• Korean Institute of Interior Design Journal
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• v.27 no.3
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• pp.136-144
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• 2018

The purpose of this study is to examined the unconscious response of the pupil in the observation toward the image in the eye-tracking experiments that target on a large complex cultural space. Twenty-five men participated in this experiment and the observation data were analyzed in seconds per minute on watching time. It could examine the unconscious response of information searching in the change of pupil size in the process of observing the space. The results could be defined as following several points. First, it was possible to outline the unconscious response characteristics of pupil by analyzing sudden changes in pupil size as total, cumulative, and individual. The response characteristics using frequency and time can be utilized as the analytical method to examine the degree of interest of spatial components according to the purpose of analysis in the future. Second, according to the over ${\pm}5%$ of cumulative variation rate on the pupil size change, during in the 60 seconds, the continuous pupil dilation was used 25.2 seconds in 8.8 rounds and the pupil reduction was used 18.0 seconds in 7.0 rounds. Third, when the variation rate of ${\pm}5%$ or more was regarded as the sudden changes on pupil size by individual variation, the pupil dilation was 7.2 rounds of 8.6 seconds and pupil reduction was 6.0 seconds in 5.0 rounds. This means that the pupil increases 9.3% in one expansion and decreases -8.5% in the reduction process. As regarding pupil changes as cumulative rate, it appeared high change rate on pupil reduction but it became higher on pupil dilation in individual.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.22 no.2
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• pp.248-255
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• 2013

The objective of this study is to optimize the Metal Injection Molding(MIM) process with design of experiments(DOE) and numerical analysis. To derive the optimal process condition, experiment or numerical analysis was performed under various process conditions. To analyze the interaction among influential factors contributing to the temperature at flow front and response surface in MIM, both central point and axial point were added to the full factorial design with 2 levels and 5 factors and then their impacts on response variable in 43 experimental conditions were analyzed and the significance was evaluated. As a result, sprue, runner, and gate were completely filled in about 0.247 seconds after injection, the front part of the green body was filled in about 0.3344 seconds, the green body except gate, etc changed to almost solid state in about 3.29 seconds, the Packinging pressure was completed in about 6.29 seconds, and the green body inside and outside and sprue, etc became solid in 13.2 seconds. The impact of individual or reciprocal action of factors on the temperature at flow front was analyzed through regular probability, test statistics, main effect, and interaction effect. As a result, of a total of 31 combinations of factors, 9 unit factors and reciprocal actions were significant, and the screening was also possible. A proper regression equation was drawn with regression analysis and response surface design on the response variable of temperature at flow front, and the applicability could be verified.

• Smart Media Journal
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• v.8 no.4
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• pp.72-79
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• 2019

The automated demand response (DR) program encourages consumers to participate in grid operation by reducing power consumption or deferring electricity usage at peak time automatically. However, successful deployment of the automated DR program sphere needs careful assessment of appliances load profile (ALP). To this end, the recent method estimates frequency, consistency, and peak time consumption parameters of the daily ALP to compute their potential score to be involved in the DR event. Nonetheless, as the daily ALP is subject to varying with respect to the DR time ALP, the existing method could lead to an inappropriate estimation; in such a case, inappropriate appliances would be selected at the automated DR operation that effected a consumer comfort level. To address this challenge, we propose a more proper method, in which all the three parameters are calculated using ALP that overlaps with DR time, not the total daily profile. Furthermore, evaluation of our method using two public residential electricity consumption data sets, i.e., REDD and REFIT, shows that our energy management systems (EMS) could properly match a DR target. A more optimal selection of appliances for the DR event achieves a power consumption decreasing target with minimum comfort level reduction. We believe that our approach could prevent the loss of both utility and consumers. It helps the successful automated DR deployment by maintaining the consumers' willingness to participate in the program.

• Journal of Microbiology and Biotechnology
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• v.23 no.6
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• pp.750-758
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• 2013

Anthrax is a bacterial disease caused by the aerobic spore-forming bacterium Bacillus anthracis, which is an important pathogen owing to its ability to be used as a terror agent. B. anthracis spores can escape phagocytosis and initiate the germination process even in antimicrobial conditions, such as oxidative stress. To analyze the oxidative stress response in B. anthracis and thereby learn how to prevent antimicrobial resistance, we performed protein expression profiling of B. anthracis strain HY1 treated with 0.3 mM hydrogen peroxide using a comparative proteomics-based approach. The results showed a total of 60 differentially expressed proteins; among them, 17 showed differences in expression over time. We observed time-dependent changes in the production of metabolic and repair/protection signaling proteins. These results will be useful for uncovering the metabolic pathways and protection mechanisms of the oxidative response in B. anthracis.

• Food Science and Biotechnology
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• v.18 no.1
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• pp.79-83
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• 2009

Acidolysis of olive oil with omega-3 (n-3) polyunsaturated fatty acids (PUFAs) was carried out to produce a structured lipid. Novozym $435^{(R)}$ from Candida antarctica was used as the biocatalyst. Response surface methodology (RSM) was used to determine optimum conditions for lipase-catalyzed enrichment of olive oil. Three factors, 5 levels, central composite design was used. The effects of incubation time, temperature, and substrate mole ratio on incorporation ratio (n-3 fatty acids/total fatty acids, %) were investigated. From the evaluation of response surface graphs, the optimal conditions for incorporation of long chain n-3 PUFAs into olive oil were $40-60^{\circ}C$ for temperature, 30-45 hr for reaction time, and 3:1-5:1 (n-3 fatty acids/olive oil) for substrate mole ratio. Experiments conducted under optimized conditions predicted by the model equation obtained from RSM yielded structured lipids with 50.8% n-3 PUFAs. This value agreed well with that predicted by the model. Oxidative stability tests showed that the product was more susceptible to oxidation than unmodified olive oil. Antioxidant addition improved the oxidative stability of the product.

• International Journal of Automotive Technology
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• v.8 no.2
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• pp.149-154
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• 2007

The engine behavior in a transient condition is important to not only emission regulations but also fuel economy. A fast response gas analyzer can be a useful tool to investigate exhaust gas in a transient operation. It should be designed to analyze gas concentration with a short time constant by a fast sampling module and an appropriate measuring method for each emission element. In this study, a new fast sampling module is introduced and flow analysis is performed by numerical simulation. The analysis has shown the proper operating condition and the sensitivity of the module for practical application. Calculated flow to the sampling module has $0.5{\sim}4%$ error, while backflow toward the expansion tube is expected when pressure in CP (Constant Pressure) chamber is over 0.6 bar. For a stable supply of flow to the optical cell, sample gas pressure should be in the range, $0.35{\sim}1.90$ bar, when the pressure in the CP camber and the optical cell are 0.2 bar and 0.158 bar, respectively.

• Nutritional Sciences
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• v.7 no.4
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• pp.208-213
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• 2004

In this study, we examined the effects of dietary 1,3-diacylglycerol (DG) compared to conventional triacylglycerol (TG) oil on the postprandial response of total and chylomicron TG, glucose, insulin, and free fatty acid (FFA). This study was conducted using a cross-over design. Ninety subjects participated in the high-fat meal tolerance test where they were randomly assigned to consume two experimental sandwiches containing mayonnaise with TG or DG oil with a seven-day interval. Blood samples were collected before ingestion and at 2, 3, 4 and 6 hr time point after ingestion and analyzed for total and chylomicron TG, glucose, insulin, FFA and phospholipid fatty acid composition. Both TG and DG ingestion had similar effects on postprandial TG response, but a different response from chylomicron TG. Compared with the TG group, TG levels were significantly lower only at 6 hr time point in the DG group. On the other hand, chylomicron TG rose steeply at 2 hr time point and decreased faster in this group. Also, the adjusted value to fasting levels was the same as the unadjusted level. Fasting levels and net differences in insulin were significantly lower at 3 hr time point where chylomicron TG levels were significantly lower in the DG group. But those of glucose and FFA in the TG and DG groups did not differ significantly. Fasting and postprandial levels of fatty acid composition in serum phospholipids in the two groups did not differ significantly. In conclusion, this study indicated that one could reduce the magnitude of postprandial lipemia without influencing glucose metabolism by consumning DG oil as a substitute for TG oil. Based on the correlation of coronary artery disease and postprandial lipemia, dietary DG ingestion might have a beneficial effect in treating such a disease. Further studies are required to clarify the long-tenn effects of dietary DG on blood lipid levels in humans.

• The Korean Journal of Food And Nutrition
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• v.17 no.2
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• pp.220-228
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• 2004

Dynamic headspace purge conditions were investigated to obtain minimum loss of high volatile compounds by breakthrough and maximum recovery of low volatile components of roasted perilla seed oil (RPSO). A response surface methodology was applied to evaluate the effect of purge temperature, purge time, and sample weight on $\ell$ n (total peak area), breakthrough ratio, and peak area of perilla ketone the least volatile component of RPSO. Sample weight was the most important factor on the $\ell$ n (total peak area) but it did not affect peak area of perilla ketone. All process variables significantly influenced breakthrough ratio. The optimum condition was determined by superimposing contour plots at purge temperature of 48$^{\circ}C$ for 12 min purge time at sample weight of 0.60 g. 2-Propanone, 2-butanone, acetic acid, 2-methyl propanal were main breakthrough compounds in RPSO flavor.

• Radiation Oncology Journal
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• v.30 no.4
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• pp.182-188
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• 2012

Purpose: For recurrent esophageal cancer after primary definitive radiotherapy, no general treatment guidelines are available. We evaluated the toxicities and clinical outcomes of re-irradiation (re-RT) for recurrent esophageal cancer. Materials and Methods: We analyzed 10 patients with recurrent esophageal cancer treated with re-RT after primary definitive radiotherapy. The median time interval between primary radiotherapy and re-RT was 15.6 months (range, 4.8 to 36.4 months). The total dose of primary radiotherapy was a median of 50.4 Gy (range, 50.4 to 63.0 Gy). The total dose of re-RT was a median of 46.5 Gy (range, 44.0 to 50.4 Gy). Results: The median follow-up period was 4.9 months (range, 2.6 to 11.4 months). The tumor response at 3 months after the end of re-RT was complete response (n = 2), partial response (n = 1), stable disease (n = 2), and progressive disease (n = 5). Grade 5 tracheoesophageal fistula developed in three patients. The time interval between primary radiotherapy and re-RT was less than 12 months in two of these three patients. Late toxicities included grade 1 dysphagia (n = 1). Conclusion: Re-RT of recurrent esophageal cancer after primary radiotherapy can cause severe toxicity.

• Molecular & Cellular Toxicology
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• v.2 no.2
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• pp.120-125
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• 2006

Phenytoin is an anti-epileptic. It works by slowing down impulses in the brain that cause seizures. The recent microarray technology enables us to understand possible mechanisms of genes related to compounds which have toxicity in biological system. We have studied that the effect of a compound related to hepatotoxin in vitro system using a rat whole genome microarray. In this study, we have used a rat liver epithelial cell line WB-F344 and phenytoin as a hepatotoxin. WB-F344 was treated with phenytoin for 1 to 24 hours. Total RNA was isolated at times 1, 6 and 24h following treatment of phenytoin, and hybridized to the microarray containing about 22,000 rat genes. After analysis with clustering methods, we have identified a total of 1,455 differentially expressed genes during the time course. Interestingly, about 1,049 genes exhibited differential expression pattern in response to phenytoin in early time. Therefore, the identification of genes associated with phenytoin in early response may give important insights into various toxicogenomic studies in vitro system.