Browse > Article

Current Progress of Next Generation Battery of Toxicology­Cellular and Molecular Toxicology, and Toxicogenomics  

Ryu, Jae-Chun (Cellular and Molecular Toxicology Laboratory, Korea Institute of Science and Technology)
Yoon, Seokjoo (Toxicogenomics Team, Korea Institute of Toxicology, KRICT)
Lee, Jong-Eun (DNA Link Inc.)
Kim, Youn-Jung (Cellular and Molecular Toxicology Laboratory, Korea Institute of Science and Technology)
Keywords
cellular and molecular toxicology; toxicogenomics; transcriptomics; proteomics; metabon/Iomics; toxicoinformatics;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Singh, N.P., McCoy, M.T., Tice, R.R., and Schneider, E.L. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175, 184-191   DOI   ScienceOn
2 Singh, N.P., Graham, M. M., Singh, V., and Khan, A. (1995). Induction of DNA single-strand breaks in human lymphocytes by low doses of $\chi$-rays. Int. J. Radiat. Biol. 68, 563-569   DOI   ScienceOn
3 Afshari, C.A., Nuwaysir, E.F., and Barrett, J.C. (1999). Application of complementary DNA microarray technologyto carcinogen identification, toxicology, and drug safetyevaluation. Cancer Res. 59, 4759-4760   PUBMED
4 Ames, B.N., Durston, W.E., Yamasaki, E., and Lee, F.D.(1973). Carcinogens are mutagens : a simple testsystem combining liver homogenates for activation andbacteria for detection. Proc. Natl. Acad. Sci. USA 70, 2281-2285   DOI   ScienceOn
5 Bittner, M., Meltzer, P., Chen, Y., Jiang, Y., Seftor, E., Hendrix, M., Radmacher, M., Simon, R., Yakhini, Z., Ben-Dor, A., Sampas, N., Dougherty, E., Wang, E., Mahncola, F., Gooden, C., Lueders, J., Glatfelter, A., Pollock, P., Carpten, J., Gillanders, E., Leja, D., Dietrich, K., Beaudry, C., Berens, M., Alberts, D., and Sondak, V.(2000). Molecular classification of cutaneous malignantmelanoma by gene expression profiling. Nature 406, 536-540   DOI   ScienceOn
6 Fairbairn, D.W., Walburger, D.K., Fairbairn, J.J., andO'NeiII, K.L. (1996). Key morphologic changes and DNA strand breaks in human lymphoid cells: discriminating apoptosis from necrosis, Scanning 18, 407-416   DOI   PUBMED   ScienceOn
7 Fenech, M., Crott, J., Turner, J., and Brown, S., (1999). Necrosis, apoptosis, cytostasis and DNA damage in human lymphocytes measured simultaneously withinthe cytokinesis-block micronucleus assay: description of the method and results for hydrogen peroxide. Mutagenesis 14, 605-612   DOI   ScienceOn
8 Frueh, F.W., Huang, S.M., and Lesko, L.J. (2004). Regulatoryacceptance of toxicogenomics data. Environ. Health Perspect. 112, A663-664   PUBMED
9 Garriott, M.L, Casciano, D.A., Schechtman, L.M., and Probst, G.S. (1995). International workshop on mouse lymphoma assay testing practices and data interpretations. Environ. Mol. Mutagenesis 25, 162-164   DOI   ScienceOn
10 Gorelick, N.J. (1995). Overview of mutation assays intransgenic mice for routine testing. Environ. Mol. Mutagenesis 25, 218-230   DOI   PUBMED   ScienceOn
11 Gossen, J.A., De Leeuw, W.J., Tan, C.H., Zworthoff, E.C., Berends, F., Lohman, P.H., Knook, D.L, and Vijg, J.(1989). Efficient rescue of integrated shuttle vectorsfrom transgenic mice: a model for studying mutations in vivo. Proc. Natl. Acad. Sci. USA 86, 7971-7975   DOI   ScienceOn
12 Hamadeh, H.K., Amin, R.P., Paules, R.S., and Afshari, C.A.(2002c). An overview of toxicogenomics. Curr. Issues Mol. Biol. 4, 45-56   PUBMED
13 Hayashi, M., Tice, R.R., MacGregor, J.T., Anderson, D., Blakey, D.H., Kirsh-Volders, M., Oleson, F.B.Jr, Pacchierotti, F., Romagna, F., Shimada, H., Sutou, S., and Vannier, B. (1994). In vivo rodent erythrocyte micronucleus assay. Mutat. Res. 312, 293-304   DOI   PUBMED   ScienceOn
14 Heddle, J.A., Hite, M., Kirkhart, B., Mavournin, K., MacGregor, J.T., Newell, G.W., and Salamone, M.F.(1983). The induction of micronuclei as a measure ofgenotoxicity. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res. 123, 61-118   DOI   PUBMED   ScienceOn
15 Kitano, H. (2002). Computational systems biology. Nature 420, 206-210   DOI   PUBMED   ScienceOn
16 McCann, J., Choi, E. Yamasaki E., and Ames, B.N. (1975). Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. Proc. Natl. Acad. Sci. USA 72, 5135-5139   DOI   ScienceOn
17 Mersch-Sundermann, V.S., Kerekordes, S., and Mochayedi,S. (1991). Sources of variability of the Escherichia coliPQ 37 genotoxicity assay (SOS chromotest). Mutat. Res. 252, 51-60   DOI   PUBMED   ScienceOn
18 Meselson, M. and Russell, K. (1977). Comparison ofcarcinogenic and mutagenic potency, In Origin of Human Cancer, H.H. Hiatt, J.D. Watson, and J.A. Winstend, eds. (Cold Spring Harbor Laboratory), PP. 1473-1481
19 Olive, P.L., Banath, J.P., and Fjell, C. D. (1994). DNA strand breakage and DNA structure influence staining with propidium iodide using the alkaline comet assay. Cytometry 16, 305-312   DOI   ScienceOn
20 Olden, K., Call, N,, Sobral, B., and Oakes, R. (2004). Toxicogenomics through the eyes of informatics: conference overview and recommendations. Environ. Health Perspect. 112, 805-7   DOI   PUBMED
21 Oltvai, Z.N. and Barabasi, A.L. (2002). Systems biology. Life's complexity pyramid, Science 298, 763-764   DOI   PUBMED   ScienceOn
22 Ostlihg, O. and Johanson, K.J. (1984). Microelectrophoretic study of radiation-induced DNA damages in individualmammalian cells. Biochem. Biophy. Res. Commun. 123, 291-298   DOI   ScienceOn
23 Pennie, W.D., Tugwood, J.D., Oliver, G.J., and Kimber, I. (2000). The principles and practice of toxicogenomics: Applications and opportunities. Toxicol. Sci. 54, 277-283   DOI   ScienceOn
24 Pennie, W.D. and Kimber, I. (2002). Toxicogenomics; transcript profiling and potential application to chemical allergy. Toxicol. In Vitro 16, 319-326   DOI   ScienceOn
25 Ryu, J.-C., Kim, S.-H., Kim, K.-R., Lee, S., Kim, M., Jung,H.-K., and Park, J. (1993b). A study on the antimutagenic effect of cinnamic acid derivatives in Escherichia coli PQ37 (SOS Chromotest) (I). Environ. Mutagens & Carcinogens13, 8-17
26 Ryu, J,-C., Youn, J.-Y., Kim, Y.-J., Kwon, O.-S., Kim, H.-T.,Cho, K.-H., and Chang, I.-M. (1999a). Mutation spectrum of 4-nitroquinoline-N-oxide in the lac 1 transgenic Big Blue Rat2 cell line. Mutat. Res. 445, 127-135   DOI   PUBMED   ScienceOn
27 Ryu, J.-C., Kim, H.-T., and Kim, Y.-J. (2002c). Studies on DNA single strand break of seven phthalate analogues in mouse lymphoma cells. Environ. Mutagens & Carcinogens 22, 164-168
28 Singh, N.P., Tice, R. R., and Stephens, R. E. (1991). A microgel electrophoresis technique for the direct quantitation of DNA and repair in individual fibroblasts cultured on microscope slides. Mutat. Res. 252, 289-296   DOI   PUBMED   ScienceOn
29 Ryu, J.-C., Kim, H.-J., Seo, Y.-R., and Kim, K.-R. (1997). Single Cell Gel Electrophoresis (Comet Assay) to detect DNA damage and Apoptosis in cell level. Environ. Mutagen & Carcinogen 17, 71-77   DOI   ScienceOn
30 Schmid, W. (1975). The micronucleus test. Mutat. Res. 31, 9-15   DOI   PUBMED
31 Ryu, J.-C., Seo, Y.-R., Smith, M.A., and Han, S.-S. (2001a). The Effect of methyl methanesu1fonate(MMS)-induced excision repair on p53-dependent apoptosis in human lymphoid cells. Res. Commun. Mol. Pathol. Pharmacol.109, 35-51   PUBMED
32 Freeman, K. (2004). Toxicogenomics data: the road toacceptance. Environ. Health Perspect. 112, A678-685   DOI   PUBMED   ScienceOn
33 OECD/IPCS Workshop, (2004). Draft guideline, Oct. 13-15, Kyoto Japan
34 Ryu, J.-C., Lee, S., Kim, K.-R., Kim, M., Chang, I.-M., and Park, J. (1993a). A study on the clastogenicity of trichothecene mycotoxins in chinese hamster lung cells. Korean J. Toxicol. 9, 13-21
35 Radman, M., Jeggo, P., and Wagner, R. (1982). Chromosomal rearrangement and carcinogenesis. Mutat. Res. 98, 249-264   DOI   PUBMED   ScienceOn
36 Clements, J. (1994). The mouse lymphoma tk assay at Hazleton Europe, Hazleton England
37 Ishidate, M. and Odashima, S. (1977). Chromosome test with 134 compounds on chinese hamster cells in vitro-Ascreening for chemical carcinogens. Mutat. Res. 48, 337-354   DOI   PUBMED   ScienceOn
38 Klaassen, C.D. (2001) Toxicology-the basic science andpoisons (6th Ed.), (McGraw-HiII Co.)
39 Neumann, N.F., and Galvez, F. (2002). DNA microarrays and toxicogenomics: applications for ecotoxicology. Biotechnol. Adv. 20, 391-419   DOI   ScienceOn
40 Ryu, J.-C., Kim, Y.-J., Kim, H.-T., and Chai, Y.-G. (2000). Genotoxicity Assessment of atrazine in the Big Blue rat2 lac / transgenic cell line, 31st Environmental Mutagen Society, New Orleans, LA, April 8-April 13. Environ. Mol. Mutagen 35 (Suppl. 31), 52
41 Suter, L., Babiss, L.E, and Wheeldon, E.B. (2004). Toxicogenomics in predictive toxicology in drug development. Chem. Biol.11, 161-71   DOI   PUBMED
42 Heddle, J.A. and Tao, K.S. (1995). The transmission rate of the lac/transgene from the Big Blue mouse. Mutat. Res.348, 63-66   DOI   ScienceOn
43 Pennie, W., Pettit, S.D., and Lord, P.G. (2004). Toxicogenomicsin risk assessment: an overview of an HESI collaborative research program, Environ. Health Perspect 112, 417-9   DOI   PUBMED   ScienceOn
44 Bartosiewicz, M., Penn, S., and Buckpitt, A. (2001a). Applications of gene arrays in environmental toxicology: fingerprints of gene regulation associated with cadmiumchloride, benzo(a)Pyrene, and trichloroethylene. Environ. Health Perspect. 109, 71-74   DOI   ScienceOn
45 Hamadeh, H.K., Bushel, P.R., Jayadev, S., DiSorbo, O., Bennett, L., Li, L., Tennant, R., Stoll, R., Barrett, J.C., Paules, R.S., Blanchard, K., and Afshari, C.A. (2002b). Prediction of compound signature using high density gene expression profiling. Toxicol Sci. 67, 232-240   DOI   ScienceOn
46 Waring, J.F. and Halbert, D.N. (2002). The promise of toxicogenomics. Curr. Opin. Mol. Ther. 4, 229-35   PUBMED
47 Singh, N.P., Stephens, R.E., and Schneider, E.L. (1994). Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage. Int. J. Radiat. Biol. 66, 23-28   DOI   ScienceOn
48 Tong, W., Harris, S., Cao, X., Fang, H., Shi, L., Sun, H., Fuscoe, J., Harris, A., Hong, H., Xie, Q., Perkins, R., and Casciano, D. (2004). development of public toxicogenomics software for microarray data management and analysis. Mutat. Res. 549, 241-253   DOI   PUBMED
49 Oberly, T.J. and Garriott, M.L. (1996). Influence of cytotoxicity on test results in the L5178Y TK+/- mouse lymphoma assay. Environ. Mol. Mutagenesis 27, 75-78   DOI   ScienceOn
50 Ryu, J.-C. and Park, K.-Y. (2001b). AnticIastogenic effect of Baechu (Chinese cabbage) Kimchi and Buchu(leek) Kimchi in supravital staining micronucleus assay using peripheral reticulocytes of mouse. Environ. Mutagens & Carcinogens 21, 51 -56
51 Lovett, R.A. (2000). Toxicologists brace for genomics revolution. Science 289, 536-537   DOI   PUBMED   ScienceOn
52 Yang, Y., Blomme, E.A., and Waring, J.F. (2004). Toxicogenomics in drug discovery: from preclinical studies to clinical trials. Chem. Biol. Interact. 150, 71-85   DOI   ScienceOn
53 Bartosiewicz, M. Jenkins, D., Penn, S., Emery, J., andBuckpitt, A. (2001b). Unique gene expression patterns inliver and kidney associated with exposure to chemicaltoxicants. J. Pharmacol. Exp. Ther. 297, 895-905   PUBMED
54 Dycaico, M.J., Provost, G.S., Kretz, P.L., Ransom, S.L., Moores, J.C., and Short, J.M. (1994). The use of shuttlevectors for mutation analysis in transgenic mice and rats. Mutat. Res. 307, 461-478   DOI   PUBMED
55 MacGregor, J.T., Wehr, C.M., and Gould, D.H. (1980). Clastogen-induced icronuclei in peripheral blooderythrocytes: The basis of an improved icronucleus test. Environ. Mutagen 2, 509-514   DOI   ScienceOn
56 Maron, D.M. and Ames, B.N. (1983), Revised methods forthe Salmonella mutagenicity test. Mutat. Res. 113, 173-215   DOI   PUBMED
57 Ryu, J.-C., Youn, J.-Y., Cho, K.-H., and Chang, I.-M. (1998a). Mutation spectrum in lacl gene of transgenic Big Blue cell line following to short term exposure 4-nitroquinoline-N-oxide. Environ. Mol. Mutagen 31(Suppl. 29), 16
58 Aederma, M.J. and MacGregor, J.T. (2002). Toxicology andgenetic toxicology in the new era of 'toxicogenomics':impact of '-omics' technologies. Mutat. Res. 499, 13-25   DOI   PUBMED   ScienceOn
59 MckeIvey-Martin, V.J., Green, M.H.L., Schemezer, P., Pool-ZobeI, B.L, De Meo, M.P., and Collins, A. (1993). The single cell gel electrophoresis assay (comet assay): A european review. Mutat. Res. 288, 47-63   DOI   PUBMED   ScienceOn
60 TNO Pharma. (2004). Toxicogenomics, http:/www.pharma.tno.nl/common/PDF/PH075_Toxicogenomics.pdf
61 Alizadeh, A.A., Eisen, M.B., Davis, R.E., Ma, C., Lossos,I.S., Rosenwald, A., Boldrick, J.C., Sabet, H., Tran, T.,Yu, X., Powell, J.I., Yang, L., Marti, G.E., Moore, T., Hudson, J., Jr., Lu, L., Lewis, D.B., Tibshirani, R., Sherlock, G., Chan, W.C., Greiner, T.C., Weisenburger, D.D., Armitage, J.O., Warnke, R., Levy, R., Wilson, W., Grever, M., Byrd, C., Botstein, D., Brown, P., and Staudt, L.M. (2000). Distinct types of diffuse large B-celllymphoma identified by gene expression profiles. Nature 403,503-511팀ꐜ鮖餜䭇퐀ఀš颖䭇픀ꆘ鮖ᦘ䭇혀Ā鲛隘䭇휀܀€鮘䭇?꒛ᘘ᪙䭇?ঀᦜ隙䭇?ᮚ鮖鲙䭇?銚鮖ᮚ䭇?⒛鮖颚䭇?￿ល䭇?ր鲛際䭇?钛鬖鮛䭇刺缚᪜䭇ಀ馜障䭇リ頖䱇ꘘ鲖ᨘ䱇ڀ鲜阘䱇￿鞜ᘙ䱇ᦜ阙䱇⌚鲖鬙䱇頚鲖ᬚ䱇阚鰖餚䱇ᤛ鲖ᤛ䱇̀鮜阛䱇ഀ鮜ᘜ䱇益ᢙ阜䱇⎘鲖鰜䱇ﯿ骜ᚘ䱇ﶚ题隘䱇ꦙ鲖鲘䱇ﰗ题隙䱇ྚ鲖   DOI   ScienceOn
62 Hayashi, M., Morita, T., Kodama, Y., Sofuni, T., and Ishidate, M. Jr. (1990). The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange- coated slides. Mutat. Res. 245, 245-249   DOI   ScienceOn
63 Kohler, S.W., Provost, G.S., Fieck, A., Kretz, P.L., Bullock,W.O., Sorge, J.A., Putman, D.L, and Short, J.M. (1991). Spectra of spontaneous and mutagen-induced mutations in the lac l gene in transgenic mice. Proc. Natl. Acad. Sci. USA 88, 7958-7962   DOI   ScienceOn
64 Mattes, W.B., Pettit, S.D., Sansone, S.A., Bushel, P.R., and Waters, M.D. (2004). Database development in toxicogenomics: issues and efforts. Environ. Health Perspect. 112, 495-505   DOI   PUBMED   ScienceOn
65 Ryu, J.-C., Kim, K.-R., and Choi, Y.-J. (1999b). in vitro mouse lymphoma thymidine kinase (tk+/-) gene forward mutation assay in mammalian cells. Environ. Mutagen & Carcinogen 19-1, 7-13
66 Sato, T., Chikazawa, K., Yamamori, H., Ose, Y., Nagase, H., and Kito, H. (1991). Evaluation of the SOS chromotest for the detection of antimutagens. Environ. Mol. Mutagenesis 17, 258-263   DOI   ScienceOn
67 Suzuki, T., Hayashi, M., Sofuni. T., and Myhr, B.C. (1993). The concomitant detection of gene mutation and micronucleus induction by mitomycin C in vivo using lac Z transgenic mice. Mutat. Res. 285, 219-224   DOI   PUBMED
68 Freeman, T. (2000). High throughput gene expressionscreening: its emerging role in drug discovery. Med. Res. Rev. 20, 197-202   DOI   PUBMED   ScienceOn
69 Ryu, J.-C. (2002a). Current Trend of Advanced Methods in Cellular and MoIecuIar ToxicoIogy. Environ. Mutagens & Carcinogens 22, 1-11
70 Zimmermann, F.K. (1971). Induction of mitotic gene conversion by mutagens. Mutat. Res. 11, 327-337   PUBMED
71 Olive, P.L., Garnet, F., and Judit, P.B., (1993). Radiation-induced apoptosis easured in tk6 Human B lymphocytes cells using the comet assay. Radiat. Res. 136, 130-136   DOI   ScienceOn
72 Clive, D., McCuen, R., Spector, J.F.S., Piper, C., and Mavournin, K.H. (1983). Specific gene mutations in L5178Y cells in culture : A report of the U.S.Environmental Protection Agency Gen-Tox Program. Mutat. Res. 115, 225-251   DOI   PUBMED   ScienceOn
73 Clive, D., Bolcsfoldi, G., Clements, J., Cole, J., Masamitsu,H., Majeska, J., Moore, M., Muller, L, Myhr, B., Oberly,T., Oudelhkim, M-C., Rudd, C., Shimada, H., Sofuni, T.,Thybaud, V., and Wilcox, P. (1995). Consensus agreementregarding protocol issues discussed during the mouselymphoma workshop. Environ. Mol. Mutagenesis 25, 165-168   DOI   ScienceOn
74 Hamadeh, H.K., Bushel, P.R., Jayadev, S., Martin, K., DiSorbo, O., Sieber, S., Bennett, L, Tennant, R., Stoll, R., Barrett, J.C., Blanchard, K., Paules, R.S., and Afshari, C.A. (2002a). Gene expression analysis reveals chemical-specific profiles. Toxicol. Sci. 67, 219-231   DOI   ScienceOn
75 Hamadeh, H.K. and Afsari, C. A. (2004). Toxicogenomics principles and applications (Jon Wiley and Sons, Inc.)
76 Tice, R.R., Agurell, E., Anderson, D., Burlinson, B., Hartmann, A., Kobayashi, H., Miyamae, Y., Rojas, E., Ryu, J.-C., and Sasaki, Y.F. (2000). Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 35, 206-221   DOI   ScienceOn
77 Mattingly, C.J., Colby, G.T., Rosenstein, M.C., Forrest, J.N.Jr., and Boyer, J.L. (2004). Promoting comparative molecular studies in environmental health research: anoverview of the comparative toxicogenomics database(CTD). Pharmacogenomics J. 4, 5-8   DOI   ScienceOn
78 Newton, R.K., Aardema, M., and Aubrecht, J. (2004). Theutility of DNA microarrays for characterizing genotoxicity. Environ. Health Perspect. 112, 420-422   DOI   PUBMED   ScienceOn
79 Fairbairn, D.W., Olive, P. L, and O'NeiII, K.L. (1995). Thecomet assay: a omprehensive review. Mutat. Res. 339, 37-59   DOI   PUBMED   ScienceOn
80 Ryu, J.-C., Kim, H.-T., and Kim, Y.-J. (2002d). Gene Expression Profiles of dibutyl phthalate and 17beta-estradiol using cDNA microarray in MCF7 Human Breast Cancer Cell Line. Environ. Mutagens & Carcinogens 22, 274-278
81 Pollack, A. (2000). DNA chip may help usher in a new era of product testing. New York Times 28, November, 2000.
82 Ryu, J.-C. and Kim, Y.-J. (2001c). Mutation spectrum of 1,2-dibromo-3-chloropropane, an endocrine disruptor, in the lac / transgenic Big Blue rat2 fibroblast cell line. Environ. Mol. Mutagenesis Vol. 37, Suppl. 32, P. 65
83 Ryu, J.-C. (2002b). Introduction of Recent Advanced Cellular and MoIecuIar ToxicoIogy. Kor. J. Pesticide Sci. 6, 157-165
84 Summers, W.C., Glazer, P.M., and Malkevich, D. (1989). Lambda phage shuttle vector for analysis of mutations in mammalian cells in cultures and in transgenic mice .Mutat. Res. 220, 263-268   DOI   PUBMED
85 Nuwaysir, E.F., Bittner, M., Trent, J., Barrett, J.C., and Afshari, C.A. (1999). Microarrays and toxicology: Theadvent of toxicogenomics. Mol. Carcinog. 24, 153-159   DOI   ScienceOn
86 Ryu, J.-C., Youn, J.-Y., Cho, K.-H., and Chang, I.-M.(1998b). Transgenic Mutagenesis assay to elucidate the mechanism of mutation in gene level. Environ. Mutagen & Carcinogen 18, 1-7   DOI   ScienceOn
87 Ryu, J.-C., Choi, Y.-J., Kim, Y.-J., Kim, H.-T., and Bang,H.-A. (1999c). Recent advanced toxicological methods for environmental hazardous chemicals. Kor. J. Environ.Toxicol. 14, 1-12   DOI
88 Toxicogenomics International Forum 2004. (2004). Oct.12-13, Kyoto Japan
89 Abbo, S., Dunford, R.P., Miller, T.E., Reader, S.M., andKing, I.P. (1993). Primer-mediated in situ detection of the B-hordein gene cluster on barley chromosomes 1H. GeneticsQO, 11821-11824
90 Irwin, R.D., Boorman, G.A., Cunningham, M.L., Heinloth,A.N., Malarkey, D.E., and Paules, R.S. (2004). Application of toxicogenomics to toxicology: basic concepts in the analysis of microarray data. Toxicol. Pathol. 32, Suppl 1, 72-83   DOI   ScienceOn
91 Bergeson, L.L., Campbell, L.M., and Bozof, R.P. (2002). Toxicogenomics The environmental forum Nov/Dec., 28-39