• Journal of Aerospace System Engineering
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• v.14 no.spc
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• pp.1-6
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• 2020

The flaw tolerance evaluation requirement prescribed in Federal Aviation Regulation (FAR) §29.571 Amendment 55 was established in 2012. As a result, there are not many datas of flaw tolerance evaluation. This paper introduces the series of processes and evaluation methods carried out for certification based on the flaw tolerance evaluation. An initial flaws were artificially formed on the main rotor actuator and then the damage tolerance test was performed, which was twice life time of design requirements, to demonstrate that the main rotor actuator of the rotorcraft is sufficiently capable of flaw tolerance.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.17 no.2
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• pp.126-136
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• 2021

During operation of nuclear power plants, the fatigue assessment should be conducted repeatedly, considering changes of operating environments. For the case that cumulative usage factors (CUFs) may exceed the acceptance limit, flaw tolerance evaluation can be an alternative method to meet the regulatory requirements. In this respect, this paper analyzes the effects of the input variables for flaw tolerance evaluation based on ASME BPVC Section XI Appendix L. The reference analysis is performed for the example problem in NUREG/CR-6934. Then effects of the crack orientation, stress intensity factor solutions, thermal stress profiles, fatigue stress decomposition and fatigue crack growth curves are considered for the sensitivity analysis. The results show that the stress analysis considering the actual environment plays a crucial role in flaw tolerance evaluation.

• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.6.1-6.12
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• 2018

Morphine tolerance remains a challenge in the management of chronic pain in the clinic. As shown in our previous study, the dopamine D2 receptor (D2DR) expressed in spinal cord neurons might be involved in morphine tolerance, but the underlying mechanisms remain to be elucidated. In the present study, selective spinal D2DR blockade attenuated morphine tolerance in mice by inhibiting phosphatidylinositol 3 kinase (PI3K)/serine-threonine kinase (Akt)-mitogen activated protein kinase (MAPK) signaling in a ${\mu}$ opioid receptor (MOR)-dependent manner. Levo-corydalmine (l-CDL), which exhibited micromolar affinity for D2DR in D2/CHO-K1 cell lines in this report and effectively alleviated bone cancer pain in our previous study, attenuated morphine tolerance in rats with chronic bone cancer pain at nonanalgesic doses. Furthermore, the intrathecal administration of l-CDL obviously attenuated morphine tolerance, and the effect was reversed by a D2DR agonist in mice. Spinal D2DR inhibition and l-CDL also inhibited tolerance induced by the MOR agonist DAMGO. l-CDL and a D2DR small interfering RNA (siRNA) decreased the increase in levels of phosphorylated Akt and MAPK in the spinal cord; these changes were abolished by a PI3K inhibitor. In addition, the activated Akt and MAPK proteins in mice exhibiting morphine tolerance were inhibited by a MOR antagonist. Intrathecal administration of a PI3K inhibitor also attenuated DAMGO-induced tolerance. Based on these results, l-CDL antagonized spinal D2DR to attenuate morphine tolerance by inhibiting PI3K/Akt-dependent MAPK phosphorylation through MOR. These findings provide insights into a more versatile treatment for morphine tolerance.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2014.04a
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• pp.191-196
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• 2014

In the evaluation of measured noise data, tolerance shall be decided based on the uncertainty. The uncertainty has frequency variations due to the different standard deviations at each frequency. Therefore, tolerance shall be differently decided for each frequency with the same confidence probability. In the report, the evaluation method considering the frequency variation of uncertainty will be introduced. From the approach, considering the actual noise distribution characteristics of the ships, the tolerance shall be decided for each frequency with the same probability, but the overall averaged value shall be kept to the value designated in each notation.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2013.05a
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• pp.461-462
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• 2013

• Journal of the Korea Institute of Military Science and Technology
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• v.5 no.2
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• pp.149-158
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• 2002

Static Characteristics of the system, such as weight, center of gravity etc., are inspected and regulated through the whole design process of a light weight torpedo system, and the nominal condition of the characteristics is prescribed for standardization of manufacturing and fabrication. It is possible that a real system or assembled system has different static characteristics from that of the nominal condition. It is required to evaluate the tolerance of the static characteristics within which the performance of the system should not be contaminated by the static characteristics. In this paper, an evaluation method of the tolerance is described for light weight torpedo systems. The method is to check on the performance and related critical parameters of light weight torpedoes. The checking items are composed of general conditions of underwater mobile systems such as stability and dynamic sensitivity and specified performance requirements for light weight torpedoes.

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.293-293
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• 2022

This study is to develop new wheat breeding material through wide hybridization with wild species harboring useful characteristics such as salt, heat, and drought tolerance. Leymus mollis, wild rye was used to improve wheat genetic quality. L. mollis, is a perennial plant harboring tolerance against salt, heat, and drought because L. mollis distributes on the seaside. The F₁ hybrids were produced by crossing between common wheat (Triticum aestivum L., Chinese Spring) and L. mollis. Genomic in situ hybridization revealed that the F₁ hybrids have L. mollis genome. For the evaluation of salt and drought tolerance, seeds from the F₂ were used. Under 2% NaCl solution, the F₃ wheat-Leymus addition plants with salt tolerance showed more tillering and longer roots than other F₃ plants without salt tolerance. Also, the F₃ plants with salt tolerance showed better shallow-rooted than other F₃ plants without salt tolerance. Finally, the F₃ plants with salt tolerance made seed-setting under 2% NaCl condition, but other F₃ plants without salt tolerance were not. Under drought conditions, the F₃ plants with drought tolerance showed longer culm and spike length than other F₃ plants without drought tolerance and even those of Chinese Spring under well-water conditions. We evaluated and selected the F₃ plants with salt or drought tolerance for generation advancement.

• Journal of Aerospace System Engineering
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• v.8 no.3
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• pp.41-46
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• 2014

Fatigue evaluations for the rotor blades of commercial or military rotorcraft have been carried out using the safe life concept since 1950s. Particularly, in the case of a rotor blade made of a composite material, a highly reliable fatigue life could be predicted by evaluation the cumulative damage using combination of fatigue life curve and load spectrum. However, there is a limit in adequately evaluating the strength reducing phenomena caused by damages or defects generated during the manufacturing process or impact damage induced by operational usages, using only the safe life concept. In this study, the fatigue evaluation process based on the damage tolerance concept is described and illustrated by means of successful application to substantiate the retirement time of composite rotor blades.

• Korean Journal of Breeding Science
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• v.42 no.4
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• pp.329-338
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• 2010

Drought, salinity and flooding are three important abiotic factors limiting soybean production worldwide. Irrigation, soil reclamation, and drainage systems are not generally available or economically feasible for soybean production. Therefore, productive soybean varieties with tolerance are a cost effective means for reducing yield losses due to these factors. Genetic variability for higher tolerance to drought, salt and flooding is important. However, only a small portion of nearly 200,000 world soybean accessions have been screened to find genotypes with tolerance for use in breeding programs. Evaluation for tolerance to drought, salinity and flooding is difficult due to lack of faster, cost effective, repeatable screening methods. Soybean strains with higher tolerance to the above stresses have been identified. Crosses with lines with drought, salt and flooding tolerance through conventional breeding has made a significant contribution to improving tolerance to abiotic stress in soybean. Molecular markers associated with tolerance to drought, salt and flooding will allow faster, reliable screening for these traits. Germplasm resources, genome sequence information and various genomic tools are available for soybean. Integration of genomic tools coupled with well-designed breeding strategies and effective uses of these resources will help to develop soybean varieties with higher tolerance to drought, salt and flooding.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.48 no.4
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• pp.339-344
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• 2003

To identify the new source of breeding materials for rice salt tolerance, the salinity tolerance of thirty-four varieties was evaluated under 0.5% saline condition at seedling stage. The salinity score showed highly significant correlations to dry weight and dead leaf ratio. The tested varieties were classified into three groups by visual score, reduction ratio of dry weight, and dead leaf ratio. Eighteen varieties were classified as the highly tolerant group (salinity scores of 1.3-3.7), seven varieties were fallen into the tolerant group (salinity scores of 4.2-5.8), and others were susceptible (salinity scores of 6.7-9.0). In highly tolerant group, most indica varieties including Getu, Dikwee and Kuatic Putic, didn't exsert a panicle under the Korean climate. But six varieties, Xiangcho V, Annapuruna, HP 3319-2wx-6-3-1, Giza 175, and GZ 2447-S-17, GZ 4255-6-3 were suitable to the Korean climate, and their heading date (6-16, August) and culm length (65-78㎝) were similar to the Korean varieties. Accordingly, these varieties can be utilized as crossing materials for the salt tolerance in japonica rice.