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Effects of Methanol Extracts from Rhynchosia nulubilis on serum Lipid Concentrations in Rats fed High Fat and High Cholesterol Diet (서목태(Rhynchosia nulubilis) 추출물이 고지방 및 고콜레스테롤 식이 급여 흰쥐의 혈청 지질 농도에 미치는 영향)

  • Han, Sung-Hee;Shin, Mee-Kyung
    • Journal of the Korean Society of Food Culture
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    • v.17 no.1
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    • pp.64-69
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    • 2002
  • The effects of the Rhynchosia nulubilis extracts on serum lipid concentrations were evaluated in rats. Forty-two male Sprague-Dawley rats weighing $100{\pm}10g$ were divided into six groups and fed high fat and high cholesterol diets for four weeks. Experimental groups were administered with following diets; basal fat diet(control) and basal and high fat diets with 1% cholesterol and Rhynchosia nulubilis extract(40mg/kg, 400mg/kg and 4000mg/kg). The concentrations of serum triglyceride in rats fed the Rhynchosis mulubilis extract, high fat, 1% cholesterol, and RN-HFC(-40, -400, -4000mg/kg) groups were lower than those in other groups. The concentrations of total cholesterol in the RN-HFC (-40, -400, -4000mg/kg) groups were lower than those in fat diet groups. The concentrations of HDL-cholesterol in serum of the RN-HFC(-40, -400, 4000mg/kg) groups were significantly higer than those of other groups. The levels of LDL-cholesterol in serum of the RN-HFC(-40, -400, -4000mg/kg) groups were tended to be lower than those of other groups. These results suggest that Rhynchosia nulubilis extract may reduce elevated levels of serum lipid concentrations in rats fed high fat diets.

Evaluation of Total, Water-soluble and Hexavalent Chromium Contents in Construction Materials(Concretes, Cements)

  • Choi, In-Ja;Yoon, Chung-Sik;Choi, Sang-Jun
    • Journal of Environmental Health Sciences
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    • v.33 no.6
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    • pp.497-501
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    • 2007
  • The objective of the study is to determine the contents of total chromium, water-soluble chromium and hexavalent chromium in cements and concretes specimens taken from manufacturing or construction sites. Chromate is an allergen that is widespread in the environment and is richly contained in cements. Metals were extracted with microwave oven and analyzed by atomic absorption spectrometer. Hexavalent chromium was analysed by ion chromatography. The concentrations of total chromium, water-soluble chromium and hexavalent chromium in cements were $36.02{\sim}108.01,\;15.95{\sim}89.01\;and\;26.77{\sim}89.61\;mg/kg$, respectively. The concentrations of hexavalent chromium in cements were higher than 2 mg/kg, a maximum value recommended in Northern European Countries. The concentrations of total chromium, water-soluble chromium and hexavalent chromium in concretes were $17.44{\sim}76.25,\;0.98{\sim}17.71\;and\;ND{\sim}24.13\;mg/kg$, respectively. Especially Hexavalent chromium was detected only from concrete specimens from construction sites. It is oxidized or reduced status by environmental condition or surrounding materials.

Recovery and Recycling of Nitrogen and Phosphorus as Struvite from Livestock Excreta (가축분뇨로부터 struvite 결정화에 의한 질소 (N), 인 (P) 회수 및 자원화 방안 고찰)

  • Ryu, Hong-Duck;Ahn, Ki Hong;Chung, Eu Gene;Kim, Yongseok;Rhew, Doughee
    • Journal of Environmental Science International
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    • v.26 no.1
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    • pp.119-131
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    • 2017
  • This study evaluated the feasibility of recovering and recycling nitrogen (N) and phosphorus (P) from livestock excreta as struvite ($MgNH_4PO_4{\cdot}6H_2O$) in South Korea. Our experimental results showed that struvite precipitation was a very effective way to recover N and P from livestock excreta. Moreover, our study demonstrated that struvite precipitates from livestock excreta (SPL) contain higher concentrations of N, P, and magnesium (Mg) as compared to compost and liquid manure from livestock excreta. In addition, although SPL contain high concentrations of copper (Cu) and zinc (Zn), they meet the fertilizer criteria for concentrations of heavy metals. In South Korea, SPL cannot currently be used as a fertilizer due to legal constraints. Legal permission for SPL use would offer greater choice in livestock excreta management. In conclusion, recovery and recycling of N and P from livestock excreta as struvite can be an effective tool for managing nutrients in livestock excreta.

Serum allergen-specific and total IgE concentrations in dogs with allergic disorders in South Korea

  • Byoung-Gook Yoon;Han-Joon Lee;Kun-Ho Song
    • Korean Journal of Veterinary Service
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    • v.46 no.3
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    • pp.219-225
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    • 2023
  • Canine atopic dermatitis (CAD) has a genetic basis and is primarily a skin disorder characterized by allergic features. It is caused by an excessive immune response, associated with immunoglobulin E(IgE), to allergens and shows clinical signs of itching and inflammation. The present study evaluated the allergen-specific and total IgE concentration in dogs with allergic disorders. Allergen-specific IgE analysis was performed using a Multiple Allergen Simultaneous Test (MAST) assay, and total IgE analysis was conducted using an ELISA in 82 dogs with CAD. The subjects were divided into two groups: dogs aged ≤3 years and dogs aged >3 years, enabling a comparison of total IgE concentrations between the two age groups. The results showed that the major affecting environmental allergen was Alternaria alternate, and the major affecting dietary allergen was raw chestnut. The results revealed that dogs aged ≤3 years had higher total IgE concentrations than dogs aged >3 years with significant difference. The results of this study can contribute to the diagnosis and treatment of CAD in South Korea.

Improvement Effect of Hyperlipidemia by Wild Haw (Crataegus pinnatifida BUNGE) (자생 산사(Crataegus pinnatifida BUNGE)의 고지혈증 개선 효과)

  • Kim, Han-Soo;Kim, Min-A;Jang, Seong-Ho
    • Journal of Environmental Science International
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    • v.23 no.5
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    • pp.787-792
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    • 2014
  • The objective of this study was to investigate the effects of the Crataegus pinnatifida BUNGE extract supplementation of non esterified fatty acid (NEFA), concentrations of serum protein and electrolyte in sera on the hyperlipidemic rats. Concentrations of NEFA and globulin were remarkably lower in the Crataegus pinnatifida BUNGE extract group (HW group) than in the hyperlipidemic group (HD group), but no difference between control group (CO group) and extract of Crataegus pinnatifida BUNGE supplement in control group (NW group). However, concentrations of electrolyte K and A/G were higher in the HW group than HD group. Concentrations of total protein, albumin, electrolyte of total Ca, Pi, Na and Cl were no difference between HW group than HD group. The results indicate that Crataegus pinnatifida BUNGE extract was in the improvement of hyperlipidemic rats.

Effects of Dioscorea batatas and Gastrodia rhizoma on Lipid Compositional Changes of Liver, Brain and Kidney in Rats (마분말과 천마분말이 흰쥐의 간, 뇌 및 신장의 지질성분 변화에 미치는 영향)

  • 박필숙;성낙주;박미연
    • Journal of the East Asian Society of Dietary Life
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    • v.9 no.2
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    • pp.188-194
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    • 1999
  • The present study tested to recommend optimum level of Gastrodia rhizoma and effect on the compositional changes of the lipids in Sprague Bawley rats which were fed control diet adding 5, 10, 15% Dioscorea batatas powder and 5, 10, 15% Gastrodia rhizoma powder for 3 weeks, respectively The contents of moisture. ash, fat, protein and carbohydrate in dried Gastrodia rhizoma were 5.9, 2.7 2.1, 0.9 and 88.4%(w/w) respectively. Concentrations of total cholesterol and free cholesterol in liver were the lowest in the 10% Gastrodia rhizoma group. Concentrations of triglyceride and phospholipid in liver were lower in the 10 and 15% Gastrodia rhizoma groups than in the other groups. Concentrations of total cholesterol, free cholesterol, triglyceride and phospholipid in brain were significantly lower in the group 6, 7 compared to the other groups. Concentrations of triglyceride and phospholipid in kidney were slightly lower in the Gastrodia rhizoma groups than those in the Dioscorea batatas groups.

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A Study on the Obesity Incidence Rate and Fat Intake, Serum Total Cholesterol/Triglyceride Concentrations by Obese Index in the Elementary School Students (초등학생의 비만 이환율 및 비만도에 따른 지방 섭취량ㆍ혈청 총콜레스테롤/중성지질 수준 연구)

  • Choi Dong-Hee;Park Eun-Sook
    • Journal of the East Asian Society of Dietary Life
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    • v.15 no.1
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    • pp.29-39
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    • 2005
  • The obesity incidence rate of children in Korea has increased from 2 to 3% in 1970 to 15% in 2004. The purpose of this study was to evaluate the effect of diet on obesity, and serum cholesterol and triglyceride concentrations by obese index in Korean elementary school students. The subjects were three hundred and thirteen students(male 157, female 156). Height, weight and body fat were measured. Dietary records by the 24-hr recall method were taken for 3 days, and serum cholesterol and triglyceride concentrations were determined. The obesity index was calculated by the Korean of Pediatrics Association standards. Nutrient intakes were calculated by CAN PRO. Almost twenty percent(19.8%) of the subjects were underweight, 60.1 % were normal, 10.2% were overweight and 9.9% were obesity. The obesity incidence rate of the males was not different from the females. Energy and nutrients intakes containing fatty acids were not significantly different by the obesity index. All the subjects had 59.7%~61.1% of carbohydrate and 24.2%~25.6% of fat for energy. Serum cholesterol concentrations of the obesity group(177.3 mg/dl) was higher than those of the underweight group(161.8 mg/dl) and normal weight group(163.5 mg/dl) and overweight group(163.8 mg/dl). Twenty nine percent of the obesity group had serum cholesterol concentrations over 200mg/dl, as compared with 4.8% of the normal and underweight group. Serum triglyceride in the obesity group(103.0mg/dl) was higher than those of the underweight group(79.7 mg/dL), normal weight group(81.0 mg/dl) and overweight group(81.1 mg/dl). Serum total cholesterol concentrations were correlated with the obese index, PIBW, R hrer index at p<0.001, with BMI at p<0.01 and with waist/hip ratio at p<0.05. Serum triglyceride concentrations were correlated with the obese index, PIBW, R hrer index at p<0.01. It is concluded that obesity increases serum total cholesterol concentrations and triglyceride concentrations, and that the obesity preventive program for normal weight children, and weight reduction program for obese children are necessary for elementary school children's education.

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The Effects of Coadministration of Haloperidol and Bethanechol on Plasma Haloperidol and Reduced Haloperidol Concentrations (Haloperidol과 bethanechol 병합사용시 혈장 haloperidol 및 reduced haloperidol 농도에 미치는 영향)

  • Kim, Hyeong-Seob;Ahn, Jee-Young;Yeo, Un-Tae;Jo, Suk-Haeng
    • Korean Journal of Biological Psychiatry
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    • v.5 no.1
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    • pp.114-121
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    • 1998
  • Bethanechol, a cholinergic agonist, has been recommended for the management of peripheral anticholinergic side effects during the treatment of antipsychotic medications. But there have been few studies which have evaluated the drug interactions of antipsychotics and bethanechol, even the treatment effects of bethanechol on anticholinergic side effects. So the authors have evaluated whether psychopathology and plasma haloperidol and reduced haloperidol concentrations are significantly changed or not when bethanechol was administrated with maintained doses of haloperidol and other coadministrated drugs(such a benztropine). Also we have evaluated the abating effects of bethanechol on anticholinergic side effects during the treatment with haloperidol. Fifteen schizophrenics with higher than 5 of total score of anticholinergic side effects of 'Rating scale for side effect' were assigned to two groups, and bethanechol 30mg/day and 60mg/day were applied on each group for 4 weeks. The daily haloperidol dosages were fixed before 2 weeks of study. We assessed anticholinergic side effects by 'Rating scale for side effect' and psychopathology by BPRS, and plasma haloperidol and reduced haloperidol concentrations by HPLC at baseline, 2nd week and 4th week. The results were as followed, 1) there was no significant change of plasma haloperidol and reduced haloperidol concentration, 2) at baseline, the dosage of haloperidol showed significant correlation with the total score of anticholinergic side effect, but not at 2nd week and 4th week, 3) in 60mg/day group, dry mouth and the total score of anticholinergic side effects were significantly improved, but not in 30mg/day group, 4) there was no significant change of BPRS except withdrawal at 2nd week. These results suggest that coadministration of bethanechol influenced neither on psychopathology nor on plasma haloperidol and reduced haloperidol concentrations and that improved dry mouth and total score of anticholinergic side effects at 60mg/day.

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Evaluation of Fugitive Emission Characteristics of Airborne Volatile Organic Compounds from Different Source Categories (발생원 유형에 따른 공기 중 휘발성 유기화합물의 비산배출 특성 평가)

  • 백성옥;김미현;서영교
    • Journal of Korean Society for Atmospheric Environment
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    • v.19 no.4
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    • pp.363-376
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    • 2003
  • In this study, the fugitive emission characteristics of airborne volatile organic compounds from different source categories were evaluated with respect to the concentrations measured in the vicinity of the sources. A total of 22 different sources were investigated, including gasoline storage and filling stations, painting spray booth, laundry, printing officer, textile industries, and a number of environmental sanitary facilities such as landfill, wastewater treatment and incineration plants. The target VOCs included 83 individual compounds, which were determined by adsorption sampling and thermal desorption coupled with GC/MS analysis. Overall, the aliphatic compounds appeared to be the most abundant class of compounds in terms of their concentrations, followed by aromatic, and halogenated hydrocarbons. As a single compound, however, toluene was the most abundant one, explaining 11% of the total VOC concentrations as an average of all the dataset. Among source categories, petroleum associated sources such as gasoline storage/filling stations, and laundry factory were identified as the most significant sources of aliphatic hydrocarbons, while aromatic VOCs were dominantly emitted from the sources handling organic solvents, such as painting booth, printing offices, and textile dyeing processes. However. there was no apparent pattern in terms of the contributions of eath group to the total VOCs concentrations in environmental sanitary facilities. It was also found that the activated carbon adsorption tower installed for the VOC emission control in some facilities do not show any effective performances, which may result in the increased VOC levels in the ambient atmosphere.

Exposure Assessment of Airborne Dust in Manufacturing Industries Using Silicon Carbide in Korea (우리나라 실리콘카바이드 취급사업장의 공기 중 분진 노출평가)

  • Lee, Jun Jung;Phee, Young Gyu
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.21 no.3
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    • pp.177-183
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    • 2011
  • Occupational exposure to silicon carbide dust of manufacturing industries has seldom been evaluated in Korea. Accordingly, we evaluated various silicon carbide dust concentrations in the breathing zone of workers between May 2010 and July 2010. To compare silicon carbide dust concentrations, three dust samplers including the Institute of Occupational Medicine (IOM) sampler, 37mm cassette sampler, and Aluminum cyclone sampler were used. A total of 5 manufacturing industries producing abrasive and refractory materials using silicon carbide were investigated. The geometric mean concentrations were 2.04, 0.97, and $0.48mg/m^3$ in inhalable, total and respirable silicon carbide dust, respectively. The geometric mean concentrations of silicon carbide in abrasive material manufacturing industries were slightly higher than that of refractory manufacturing industries, and finishing operations were higher than that of other operations. It was found that the results of exposure assessment in airborne dust at manufacturing industries using silicon carbide in Korea showed exceeding rate to American Conference of Governmental Industrial Hygienists Threshold Limit Value ($3mg/m^3$) was 10% in respirable dust samples. Therefore, with the consideration of the close relationship between smaller dust size and the occurrence of occupational respiratory diseases, it is suggested to promulgate the new occupational exposure limit for respirable silicon carbide dust.