• 공학논문집
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• 제2권1호
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• pp.49-56
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• 1997

Emission computed tomography에 있어서 Bayesian방법에 근거한 통계학적 영상 재구성법이 수년간에 걸쳐 중요한 관심사로 대두되어 왔다. 이는 Bayesian 접근 방법을 사용할 경우 영상 재구성 알고리즘에 재구성하고자 하는 영상에 대한 사전정보를 포함시킬 수 있기 때문이었다. 이러한 방법은 경우에 따라 향상된 성능을 보이고 있으나, 막대한 계산시간으로 인해 실제 임상에 적용되기가 매우 어려운 상황이다. 한편, filtered backprojection(FBP)은 알고리즘 자체가 간단하고 계산시간도 매우 단축되므로 대부분의 임상에 널리 적용되고 있다. 본 연구에서는 Bayesian 영상 재구성에서 매우 유용하게 사용되는 spline 모델을 FBP의 고주파 감쇠를 위한 정칙자로 사용함으로써 FBP 영상 재구성에 Bayesian 방법과 유사한 효과를 얻을 수 있음을 보인다.

• Nuclear Medicine and Molecular Imaging
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• 제42권6호
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• pp.425-434
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• 2008

Dopamine transporter imaging is useful in the diagnosis of Parkinson's disease and the most successful technique in the clinical use of neuroreceptor imaging. Recently, several radiopharmaceuticals including I-123 FP-CIT, Tc-99m TRODAT, and F-18 FP-CIT for dopamine transporter imaging have been approved for the routine clinical use in several European countries, Taiwan and Korea, respectively. This review summarized the practical issue for the routine clinical examination of dopamine transporter imaging.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 2005년도 제44차 추계학술대회 및 총회
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• pp.343.1-343.1
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• 2005

• 대한의용생체공학회:의공학회지
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• 제12권1호
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• pp.43-48
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• 1991

As the computerized methods and equipments In nuclear medicine imaging increases, quantitative information is needed on the single photon emission computed tomographic Images as well as on the conventional nuclear medicine images. In this paper, the authors investigated the effect of several clinician - friendly reconstrution filters on the resultant transverse slices of backprojected Profiles of radioisotope distribution from the Quantitative point of view, and reduced the filter parameters such as cutoff frequency and order of filter which are neces mary to minimize the quantification error using computer-generated phantoms.

• Journal of Gastric Cancer
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• 제14권1호
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• pp.1-6
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• 2014

Aerobic glycolysis has been the most important hypothesis in cancer metabolism. It seems to be related to increased bioenergetic and biosynthetic needs in rapidly proliferating cancer cells. To this end, F-18 fluorodeoxyglucose (FDG), a glucose analog, became widely popular for the detection of malignancies combined with positron emission tomography/computed tomography (PET/CT). Although the potential roles of FDG PET/CT in primary tumor detection are not fully established, it seems to have a limited sensitivity in detecting early gastric cancer and mainly signet ring or non-solid types of advanced gastric cancer. In evaluating lymph node metastases, the location of lymph nodes and the degree of FDG uptake in primary tumors appear to be important factors affecting the diagnostic accuracy of PET/CT. In spite of the limited sensitivity, the high specificity of PET/CT for lymph node metastases may play an important role in changing the extent of lymphadenectomy or reducing futile laparotomies. For peritoneal metastases, PET/CT seems to have a poorer sensitivity but a better specificity than CT. The roles of PET/CT in the evaluation of other distant metastases are yet to be known. Studies including primary tumors with low FDG uptake or peritoneal recurrence seem suffer from poorer diagnostic performance for the detection of recurrent gastric cancer. There are only a few reports using FDG PET/CT to predict response to neoadjuvant or adjuvant chemotherapy. A complete metabolic response seems to be predictive of more favorable prognosis.

• Tuberculosis and Respiratory Diseases
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• 제80권4호
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• pp.368-376
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• 2017

Background: A ground-glass nodule (GGN) represents early-stage lung adenocarcinoma. However, there is still no consensus for preoperative staging of GGNs. Therefore, we evaluated the need for the routine use of positron emission tomography/computed tomography (PET)/computed tomography (CT) scans and brain magnetic resonance imaging (MRI) during staging. Methods: A retrospective analysis was undertaken in 72 patients with 74 GGNs of less than 3 cm in diameter, which were confirmed via surgery as malignancy, at the Samsung Medical Center between May 2010 and December 2011. Results: The median age of the patients was 59 years. The median GGN diameter was 18 mm. Pure and part-solid GGNs were identified in 35 (47.3%) and 39 (52.7%) cases, respectively. No mediastinal or distant metastasis was observed in these patients. In preoperative staging, all of the 74 GGNs were categorized as stage IA via chest CT scans. Additional PET/CT scans and brain MRIs classified 71 GGNs as stage IA, one as stage IIIA, and two as stage IV. However, surgery and additional diagnostic work-ups for abnormal findings from PET/CT scans classified 70 GGNs as stage IA, three as stage IB, and one as stage IIA. The chest CT scans did not differ from the combined modality of PET/CT scans and brain MRIs for the determination of the overall stage (94.6% vs. 90.5%; kappa value, 0.712). Conclusion: PET/CT scans in combination with brain MRIs have no additional benefit for the staging of patients with GGN lung adenocarcinoma before surgery.

• Korean Journal of Radiology
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• 제22권4호
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• pp.604-611
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• 2021

Objective: The aim of this pilot study was to investigate the potential of early-phase single-photon emission computed tomography (SPECT)/computed tomography (CT) using technetium-99m methyl diphosphonate (^99mTc-MDP) for diagnosing osteomyelitis (OM). Materials and Methods: Twenty-one patients with suspected OM were enrolled retrospectively. Three-phase bone scan (TPBS), early-phase SPECT/CT (immediately after blood pool planar imaging), and delayed-phase SPECT/CT (immediately after delayed planar imaging) were performed. The final diagnoses were established through surgery or clinical follow-up for over 6 months. We compared three diagnostic criteria based on (I) TPBS alone, (II) combined TPBS and delayed-phase SPECT/CT, and (III) early-phase SPECT/CT alone. Results: OM was diagnosed in 11 of 21 patients (nine surgically and two clinically). Of the 11 OM patients, criterion-I, criterion-II, and criterion-III were positive in six, seven, and 10 patients, respectively. Of the 10 non-OM patients, criterion-I, criterion-II, and criterion-III were negative in five, five, and seven patients, respectively. The sensitivity/specificity/accuracy of criterion-I, criterion-II, and criterion-III for diagnosing OM were 54.5%/50.0%/55.0%, 63.6%/50.0%/57.1%, and 90.9%/70.0%/87.5%, respectively. Conclusion: This pilot study demonstrated the potential of using the early-phase SPECT/CT to diagnose OM. Based on the results, prospective studies with a larger sample size should be conducted to confirm the efficacy of early-phase SPECT/CT.

• Annals of Clinical Neurophysiology
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• 제10권1호
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• pp.13-24
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• 2008

Functional neuroimaging, especially positron emission tomography (PET) and functional magnetic resonance imaging (MRI), is the main tool that allows the unveiling of the neurovascular events during a migraine attack. In migraine with aura, functional neuroimaging has contributed greatly to the understanding of the fundamental pathophysiology of the visual aura, whereas in migraine without aura, the PET findings of brainstem activation suggest a pivotal role of brainstem in the generation of migraine headache. In addition, voxel-based morphometry (VBM) method has provided an insight into the morphometric changes of the brain, which might be considered as a consequence of repeated migraine attacks. In this article, I will briefly discuss the main neuroimaging findings pertaining to the pathophysiology of migraine.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1998년도 춘계학술발표회논문집(2)
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• pp.705-710
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• 1998

We describe a multigrid wavelet-based natural pixel (WNP) method for image reconstruction in emission computed tomography (ECT). The ECT is used to identify the tagged radioactive material's position in the body for detection of abnormal tissue such as tumor or cancer, as in SPECT and PET. With ECT methodology in parallel beam mode, we formulate a matrix-based reconstruction method for radionuclide sources in the human body. The resulting matrix for a practical problem is very large and nearly singular. To overcome this ill-conditioning, wavelet transform is considered in this study. Wavelets have inherent de-noising and multiscale resolution properties. Therefore, the multigrid wavelet-based natural pixel (WNP) method is very efficient to reconstruct image from projection data that is noisy and incomplete. We test this multigrid wavelet natural pixel (WNP) reconstruction method with the MCNP generated projection data for diagnosis of the simulated cancerous tumor.

• Nuclear Medicine and Molecular Imaging
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• 제42권2호
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• pp.118-126
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• 2008

Statistical image reconstruction methods have played an important role in emission computed tomography (ECT) since they accurately model the statistical noise associated with gamma-ray projection data. Although the use of statistical methods in clinical practice in early days was of a difficult problem due to high per-iteration costs and large numbers of iterations, with the development of fast algorithms and dramatically improved speed of computers, it is now inevitably becoming more practical. Some statistical methods are indeed commonly available from nuclear medicine equipment suppliers. In this paper, we first describe a mathematical background for statistical reconstruction methods, which includes assumptions underlying the Poisson statistical model, maximum likelihood and maximum a posteriori approaches, and prior models in the context of a Bayesian framework. We then review a recent progress in developing fast iterative algorithms.