• Title/Summary/Keyword: Toxicology

Search Result 5,316, Processing Time 0.031 seconds

EFFECTS OF SUBCHRONIC PATERNAL EXPOSURE TO CYCLOPHOSPHAMIDE AND ACROLEIN ON MALE FERTILITY AND EARLY EMBRYONIC DEVELOPMENT IN RATS

  • Oran-Kwon;Kwack, Seung-Jun;Shin, Jae-Ho;Kim, Soon-Sun;Sohn, Kyung-Hee;Kim, So-Hee;Lee, Rhee-Da;Kim, Byung-Ho;Park, Chul-Hoon;Ha, Won-Kwang;Park, Kui-Lea
    • Proceedings of the Korean Society of Toxicology Conference
    • /
    • 2001.05a
    • /
    • pp.138-138
    • /
    • 2001

  • The purpose of the present studies was to investigate the effects of subchronic paternal treatment of cyclophosphamide (CP) and acrolein on male fertility and early embryonic development. Two approaches were pursued. The first was to perform in vivo test for observing the adverse effects of CP and acrolein on the function og male reproductive system and pregnancy outcome.(omitted)

  • PDF

Nasal and Pulmonary Toxicity of Titanium Dioxide Nanoparticles in Rats

  • Kwon, Soonjin;Yang, Young-Su;Yang, Hyo-Seon;Lee, Jinsoo;Kang, Min-Sung;Lee, Byoung-Seok;Lee, Kyuhong;Song, Chang-Woo
    • Toxicological Research
    • /
    • v.28 no.4
    • /
    • pp.217-224
    • /
    • 2012

  • In recent decades, titanium dioxide ($TiO_2$) nanoparticles have been used in various applications, including paints, coatings, and food. However, data are lacking on the toxicological aspects associated with their use. The aim of this study was to assess the inhalation toxicity of $TiO_2$ nanoparticles in rats by using inhalation exposure. Male Wistar rats were exposed to $TiO_2$ nanoparticles for 2 weeks (6 hr/day, 5 days/week) at a mean mass concentration of $11.39{\pm}0.31mg/m^3$. We performed time-course necropsies at 1, 7, and 15 days after exposure. Lung inflammation and injury were assessed on the basis of the total and individual cell counts in bronchoalveolar lavage fluid (BALF), and by biochemical assays, including an assay for lactate dehydrogenase (LDH). Furthermore, histopathological examination was performed to investigate the lungs and nasal cavity of rats. There were no statistically significant changes in the number of BALF cells, results of biochemical assays of BALF and serum, and results of cytokine analysis. However, we did observe histopathological changes in the nasal cavity tissue. Lesions were observed at post-exposure days 1 and 7, which resolved at post-exposure day 15. We also calculated the actual amounts of $TiO_2$ nanoparticles inhaled by the rats. The results showed that the degree of toxicity induced by $TiO_2$ nanoparticles correlated with the delivered quantities. In particular, exposure to small particles with a size of approximately 20 nm resulted in toxicity, even if the total particle number was relatively low.

  • https://doi.org/10.5487/TR.2012.28.4.217 인용 PDF KSCI

Subacute toxicities and toxicokinetics of CJ-10882, a type IV phosphodiesterase inhibitor, after 4-week repeated oral administration in dogs

  • Junghee Han;Cha, Shin-Woo;Im, Doo-Hyun;Chung, Moon-Koo
    • Proceedings of the Korean Society of Toxicology Conference
    • /
    • 2003.05a
    • /
    • pp.43-44
    • /
    • 2003

  • The subacute toxicity and toxicokinetics of a type IV phosphodiesterase inhibitor, CJ-10882, were evaluated after single (on the 1st day) and 4-week (on the 27th day) oral administration of the drug, in doses of 0 (to serve as a control), 2, 10 and 50 mg/kg/d, to male and female dogs (n = 3 for male and female dogs for each dose). During the test period, clinical signs, mortality, body weight, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross findings, organ weight and histopathology were examined.(omitted)

  • PDF