• Parasites, Hosts and Diseases
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• 제59권3호
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• pp.311-317
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• 2021

The present study reports a rare case of Taenia saginata infection, which was initially diagnosed as acute cholecystitis in a Tibetan patient at the Qinghai-Tibetan Plateau pastoral area, China. A 45-year-old female was initially diagnosed with acute cholecystitis at a hospital in China. She had a slight fever, weight loss and constipation and complained of pain in the upper abdomen and left back areas. Increase of monocyte, eosinophil and basophil levels were shown. Taenia sp. eggs were detected in a fecal examination. An adult tapeworm approximately 146 cm in length, whitish-yellow color, was collected from the patient after treatment with traditional Chinese medicine. The adult tapeworm had a scolex and proglottids with genital pores. The scolex was rectangular shape with 4 suckers and rostellum without hooklet. The cox1 gene sequence shared 99.5-99.8% homology with that of T. saginata from other regions in China. The patient was diagnosed finally infected with T. saginata by morphological and molecular charateristics.

• 대한예방한의학회지
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• 제19권2호
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• pp.113-121
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• 2015

Objective : This study was aimed to classify diseases that Traditional Chinese Medicine(TCM) is better at treating. Method : Literature was searched on China National Knowledge Infrastructure(CNKI) and categorized according to literature type, published date and research method. Studied six types of research papers and four types of published books. Results : Experts were surveyed and interviewed, medical records were studied retrospectively, and doubleblind method was used in selecting diseases that TCM was better at treating. There were a total of 372 diseases that TCM was better at treating. By the KCD classification, 45 were in gastrointestinal (12.1%), 39 in urogenital (10.5%), 36 in circulatory (9.7%), 35 in musculoskeletal or connective tissues (9.4%). Conclusion : Total of 372 diseases were classified as diseases that TCM was better at treating, and if the results are used adequately, the values of western and TCM can be maximized and benefit the government, patients and the medical practitioners.

• 대한한의학원전학회지
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• 제22권4호
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• pp.241-247
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• 2009

Body constitution research in Korean traditional medicine adopt the diagnosis and treatment theory of "image-differentiation[body constitution differentiation, disease differentiation] in combination with syndrome differentiation diagnostic model and symptoms and signs of herbal property belong to image" as its core, which is key national medical science research project of State Administration of Traditional Chinese Medicine, the project brought up 4 key scientific problem ? body constitution differentiation theory, correlation theory of body constitution and disease, body constitution adjustable theory and symptoms and signs of herbal property belong to image theory. In body constitution pathology, it brought up "correlation between body constitution and symptoms", "differentiation between body constitution and symptoms" which increase the diagnostic level and diagnostic accuracy rate. In the condition of pathology, it obviously has low reliability according to body constitution differentiation, sometimes happen the description not comply with body constitution and disease symptoms, which lead to decrease the clinic diagnostic and treatment level, treatment effect not satisfying too. Now taking 4 key scientific achievement as criterion to illustrate the body constitution and disease symptoms.

• 대한예방한의학회지
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• 제19권1호
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• pp.47-59
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• 2015

Objective : The purpose of this study was to analyze the trend of clinical research on 'mild and sub-clinical depressions' in China. Method : The journal search was performed using China National Knowledge Infrastructure(CNKI). Our inclusion criteria were as follows: TCM clinical trials for mild, sub-clinical, early stage of depression. Exclusion criteria were the following: non-TCM clinical trials, disease-associated depression related clinical trials. Results : We included 16 papers in this study. 1. In this study, we realized there have been several mild and sub-clinical depressions related clinical trials conducted in the field of TCM. 2. The result of 10 Journals used the Hamilton Depression Rating Scale for diagnosis and assessment criteria of mild and sub-clinical depressions. 3. The selected journals categorized by various interventions, such as, herbal medicine(7), acupuncture(4), miscellaneous(5). 4. Also, 7 Journals showed the significant improvements in patients with mild and sub-clinical depressions by TCM interventions, and 5 studies of TCM patent prescription reported that herbal medicine therapy has less side effect than the western medicine. Conclusion : Through this study, we found out that several researchers in China performed clinical trials on mild and sub-clinical depressions constantly. From the result of this study, we need to concern about the necessity of research on the mild and sub-clinical depression in Korea. Therefore, this result could be used as a meaningful reference for the design of future clinical trials.

• 대한한방부인과학회지
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• 제32권4호
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• pp.55-66
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• 2019

Objectives: This review is to figure out evidence that suggests the effectiveness of Korean Medicine treatments against Human Papilloma virus (HPV) infection and Cervical Dysplasia. Methods: Studies on HPV infection and cervical dysplasia were searched through 5 databases: Oriental Medicine Advanced Searching Integrated System (OASIS), Korean Studies Information Service System (KISS), the Journal of Korean Obstetrics & Gynecology, China Academic Journal (CAJ), Pubmed. After that, the articles were extracted with reference point of Korean Traditional Medicine. Results: 21 studies were included lastly according to selection criteria. In 21 studies, HPV turning - negative rate of Korean Medicine treatment group was higher than the control treatment group. Conclusions: 21 studies indicates that Korean Medicine treatment is effective in HPV infection and Cervical Dysplasia.

• Molecules and Cells
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• 제39권12호
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• pp.869-876
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• 2016

Cantharidin (CTD) is an active compound isolated from the traditional Chinese medicine blister beetle and displayed anticancer properties against various types of cancer cells. However, little is known about its effect on human chronic myeloid leukemia (CML) cells, including imatinib-resistant CML cells. The objective of this study was to investigate whether CTD could overcome imatinib resistance in imatinib-resistant CML cells and to explore the possible underlying mechanisms associated with the effect. Our results showed that CTD strongly inhibited the growth of both imatinib-sensitive and imatinib-resistant CML cells. CTD induced cell cycle arrest at mitotic phase and triggered DNA damage in CML cells. The ATM/ATR inhibitor CGK733 abrogated CTD-induced mitotic arrest but promoted the cytotoxic effects of CTD. In addition, we demonstrated that CTD downregulated the expression of the BCR-ABL protein and suppressed its downstream signal transduction. Real-time quantitative PCR revealed that CTD inhibited BCR-ABL at transcriptional level. Knockdown of BCR-ABL increased the cell-killing effects of CTD in K562 cells. These findings indicated that CTD overcomes imatinib resistance through depletion of BCR-ABL. Taken together, CTD is an important new candidate agent for CML therapy.

• 동의생리병리학회지
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• 제30권4호
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• pp.209-218
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• 2016

The objective of this study was to investigate the diagnosis and treatment of Retinal vein occlusion such as syndrome differentiation and herbal medicine by reviewing Chinese traditional medicine`s journals. The journal search was carried out using China National Knowledge Infrastructure and Pubmed from January 2000 to December 2014. Searching key words were the various combination of "Retinal vein occlusion", "traditional chinese medicine", "syndrome differentiation". The final selection of 11 studies were selected and summarized by researchers. The effective rate was significantly higher than control but, methodological quality of the trials was generally low questioning their liability. The syndrome differentiation was classified as hyperactivity of liver yang and blood stasis. The most frequently prescribed herbal medication was Hyulbuchookeotang, Boyanghwanotang and Cheomagudeungum. This finding could be widely utilized in future clinical practice and form the basis for the development of clinical practice guidelines in advance.

• 한방비만학회지
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• 제19권1호
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• pp.56-67
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• 2019

Objectives: The purpose of this study is to review clinical studies of herb medicine and acupuncture treatment on obesity in menopausal women. Methods: Key words "Obesity", "Menopause", "Herb medicine", "Acupuncture", "Moxibustion", "Catgut embedding" were searched on 9 database systems (PubMed Central, Cochrane Controlled Register of Trials, Embase, China Academic Journals, Korean Traditional Knowledge Portal, Oriental Medicine Advanced Searching Integrated System, Korean Studies Information Service System, National Digital Science Library, DBpia) on April 30th 2019. Results: 1 case report and 17 clinical trials were collected in accordance with the selection and exclusion criteria. Among the 17 trials, 6 were randomized controlled trials, 1 was controlled clinical trial, and 10 were single-arm trials. The types of intervention were herb medicine, electroacupuncture, acupuncture, auricular acupuncture, warm needle acupuncture, moxibustion, laser acupuncture, and catgut embedding. The study design, study results and method of intervention were analyzed. Conclusions: 1 case report described the effectiveness of pharmacopuncture, 4 trials described the effectiveness of herbal medicine, 2 of electroacupuncture, 1 of laser acupuncture, and 2 of catgut embedding. Among the 17 trials, 2 studies showed that herbal medicine treatment was more effective than no treatment or selective serotonin reuptake inhibitors, and 1 study showed that electroacupuncture was more effective than hormone therapy. All of 18 selected studies reported the effectiveness of weight reduction and abdominal obesity reduction after the traditional Korean medicine treatment for obesity in menopausal women.

• The Korean Journal of Physiology and Pharmacology
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• 제27권3호
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• pp.221-230
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• 2023

Diabetic kidney disease is one of the most serious complications of diabetes. Although diabetic kidney disease can be effectively controlled through strict blood glucose management and corresponding symptomatic treatment, these therapies cannot reduce its incidence in diabetic patients. The sodium-glucose cotransporter 2 (SGLT2) inhibitors and the traditional Chinese herb "Gegen" have been widely used in diabetes-related therapy. However, it remains unclear whether the combined use of these two kinds of medicines contributes to an increased curative effect on diabetic kidney disease. In this study, we examined this issue by evaluating the efficacy of the combination of puerarin, an active ingredient of Gegen, and canagliflozin, an SGLT2 inhibitor for a 12-week intervention using a mouse model of diabetes. The results indicated that the combination of puerarin and canagliflozin was superior to canagliflozin alone in improving the metabolic and renal function parameters of diabetic mice. Our findings suggested that the renoprotective effect of combined puerarin and canagliflozin in diabetic mice was achieved by reducing renal lipid accumulation. This study provides a new strategy for the clinical prevention and treatment of diabetic kidney disease. The puerarin and SGLT2 inhibitor combination therapy at the initial stage of diabetes may effectively delay the occurrence of diabetic kidney injury, and significantly alleviate the burden of renal lipotoxicity.

• 한국한의학연구원논문집
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• 제1권1호
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• pp.29-46
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• 1995

In the literature study by the comparative method was carried out on the book of an Introduction to oriental medicine, which was published in China, recently. The results were as follows: The contents of the book was divided by Introduction, Um-Yang-O-Hang(陰陽五行), Qi-Hyul-Chinec(氣血津液), Jang-Bu(臟腑學說), Meridian(經絡), Etiology, Diagnosis, and treatment. This study did not treat the Ancient Chineses character hard to understnad, methodlolgy of traditional literature, and comparison to the western medicine.