• Natural Product Sciences
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• v.23 no.3
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• pp.217-221
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• 2017

Eleven compounds (1-11) were isolated from the rhizomes of Osmunda japonica, and their structures were elucidated based on $^1H$, $^{13}C-NMR$ and LC-IT-TOF MS data. Of these compounds, all compounds (1 - 11) have been previously reported, although five (6 - 9, 11) have not previously been isolated from this plant. The antioxidant activities of isolated compounds (1 - 11) were measured by DPPH and ABTS assays, and compound 10 showed the high antioxidant activity.

• The Journal of Korean Medicine
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• v.44 no.4
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• pp.14-25
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• 2023

Objectives: South Korea, the United States, and the United Nations have imposed extensive economic sanctions against North Korea, which increased the use of traditional Korean medicine in North Korea to maintain its national health care system. This study attempts to study the latest trends of traditional Korean medicine research through bibliographic analysis of one of the North Korean medical journals. It will then provide insights into how traditional Korean medicine is used in North Korea. Methods: This study is based on 611 clinical research articles out of 931 articles extracted from 13 volumes of Koryo Medicine (2016 ~ 2019). The articles were classified according to the researched treatment, diseases and use alongside conventional drugs. Results: Based on the analysis of Koryo Medicine, the proportion of clinical research articles investigating the treatment effects was very high (65.6%). Also, clinical research using herbal medicine as treatment was the most common, accounting for 17.69% of the total. Some of the clinical research in Koryo Medicine were conducted in tandem with conventional drug treatment, especially on acupuncture. Conclusion: This study conducted a bibliographic analysis of Koryo Medicine to understand the current status of traditional Korean medicine within North Korea. The analysis identified main diseases, treatment methods, and integration with conventional drugs in the clinical research of traditional Korean medicine. As a country actively seeking to use traditional Korean medicine, North Korea will become an interesting field of global traditional medicine and complementary medicine research.

• Journal of Ginseng Research
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• v.46 no.6
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• pp.759-770
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• 2022

Background: Aerobic cellular respiration provides chemical energy, adenosine triphosphate (ATP), to maintain multiple cellular functions. Sirtuin 1 (SIRT1) can deacetylate peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) to promote mitochondrial biosynthesis. Targeting energy metabolism is a potential strategy for the prevention and treatment of various diseases, such as cardiac and neurological disorders. Ginsenosides, one of the major bioactive constituents of Panax ginseng, have been extensively used due to their diverse beneficial effects on healthy subjects and patients with different diseases. However, the underlying molecular mechanisms of total ginsenosides (GS) on energy metabolism remain unclear. Methods: In this study, oxygen consumption rate, ATP production, mitochondrial biosynthesis, glucose metabolism, and SIRT1-PGC-1α pathways in untreated and GS-treated different cells, fly, and mouse models were investigated. Results: GS pretreatment enhanced mitochondrial respiration capacity and ATP production in aerobic respiration-dominated cardiomyocytes and neurons, and promoted tricarboxylic acid metabolism in cardiomyocytes. Moreover, GS clearly enhanced NAD⁺-dependent SIRT1 activation to increase mitochondrial biosynthesis in cardiomyocytes and neurons, which was completely abrogated by nicotinamide. Importantly, ginsenoside monomers, such as Rg1, Re, Rf, Rb1, Rc, Rh1, Rb2, and Rb3, were found to activate SIRT1 and promote energy metabolism. Conclusion: This study may provide new insights into the extensive application of ginseng for cardiac and neurological protection in healthy subjects and patients.

• Journal of Korean Medical classics
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• v.23 no.6
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• pp.15-26
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• 2010

Objective This is a previous study for including traditional Korean medical terms into the UMLS(The Unified Medical Language System) and achieving the interoperability between various medical systems. Method First, the traditional medical terms were divided into 4 categories : basic theory, acupuncture, herb and formulae. And then, searching these terms through metathesaurus in UMLSKS(UMLS Knowledge Source Server), terminology information was investigated and analyzed. Results In the case of TM title, traditional Korean medicine was categorized as different semantic type from Traditional medicine, Traditional Chinese medicine and Kampo medicine. Acupuncture points were described only as abbreviation and herbs were conceptualized inconsistently, as some belonged to scientific name and some belonged to Chinese pronunciation. Formulaes are described as Chinese, Japanese and Korean pronunciations. Conclusions More research is needed on diagnosis/disease terms and semantic types for the unique concepts in traditional Korean medicine in order to including the international standard.

• Journal of Ginseng Research
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• v.46 no.2
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• pp.315-319
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• 2022

• Proceedings of the Korean Nutrition Society Conference
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• 2003.05a
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• pp.269.1-269.1
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• 2003

• Korean Journal of Oriental Medicine
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• v.8 no.2 s.9
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• pp.67-74
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• 2002

The Objective of this study was to investigate present conditions of research institutes on traditional medicine in China, Chinese taipei, Japan and U.S.A. The subject institutes were China academy of traditional chinese medicine, National research institute of chinese medicine, Oriental medicine research center of the Kitasato institute, Institute of natural medicine in Toyama medical and pharmaceutical university, National center for complementary and alternative medicine. Various publications printed by each institute were collected and each web site wis searched. For further analysis, Interviews with managers and researchers of each institute were carried out.

• Advances in Traditional Medicine
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• v.8 no.1
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• pp.17-23
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• 2008

While full recognition of the practical value of Traditional Chinese Medicine is being endorsed, the current stand on the research methodology of this field should be worked out. Since modern medicine has already developed a logical system of research methodology basing on the principles of deduction, any research on any system of medicine need to take reference to what is most popularly used and commonly recommended. The best way to approach research on Chinese Medicine, therefore, would be one that would take full reference to the methodology being used in modern medicine, while at the same time respecting the traditional approach. This would enable traditional medicine to be elevated to the level of general modern recognition. Nevertheless, innate problems in traditional medicine are making its research difficult. The problems lie in difficulties to achieve uniform herb supply, principles of randomization and placebo arrangements, uncertain chemical structures and toxicology etc. A practical approach centered on carefully planned evidence-based clinical trials, with parallel studies on biological activities and herb authentication is being recommended.

• The Journal of Korean Medicine
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• v.32 no.2
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• pp.79-91
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• 2011

Objectives: The purpose was to study the market of traditional Korean medical devices and survey, list and number medical devices in traditional Korean medical clinics. Methods: we researched in three ways. 1. We investigated the list of devices regarded as traditional Korean medical devices in 'Report on production, export, and import of medical devices.' 2. We investigated the statistics of medical devices equipped in traditional Korean medical clinics through the website of the Health Insurance Review & Assessment Service. 3. We surveyed medical devices in traditional Korean medical clinics by mail. Results: 1. We could not directly investigate the market for traditional Korean medical devices because they were not categorized as such ('traditional Korean medical devices'). 2. The number of medical devices in traditional Korean medical clinics has increased alongside the increase of traditional Korean medical clinics. 3. Traditional Korean medical clinics hold over 64,962 medical devices and have below 50 percent of traditional Korean medical diagnosis devices. 4. Meridian function testing machines, pulse diagnosis devices, and yangdorak showed ranking of equipment-ratio equal to ranking of insurance fees. Conclusions: Traditional Korean medical device regulations should be enacted following definitive and concrete Korean traditional medical concepts by the Korean traditional medical society.

• The Journal of Korean Medicine
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• v.33 no.2
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• pp.56-63
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• 2012

Objectives: To undertake manpower-related improvements based on a comparison between specialists in the traditional Korean medicine hospitals(TKMH) and their counterparts in Western medicine Methods: A survey of the TKMH based on questionnaire sheets dispatched to them by mail(57 of 142 responded) in the June December, 2008 period, and on almanac statistics provided by the Ministry for Health, Welfare and Family Affairs of Korean Government. Results: Overall, the workforce engaged in the traditional Korean medicine hospitals comprises traditional Korean medical doctors(28%), nurses(23%), administrative staffs(19%), assistant nurses(9%), medical record keepers(2%), nutritionists(2%), herbal pharmacists(1%), and others(16%). Each hospital has 16.5 traditional Korean medical doctors on average, which can be broken down into 6.2 specialists, 1.3 generalists, and 9.3 residents/interns. Only 10.7% of whole of traditional Korean medical doctors work in the hospitals, compared to 54.5% of Western medicine doctors. The ratio of traditional Korean medical doctors to the entirety of employees in the TKMH is 2.5 times higher than their Western medicine counterparts, while the ratio of medical technicians to the entire employees in the TKMH is 20 times lower than in the Western medicine counterparts. Conclusions: To provide more qualified medical service in the TKMH, they will be required to increase the proportion of non medical doctor employees, like Western medicine counterparts.