Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Subungal Abscess and Onycholysis Induced by Docetaxel

Docetaxel 투여 후 발생한 조갑하 농양 및 조갑 박리증 1예

  • Jung, Han Young (Department of Internal Medicine, The Yonsei University College of Medicine) ;
  • Lee, Chang Youl (Department of Internal Medicine, The Yonsei University College of Medicine) ;
  • Kim, Hyung Jung (Department of Internal Medicine, The Yonsei University College of Medicine) ;
  • Ahn, Chul Min (Department of Internal Medicine, The Yonsei University College of Medicine) ;
  • Chang, Yoon Soo (Department of Internal Medicine, The Yonsei University College of Medicine)
  • 정한영 (연세대학교 의과대학 내과학교실) ;
  • 이창률 (연세대학교 의과대학 내과학교실) ;
  • 김형중 (연세대학교 의과대학 내과학교실) ;
  • 안철민 (연세대학교 의과대학 내과학교실) ;
  • 장윤수 (연세대학교 의과대학 내과학교실)
  • Received : 2006.12.11
  • Accepted : 2007.02.08
  • Published : 2007.02.28
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Abstract

Docetaxel is a taxoid antineoplastic drug, which is widely used to treat locally advanced or metastatic non-small cell lung cancer (NSCLC). Among the adverse dermatological reactions, nail disorders such as bending, onycholysis, hypoor hyperpigmentation are rare. We report a case of a 62-year-old male with advanced NSCLC (cT4N3M1, stage IV), who developed purulent discharge and onycholysis in the nail of all his fingers and the left great toe after five courses of anti-neoplastic chemotherapy, which included docetaxel (cumulative dose: $370mg/m^2$, 590 mg). Seven days after the final session of chemotherapy, the patient had become aware of discoloration and swelling of the nail beds with out pain. Three days later, greenish-yellow purulent discharge oozed out from the involved nails. Microbiologic studies revealed Pseudomonas aeruginosa. Intravenous and topical antibiotics (mupirocin) were applied. After 2 weeks, regrown nails were observed and the onycholysis had improved.

Docetaxel은 비소세포암에서 널리 사용되는 taxoid 계열의 항암제로, 조갑변화의 부작용은 한국에서 드물게 알려져 있다. 저자들은 비소세포암 4기인 62세 남환이 5차례 docetaxel 및 carboplatin 항암치료시행 7일 후 발생한 조갑하 농양 및 조갑 박리의 진단과 치료 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

Keywords

References

  1. Miller VA, Krug LM, Ng KK, Pizzo B, Perez W, Heelan RT, et al. Phase II trial of docetaxel and vinorelbine in patients with advanced non-small-cell lung cancer. J Clin Oncol 2000;18:1346-50 https://doi.org/10.1200/JCO.2000.18.6.1346
  2. Janinis J, Papadakou M, Panagos G, Panousaki A, Georgoulias V, Hatzidaki D, et al. Sequential chemo-radiotherapy with docetaxel, cisplatin, and 5-fluorouracil in patients with locally advanced head and neck cancer. Am J Clin Oncol 2001;24:227-31 https://doi.org/10.1097/00000421-200106000-00003
  3. Tinio P, Bershad S, Levitt JO. Docetaxel-induced onycholysis. J Am Acad Dermatol 2005;52:350-1 https://doi.org/10.1016/j.jaad.2004.07.057
  4. Obermair A, Binder M, Barrada M, Bancher-Todesca D, Asseryanis E, Kubista E. Onycholysis in patients treated with docetaxel. Ann Oncol 1998;9:230-1 https://doi.org/10.1093/oxfordjournals.annonc.a010964
  5. Almagro M, Pozo JD, Garcia J, Vasquez A, Fonseca E. Nail alterations secondary to paclitaxel therapy. Eur J Dermatol 2000;10:146-7
  6. Moisidis C, Mobus V. Erythema multiforme major following docetaxel. Arch Gynecol Obstet 2005;271: 267-9
  7. Minisini AM, Tosti A, Sobrero AF, Mansutti M, Piraccini BM, Sacco C, et al. Taxane-induced nail changes: incidence, clinical presentation and outcome. Ann Oncol 2003;14:333-7 https://doi.org/10.1093/annonc/mdg050
  8. Correia O, Azevedo C, Pinto Ferreira E, Braga Cruz F, Polonia J. Nail changes secondary to docetaxel (Taxotere). Dermatology 1999;198:288-90 https://doi.org/10.1159/000018132
  9. Vanhooteghem O, Andre J, Vindevoghel A, Vandenbossche L, Vandeveire A, Song M. Docetaxel-induced subungal hemorrhage. Dermatology 1997;194:419-20 https://doi.org/10.1159/000246166
  10. Lee MS, Kim HO, Park YM. A case of subungal abscess and onycholysis related to docetaxel. Korean J Dermatol 2003;41:1393-5
  11. Nicolopoulos J, Howard A. Docetaxel-induced nail dystrophy. Australas J Dermatol 2002;43:293-6 https://doi.org/10.1046/j.1440-0960.2002.00616.x
  12. Wasner G, Hilpert F, Schattschneider J, Binder A, Pfisterer J, Baron R. Docetaxel-induced nail changes: a neurogenic mechanism: a case report. J Neurooncol 2002;58:167-74 https://doi.org/10.1023/A:1016002329546
  13. Jones R, Ryan M, Friedlander M. Carboplatin hypersensitivity reactions: retreatment with cisplatin desensitisation. Gynecol Oncol 2003;89:112-5 https://doi.org/10.1016/S0090-8258(03)00066-0
  14. Scotte F, Tourani JM, Banu E, Peyromaure M, Levy E, Marsan S, et al. Multicenter study of a frozen glove to prevent docetaxel-induced onycholysis and cutaneous toxicity of the hand. J Clin Oncol 2005;23: 4424-9 https://doi.org/10.1200/JCO.2005.15.651