• Advances in Traditional Medicine
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• 제5권3호
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• pp.188-194
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• 2005

The Angelicae dahuricae radix (ADR) has been used a traditional medicine to treat acne, erythema, headache, toothache, sinusitis, colds, and flu in Korea, Japan and China. Here, we report the effect of ADR on compound 48/80-induced ear-swelling and the phorbol myristate acetate (PMA) plus calcium ionophore A23187-induced inflammatory cytokine secretion in the human mast cell line, HMC-1. ADR dose-dependently inhibited the ear-swelling response induced by intradermal injection of compound 48/80, In vitro model, PMA plus A23187 significantly increased interleukin $(IL)-1{\beta}$, IL-8, granulocyte macrophage colony stimulating factor (GM-CSF), and tumor necrosis factor $(TNF)-{\alpha}$ secretion compared with media control. We also show that the increased cytokines $IL-1{\beta}$, IL-8, GM-CSF, and $TNF-{\alpha}$ level was significantly inhibited by treatment of ADR. In addition, ADR partially blocked PMA plus A23187-induced extracelluar signal-regulated kinases phosphorylation. These results suggest that ADR might explain its beneficial effect in the treatment of mast cell-mediated inflammatory diseases.

• 치위생과학회지
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• 제1권1호
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• pp.39-45
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• 2001

1999년 9월 20일에서 10월 23일까지 서울 및 경기도 소재의 사회복지시설과 의료시설 6곳을 선정하여 설문조사를 실시하여 치과를 이용하는 장애아동의 구강보건 행동과 태도를 조사 분석한 결과는 다음과 같다. 1. 장애인들은 자신의 치아가 대체로 건강하지 않다가 49.7%로 높게 나타났다. 2. 장애인들의 양치횟수는 장애유형에 따른 차이가 통계적으로 유의하게 조사되었다 (p<0.05). 3. 장애인들은 scaling(치석제거)경험이 없는 경우가 56.7%로 높게 나타났다. 4. 장애인들은 치통이나 잇몸 출혈 경험이 58.9%로 높게 나타났다. 5. 구강보건교육에 참석하겠다는 장애인은 64.4%로 통계적으로 유의한 차이가 있었다 (p<0.05). 6. 치과이용빈도는 불규칙한 방문을 하는 경우가 65.1%로 정기적인 치과방문으로 구강을 관리하는 비율이 낮았다. 7. 의료보험카드는 41.6%가 의료보호카드를 소지하고 있었다. 8. 장애와 구강건강은 관계가 있다가 61.8%로 통계적으로 유의한 차이가 있었다 (p<0.05).

• 치위생과학회지
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• 제16권5호
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• pp.378-383
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• 2016

질병발생 양상이 변화되고 건강에 대한 관심이 증가하며, 건강에 대한 임상적이며 객관적인 평가와 동시에 환자의 주관적 인식을 포괄하는 건강 상태를 평가하기 위한 노력이 계속되고 있다. HRQoL을 측정하는 것을 이러한 노력 중 하나로 꼽을 수 있는데, 본 연구는 일반적인 HRQoL과 구강건강 상태와의 관련성을 알아보기 위해 수행되었다. 대표성 있는 국민건강영양조사 자료 중 제6기 2차년도(2014년) 자료를 활용하여 분석을 수행하였다. EQ-5D로 측정된 일반적인 HRQoL에 영향을 미치는 요인은 성별, 연령, 교육수준, 소득수준, 민간건강보험 가입 여부, 주관적으로 인식하는 전신건강상태, 최근 1년간 치통 경험, 현존 치아 수로 확인되었다(p<0.05). 구강건강은 전반적인 건강상태를 결정짓는데 중요한 역할을 하기 때문에 객관적인 구강건강 상태가 전신건강에 영향을 미치고, 이는 결국 일반적인 HRQoL에 관련성이 있는 것으로 볼 수 있다.

• 대한임상독성학회지
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• 제2권1호
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• pp.20-22
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• 2004

Acute mercury inhalation poisoning is a rare cause of acute peripheral neuropathy. A 44-year-old female inhaled the fume from heating mercury to treat her palmar dermatitis. For 4 days, this procedure was done for 2-3 minutes after each meal. She subsequently complained flu like symptoms, such as headache, toothache, myalgia and arthralgia. She was admitted for 9 days and then symptoms disappeared. About 3 weeks after exposure, both knee pain developed and then she could not walk. To treat mercury intoxication, she was referred to our hospital. At that time, initial laboratory data were within normal limits, but blood and urinary mercury level were 5.6 11$\mu$g/dl, 132.8 $\mu$g/L. After treatment with D-penicillamine for 7 days, blood and urinary mercury level were 3.9 1$\mu$g/dl, 177.3 $\mu$g/L. During the following 1 month, both leg symptoms remained. Nerve conduction studies were performed, both leg sensory nerve amplitude decreased. These findings were suggestive of peripheral polyneuropathy.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제31권1호
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• pp.35-40
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• 2009

Dental emergency varies from toothache to trauma of oromaxillofacial area. Recently, the number of emergency cases after dental treatment is increasing because surgical treatments such as implant installation rise. Dental emergency patients have been looking for emergency room of general hospital and they could be treated only when the dentist of night duty exists. Although there are many analyses on the dental emergency patients visiting general hospitals, research on the dental treatment only has not been provided enough. We anticipated different aspects between the dental emergency patients visiting independent dental hospital and general hospitals. We analyzed dental emergency patients' chief complaints and received procedures for almost 1-year period in Won-Kwang dental hospital in Dae-jeon where there had been no dental emergency settings. With this 1574 patients' result, we tried to find appropriate treatment plans regarding dental emergency patients occurring at night and holidays.

• 디지털융복합연구
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• 제16권7호
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• pp.267-275
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• 2018

본 연구는 노인의 중대 구강병 영향요인을 분석하여, 구강건강 관련 삶의 질 저해요인 관리의 필요성을 제안하고자 실시하였다. 본 연구는 6기 3차년도(2015) 국민건강영양조사 자료를 이용하였다. 본 연구의 종속변수는 중대 구강병으로, 독립변수는 인구사회학적 특성, 건강상태 및 행태, 구강건강상태 및 행태로 하였으며, 주요 결과는 다음과 같다. 치아우식증 영향요인은 소득(p<.01), 건강검진 수진여부(p<.05), 최근 1년간 치통 경험 여부(p<.05), 구강위생용품 사용여부(p<.01)로 나타났다. 치주질환 영향요인은 연령(p<.05), 직업(p<.05), 동반질환 여부(p<.05)로 나타났다. 이러한 결과를 토대로 관련 연구가 활성화되어 노인기의 구강건강 증진을 위한 정책 대안이 마련되어야 할 것이다.

• Advances in Traditional Medicine
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• 제9권2호
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• pp.186-191
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• 2009

Eriocaulon sieboldianum (ES) is used in traditional oriental medicine for various medicinal purposes including headache, toothache, and inflammation. However, the anti-cancer effect of the ES is still not fully understood. In the present study, the human leukemia cell line HL-60 was used to characterize the apoptotic effects of ES. ES induced cytotoxicity of HL-60 cells in a dose- and time-dependent manner. ES induced the generation of reactive oxygen species, and the release of cytochrome c in a dose-dependent manner. In addition, we showed that ES-induced apoptosis was accompanied by activation of caspase-3. Taken together, our results demonstrate that ES possesses anti-cancer activity in HL-60 cells.

• 대한약침학회지
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• 제4권2호
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• pp.35-47
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• 2001

Objectives : Through the literatures on the effets of Bufonis Venenum, we are finding out the clinical possibility and revealing the more effective to intractable diseases. Methods : We investigated the literatures of Oriental Medicine and experimental reports about Bufonis Venenum. Results : 1. Bufonis Venenum is made of bufonidae bufo bufo gargarizans cantor or bufo melanostictus schneider of white serum which secreted from parotid gland or dermato gland, and it is dried for using. 2. In oriental medicine, Bufonis Venenum has been mainly used on the tumors, cacanthrax and dermatic disease, and then it has been clinically used on infantile athrepsia, tetanus, sore throat, toothache, and so on. 3. The pharmacological effects of Bufonis Venenum are cardiotonic, respiration stimulation, depressor or vasopressor, topical anesthcsia, hallucination, striped muscle stimulation, antiasthmatic, antibacterial, antiinflammatory, anticancer, diuretic, immuno effects, etc. 4. Bufonis Venenum is largely divided in ether binding steroid compound, hydroxyl steroid compound, carboxyl or aldehyde steroid compound, indole compound, and adrenaline, cholesterole, etc. 5. Symptoms of Bufonis Venenum poisoning in digestive system are vommitig, abdominal pain, diarrhea, dehydration, in circulatory system are palpitation, shock, bradycardia, in nervous system are vertigo, somnolentia, muscle-tendon reflex weakness, and critical conditions to tissue necrosis and heart attack. 6. Ways to treat Bufonis Venenum poisoning include gastric irrigation with $0.2~0.5\%$ potassium permanganate fluid and atropine $0.5{\sim}1.0mg$ subcutaneous injection. From the chinese book of Bon Cho Gang Moke(本草綱目), if white serum of Bufonis Venenum enter the eyes, it happens the edema and pain. And then washed the eyes by juice of Lithospermi Radix(紫草) that the edema is removed. Conclusions and Discussion : The results from above literary studies show that prescriptions and Aqua-acupuncture of Bufonis Venenum could be clinically used to sedative, anticonvulsant, antibacterial, antiinflammatory, anticancer and topical ataralgesia. However it is expected that pharmacological and side effects of Bufonis Venenum are further studied.

• Natural Product Sciences
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• 제13권4호
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• pp.304-310
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• 2007

Saussurea costus (Falc.) Lipchitz syn S. lappa C. B. Clarke (commonly known as 'Kuth') belonging to the family Asteraceae is a well known medicinal plant which finds wide usage in different indigenous systems of medicine of India, China, Korea & Tibet. In different folk medicines the roots of S. costus are used to treat various disorders like ulcer, stomachache, malaria, leprosy, dysentery and toothache. However due to over exploitation, it has become endangered and has become the concern of different governmental bodies in India. The increasing demand of this endangered Himalayan species has resulted in a situation where it is often substituted, knowingly or unknowingly, by other morphologically similar species. Arctium lappa, belonging to the same family, is one such plant that has often been found to be present in the market samples of 'Kuth'. The present study was thus carried out and morphoanatomical characters, physicochemical as well as chemical parameters were developed for proper identification of roots of S. costus and its differenciation from A. lappa as well as authentication of the commercial market samples. The detailed morphoanatomical studies revealed that roots of S. costus can be distinguished from A. lappa on the basis of some important microscopial characters eg. the schizogenous resin ducts observed in roots of S. costus, were absent in A. lappa.. Besides, the HPTLC fingerprint profile showed a distinct band at Rf. 0.72 in S. costus, which was totally absent in A. lappa and a band at $R_f$ 0.64 in A. lappa which was absent in S. costus Chlorogenic acid, used as a chemical marker for HPTLC analysis, was estimated to be 0.077% in S. costus as compared to 0.107% in A. lappa. Thus these detailed pharmacognostical parameters can be successfully used to distinguish between roots of S. costus and A. lappa.

• Journal of Dental Anesthesia and Pain Medicine
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• 제17권4호
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• pp.253-263
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• 2017

Regardless of whether it is acute or chronic, the assessment of pain should be simple and practical. Since the intensity of pain is thought to be one of the primary factors that determine its effect on a human's overall function and sense, there are many scales to assess pain. The aim of the current article was to review pain intensity scales that are commonly used in dental and oral and maxillofacial surgery (OMFS). Previous studies demonstrated that multidimensional scales, such as the McGill Pain Questionnaire, Short form of the McGill Pain Questionnaire, and Wisconsin Brief Pain Questionnaire were suitable for assessing chronic pain, while unidimensional scales, like the Visual Analogue Scales (VAS), Verbal descriptor scale, Verbal rating scale, Numerical rating Scale, Faces Pain Scale, Wong-Baker Faces Pain Rating Scale (WBS), and Full Cup Test, were used to evaluate acute pain. The WBS is widely used to assess pain in children and elderly because other scales are often difficult to understand, which could consequently lead to an overestimation of the pain intensity. In dental or OMFS research, the use of the VAS is more common because it is more reliable, valid, sensitive, and appropriate. However, some researchers use NRS to evaluate OMFS pain in adults because this scale is easier to use than VAS and yields relatively similar pain scores. This review only assessed pain scales used for post-operative OMFS or dental pain.