• Journal of the Korean Society of Food Science and Nutrition
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• v.28 no.2
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• pp.409-416
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• 1999

Microwave extraction system equipped with closed vessels was applied to confirm its capability of extracting ginseng solubles including saponin, which was monitored to optimize extraction con ditions by response surface methodology. Total yield increased with the decrease in particles size and more extraction steps. Soluble components were completely extracted by operating the system within 6 min per one step, which should be repeated by 3 or 4 times. Optimized conditions for maxi mum extraction of response variables(total yield, crude saponin) were 40~50% of ethanol concentration, about 140oC of extraction temperature, and within 6 min of the extraction time. The extraction effi ciency of total yield was dependent on the decrease of ethanol concentration, while crude saponin content was favored on the higher degree of ethanol concentration. According to the temperature guideline, below 90oC of extraction temperature, the optimal ranges of extraction conditions were predicted as 30~50% of ethanol concentration and 2.5~6.5 min of extraction time. Estimated values of total yield and crude saponin were in good agreement with experimental values.

• Nuclear Engineering and Technology
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• v.54 no.5
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• pp.1902-1908
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• 2022

In many of the complex systems modeled in the field of nuclear engineering, it is often useful to use linear regression-based analyses to analyze relationships between model parameters and responses of interests. In cases where the response of interest is calculated by a simulation which uses Monte Carlo methods, there will be some uncertainty in the responses. Further, the reduction of this uncertainty increases the time necessary to run each calculation. This paper presents some discussion on how the Monte Carlo error in the response of interest influences the error in computed linear regression coefficients. A mathematical justification is given that shows that when performing linear regression in these scenarios, the error in regression coefficients can be largely independent of the Monte Carlo error in each individual calculation. This condition is only true if the total number of calculations are scaled to have a constant total time, or amount of work, for all calculations. An application with a simple pin cell model is used to demonstrate these observations in a practical problem.

• Journal of the Optical Society of Korea
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• v.17 no.2
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• pp.200-204
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• 2013

We propose a cell structure for the fast switching of liquid crystals by the fringe field. By forming protrusion between patterned electrodes, we can obtain enhancement of response time. The protrusion reduces the effective cell gap, with which a fast response time can be realized. There is little decrease in the transmittance because the protrusion is located between patterned electrodes. We confirmed that the total response time can be decreased by 33% with little loss of the transmittance by optimizing the shape of the protrusion structure.

• Journal of Acupuncture Research
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• v.17 no.1
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• pp.169-174
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• 2000

The immune response of Bee Venom Therapy is commonly appear in clinics. It is whole body delayed allergy type and generally like fatigue. Therefore, in order to analysis the clinical form, we have observed immune response of 100 patients who visited Sangji University Oriental Medical Hospital and treated Bee Venom Therapy over 10 times from November 1998 to October 1999. The results were summarized as follows. 1. The distribution of Sex was 60 females, 40 males, and the average of patients age was $50.6{\pm}1.5years$. 2. The distribution of disease was degenerative arthritis, HIVD of L-spine, RA, etc. 3. The total treated time is 2765 and is observed 361 immume responses. 4. The average of keeping time in immume response is $11.8{\pm}0.6(hr)$, and the cases of over 24hrs is occupied 24.0%. 5. In the correlation between treated times and immume response is generally in inverse proportion. 6. The general aspect of immume response is chilling, heating, powerless, headache, dizziness, etc. 7. $M{\ddot{u}}ller$ Grade II-III was observed only 1%.

• Food Science and Preservation
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• v.24 no.1
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• pp.74-83
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• 2017

This study was conducted to obtain the optimal conditions of hot air drying for Cudrania tricuspidata by response surface methodology (RSM). The independent variables were blanching time (60, 120, 240 sec), drying temperature (40, 60, $80^{\circ}C$) and drying time (12, 24, 36 h). The dependant variables were total polyphenol content (TPC), total flavonoid content (TFC), DPPH radical scavenging activity (DPPH), and color difference (${\Delta}E$). Viable cell colony was counted according to changes of blanching time. It was confirmed that microorganisms gradually decreased with increasing blanching time. From RSM results, the predicted values of TPC, TFC, DPPH, and ${\Delta}E$ were 8.62 mg GAE/g, 56.65 mg RE/g, 40.26% and 11.69, respectively. Experimental values within the optimal range (240 sec, blanching time; $60^{\circ}C$, drying temperature; 24 h, drying time) were 10.06 mg GAE/g, 49 mg RE/g, 44.99% and 10.53, respectively. The predicted values were similar to the experimental values. Comparing drying tendency according to changes of blanching time, moisture reduction was bigger in the blanched sample than that in control at $40^{\circ}C$. However, the differences between blanched and control decreased with increase of drying temperature. Viable cell gradually decreased as increasing blanching time.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.54 no.1
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• pp.9-15
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• 2021

Sargassum serratifolium is a rich source of antioxidant meroterpenoids. The optimal extraction temperature and time for obtaining maximal antioxidant yield, antioxidant activity, and phenolic content from Sargassum serratifolium were determined using response surface methodology (RSM). The ranges of the independent variables for extraction temperature and time were 30-70℃ and 12-36 h, respectively. With increasing temperature and time, the yield increased significantly, while DPPH (2,2-dipheny-1-picrylhydrazyl) radical-scavenging activity and total phenolic content decreased significantly. The optimal extraction temperature and time obtained by RSM were 54℃ and 7 h, respectively, providing a yield of 8.2%, DPPH radical-scavenging activity of 60%, and total phenolic content of 163 mg GAE/g. The findings of this study provide useful information for the development of Sargassum serratifolium extraction processes for the food and cosmetic industries.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1649-1654
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• 2013

Objective: This work aimed to evaluate the safety and clinical efficacy of transcatheter arterial chemoembolization (TACE) combined with c-arm cone-beam CT guided synchronous radiofrequency ablation (RFA) in treatment of large hepatocellular carcinoma (HCC). Methods: 21 patients with large HCC were studied from January 2010 to March 2012. TACE combined with synchronous C-arm cone-beam CT guided RFA were performed on a total of 25 lesions. Conventional imaging examination (CEUS, enhanced CT or MRI) and AFP detection were regularly conducted to evaluate the technical success rate of combined treatment, complications, treatment response, time without disease recurrence and survival rate. Results: The technical success rate of combined treatment was 100%, without any significant complication. After 1 month, there were 19 cases with complete response and 2 cases with partial response, with an complete response rate of 90.4% (19/21) and a clinical effective rate of 100% (21/21). The complete response rates of single nodular lesions (100%, 17/17) was significantly higher than that of multiple nodular lesions (50%, 2/4) (P<0. 05). During 2 to 28 months of follow-up, in 19 cases with complete response, the average time without disease recurrence was $10.8{\pm}6$ months. The total survival rates of 6, 12 and 18 months in 21 patients were 100%, respectively. Conclusion: TACE combined with synchronous C-arm CT guided RFA is safe and effective for treatment of large HCC. The treatment efficacy for single nodular lesion is better than that for multiple nodular lesions.

• New & Renewable Energy
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• v.7 no.4
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• pp.3-9
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• 2011

Optimization of initial total sugar concentration of sweet sorghum juice, aeration time and aeration rate on ethanol production was performed by response surface methodology (RSM). The optimum conditions for ethanol production from concentrated sweet sorghum juice were determined as follows: initial total sugar concentration, 21.2 Brix; aeration time, 7.66h; aeration rate, 1.22 vvm. At the optimum conditions, the maximum ethanol yield was predicted to be 91.65% by model prediction. Similarly, 92.98% of ethanol yield was obtained by verification experiment using optimum conditions after 48 h of fermentation. This result was in agreement with the model prediction.

• Structural Engineering and Mechanics
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• v.26 no.6
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• pp.635-650
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• 2007

In this paper, the equivalent exciting force caused by electric excitation is derived. By dividing load and displacement vectors into mean values and time-varying ones, the dynamic equations of the system are transformed into linear ones for time-varying portion of the displacements. The analytical equations of the forced time responses of the drive system to electric excitations are obtained. Using the Laplace transformation, the transfer function of the drive system is obtained. These equations are used to analyze the time and frequency responses of the drive system to the electric excitation. It is known that electric excitation can cause forced responses of the drive system, the total dynamic responses are decided by three phase exciting voltages, exciting frequency and natural frequencies of the drive system, and the drive parameters have obvious influence on the time and frequency responses.

• Journal of Korean Academy of Nursing
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• v.31 no.6
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• pp.998-1011
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• 2001

In order to improve self-management of elderly hypertensives in this study, the researcher examined the effect of blood pressure regulation by an abdominal relaxed breathing training which regulates physical response to stress and lessens the activity of the sympathetic nerve. Method: A quasi-experimental pre-test and post-test design was used. Thirty elderly hypertensive patient ; Sixteen in the abdominal breathing group and fourteen in the control group participated in this study. The abdominal relaxed breathing training consisted of eight sessions twice a week for four weeks. There was no intervention for the control group. Result: 1. There was a significant decrease in systolic and diastolic blood pressure between the experimental group and control group over three different times, and interaction by groups and over time. 2. There was no significant difference in the level of total stress response, physical stress response, behavioral-cognitive stress response between the experimental group and control group over three different times, and interaction by groups and over time. Conclusion: Findings indicate that this study will contribute to develop nursing strategies for the regulation of blood pressure for the elderly, which is easy for the elderly to learn as a nonpharmacologic approach.