tokyuksan National Park in 1993. The entire width, bare width, maximum depth and slope of trail as the trail condition were significantly greater on the more heavily used trail. Percentages of rock-exposed, deepening, root-exposed points as the deterioration types of trail which were surveyed at the total of 106 points were higher and trail conditions were significantly different from those of non-deteriorated points. On the Paekryon trail, the damaged area more severe than Class 4 reaches about 910$m^2$/km and the use impact and deterioration on campsites were accelerated. The dominant trees of the the upper and lower layer in trail edge vegetation could be Quercus serrata and Acer pseudo-sieboldianum for Paekryon trail, Q. mongolica and Tripterigium regelii for the other trails. A. pseudo-sieboldianum, Q. serrata, Rhus trichocarpa, Fraxinus sieboldiana, Lespedeza maximowiczii, Symplocos chinensis for Pilosa were classified for tolerant species to use impacts.

• Journal of agriculture & life science
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• v.46 no.1
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• pp.17-27
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• 2012

The purpose of this study is to analyze the trail deterioration condition and to obtain the information for the desirable maintenance and restoration of trail in national parks. The results obtained from this study were summarized as follows; The physical characteristics of trail were surveyed at the total 778 point for 204.5 km in length. As a result, the average degree of trail was $14.6^{\circ}$, average trail width was 1.5m and average bared trail width was 1.1 m. Major deterioration types of trail were trail deepen (37%), root exposed, widen, diverged, rock exposed and slope erosion in order of frequency. Deterioration class of trail were that non-deterioration was 165.34 km (80.9%), heavy class was 9.08 km, middle class was 12.69 km and light class was 17.39 km and the deterioration rate was 19.1%.

• Journal of Life Science
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• v.30 no.8
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• pp.661-671
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• 2020

The resistance of cancer cells to anti-cancer drugs is the leading cause of chemotherapy failure. The clinical use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been gradually extended to cancer treatment through combination with anti-cancer drugs. In the current study, we investigated whether NSAIDs including celecoxib (CCB), 2,5-dimethyl celecoxib (DMC), and ibuprofen (IBU) could enhance the cytotoxic effects of imatinib and TNF-related apoptosis inducing ligand (TRAIL) on human cancer cells. We found that the NSAIDs potentiated TRAIL and imatinib cytotoxicity against human hepatocellular carcinoma (HCC) cell lines SNU-354, SNU-423, SNU-449, and SNU-475/TR and against leukemic K562 cells with high level of CD44 (CD44^highK562), respectively. More specifically, CCB induced endoplasmic reticulum stress via up-regulation of ATF4/CHOP which is associated with the induction of autophagy against HCC and CD44^high K562 cells. NSAID-induced autophagic activity accelerated TRAIL cytotoxicity of HCC cells through up- and down-regulation of DR5 and c-FLIP, respectively. The NSAIDs also potentiated imatinib-induced cytotoxicity and apoptosis through down-regulation of markers in CD44^highK562 cells that express a stemness phenotype. Our results suggest that the ability of NSAIDs to induce autophagy could enhance the cytotoxicity of TRAIL and imatinib, leading to a reverse resistance to these drugs in the cancer cells. In conclusion, NSAIDs in combination with low-dose TRAIL or imatinib may constitute a novel clinical strategy that maximizes therapeutic efficacy of each drug and effectively reduces the toxic side effects.

• Journal of the Korean Institute of Landscape Architecture
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• v.40 no.6
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• pp.60-69
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• 2012

The project on Geonjisan Universal Design Forest Trail in Jeonju City was designed and constructed by an NGO called 'Jeonbuk Forest for Life' which was a winner for the '2008 Open Competition by the 'Committee for Greening Society' established in Korea Land Corporation. The purpose of this study is to evaluate the design satisfaction of UD forest trail. Post Occupancy Evaluation (POE) method was applied to measure the user satisfaction and the total number of users. The main result of the study were as follows: the major users of the Geonjisan UD forest trail were people aged over 60 years old(37%) and the main purpose of trail usage were to 'walk and rest'(51.5%) and to 'exercise and rehabilitation' (40.6%). Furthermore, the overall user rating for the UD forest trail design was "satisfied"(3.91 point in 5-point Likert Scale). The three most influencing factors of the overall user satisfaction were facility management, user conflict, and trail width and slope. About forty-five people were found to be End-user in the UD forest trail while six people were found as End-user in non-UD trails. Most importantly, the number of End-user observed on the UD forest trail was greater than the number found in non-UD forest trail. The result implies that the UD forest trail attracts more End-users and provides opportunity for gathering and interaction with the other users. Moreover, the satisfaction rate for the UD forest trail landscape is found to be high in Likert scale, which we can assume that the well-grown existing trees and topographic features as well as appropriately designed wood-paths influence the high satisfaction rate of the users. The POE of UD forest trail revealed the importance of universal design concept due to its convenient uses of the handicapped, old, weak, pregnant woman or children.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.29 no.3
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• pp.33-39
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• 2011

The purpose of this study is to present the raw data for establishing the conservation and restoration trail about Wolseong by objective and systematical trail deterioration in Wolseong as UNESCO, world heritage site, Gyeongju-si, Korea. To accomplish the purpose, not only trail condition such as altitude, entire width, bare width, maximum depth and slope of trail, but also deterioration types of trail were surveyed at the total 97 points for 2.145km in length on the 11 access trails to Wolseong. Major deterioration types of trail were root exposure(48%), rock exposure(40%), trail deeping(9%) in order of frequency. To grasp the deterioration condition of the trail, assessment on impact rating class of trail that the 11 access trail were investigated. Putting these results together informs us that the deterioration condition of the trail in Wolseong is reached the level of grave concern yet, prompt countermeasure to maintain the existing condition has to be considered with regard for the conditions of location and the containing amounts of use.

• Journal of Korean Society of Forest Science
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• v.110 no.1
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• pp.91-105
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• 2021

We conducted a study to identify the relationships between the investigated factors and provide a methodology and generate data by applying deterioration classes to the Seonjaryeong Forest Trail (4.3 km) in the Baekdudaegan Ridge. The average trail width (1.7 m) and bare width (1.4 m) were wider than those obtained in the previous studies. The frequency of trail deterioration was also high. Specific data on deterioration classes were obtained and evaluated using qualitative criteria. Specific data for heavy class stands at 20.1% in trail grade, 13.3 cm on average, and 16.1 cm in the center of erosion depth, 16.2 cm of CSA, 12.3 kg/cm (20.1 mm) on average and maximum 39.3 kg/cm (29.6 mm) of soil hardness. We observed a positive correlation between the deterioration class and trail grade, and the average and maximum soil erosion depths of the hill side were deeper than those of the ridge. The soil hardness data showed a statistically significant difference in terms of the transect site and calculation method (㎏/㎠, mm). Therefore, trail deterioration was observed at the sites having ≥20% trail grade; thus, continuous monitoring at fixed sites over time will be required for sustainability. Furthermore, the trail grade should be of the utmost priority in trail design and management.