• 전자공학회논문지CI
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• 제44권1호
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• pp.56-63
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• 2007

본 논문은 신경망 (neural network: NN)과 mean-shift알고리즘을 이용하여 복잡한 배경에서 사용자의 눈을 정확히 추출하고 추적할 수 있는 눈 추적 시스템을 제안한다. 머리의 움직임에 강건한 시스템을 개발하기 위해서 먼저 피부색 모델과 연결 성분분석을 이용하여 얼굴영역을 추출한다. 그 다음 신경망기반의 텍스처 분류기를 이용하여 얼굴 영역(face region)을 눈 영역(eye region)과 비눈 영역(non-eye region)으로 구분함으로써 눈을 찾는다. 이러한 눈 검출 방법은 안경의 착용 유무에 상관없이 사용자의 눈 영역을 정확히 검출 할 수 있게 한다. 일단 눈 영역이 찾아지면 이후 프레임에서의 눈 영역은 mean-shift알고리즘에 의해 정확하게 추적된다. 제안된 시스템의 효율성을 검증하기 위해서 제안된 시스템은 눈의 움직임을 이용한 인터페이스 시스템에 적용되었고, 이 인터페이스를 이용한 'aliens game'이 구현되었다. 25명의 사용자에 대해 실험한 결과는 제안된 시스템이 보다 편리하고 친숙한 인터페이스로 활용될 수 있다는 것을 보여주었으며, 또한 $320{\times}240$ 크기의 영상을 초당 30프레임의 빠른 속도로 처리함으로써 실시간 시스템에 적용될 수 있음을 보여주었다.

• 농업과학연구
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• 제37권3호
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• pp.393-398
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• 2010

Early pregnancy diagnosis of bovine is an essential component for efficient reproductive plan in farms because long term of non-pregnancy results in economic losses by failure of offspring production and low milk yield in dairy cattle. The major steroid hormones related with reproduction are known to be progesterone and estrogen in bovine pregnancy. To evaluate detection level of hormones in milk, plasma and milk progestrone and estrogen of Holstein cows was analyzed during artificial insemination (AI) and embryo transfer (ET). Progesterone concentration at 21 days postestrus was significantly different in plasma and milk between pregnant and non-pregnant cows. Estrogen concentration at estrus was higher in pregnant recipients than that in non-pregnant recipients. To analyze correlation between hormone levels and conception rates in Holstein, the conception and return rates were checked following AI, and the returned cows were on the track of pregnancy after consecutive AI. Pregnant cows following first AI were considered as high conception group while pregnant cows following third AI were rated as low conception group. Proportion of high and low conception groups in this study was 78.2% and 9.1%, respectively. Hormone analysis indicated that high conception group had higher estrogen level during estrus than low conception group ($26.45{\pm}3.32$ vs $19.017{\pm}2.97$). Progesterone level was not different between high and low conception groups during estrus but increased significantly after 21 days postestrus (21 day: $4.95{\pm}1.12$ vs $0.95{\pm}0.23$, 35 day: $12.47{\pm}3.82$ vs $2.41{\pm}1.21$). In conclusion, the pattern of progesterone and estrogen secretion in Holstein milk samples could be a good candidate for early pregnancy detection and selection of recipients during ET.

• 지구물리와물리탐사
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• 제5권3호
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• pp.157-168
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• 2002

Magsat 인공위성의 자력계로부터 관측된 동아시아 (동경90도-50도, 남위10도-북위50도) 암권의 자기이상을 추출하기 위한 연구를 수행하였다. 이를 위해 ring current correction, ionospheric correction, pass-by-pass correlation등을 실시하였고, 위성트랙 잡음을 효율적으로 제거하기 위한 spectral reconstruction을 실시하였다. 최종적으로 추출된 자기이상의 신뢰도를 검증하기 위해 항공자기이상과 대비하였고, 이를 위해 항공자기이상에 low-pass필터를 적용하여 인공위성 고도에서 관측 불가능한 고주파성분을 제거하였다. 결과적으로 위성자기이상과 항공자기이상은 0.243의 비교적 낮은 상관관계를 보이나 연구지역내 많은 부분에서 양(+)의 상관관계를 갖고 있음이 밝혀졌다. 일반적으로 낮은 상관계수는 각 주파수별 성분의 양과 음의 장관계수가 혼합되어 나타나며, 따라서 본 연구와 같은 포텐셜상의 경우에는 이상체의 심도 및 누중 때문에 양과 음의 상관관계를 갖는 이상체를 분류하는 것이 매우 어렵다. 본 연구에서는 인공위성 자력계 관측값으로부터 연구지역 암권의 자기이상을 성공적으로 추출하였으며 항공자기이상과도 양호한 상관관계를 갖고 있음이 밝혀졌다.

• 한국산학기술학회논문지
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• 제19권11호
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• pp.541-549
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• 2018

본 연구에서는 국내 화물 및 여객차량들을 견인하는 디젤전기 기관차의 제동에 따른 동적 거동을 분석하기 위하여 제동장치에 영향을 미치는 마찰계수, 제동압력, 주행저항 등을 시험하였다. 마찰계수는 UIC 541-4를 참고로 Dynamo 시험을 수행하였으며 시험결과는 다변량 회귀분석을 통해 제동하중, 제동초기 속도와의 관계를 분석하여 제시하였다. 제동압력은 상용제동과 비상제동으로 구분하였으며, 제동밸브와 배관의 특성을 반영하기 위하여 시간에 따른 제동압력 변화를 대상 차량에서 측정하였다. 차량에 작용하는 외력을 반영하기 위하여 EN 14067-4의 타행시험을 수행하고 2차 다항식 형태의 주행저항을 제시하였다. 도출한 주행저항을 동일 차종에 대하여 각 국가별로 사용하고 있는 주행저항들과 비교하였다. 차량의 재원, 마찰계수, 제동압력, 주행저항을 바탕으로 직선 평탄 선로를 주행하는 디젤전기기관차의 동적 거동을 EN 14531-1에서 제시된 시간적분을 이용하여 해석하였다. 해석 결과는 상용제동과 비상제동에 대하여 각각 차량의 속도이력 시험결과와 비교 검증하였으며 상당히 합리적인 결과를 도출하였다. 본 연구의 결과들은 철도차량들을 연결하여 운행하는 열차의 동적 거동해석에 활용할 수 있을 뿐 아니라 차량 설계에서 제동에 영향을 미치는 다양한 파라미터들을 분석하고 성능향상의 기초자료로 활용할 수 있을 것으로 기대된다.

• 생태와환경
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• 제52권4호
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• pp.324-332
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• 2019

본 연구는 Laser ablation ICP/MS (이하 LA-ICP/MS)를 이용한 환경오염 추적연구를 위하여 어류 내 이석을 분석하였다. 어류의 이석은 어류가 서식하는 환경에 영향을 받는 것으로 알려져 있어 국외에서는 이를 활용한 연구가 활발하나 국내에서는 이에 대한 연구가 미비한 실정이다. 그래서 본 연구에서는 환경오염의 지표로 사용되는 금속 원소의 성분 분석을 통하여 어류 이석을 이용한 환경오염 추적 가능성을 파악하고자 하였다. 또한 금속 원소의 성분 분석을 위해서는 전처리 과정을 줄여 분석 시간을 단축시킬 수 있는 것으로 알려진 LA-ICP/MS를 이용하였다. 시료채취는 연구지역과 배경지역으로 나누어 실험을 진행하였고, 실험 어종은 담수종인 잉어를 선정하였다. LA-ICP의 분석 최적 조건을 정립하기 위하여 이석 표준물질인 FEBS-1을 이용하여 9개 금속 원소(Li, Mg, Mn, Cu, Zn, Sr, Ba, Pb, U)의 정확도와 정밀도를 확인하였다. 정립한 조건을 이용하여 실제시료를 분석한 결과, 연구지역에서 채집한 어류 이석 내 금속 원소 성분의 총 농도가 2202.9 mg kg^-1으로 배경 지역의 1086.3 mg kg^-1보다 2.03배 높게 측정되었다. 원소별로는 Li과 U을 제외한 모든 원소가 연구 지역이 배경지역보다 높게 나타났다. 그리고 퇴적물 측정망 분석 자료와 비교한 결과, Zn, Pb, Cu가 두 지역의 퇴적물 금속 원소 농도 분포와 어류 이석 내 금속 원소 농도 분포 경향이 유사하게 나타났다. 이러한 결과로 보아 어류 내 이석은 퇴적물과 같이 환경오염원을 추적하는 데 활용할 수 있다는 것을 확인하였다.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.1031-1031
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• 2001

The mammary gland is made up of remarkably sensitive tissue, which has the capability of producing a large volume of secretion, milk, under normal or healthy conditions. When bacteria enter the gland and establish an infection (mastitis), inflammation is initiated accompanied by an influx of white cells from the blood stream, by altered secretory function, and changes in the volume and composition of secretion. Cell numbers in milk are closely associated with inflammation and udder health. These somatic cell counts (SCC) are accepted as the international standard measurement of milk quality in dairy and for mastitis diagnosis. NIR Spectra of unhomogenized composite milk samples from 14 cows (healthy and mastitic), 7days after parturition and during the next 30 days of lactation were measured. Different multivariate analysis techniques were used to diagnose the disease at very early stage and determine how the spectral properties of milk vary with its composition and animal health. PLS model for prediction of somatic cell count (SCC) based on NIR milk spectra was made. The best accuracy of determination for the 1100-2500nm range was found using smoothed absorbance data and 10 PLS factors. The standard error of prediction for independent validation set of samples was 0.382, correlation coefficient 0.854 and the variation coefficient 7.63%. It has been found that SCC determination by NIR milk spectra was indirect and based on the related changes in milk composition. From the spectral changes, we learned that when mastitis occurred, the most significant factors that simultaneously influenced milk spectra were alteration of milk proteins and changes in ionic concentration of milk. It was consistent with the results we obtained further when applied 2DCOS. Two-dimensional correlation analysis of NIR milk spectra was done to assess the changes in milk composition, which occur when somatic cell count (SCC) levels vary. The synchronous correlation map revealed that when SCC increases, protein levels increase while water and lactose levels decrease. Results from the analysis of the asynchronous plot indicated that changes in water and fat absorptions occur before other milk components. In addition, the technique was used to assess the changes in milk during a period when SCC levels do not vary appreciably. Results indicated that milk components are in equilibrium and no appreciable change in a given component was seen with respect to another. This was found in both healthy and mastitic animals. However, milk components were found to vary with SCC content regardless of the range considered. This important finding demonstrates that 2-D correlation analysis may be used to track even subtle changes in milk composition in individual cows. To find out the right threshold for SCC when used for mastitis diagnosis at cow level, classification of milk samples was performed using soft independent modeling of class analogy (SIMCA) and different spectral data pretreatment. Two levels of SCC - 200 000 cells/$m\ell$ and 300 000 cells/$m\ell$, respectively, were set up and compared as thresholds to discriminate between healthy and mastitic cows. The best detection accuracy was found with 200 000 cells/$m\ell$ as threshold for mastitis and smoothed absorbance data: - 98% of the milk samples in the calibration set and 87% of the samples in the independent test set were correctly classified. When the spectral information was studied it was found that the successful mastitis diagnosis was based on reviling the spectral changes related to the corresponding changes in milk composition. NIRS combined with different ways of spectral data ruining can provide faster and nondestructive alternative to current methods for mastitis diagnosis and a new inside into disease understanding at molecular level.

• 한국지구과학회지
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• 제30권6호
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• pp.721-733
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• 2009

북서태평양에서 발생하는 열대 저기압의 이동경로에 대한 변화패턴을 1951-2007년의 열대 저기압 경로 자료에 경험적 직교함수(Empirical Orthogonal Function, EOF)법을 적용하여 분석하였다. 북서태평양을 $5^{\circ}\times5^{\circ}$의 격자간격으로 나뉘어 연별 열대 저기압의 이동빈도를 각 격자에서의 변수로 정의하였다. 첫번째 모드는 동서성분(동경125도 기준)을, 두번째 모드는 남북성분(필리핀 동쪽해상에서 남지나해를 가로지르는 축 중심)을, 그리고 세번째 모드는 대각성분(타이완 동쪽 해상을 중심으로 동북방향과 동남방향을 축으로 하는)으로 나누어짐을 알 수 있었다. 첫번째와 두번째 모드의 주성분 시계열에서 각각 1997년과 1991년 부근을 기점으로 해서 주성분들의 부호가 교차되는 데, 이는 1990년대 이전 약 20년 동안에 남중국해 부근지역에서의 열대 저기압 이동 빈도가 동아시아 중위도 지역에서는 최근 20년 동안에 더 높았던 것과 관련성이 있는 것으로 보였다. 열대 저기압 발생의 경우, 첫번째와 두번째 모드에서 고유벡터 값이 음이고 진로가 북서태평양으로 주로 이동했던 열대 저기압은 고유벡터가 양의 값을 보였던 열대 저기압보다 더 동쪽에서 발생했던 것으로 나타났다. 이동특성에 있어 첫번째 모드는 바이칼호 남쪽에서 형성되는 기압 패턴에, 두번째 모드는 $30^{\circ}N$ 부근을 중심으로 남과 북 사이에 형성된 진동패턴에, 세번째 모드는 일본 부근에 위치한 기압패턴에 의해 열대 저기압의 이동경향이 많은 영향을 받는 것을 알 수 있었다. 또한, 해수면 온도 아노말리 값과 상관분석결과 첫번째 모드는 $Ni\tilde{n}o$-3.4 지수와 높은 음의 상관관계를 보여 ENSO의 영향을 받고 있음을 알 수 있었다.

• 지구물리
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• 제2권1호
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• pp.27-38
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• 1999

최근 공개된 위성중력을 이용하는 오차 최소화 기법을 적용하여 선상중력내 존재하는 구간 측선간 오차나 교차점 오차를 성공적으로 보정하였으며, 보정된 선상중력을 위성중력과 결합하여 고해상 중력분포를 도출하였다. 오차 최소화 과정에서 울릉분지의 선상중력은 위성중력보다 장주기 성분에서 상대적으로 크게 보정되었으나 단주기 성분은 그대로 보존되었다. 이것은 선상중력이 갖는 단주기의 중력 성분이 훼손되지 않은 채 안정되고 연속성을 갖는 장주기의 인공위성 중력분포에 잘 접합될 수 있다는 것을 보여 준다. 통합된 후리에어이상도는 위성중력의 장주기 성분과 선상중력의 단주기 성분을 모두 표현하므로 해저지형 및 지질분포의 해석에서 보다 상세하고 신뢰성 있는 정보를 제공한다. 후리에어이상은 수심이 깊은 분지 중앙 지역이 해저산이나 대지 등 높은 지형으로 이루어진 분지 주변부 보다 상대적으로 낮게 분포하는 등 전반적으로 해저지형의 분포 경향에 부합되어 변화한다. 그러나 대륙사면을 이루고 있는 분지의 서쪽 및 동쪽 주변부를 따라서는 지역적으로 함몰된 퇴적기반과 두꺼운 퇴적층 및 대륙 주변부에서 특징적인 가장자리 효과로 인한 저이상대가 발달하고 있다. 울릉도 북동부에 위치한 한국대지 및 울릉대지에서 북동-남서방향의 선형분포를 갖는 중력이상은 동해가 열개되는 동안 균열된 지각 사이를 따라 일어난 화산활동의 결과로 형성된 해산이나 관입암체가 선형으로 배열함으로서 기인한 것으로 해석된다. 선형으로 배열된 고중력분포는 울릉대지 서쪽 경계부에서 급구배를 보이는 북북서-남남동 방향의 직선적인 중력분포에 의해 절단되고 있는 데 이 급구배의 중력이상은 울릉대지 서부 경계를 이루는 단층선애에 기인한다. 울릉대지가 서쪽으로 뚜렷한 단층 접촉을 나타내고 있으나 지형적인 형태에 있어서 대비되지 않는 것은 울릉대지가 단층을 경계로 분리되어 이동되어 왔을 가능성을 시사한다. 분지의 중앙 북동부에서는 수심이 깊어지는 데 비해 중력치는 오히려 높아지는 경향을 나타내고 있는 것은 맨틀이 주변부에 비해서 상대적으로 천부에 존재하고 있는 것이 가장 큰 요인이며, 해저지각의 두께가 얇은 대신 지각의 밀도가 주변 대륙보다 높은 데도 기인한다.

• 자원환경지질
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• 제56권2호
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• pp.139-153
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• 2023

이 연구는 경안천 유역의 상류로부터 하류까지 본류와 하위 소유역의 배출 지점에서 관측되는 경안천 내 질소함량의 시공간적 변화를 이해하고, 이러한 질소류의 기원을 확인하고자 수행되었다. 2021년 11월부터 2022년 11월까지, 분기별 현장 조사와 실내 수질분석, 질산염과 붕소의 환경동위원소 분석을 수행하였다. 경안천의 유량지속곡선을 도출하여, 건조 기간(2021년 12월 중순부터 2022년 6월 중순)과 습윤 기간(2022년 6월 중순부터 11월 초까지)을 설정하였다. 연구 지역에서의 총 질소(T-N) 농도는 월단위 시간적 변동을 기준으로 할 때, 건조 기간에 속하는 1~2월에 농도가 가장 높았다가 5~6월까지 지속적으로 낮아진다. 홍수기인 7~9월 이후 T-N의 농도가 낮아지는 소유역 단위 최상류 지점들(Group 1: MS-0, OS-0, GS-0)과, 반대로 높아지는 경안천 본류와 소유역 하류 지점들(Group 2: MS-1~8, OS-1, GS-1)이 분리된다. 공간적으로, 경안천 본류의 T-N 농도는 상류에서 하류로 갈수록 증가하는 경향성을 보이지만, 소유역인 오산천과 곤지암천이 각각 합류되는 지점에서는 이들의 유입에 의해 본류의 T-N 농도 값에 의해 본류의 농도가 높아지거나 낮아지는 영향을 받고 있다. 환경동위원소비를 통해 모든 시료의 질소가 분뇨(manure) 기원으로 규명되었고, 수리화학적 특성의 변화와 T-N 농도의 변화에서 경안천으로 분뇨 기원의 질소가 유입될 수 있는 기작으로, (1) 축산단지의 분뇨, 폐수의 강우에 의한 유입, (2) 환경기초시설 방류수를 통한 유입, (3) 농업 활동 과정에서 축적된 질소류의 지하수 기저유출을 통한 유입 등이 제시되었다. 궁극적으로 경안천 유역의 수질관리는, 공간적 관점에서 지류를 포함하는 소유역 단위의 오염원 관리가 필요하며, 오염총량 관리 측면에서는 하천 유량의 수문성분을 구분하고, 각각 성분의 유량과 수질을 모니터링 할 수 있는 시스템의 구축과 운용이 선결되어야 한다.

• 대한의용생체공학회:의공학회지
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• 제6권2호
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• pp.1-8
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• 1985

The wall shear stress in the vicinity of end-to end anastomoses under steady flow conditions was measured using a flush-mounted hot-film anemometer(FMHFA) probe. The experimental measurements were in good agreement with numerical results except in flow with low Reynolds numbers. The wall shear stress increased proximal to the anastomosis in flow from the Penrose tubing (simulating an artery) to the PTFE: graft. In flow from the PTFE graft to the Penrose tubing, low wall shear stress was observed distal to the anastomosis. Abnormal distributions of wall shear stress in the vicinity of the anastomosis, resulting from the compliance mismatch between the graft and the host artery, might be an important factor of ANFH formation and the graft failure. The present study suggests a correlation between regions of the low wall shear stress and the development of anastomotic neointimal fibrous hyperplasia(ANPH) in end-to-end anastomoses. 30523 T00401030523 ^x Air pressure decay(APD) rate and ultrafiltration rate(UFR) tests were performed on new and saline rinsed dialyzers as well as those roused in patients several times. C-DAK 4000 (Cordis Dow) and CF IS-11 (Baxter Travenol) reused dialyzers obtained from the dialysis clinic were used in the present study. The new dialyzers exhibited a relatively flat APD, whereas saline rinsed and reused dialyzers showed considerable amount of decay. C-DAH dialyzers had a larger APD(11.70$\pm$1.32mmHg/min)compared to CF dialyzers(4.32$\pm$0.55mmHg/min)(p<0.05). However, there was no observable difference in the UFR between the two dialyzers. Neither APD nor UFR showed any significant increase with an increasing number of reuses for up to more than 20reuses. A substantial number of failures observed in APD(larger than 20mmHe/min)on the reused dialyzers(2 out of 40 CP and S out 26 C-DAK) were attributed to the Possible damage on the fibers. The CF 15-11 HFDs which failed APD test did not show changes in the UFR compared to normal dialyzers indicating that APD is a more sensitive test than UFR test to evaluate the integrity of the fibers. 30527 T00401030527 ^x For quantitative measurement of reflected light from a clinical diagnostic strip, a prototype old reflectance photometer was designed. The strip loader and cassette were made to obtain more accurate reflectance parameters. The strip was illuminated at 45˚c through optical fiber and the intensity of reflected light was determined at rectanguLat angle using a photodiode. The kubelka-munk coefficient and reflection optical density were determined ar four different wavelengths(500, 550, 570 and 610nm) for blood glucose strip. For higher concentration than 300mg/41 about glucose, a saturation state of abforbance was observed at 500, 550 and 570nm. The correlation between glucose concentration and parameters was the best at 610nm. 30535 T00401030535 ^x Radiation-induced fibrosarcoma tumors were grown on the flanks of C3H mice. The mice were divided into two groups. One group was injected with Photofrin II, intravenously (2.5mg/kg body weight). The other group received no Photofrin II. Mice from both groups were irradialed for approximately 15 minutes at 100, 300, or 500 mW/cm2 with the argon (488nm/514.5 nm), dye(628nm) and gold vapor (pulsed 628 nm) laser light. A photosensitizer behaved as an added absorber. Under our experimental conditions, the presence of Photolfrin II increased surface temperature by at least 40% and the temperature rise due to 300 mW/cm2 irradiation exceeded values for hyperthermia. Light and temperature distributions with depth were estimated by a computer model. The model demonstrated the influence of wavelength on the thermal process and proved to be a valuable tool to investigate internal temperature rise. 30536 T00401030536 ^x We investigated the structural geometry of thirty-eight Korean femurs. The purpose of this study is to identify major geometrical differences between Korean femurs 3nd others that we believe belong to Caucasians so that we would be able to get insights into the femoral component design that fits Asians including Koreans. We utilized computerized tomography (CT) images of femurs extracted from cadavers. The CT images were transformed into bitmap data by using a film scanner, and then analyzed by using a commercially available software called Image v.1.0 and a Macintosh IIci computer.The resulting data were compared with already published data. The major results show that the geometry of the Korean femurs is significantly different from that of Caucasians: (1) the anteversion angle and the canal flare index are greater by the amount of approximately 8˚ and 0.5, respectively, (2) the shape of the isthmus cross section is more round, and (3) the distance between the teaser trochanter and the proximal border of the isthmus is shelter by about 15 mm. The results suggested that the femoral component suitable for Asians should be different from the currently-used components designed and manufactured mostly by European or American companies. 30537 T00401030537 ^x It is well known that nonlinear propagation characteristics of the wave in the tissue may give very useful information for the medical diagnoisis. In this paper, a new method to detect nonlinear propagation characteristics of the internal vibration in the tissue for the low frequency mechanical vibration by using bispectral analysis is proposed. In the method, low frequency vibration of f0( = 100Hz) is applied on the surface of the object, and the waveform of the internal vibration x (t) is measured from Doppler frequency modulation of silmultaneously transmitted probing ultrasonic waves. Then, the bispectra of the signal x (t) at the frequencies (f0, f0) and (f0, 2f0) are calculated to estimate the nonlinear propagation characteristics as their magnitude ratio, w here since bispectrum is free from the gaussian additive noise we can get the value with high S/N. Basic experimental system is constructed by using 3.0 MHz probing ultrasonic waves and the several experiments are carried out for some phantoms. Results show the superiority of the proposed method to the conventional method using power spectrum and also its usefulness for the tissue characterization. 30541 T00401030541 ^x This paper describes the implementation of a computerized radial pulse diagnosis by aids of a clinical expert. On this base, we composed of the radial pulse diagnosis system in korean traditional medicine. The system composed of a radial pulse wave detection system and a radial pulse diagnosis system. With a detection system, we detected Inyoung and Cheongu radial pulse wave and processed it. Then, we have got the characteristic parameters of radial pulse wave and also quantified that according to the method of Inyoung-Cheongu Comparison Radial Pulse Diagnosis. We defined the jugement standard of radial pulse diagnosis system and then we confirmed the possibility for realization of automatic radial pulse diagnosis in korean traditional medicine. 30545 T00401030545 ^x Microspheres are expected to be applied to biomedical areas such as solid-phase immunoassays, drug delivery systems, immunomagnetic cell separation. To synthesize microspheres for biomedical application, "two stage shot growth method" was developed. The uniformity ratio of synthesized microspheres was always smaller than 1.05. And the surface charge density (or the number of ionizable functional groups) of the microspheres synthesized by "two stage shot growth method" was 6~13 times higher than that of the microspheres synthesized by conventional seeded batch copolymerization. As a previous step for biomedical application, adsorption experiments of bovine albumin on microspheres were carried out under various conditions. The maximum adsorbed amount was obtained in the neighborhood of pH 4.5. Isoelectric point of bovine albumin is pH 5.0, so experimental result shows that it shifted to acid area. The adsorption isotherm was obtained, the plateau region was always reached at 2.Og/L (bulk concentration of bovine albumin).The effect of the kind and the amount of surface functional group was also examined. 30575 T00401030575 ^x A medical image workstation was developed using multimedia technique. The system based on PC-486DX was designed to acquire medical images produced by medical imaging instruments and related audio information, that is, doctors' reporting results. Input information was processed and analyzed, then the results were presented in the form of graph and animation. All the informations of the system were hierarchically related with the image as the apex. Processing and analysis algorithms were implemented so that the diagnostic accuracy could be improved. The diagnosed information can be transferred for patient diagnosis through LAN(local area network). 30592 T00401030592 ^x In the conventional infrared imaging system, complex infrared lens systems are usually used for directing collimated narrow infrared beams into the high speed 2-dimensional optic scanner. In this paper, a simple reflective infrared optic system with a 2-dimensional optic scanner is proposed for the realization of medical infrared thermography system. It has been experimentally proven that the intfrared thermography system composed of the proposed optic system has the temperature resolution of 0.1˚c under the spatial resolution of lmrad, the image matrix size of 256 X 240, and tile imaging time of 4 seconds. 30593 T00401030593 ^x In this paper, MIIS (Medical Image Information System) has been designed and implemented using INGRES RDBMS, which is based on a client/server architecture. The implemented system allows users to register and retrieve patient information, medical images and diagnostic reports. It also provides the function to display these information on workstation windows simultaneously by using the designed menu-driven graphic user interface. The medical image compression/decompression techniques are implemented and integrated into the medical image database system for the efficient data storage and the fast access through the network. 30594 T00401030594 ^x In this paper, computerized BEAM was implemented for the space domain analysis of EEG. Trans-formation from temporal summation to two-dimensional mappings is formed by 4 nearest point inter-polaton method. Methods of representation of BEAM are two. One is dot density method which classify brain electrical potential 9 levels by dot density of gray levels and the other is colour method which classify brain electrical 12 levels by red-green colours. In this BEAM, instantaneous change and average energy distribution over any arbitrary time interval of brain electrical activity could be observed and analyzed easily. In the frequency domain, the distribution of energy spectrum of a special band can easily be distinguished normality and abnormality. 30608 T00401030608 ^x Laboratory information system (LIS) is a key tool to manage laboratory data in clinical pathology. Our department has developed an information system for routine hematology using down-sized computer system. We have used an IBM 486 compatible PC with 16MB main memory, 210 MB hard disk drive, 9 RS-232C port and 24 pin dot printer. The operating system and database management system were SCO UNIX and SCO foxbase, respectively. For program development, we used Xbase language provided by SCO foxbase. The C language was used for interface purpose. To make the system use friendly, pull-down menu was used. The system connected to our hospital information system via application program interface (API), so the information related to patient and request details is automatically transmitted to our computer. Our system interfaced with fwd complete blood count analyzers(Sysmex NE-8000 and Coulter STKS) for unidirectional data tansmission from analyzer to computer. The authors suggests that this system based on down-sized computer could provide a progressive approach to total LIS based on local area network, and the implemented system could serve as a model for other hospital's LIS for routine hematology. 30609 T00401030609 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed a composite that is consisted of calcium phosphate and collagen. To use as the structural matrix of the composite, collagen was purified from human umbilical cord. The obtained collagen was treated by pepsin to remove telopeptides, and finally, the immune-free atelocollagen was produced: The cross linked atelocollagen was highly resistant to the collagenase induced collagenolysis. The cross linked collagen demonstrated an improved tensile strength. 30618 T00401030618 ^x This paper is a study on the design of adptive filter for QRS complex detection. We propose a simple adaptive algorithm to increase capability of noise cancelation in QRS complex detection with two stage adaptive filter. At the first stage, background noise is removed and at the next stage, only spectrum of QRS complex components is passed. Two adaptive filters can afford to keep track of the changes of both noise and QRS complex. Each adaptive filter consists of prediction error filter and FIR filter The impulse response of FIR filter uses coefficients of prediction error filter. The detection rates for 105 and 108 of MIT/BIH data base were 99.3% and 97.4% respectively. 30619 T00401030619 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed and produced a composite that is consisted of calcium phosphate and collagen. Human umbilical cord origin pepsin treated type I atelocollagen was used as the structural matrix, by which sintered or non-sintered carbonate apatite was encapsulated to form an inorganic-organic composite. With cross linking atelocollagen by UV ray irradiation, the resistance to both compressive and tensile strength was increased. Collagen degradation by the collagenase induced collagenolysis was also decreased. 30620 T00401030620 ^x We have developed a monoleaflet polymer valve as an inexpensive and viable alternative, especially for short-term use in the ventricular assist device or total artificial heart. The frame and leaflet of the polymer valve were made from polyurethane, To evaluate the hemodynamic performance of the polymer valve a comparative study of flow dynamics past a polymer valve and a St. Jude Medical prosthetic valve under physiological pulsatile flow conditions in vitro was made. Comparisons between the valves were made on the transvalvular pressure drop, regurgitation volume and maximum valve opening area. The polymer valve showed smaller regurgitation volume and transvalvular pressure drop compared to the mechanical valve at higher heart rate. The results showed that the functional characteristics of the polymer valve compared favorably with those of the mechanical valve at higher heart rate. 30621 T00401030621 ^x Explosive evaporative removal process of biological tissue by absorption of a CW laser has been simulated by using gelatin and a multimode Nd:YAG laser. Because the point of maximun temperature of laser-irradiated gelatin exists below the surface due to surface cooling, evaporation at the boiling temperature is made explosively from below the surface. The important parameters of this process are the conduction loss to laser power absorption (defined as the conduction-to-laser power parameter, Nk), the convection heat transfer at the surface to conduction loss (defined as Bi), dimensionless extinction coefficient (defined as Br.), and dimensionless irradiation time (defined as Fo). Dependence of Fo on Nk and Bi has been observed by experiment, and the results have been compared with the numerical results obtained by solving a 2-dimensional conduction equation. Fo and explosion depth (from the surface to the point of maximun temperature) are increased when Nk and Bi are increased.To find out the minimum laser power for explosive evaporative removal process, steady state analysis has been also made. The limit of Nk to induce evaporative removal, which is proportional to the inverse of the laser power, has been obtained. 30622 T00401030622 ^x N1 and N2 gross neural action potentials were measured from the round window of the guinea pig cochlea at the onset of the acoustic stimuli. N1-N2 audiograms were made by means of regulating stimulant intensities in order to produce constant N1-N2 potentials as criteria for different input tone pip frequencies. The lowest threshold was measured with an input tone pip I5 dB SPL in intensity and 12 KHz in frequency when the animal was in normal physiological condition. The procedure of experimental measurements is explained in detail. This experimental approach is very useful for the investigation of the Cochlear function. Both noN1inear and active functions of the Cochlea can be monitored by N1-N2 audiograms. 30623 T00401030623 ^x In electrical impedance tomography(EIT), we use boundary current and voltage measurements toprovide the information about the cross-sectional distribution of electrical impedance or resistivity. One of the major problems in EIT has been the inaccessibility of internal voltage or current data in finding the internal impedance values. We propose a new image reconstruction method using internal current density data measured by NMR. We obtained a two-dimensional current density distribution within a phantom by processing the real and imaginary MR images from a 4.77 NMR machine. We implemented a resistivity mage reconstruction algorithm using the finite element method and sensitivity matrix. We presented computer simulation results of the mage reconstruction algorithm and furture direction of the research. 30624 T00401030624 ^x A new method of digital image analysis technique for discrimination of cancer cell was presented in this paper. The object image was the Thyroid eland cells image that was diagnosed as normal and abnormal (two types of abnormal: follicular neoplastic cell, and papillary neoplastic cell), respectively. By using the proposed region segmentation algorithm, the cells were segmented into nucleus. The 16 feature parameters were used to calculate the features of each nucleus. A9 a consequence of using dominant feature parameters method proposed in this paper, discrimination rate of 91.11% was obtained for Thyroid Gland cells. 30625 T00401030625 ^x An electrical stimulator was designed to induce locomotion for paraplegic patients caused by central nervous system injury. Optimal stimulus parameters, which can minimize muscle fatigue and can achieve effective muscle contraction were determined in slow and fast muscles in Sprague-Dawley rats. Stimulus patterns of our stimulator were designed to simulate electromyographic activity monitored during locomotion of normal subjects. Muscle types of the lower extremity were classified according to their mechanical property of contraction, which are slow muscle (msoleus m.) and fast muscle (medial gastrocneminus m., rectus femoris m., vastus lateralis m.). Optimal parameters of electrical stimulation for slow muscles were 20 Hz, 0.2 ms square pulse. For fast muscle, 40 Hz, 0.3 ms square pulse was optimal to produce repeated contraction. Higher stimulus intensity was required when synergistic muscles were stimulated simultaneously than when they were stimulated individually. Electrical stimulation for each muscle was designed to generate bipedal locomotion, so that individual muscles alternate contraction and relaxation to simulate stance and swing phases. Portable electrical stimulator with 16 channels built in microprocessor was constructed and applied to paraplegic patients due to lumbar cord injury. The electrical stimulator restored partially gait function in paraplegic patients. 30626 T00401030626 ^x Two-Dimensional modelling of the Cochlear biomechanics is presented in this paper. The Laplace partial differential equation which represents the fluid mechanics of the Cochlea has been transformed into two-dimensional electrical transmission line. The procedure of this transformation is explained in detail. The comparison between one and two dimensional models is also presented. This electrical modelling of the basilar membrane (BM) is clearly useful for the next approach to the further. Development of active elements which are essential in the producing of the sharp tuning of the BM. This paper shows that two-dimension model is qualitatively better than one-dimensional model both in amplitude and phase responses of the BM displacement. The present model is only for frequency response. However because the model is electrical, the two-dimensional transmission line model can be extended to time response without any difficult. 30627 T00401030627 ^x A method has been proposed for the fully automatic detection of left ventricular endocardial boundary in 2D short axis echocardiogram using geometric model. The procedure has the following three distinct stages. First, the initial center is estimated by the initial center estimation algorithm which is applied to decimated image. Second, the center estimation algorithm is applied to original image and then best-fit elliptic model estimation is processed. Third, best-fit boundary is detected by the cost function which is based on the best-fit elliptic model. The proposed method shows effective result without manual intervention by a human operator. 30628 T00401030628 ^x The intelligent trajectory control method that controls moving direction and average velocity for a prosthetic arm is proposed by pattern recognition and force estimations using EMG signals. Also, we propose the real time trajectory planning method which generates continuous accelleration paths using 3 stage linear filters to minimize the impact to human body induced by arm motions and to reduce the muscle fatigue. We use combination of MLP and fuzzy filter for pattern recognition to estimate the direction of a muscle and Hogan's method for the force estimation. EMG signals are acquired by using a amputation simulator and 2 dimensional joystick motion. The simulation results of proposed prosthetic arm control system using the EMf signals show that the arm is effectively followed the desired trajectory depended on estimated force and direction of muscle movements. 30638 T00401030638 ^x A new neural network architecture for the recognition of patterns from images is proposed, which is partially based on the results of physiological studies. The proposed network is composed of multi-layers and the nerve cells in each layer are connected by spatial filters which approximate receptive fields in optic nerve fields. In the proposed method, patterns recognition for complicated images is carried out using global features as well as local features such as lines and end-points. A new generating method of matched filers representing global features is proposed in this network. 30659 T00401030659 ^x An implementation scheme of the magnetic nerve stimulator using a switching mode power supply is proposed. By using a switching mode power supply rather than a conventional linear power supply for charging high voltage capacitors, the weight and size of the magnetic nerve stimulator can be considerably reduced. Maximum output voltage of the developed magnetic nerve stimulator using the switching mode power supply is 3, 000 volts and switching time is about 100 msec. Experimental results or human nerve stimulations using the developed stimulator are presented. 30768 T00401030768 ^x In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO2 with Plethysmograph.SpO2 with Plethysmograph.