• 한국의학물리학회지:의학물리
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• 제11권1호
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• pp.85-90
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• 2000

방사선치료에서 치료의 효과는 총선량, 치료회수, 1회 조사선량 등에 의해서 결정된다. 선량강도조절법을 사용하여 방사선치료를 행할 때 치료회수나 1회 조사선량을 고려하여 총선량에 미치는 효과를 살펴보고자 한다. 방사선치료의 목적은 암조직에는 충분한 선량을 조사하면서 주위 정상 조직에는 최소한의 선량을 조사되게 하여 치료성적의 향상으로 암환자의 생존율과 삶의 질을 높이는데 목적이 있다. 이러한 문제를 해결하기 위하여 많은 연구자들이 여러 가지 방법으로 해결하고자 노력한 결과 CT의 영상을 치료계획에 이용할 수 있게 되어 three dimensional conformal radiation therapy(3DCRT)를 개발하였다. 선량강도조절법을 시행하여 총선량을 75, 80, 85, 90Gy를 조사할 때, 처음부터 선량강도조절법을 사용하여 치료하는 경우와 일차적으로 45Gy를 조사하고 boost를 조사할 때 나머지 선량을 선량강도조절 법으로 사용하는 것을 TDF 환산법을 사용하여 비교하였다. 처음부터 선량강도조절법으로 치료할 경우에는 총선량에서 약 12.5 - 15 Gy 정도 감해서 조사하여야 하는 것으로 나타났다.

• 생물정신의학
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• 제25권3호
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• pp.60-71
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• 2018

Objectives A growing body of evidence has suggested that morphologic changes in cerebellum may be implicated with pathophysiology of major depressive disorder (MDD). The aim of this study is to investigate a difference in the volume and cortical thickness of the specific region of cerebellum between patients with MDD and healthy controls (HC). Methods A total of 127 patients with MDD and 105 HC participated in this study and underwent T1-weighted structural magnetic resonance imaging. We analyzed volume and cortical thickness of each twelve cerebellum regions divided by left and right and the volume and cortical thickness of the whole cerebellum from T1-weigted image of participants. One-way analysis of covariance was used to investigate the volume and cortical thickness difference of total and specific regions between two groups adjusting for age, gender, medication, and total intracranial cavity volume. Results We found that the patients with MDD had significantly greater volume in the left cerebellum lobule III region [false discovery rate (FDR)-corrected p = 0.034] compared to HC. Also, our findings indicate that cortical thickness of left lobule VIIB (FDR-corrected p = 0.032) and lobule VIIIB (FDR-corrected p = 0.032) are significantly thinner in the patients with MDD compared with the HC. No significant volume and cortical thickness differences were observed in other sub-regions of the cerebellum. The volumes and cortical thickness of whole cerebellum between patients with MDD and HC did not differ significantly. Conclusions We observed the region-specific volume and cortical thickness difference in cerebellum between the patients with MDD and HC. The results of our study implicate that the information about structural alterations in cerebellum with further replicative studies might provide a stepping stone toward a specific marker to diagnose MDD.

• 한국의류학회지
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• 제34권1호
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• pp.67-78
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• 2010

This paper analyzes how to measure breast volume and the change in breast volume after wearing a brassiere. Measurement using a breast replica is used to measure the breast volume of 41 women in their twenties. The rate of persons having flat and hemispherical breast are high. The majority of subjects are size 75A, 80A, and 75B, and their under-bust size is 70. The current size specification should be refined for fitting according as the girth under bust decreases. The correlation between breast volume and the circumference of the breasts was high. It was more reliable to set up the cup size of a brassiere using the breast circumference. The mean breast volume is 263.68cc (nude) and the total volume wearing brassiere is 342.05cc. The volume difference according to wearing a brassiere is 78.37cc, which is less than the brassiere volume itself. The results show, the less breast volume of a subject, then the greater volume in wearing a brassiere.

• Archives of Plastic Surgery
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• 제43권5호
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• pp.430-437
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• 2016

Background Accurate breast volume assessment is a prerequisite to preoperative planning, as well as intraoperative decision making in breast reconstruction surgery. The use of three-dimensional surface imaging (3D scanning) to assess breast volume has many advantages. However, before employing 3D scanning in the field, the tool's validity should be demonstrated. The purpose of this study was to confirm the validity of 3D-scanning technology for evaluating breast volume. Methods We reviewed the charts of 25 patients who underwent breast reconstruction surgery immediately after total mastectomy. Breast volumes using the Axis Three 3D scanner, water-displacement technique, and magnetic resonance imaging (MRI) were obtained bilaterally in the preoperative period. During the operation, the tissue removed during total mastectomy was weighed and the specimen volume was calculated from the weight. Then, we compared the volume obtained from 3D scanning with those obtained using the water-displacement technique, MRI, and the calculated volume of the tissue removed. Results The intraclass correlation coefficient (ICC) of breast volumes obtained from 3D scanning, as compared to the volumes obtained using the water-displacement technique and specimen weight, demonstrated excellent reliability. The ICC of breast volumes obtained using 3D scanning, as compared to those obtained by MRI, demonstrated substantial reliability. Passing-Bablok regression showed agreement between 3D scanning and the water-displacement technique, and showed a linear association of 3D scanning with MRI and specimen volume, respectively. Conclusions When compared with the classical water-displacement technique and MRI-based volumetry, 3D scanning showed significant reliability and a linear association with the other two methods.

• Journal of Nutrition and Health
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• 제26권4호
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• pp.405-413
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• 1993

The longitudinal changes on human milk volume of 27 Korean lactating women (primiparae=10, multiparac=17) from 0.5 to 6 months after parturition have been studied by test-weighing method in Cheongju and Anseong area. The human milk volume per day increased to 2 months postpartum, and then decreased during lactation. The mean volume(g/day) at 0.5, 1, 2, 3, 4, 5, and 6 months were 634, 810, 847, 840, 844, 810, and 732g, respectively. The average volume were 791 ($\pm$149) and 786($\pm$131)g for primiparae and multiparae, respectively. The overall mean volume was 788$\pm$135g/day. The distributions of the individual mean volume during the first 6 months of lactation were found 450~549g(3.7%), 550~649g(11.1%), 650~749g(22.2%), 750~849%(37.1%), 850~949g(18.6%), 950~1049g(3.7%), and 1050~1149g(3.7%). The mean volume between primiparae and multiparase was significantly lower than other periods. The peak milk volume during the lactation was observed at 3 months postpartum for primiparae(40%), 2 months postpartum for multiparae(35.3%), and 2 months postpartum for total lactating women(29.6%). The volume of human milk had a significant positive correlation with peak volume and infant milk intake, but no correlation with maternal age, weight before delivery, height, and birth weight.

• Archives of Plastic Surgery
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• 제33권2호
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• pp.161-167
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• 2006

After total glossectomy, recovery of swallowing and speech function can greatly improve quality of life. The reconstructed tongue must be thick enough to contact with the hard palate for articulation. If the free flap is denervation, it may procede to have atrophy postoperatively. Therefor it is difficult to maintain the tongue volume for a long period of time. To resolve this problem, we have used a innervated rectus abdominis musculocutaneous flap and maintaining the volume through a neurorrhaphy. 7 patients underwent immediate reconstruction using a reinnervated rectus abdominis musculocutaneous free flap in which included intercostal nerve was anastomosed to the remaining hypoglossal nerve. The reinnervated rectus abdominis musculocutaneous free flap has provided good tongue contour with sufficient bulk and shown no obvious atrophy in all patients even though postoperative 9 months later. Considering swallowing and articulation, we concluded that reinnervated rectus abdominis musculocutaneous flap is a viable method after total glossectomy

• Journal of Chest Surgery
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• 제21권2호
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• pp.211-222
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• 1988

Tetralogy of Fallot is a cyanotic congenital heart disease characterized by large ventricular septal defect[VSD] and stenosis of right ventricular outflow tract[RVOT] and the degree of RVOT stenosis and the state of pulmonary arteries are the major determinant of prognosis of this anomaly after operation. The sum of blood flow through RVOT and collateral flow from systemic arteries determine the total pulmonary blood flow and it is drained to left atrium and left ventricle. Therefore the degree of development of left ventricle not only reflects pulmonary blood flow and the status of peripheral pulmonary arteries but also affects postoperative prognosis as a systemic ventricle. In this article, left ventricular volume and its influence on postoperative cardiac function in tetralogy of Fallot were studied in 34 patients operated on at Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital in 1985. Mean age of the patients was 5 1/12*3 9/12 years[range 9/12 - 14 8/12 years], mean body surface area[BSA] 0.65*0.20m2[range 0.38 - 1.22m2], mean body weight 15.6k6.48kg[range 7.0 - 36kg]and mean hematocrit 50.6*9.77%[range 32.0 - 73.5%]. Left ventricular end-diastolic volume[LVEDV] of them were from 11.2 to 113cc and there was a good linear correlation between BSA[m2, X]and LVEDV[cc, Y][Y= - 20.0+923x, r= 0.84, p < 0.005]. Mean LVEDV/m2 was [57.6 * 18.3 cc / m2[range 28.7 - 95.8 cc / m2] and there was a significant reduction of volume compared with normal value. As body surface increases, there was a increasing tendency in LVEDV/m2 but there was no statistical significance. Mean total amount of postoperatively infused dopamine in these 33 patients[except one who expired postoperatively] was 65.6*74.5mg / kg and it was 40.6*44.0mg / kg in routine RVOT widening group [Group I] and 205*49.3mg / kg in transannular RVOT widening group[Group II]. There was a statistically significant difference between two groups. In group I patients there was a good linear inverse correlation between dopamine total amount[mg / kg, Y] and LV volume[cc / m2, X] [Y = 150 - 1.89 X, r = - 0. 77, p < 0.005]. But there were no correlations between dopamine total amount and Hct, cardiopulmonary bypass time and aorta cross clamp time. In conclusion, the patient with small preoperative left ventricular volume required more amount of dopamine as an inotropic agent for the maintenance of a cardiac function in postoperative period. But this is a result of immediate postoperative period and does not reflect the long term effect of left ventricular volume in tetralogy of Fallot. There must be more study for the evaluation of its long term effect.

• 화약ㆍ발파
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• 제33권4호
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• pp.1-6
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• 2015

본 연구에서는 3차원 레이저 스캐너를 이용하여 채광 중인 광산을 대상으로 굴진장, 여굴, 미굴 등의 요소들을 효율적으로 산정하고 평가하고자 하였다. 이를 위하여 3차원 레이저 스캐너를 활용하여 공간좌표를 기록하는 point-cloud를 획득하였고, 3차원 모델링 프로그램을 이용하여 지하 공동을 모델링 하였다. 연구결과를 통해 각 요소들을 고찰하였을 때 심발부 굴진장은 평균 2.6m, 전체는 평균 2.4m로 나타났으며, 천공장 3.8m를 기준하여 굴진율은 평균 심발부 67%, 전체 64%로 평가되었다. 또한 설계 단면을 기준으로 여굴량을 측정한 결과로 평균 좌측벽 $4.5m^3$, 우측벽 $4.5m^3$, 천반 $5m^3$, 총 $14m^3$로 측정되었으며, look-out을 기준으로 여굴량을 측정한 결과 좌측벽 $3m^3$, 우측벽 $3.1m^3$, 천반 $2.3m^3$, 총 $8.4m^3$로 측정되었다. 평균 굴착량 대비 여굴량은 설계 단면 기준 약 8%, look-out 기준 약 5%로 평가되었다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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• pp.143-143
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• 1998

Antagonists acting at the glycine site of the NMDA receptor have been gaining safer alternatives for stroke therapy because they have few adverse effect competitive and noncompetitive NMDA antagonists. Therefore, the neuroprotect novel glycine site antagonist KC0244 were evaluated in a rat model of transient comparison with GV150526A in a developmental phase. Middle cerebral artery oc was produced by insertion of a silicone-coated 4-0 nylon monofilament to the o in male Sprague-Dawley rats under isoflurane anesthesia. After 90 or 120 min retracted and the ischemic tissue reperfused. In 90-min MCAO model, GV150526A was administered 30 min before MCAO or immediately after MCAO. In 120-min MC KC0244 or GV150526A (10 mg/kg, i.p.) was administered 1 hr before MCAO or imme MCAO. Infarct volume was measured 24 hr after MCAO using the 2,3,5-triphe chloride staining method. In 90-min MCAO model, treatments with GV1505 significantly reduce infarct volume although they tended to slightly reduce cor approximately 19% compared with the nontreated group. In 120-min MCAO model with GV150526A did not either significantly reduce infarct volume although the reduce total infarct volume by approximately 16% compared with the vehicle-tre However, 1-hr preischemic and immediate treatments with KC0244 reduced total i 39 and 30% (corrected total infarct volume by 44 and 32%), respectively, co vehicle-treated control group. The results suggest that KC0244 can provid against transient focal ischemic damage with greater in vivo potency than GV150

• 대한한방부인과학회지
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• 제34권3호
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• pp.137-156
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• 2021

Objectives: The purpose of this study is to assess the effect of taking herbal medicine for the postpartum lactation. Methods: We searched 9 databases for recent three years, that contained four english, two chinese, one japanese and two korean database from September 17, 2016 to December 31, 2020. Randomized controlled trials (RCTs) were eligible. Measurement of outcome included total curative effective rate, volume of lactation, volume of milk supplement, and serum prolactin concentration. The risk of bias was assessed by two independent authors using the Cochrane risk of bias tool. Results: Total 725 of studies was screened, 11 RCTs were finally selected. Number of participants per study ranged from 60 to 257. The treatment group of taking a herbal medicine is effective for improving total curative effective rate, volume of lactation, volume of milk supplement, and serum prolactin concentration compared with control group. Because most of the studies had considerable heterogeneity in terms of type of intervention and comparison for outcome measurement, meta analysis for quantitative analysis was impossible. Conclusions: This studies showed that taking a herbal medicine is effective on increasing volume of lactation and speeding up the start of the first breastfeeding. However, included studies suffered from incomplete reporting, high or unclear risk of bias and substantial heterogeneity between studies. In the Future, further high-quality RCTs are needed to prove effectiveness of herbal medicine for breastfeeding and reduce the risk of bias.