• Steel and Composite Structures
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• v.42 no.2
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• pp.257-264
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• 2022

The analysis of the progressive collapse resistance of structures is a well-known issue among structural engineers. Large-span reticulated dome structures are commonly utilized in large public buildings, necessitating research into their progressive collapse resistance to assure user safety. The most significant part of improving the structural resilience of reticulated domes is to evaluate their key elements. Based on a stiffness-based evaluation approach, this work offers a calculating procedure for element importance coefficient. For both original and damaged structures, evaluations are carried out using the global stiffness matrix and the determinant. The Kiewitt, Schwedler, and Sunflower reticulated domes are investigated to explore the distribution characteristic of element importance coefficients in the single-layer dome structures. Moreover, the influences of the load levels, load distributions, geometric parameters and topological features are also discussed. The results can be regarded as the initial concept design reference for single-layer reticulated domes.

• Herbal Formula Science
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• v.32 no.1
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• pp.11-28
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• 2024

Objectives : GunRyeong-Tang(GRT) is a traditional herbal prescription that combines Oryeongsan and Sagunja-tang. This study employed network analysis methods on the components of GRT and target genes related to diabetes complications to predict the improvement effects of GRT on diabetes complications. Methods : The collection of active compounds of GRT and related target genes involved the utilization of public databases and the PubChem database. We selected diabetes complication-related genes using GeneCards and confirmed their correlation through comparative analysis with the target genes of GRT. We constructed a network using Cytoscape 3.9.1 and conducted topological analysis. To predict the mechanism, we performed functional enrichment analysis based on Gene Ontology (GO) biological processes and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Results : Through network analysis, 234 active compounds and 1361 related genes were collected from GRT. A total of 9,136 genes related to diabetes complications were collected, and 1,039 target genes overlapping with the components of GRT were identified. The core genes of this network were TP53, INS, AKT1, ALB, and EGFR. In addition, GRT significantly reduced the H9c2 cell size and the expression of myocardial hypertrophy biomarkers (ANP, BNP), which were increased by high glucose (HG). Conclusions : Through this study, we were able to predict the activity and mechanism of action of GRT on diabetes and diabetic complications, and confirmed the potential of GRT as a treatment for diabetes complications through the effect of GRT on improving myocardial hypertrophy for diabetic cardiomyopathy.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2004.11a
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• pp.265-271
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• 2004

The interaction network of protein -protein plays an important role to understand the various biological functions of cells. Currently, the high -throughput experimental techniques (two -dimensional gel electrophoresis, mass spectroscopy, yeast two -hybrid assay) provide us with the vast amount of data for protein-protein interaction at the proteome scale. In order to recognize the role of each protein in their network, the efficient bioinformatical and computational analysis methods are required. We propose a systematic and mathematical method which can analyze the protein -protein interaction network rigorously and enable us to capture the biological and physical essence of a topological character and stability of protein -protein network, and sensitivity of each protein along the biological pathway of their network. We set up a Laplacian matrix of spectral graph theory based on the protein-protein network of yeast proteome, and perform an eigenvalue analysis and apply a perturbation method on a Laplacian matrix, which result in recognizing the center of protein cluster, the identity of hub proteins around it and their relative sensitivities. Identifying the topology of protein -protein network via a Laplacian matrix, we can recognize the important relation between the biological pathway of yeast proteome and the formalism of master equation. The results of our systematic and mathematical analysis agree well with the experimental findings of yeast proteome. The biological function and meaning of each protein cluster can be explained easily. Our rigorous analysis method is robust for understanding various kinds of networks whether they are biological, social, economical...etc

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6375-6378
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• 2012

Background: Small-cell lung cancer (also known as SCLC) is an aggressive form and untreated patients generally die within about 3 months. To obtain further insight into mechanism underlying malignancy with this cancer, an miRNA synergistic regulatory network was constructed and analyzed in the present study. Method: A miRNA microarray dataset was downloaded from the NCBI GEO database (GSE27435). A total of 546 miRNAs were identified to be expressed in SCLC cells. Then a miRNA synergistic network was constructed, and the included miRNAs mapped to the network. Topology analysis was also performed to analyze the properties of the synergistic network. Consequently, we could identified constitutive modules. Further, common target genes of each module were identified with CFinder. Finally, enrichment analysis was performed for target genes. Results: In this study, a miRNA synergistic network with 464 miRNAs and 2981 edges was constructed. According to the topology analysis, the topological properties between the networks constructed by LC related miRNAs and LC unrelated miRNAs were significantly different. Moreover, a module cilque0 could be identified in our network using CFinder. The module included three miRNAs (hsa-let-7c, hsa-let-7b and hsa-let-7d). In addition, several genes were found which were predicted to be common targets of cilque0. The enrichment analysis demonstrated that these target genes were enriched in MAPK signaling pathways. Conclusions: Although limitations exist in the current data, the results uncovered here are important for understanding the key roles of miRNAs in SCLC. However, further validation is required since our results were based on microarray data derived from a small sample size.

• Journal of the Korean Geographical Society
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• v.43 no.4
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• pp.526-543
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• 2008

Based on the social network analysis(SNA), this study examines the structural and spatial characteristics of the actor networks of the manufacturing industries for the elderly. In the field of economic geography, former researches on network have mainly focused on the network governance. However, this study focused on the social network analysis. Centrality indexes are used to analyze the topological structure of actor networks of firms and organizations. In order to investigate the spatial structure of actor networks, not only the regional distribution of actors but also the correlation between centrality index and distance are analyzed. Network matrixes among actors are transformed to network matrixes among regions using block modeling method to reveal the spatial characteristics of the actor networks. In spite of the importance of the Capital Region, networks in the non-Capital Region like Chungnam and Pusan were showed high network density. This suggested that some kinds of policy project operating in the non-Capital Region had the influence on this network in the initial stage of industry.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.8
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• pp.3806-3825
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• 2016

This paper brings out a neoteric frame of reference for visual semantic based 3d video search and retrieval applications. Newfangled 3D retrieval application spotlight on shape analysis like object matching, classification and retrieval not only sticking up entirely with video retrieval. In this ambit, we delve into 3D-CBVR (Content Based Video Retrieval) concept for the first time. For this purpose we intent to hitch on BOVW and Mapreduce in 3D framework. Here, we tried to coalesce shape, color and texture for feature extraction. For this purpose, we have used combination of geometric & topological features for shape and 3D co-occurrence matrix for color and texture. After thriving extraction of local descriptors, TB-PCT (Threshold Based- Predictive Clustering Tree) algorithm is used to generate visual codebook. Further, matching is performed using soft weighting scheme with L₂ distance function. As a final step, retrieved results are ranked according to the Index value and produce results .In order to handle prodigious amount of data and Efficacious retrieval, we have incorporated HDFS in our Intellection. Using 3D video dataset, we fiture the performance of our proposed system which can pan out that the proposed work gives meticulous result and also reduce the time intricacy.

• Transactions of the Korean Society of Automotive Engineers
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• v.10 no.3
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• pp.151-158
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• 2002

Automotive engineers involved in a new car project use various CAD systems that are chosen based on work requirements. For example, engineers in Hyundai Motors are using Pro/Designer and Alias fur the style design, but they use CATIA to design parts and assemblies, ANSYS for FEM analysis, and Pro/Engineer to design engines. Because they use different CAD systems, they have difficulties in collaborative design. Data, which contains errors, is transferred between CAD systems. It is difficult to find out such errors in a large CAD model. An evaluation method for CAD models has been developed in this study. This diagnosis tool analyses a STEP or an IGES file generated from a CAD system, and produces a quantitative error report. The tool has been tested with actual data sets. This paper proposes an algorithm that produces mathematical error values of entities of IGES models that have geometrical data, and entities of STEP models that have topological data, and inspects every part off model. To develop this system, we have used the OpenCASCADE kernel, which is an open source kernel developed by Matra Datavision of France.

• Korean Institute of Interior Design Journal
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• v.20 no.2
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• pp.139-146
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• 2011

An attempt is made to illuminate the characteristics of Korean high-rise apartment plans built after the 1990s in Seoul. Unlike the typical slab block plans of the past century, these plans were accommodated in a super-highrise building which normally integrates some portion of commercial areas on the lower floors. Thus, they are much different from the pre-1990s plans, so needs to have different strategy to adapt to the Korean dwellers' domestic requirements. This study reveals the topological patterns that appear in these new plans, and tries to relate these patterns to the old configuration patterns of the slab-type apartment houses. From the analysis, it was found that some important Korean dwellers' characteristics are still preserved, but at the same time, some unprecedented patterns were beginning to be absorbed into the spatial arrangement. At the end, suggestions are made on how this emerging trend of super-high rise can be better understood and evolved to enhance the living quality in a new multi-unit setting.

• Journal of Korean Society for Quality Management
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• v.37 no.3
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• pp.39-53
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• 2009

This paper suggests a new process structuring method, which we call process modularization, for decomposing and grouping activities in a process. Above all, we propose the concept of a module that is a group of activities positioned on the same flow before and after control constructs. Since activities in a module are relatively strongly interrelated with one another, it is important to take into consideration of these together. A design structure matrix (DSM) is used to structure the process because it has a lot of advantages in process modeling and analysis. We developed two algorithms: the restricted topological sorting (RTS) algorithm for ordering activities and the module finding (MF) algorithm for detecting modules in a process, which utilize the DSM. The suggested approach enables a firm's manager to design and analyze the process effectively. We also developed a supporting tool to accelerate the progress of process modularization. The supporting tool aids the process manager in finding the module and understanding the process structure easily. An illustrative example is addressed to show operations of the suggested approach.

• Korean Institute of Interior Design Journal
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• v.13 no.2
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• pp.29-37
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• 2004

This study analyze the architectural space in the aspect of the 'Raumplan' and 'Plan Libre'. These concepts based on the 'Raumplan versus Plan Libre' exhibition in Delft University, Netherlands. It is generally agreed that the concept of 'Plan Libre' in connection with Le Corbusie architecture and 'Raumplan' related to Adolf Loos's works. that exhibition contents was focused an extent of modem architecture. But, These concepts continually influence contemporary architecture and offer diverse vision in architecture. Therefore, this study focused on the analysis that look for common element in the space through the case study and space element connection in change of the values, technical growth. This Paper reveals that Adolf Loos's Raumplan is similar to Louis I. Kahn's 'Room' concept and Ando Tadao's centrifugal space composition method In the dwelling architecture. And the concept 'Plan Libre': non-definitive formal system and the elements : column, free form screening wall is revived as formal application of 3 dimension composition in architecture. and transfer lots, void, and linear space in Rem Koolhaas's urban design projects. These aspects is so called topology. This topological concept is an attempt in view of the space connection state rather than formative viewpoint.