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A Case of Subungal Abscess and Onycholysis Induced by Docetaxel (Docetaxel 투여 후 발생한 조갑하 농양 및 조갑 박리증 1예)

  • Jung, Han Young;Lee, Chang Youl;Kim, Hyung Jung;Ahn, Chul Min;Chang, Yoon Soo
    • Tuberculosis and Respiratory Diseases
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    • v.62 no.2
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    • pp.125-128
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    • 2007
  • Docetaxel is a taxoid antineoplastic drug, which is widely used to treat locally advanced or metastatic non-small cell lung cancer (NSCLC). Among the adverse dermatological reactions, nail disorders such as bending, onycholysis, hypoor hyperpigmentation are rare. We report a case of a 62-year-old male with advanced NSCLC (cT4N3M1, stage IV), who developed purulent discharge and onycholysis in the nail of all his fingers and the left great toe after five courses of anti-neoplastic chemotherapy, which included docetaxel (cumulative dose: $370mg/m^2$, 590 mg). Seven days after the final session of chemotherapy, the patient had become aware of discoloration and swelling of the nail beds with out pain. Three days later, greenish-yellow purulent discharge oozed out from the involved nails. Microbiologic studies revealed Pseudomonas aeruginosa. Intravenous and topical antibiotics (mupirocin) were applied. After 2 weeks, regrown nails were observed and the onycholysis had improved.

The Effects of Dual-Task on Stepping Over Obstacles From a Position of Quiet Stance in Younger and Older Adults: A Pilot Study (장애물 보행시 젊은 사람과 노인들의 보행 양식에 대한 이중과업 수행의 효과)

  • Kim, Hyeong-Dong;Yoon, Bum-Chull
    • Physical Therapy Korea
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    • v.9 no.4
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    • pp.1-11
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    • 2002
  • 본 연구의 목적은 이중과업 방법론(dual task methology)을 사용해서 젊은 사람과 노인을 대상으로 독립된 두 사건(two separate concurrent events)을 동시에 수행하는데 요구되는 주의력에 대한 분석과 노인에서의 특징적 차이를 찾는 것이다. 본 실험은 대상자가 힘판(force plate) 위에서 장애물(10cm) 보행시에 경피자극(cutaneous stimulation)에 대하여 마이크로 스위치(micro-switch)를 사용하여 반응하면서 시행되었다. 힘판과 시간(temporal events) 그리고 반응시간(reaction time)에 관한 자료들은 1000 Hz의 주파수로 수집되었다. 반응시간은 대상자들이 서 있는 상태(baseline) 장애물 보행시(dual task)에서 수집되었다. 반응시간은 아중과업 조건에서 대상자 모두에게서 긴 것으로 나타났으며 특히 노인에서 정상 성인보다 반응시간이 긴 것으로 나타났다. 이중과업 조건 하에서 노인 대상자가 정상 성인에 비해 발가락이 장애물에 닫지 않고 통과할 수 있는 공간, 즉 토우 클리어런스( toe-clearance)와 슬관전 굴곡(knee flexion) 각도가 훨씬 큰 것으로 나타났다. 이중과업 조건하에서 모든 대상자가 족관절 배측굴곡(ankle dorsiflexion) 각도를 감소시키는 것으로 나타났다. 노인들은 젊은 대상자들보다 훨씬 더 긴(124 ms) 유각시간을 보여 주었으며 정상 장애물 보행시 유각 시간은 이중과업보다 50 ms 긴 것으로 나타났다. 이러한 보행 특성의 차이는 노인대상자들이 젊은 대상자들보다 장애물 보행시에 이중과업의 영향을 더 받았기 때문인 것으로 판단된다. 이중 과업 시행시 이러한 토우 클리어런스의 감소와 장애물 통과시에 보행 속도의 증가는 아마도 낙상의 가능성을 증가시키는 요인이 될 수 있는 것으로 보여진다. 본 연구의 결과는 다중과업(multitasks)을 필요로 하는 보행 훈련 프로그램(gait training program)의 개발과 시행에 있어서 기초적인 자료를 제공할 수 있는 것으로 보여진다.

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Comparison of the Balance Relations Between Healthy Subjects and Patients With Chronic Low Back Pain (만성 요통환자와 정상인의 균형반응 비교)

  • Yang, Hoi-Song;Lee, Kang-Woo
    • Physical Therapy Korea
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    • v.9 no.2
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    • pp.1-17
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    • 2002
  • The purpose of this study was to identify the differences of the static and the dynamic balance reactions in the flexion syndrome (FS) and the extension syndrome (ES) group of the patients with chronic lowback pain (LBP) and healthy subjects. Twenty subjects were included in each group. By using EquiTest 5.02, the static balance was measured by the equilibrium score and the strategy score of sensory organization test (SOT), while the dynamic balance was measured by the latency of motor control test (MCT) and the sway energy of adaptation test (ADT). Oswestry Disability Index (OSI) was used to measure level of the disability in patients with chronic LBP. The equilibrium scores, the strategies of SOT, and thelatencies of MCT of three groups were compared with one way ANOVA, while the sway energy of ADT was compared with repeated measures one way ANOVA. The results of this study showed that the equilibrium scores and the strategy scores of SOT were significantly lower in patients with chronic LBP than in healthy subjects. The equilibrium scores and the strategy scores of SOT were significantly differences between the FS and ES groups in condition 5 (support surface was sway-referenced and visual information waseliminated by eye closure), and 6 (support surface was sway-referenced and visual information was altered by sway-referencing). The FS group showed delayed average reaction time at large posterior translation, however, the ES group showed delayed average reaction time at large anterior translation, Even though the sway energy of the patients with chronic LBP were greater than that of healthy subjects during the toe down (plantar flexion rotation), the values between the FS and ES groups didn't show any significant difference. The disability level showed highly correlation with the equilibrium score of the condition 5. As the results, the FS and ES groups divided by the their symptoms and signs in patients with chronic LBP showed different balance reaction. Therefore, more accurate evaluation and balance treatments are needed to focus on their symptoms and signs in patients with chronic LBP.

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Optimization of Culture Conditions for toe Production of Chitinase (Chitinase 생성을 위한 배did 조건 최적화)

  • 차진명;석근영;차월석
    • KSBB Journal
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    • v.16 no.4
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    • pp.365-369
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    • 2001
  • Chitinase producing microorganism, Serratia marcescens KY, was isolated from seashore mud around Beobseongpo in Chunnam province by selective enrichment culture. As the colloidal chitin concentration increased, chitinase production was increased. But chitinase production with addition of other carbon sources (glucose, fructose, galactose, maltose, sucrose, starch) was decreased. The effect of nitrogen sources on the chitinase production with serratia marcescens KY was as fellows. The opitimum mineral concentration for chitinase production was K$_2$HPO$_4$ 0.2 g/L and MgSO$_4$ 0.20 ∼ 0.25 g/L, respectively. The effect of nitrogen sources on chitinase production by Serratia marcescens KY was increased as follows, tryptone > yeast extract > beef extract > asparagine.

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Characteristics of Mannitol Production by Leuconostoc sp. KY-002 (Leuconostoc sp. KY-002의 Mannitol 생산 특성)

  • 류병호;김동현윤종원
    • KSBB Journal
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    • v.11 no.6
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    • pp.636-641
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    • 1996
  • The production of extracellular mannitol by a new mannitol-producing bacterium, Leuconostoc sp. KY-002 was studied in shake flask cultures. The new isolate has a capability of utilizing fructose and sucrose for mannitol formation. Maximum mannitol production was obtained with fructose as the sole carbon source. Under the optimal culture conditions, within 70 hours of incubation, a final concentration of 26 g/L of mannitol from 50 g/L fructose was obtained with an indicated yield of 52% based on fructose consumed. However, higher concentrations of fructose ranging from 100 to 250 g/L could not effectively be transformed to mannitol due to a lack of osmotolerance. The strain produced no other polyols such as glycerol and sorbitol as by-products. Yeast extract was the best nitrogen source and high levels of inorganic phosphate up to 10 g/L promoted mannitol formation. Any mineral ions and salts did not play important role in both cell growth and mannitol production. Nicotinic acid enhanced mannitol production by 16%. The optimum culture temperature and initial pH were $35^{\circ}C$ and 6, respectively.

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A Study on Electric Capacity and CO2 by the Roof Top PV System of the Industrial Building in Korea (한국 산업용 건물지붕 적용 PV에 의한 발전량 및 CO2 분석연구)

  • Kim, Ji-Su;Lee, Eung-Jik;Hwang, Jung-Ha
    • Journal of the Korean Solar Energy Society
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    • v.30 no.6
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    • pp.131-136
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    • 2010
  • The purpose of this study is to provide foundational data for expansion of solar generation in building application, a clean energy, by introducing applicability of solar power generation system on roofs of industrial buildings and computing expected amounts of power and carbon dioxides reduction. As methodologies of this study, after reviewing 120,000 domestic factories to verify the BIPV feasibility for industrial building sthrough theoretical considerations of solar generation system, we calculated BIPV application methods and subsequent expected power generation quantity and carbon dioxide reductions through roof type analysis. we analyzed four cases of expected power generation amounts of solar batteries according to application methods, and when considering that the main type of roofs are slant roofs according to the investigation result about roof forms of domestic industrial complexes, we believe that the module angle of a slant roof around $17^{\circ}$(case3) is most suitable for the application. Finally, we came up with 517,944[TOE] as the corresponding petroleum tonnage based on this computed expected power generation amount and the amount of 1,214,836[$tCO_2$] carbon dioxide reductions by calculating them by energy sources.

A Study on the Effect of Arch Support for Improvement of Muscle Activity (운동효과 증진을 위한 Arch Support 효과에 관한 연구)

  • Lee, Chang-Min;Kim, Jin-Hoon;Oh, Yeon-Ju;Kim, Dae-Woong
    • Journal of the Ergonomics Society of Korea
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    • v.27 no.3
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    • pp.71-79
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    • 2008
  • Walking shoes for walking and jogging have been used to enjoy lots of leisure time. Functional shoes such as walking shoes have special functions to improve body motility by changing of shoe shapes. The walking shoes could improve the motility by structural transformation of outsole as increase degrees of heel and toe. The study on insoles has not been conducted enough on the contrary of the study of outsole. The purpose of this study is to perform ergonomics analysis whether the Arch Supported insoles have an improving effect of muscle activities or not. Experiments were performed with 6 subjects who are health and haven't experienced any diseases past. EMG(Electromyography) and Foot Pressures were measured repeatedly for 5 seconds at 0 hour, after 1 hour and after 2 hours of walking. Insoles used for experiment are normal insole, insole inserted Arch Support and pad. The electrodes for EMG measurement were set on waist (erector spinae), and thigh (vastus lateralis), calf (gastrocnemius). Evaluations of EMG were analyzed by shift of MF (Median Frequency) and MPF (Mean Power Frequency). Foot Pressure was analyzed by mean pressure of feet and change of walking time. As results, Arch Support insole had larger frequency shift value than that of normal insole. Frequency shift between Arch Support insoles and normal insole showed significant difference on 95% confidence interval. And insole 1 has the highest value of frequency shift. For results of foot pressure, Arch Support insoles show continuous decreasing tendency when comparing with normal insoles by changing of times. Also, insole 1 has the highest decreasing value of foot pressure. Therefore, this study presented that the Arch Support insole can promote muscle activities and improves comfort for a prolonged walking.

A Research on Kimchi Culture for Koreans in CIS(III) -Materials of Kimchi- (구소련(독립국가연합) 거주 한인들의 김치 이용 실태에 관한 조사(III) -김치재료-)

  • 김영숙;이경임;신애숙;김영희
    • Journal of the East Asian Society of Dietary Life
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    • v.8 no.1
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    • pp.66-74
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    • 1998
  • To investigate the materials in the preparation of kimchi for Koreans in the Commonwealth of Independent States(CIS) a survey was completed by 199 Koreans living in Moscow, Sahalin, Uzbekistan and Jazahstan, In the way to purvey the materials of Kimchi, the frequency to get all the materials of Kimchi in the markets is 74.7% on the whole and by regional groups the frequency is relatively high in Moscow and Kazahstan, For the main ingredients most respondents use Chinese cabbage, cabbage, or turnips. In general Chinese cabbage is used most, But the respondents who live in Moxcow and Kazahstan. For the main ingredients most respondents use Chinese cabbage, cabbage, or turnips. In general Chinese cabbage is used most, But the respondents who live in Moscow and Kazahstan. 쫴 are younger, or belong to higher emigrant generation, prefer cabbage kimchi. For the additional vegetables many respondents use carrots. For the seasonings, garlic, red pepper powder, and salt are added to Kimchi, but the use of ginger, whole seasame seed, and waxy rice paste is relatively low. The coriander, which is not added to kimchi in Korea, is used in Kimchi By above 80% of the respondents living in the three regions except Sahalin. It is considered to be due to the effect of the western dining cultural area. For the animal materials, 74.4% of the respondents add lightly salted fish to Kimchi and all toe respondents in Sahalin add salt-fermented sea food, the kind of which is mainly salt-fermented croaker. The reasons given for not adding salt-fermented seafood to Kimchi in the three regions except Sahalin, 59.9% of the respondents said it was because of the difficulty to purvey, 21.1% because of the fishy taste, and 16.8% because of not considering the addition of self-fermented sea food in Kimchi. The higher the emigrant generation of respondents, the less seasonings of strong flavor like garlic, red pepper powder, and salt-fermented sea food are used, and the more coriander is used. In the salting of Kimchi preparation, 97.8% of the respondents salt the main vegetables by soaking in brine and its concentration is controlled by experience.

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The correlation between the physical power of golf players and the Titleist Performance Institute Level 1 test

  • Kim, Jaeeun;Yim, Jongeun;Do, Kwangsun
    • Physical Therapy Rehabilitation Science
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    • v.7 no.1
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    • pp.13-17
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    • 2018
  • Objective: This was a correlation study for predicting the power to improve the distance of golf players and developing an effective power program. Design: Cross-sectional study. Methods: The subjects of this study were 24 healthy males and females in their 20s and 30s who were golf athletes living in Seoul and Gyeonggi-do. In the Titleist Performance Institute (TPI) Level 1 test, the twelve swing characteristics include components of stability, mobility, body conditioning ability, and balance. The power test consisted of a vertical jump (VJ) in order to examine the power of the lower body, the seated chest pass (SCP) was used to examine upper body power, and the sit up and throw (SUAT) was used to examine the power of the upper body and core for the TPI Level 2 test. Results: The results of this study showed that the 90/90 was correlated with VJ, SUAT, and SCP scores (p<0.05). Single leg stance was correlated with VJ, SUAT, over head deep squat, and bridge with leg extension were correlated with VJ (p<0.05). The toe touch was correlated with SUAT results (p<0.05). Conclusions: The results of this study showed that the TPI Level 1 test and power test were correlated with the performance of the golf players. Future studies have shown that fitness program development and further research are needed.

A Empirical Study on the Factors of Taxation Cognition for Medical Institutions in Korea (우리나라 의료기관에 대한 과세인식에 영향을 미치는 요인에 관한 실증연구)

  • Hong, Ki-Yong;Park, Young-Kyu;Kum, Chung-Kap
    • Korea Journal of Hospital Management
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    • v.9 no.4
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    • pp.21-44
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    • 2004
  • Toe objective of this study is to verify the factors influencing the taxation cognition of medical institutions and to verify the difference of taxation cognition among the interest groups in medical services. The factors that influence taxation cognition are supposed to be five: cognition of public benefits on medical services, cognition of profits from medical institutions, cognition of self-responsibility of medical institutions, cognition of distinction of medical institutions, and cognition of the importance of medical services. The interest groups are divided into four: medical institution employees, medical treatment consumers, taxation experts, and tax officials. As a result of this study, first, cognition of public benefits, cognition of profits, and cognition of distinction are verified to have statistical significance as factors for taxation cognition. It means that cognition of the public benefits of medical services is low, while cognition of profits is high, and taxation cognition such as tax supports and tax exemption appears low in accordance with lowness of cognition of distinction of medical institutions. Second, taxation cognition of the interest groups about medical service shows statistical significance between the group of medical institution employees and the group of tax officials, and between the group of medical institution employees and the group of taxes experts. This study is expected to contribute to tax policy, which can support medical institutions to provide medical consumers with good medical services, by analyzing the factors that influence taxation cognition on medical institutions.

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