• 제목/요약/키워드: Toxicology

검색결과 5,313건 처리시간 0.029초

Effect of Genistein on the Wnt Signaling Pathway and Cell Growth

  • Moon, Hyun-Ju;Ryu, Sung-Yeoul;Kang, Tae-Seok;Kang, Ho-ll;Kang, ll-Hyun;Kim, Tae-Sung;Hong, Jin;Han, Soon-Young;Choi, Kang-Yell;Kwon, Ki-Sung
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2005년도 춘계 국제심포지엄 및 학술대회
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    • pp.189-189
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    • 2005
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Effects of Benomyl and Lindane during late pregnancy in the rat

  • Moon, Hyun-Ju;Shin, Jae-Ho;Lee, Sujung;Kang, Il-Hyun;Kim, Tae-Sung;Hoon Bae;Ryu, Seung-Yeoul;Seok, Ji-Hyun;Ahn, Ji-Yeon
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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    • pp.165-165
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    • 2002
  • These experiments tested whether exposure to benomyl (BN) or lindane (LD) during late pregnancy affect the development of reproductive tract in adult offspring. Timed pregnant Sprague Dawley rats (N=7∼8/treatment) were gavaged with LD (1, 5, or 10 mg/kg), BN (50, 250, or 500 mg/kg), or com oil on gestation days 15∼19.(omitted)

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Inhalation of Carbon Black Nanoparticles Aggravates Pulmonary Inflammation in Mice

  • Saputra, Devina;Yoon, Jin-Ha;Park, Hyunju;Heo, Yongju;Yang, Hyoseon;Lee, Eun Ji;Lee, Sangjin;Song, Chang-Woo;Lee, Kyuhong
    • Toxicological Research
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    • 제30권2호
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    • pp.83-90
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    • 2014
  • An increasing number of recent studies have focused on the impact of particulate matter on human health. As a model for atmospheric particulate inhalation, we investigated the effects of inhaled carbon black nanoparticles (CBNP) on mice with bleomycin-induced pulmonary fibrosis. The CNBPs were generated by a novel aerosolization process, and the mice were exposed to the aerosol for 4 hours. We found that CBNP inhalation exacerbated lung inflammation, as evidenced by histopathology analysis and by the expression levels of interleukin-6 protein, fibronectin, and interferon-${\gamma}$ mRNAs in lung tissues. Notably, fibronectin mRNA expression showed a statistically significant increase in expression after CBNP exposure. These data suggest that the concentration of CBNPs delivered (calculated to be $12.5{\mu}g/m^3$) can aggravate lung inflammation in mice. Our results also suggest that the inhalation of ultrafine particles like PM 2.5 is an impactful environmental risk factor for humans, particularly in susceptible populations with predisposing lung conditions.

Regeneration of nitrate and phosphate from toilet wastewater using waste alumina adsorbent for cultivation of Spirulina platensis

  • Lee, Sang-Jun;Park, Seonghwan;Noh, Won;Yeom, Dong-Hyuk;Kim, Sooyeon;Kim, Dae-wook;Kim, Jungmin
    • Environmental Engineering Research
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    • 제25권3호
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    • pp.393-399
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    • 2020
  • The use of different types of wastewater (WW) for the cultivation of microalgae and cyanobacteria during recent decades has provided important economic and environmental benefits. However, direct use of WW can lead to growth inhibition and biomass contamination. In the present study, we separated the key WW nutrients, namely nitrate and phosphate, by adsorption and regeneration and used the resulting regenerated water to cultivate the cyanobacterium Spirulina platensis. The adsorbent was granular γ-alumina derived from waste aluminum cans. This procedure recovered 19.9% of nitrate and 23.7% of phosphate from WW. The cyanobacterial cultures efficiently assimilated the nutrients from the medium prepared using regenerated WW, and the growth and nutrient uptake were similar to those in a synthetic medium. In addition, imposing nutrient limitations to increase carbohydrate productivity was easily achieved using regenerated wastewater nutrients, without requiring additional dilution or complex processing. In acute toxicity tests, the harvested biomass in a regenerated medium had similar toxicity levels compared to the biomass obtained from a synthetic medium. The proposed method of using regenerated WW to produce contamination-free biomass has broad potential applications.