• Geomechanics and Engineering
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• v.30 no.2
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• pp.169-185
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• 2022

The urbanization and increasing rate of population demands effective means of transportation system (basement and tunnels) as well as high-rise building (resting on piled foundation) for accommodation. Therefore, it unavoidable to construct basements (i.e., excavation) nearby piled foundation. Since the basement excavation inevitably induces soil movement and stress changes in the ground, it may cause differential settlements to nearby piled raft foundation. To understand settlement and load transfer mechanism in the piled raft due to excavation-induced stress release, numerical parametric studies are carried out in this study. The effects of excavation depths (i.e., formation level) relative to piled raft were investigated by simulating the excavation near the pile shaft (i.e., H_e/L_p=0.67), next to (H_e/L_p=1.00) and below the pile toe (H_e/L_p=1.33). In addition, effects of sand density and raft fixity condition were investigated. The computed results have revealed that the induced settlement, tilting, pile lateral movement and load transfer mechanism in the piled raft depends upon the embedded depth of the diaphragm wall. Additional settlement of the piled raft due to excavation can be account for apparent loss of load carrying capacity of the piled raft (ALPC). The highest apparent loss of piled raft capacity ALPC (on the account of induced piled raft settlement) of 50% was calculated in in case of H_e/L_p = 1.33. Furthermore, the induced settlement decreased with increasing the relative density from 30% to 90%. On the contrary, the tilting of the raft increases in denser ground. The larger bending moment and lateral force was induced at the piled heads in fixed and pinned raft condition.

• Geomechanics and Engineering
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• v.27 no.5
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• pp.447-463
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• 2021

Caisson-type structures are widely used as quay walls in coastal areas. In Korea, for a long time, many caisson-type quay walls have been constructed with a low front water depth. These facilities can no longer meet the requirements of current development. This study developed a new technology for deepening existing caisson-type quay walls using grouting and rubble mound excavation to economically reuse them. With this technology, quay walls could be renovated by injecting grout into the rubble mound beneath the front toe of the caisson to secure its structure. Subsequently, a portion of the rubble mound was excavated to increase the front water depth. This paper reports the results of an investigation of the seismic behavior of a renovated quay wall in comparison to that of an existing quay wall using centrifuge tests and numerical simulations. Two centrifuge model tests at a scale of 1/120 were conducted on the quay walls before and after renovation. During the experiments, the displacements, accelerations, and earth pressures were measured under five consecutive earthquake input motions with increasing magnitudes. In addition, systematic numerical analyses of the centrifuge model tests were also conducted with the PLAXIS 2D finite element (FE) program using a nonlinear elastoplastic constitutive model. The displacements of the caisson, response accelerations, deformed shape of the quay wall, and earth pressures were investigated in detail based on a comparison of the numerical and experimental results. The results demonstrated that the motion of the caisson changed after renovation, and its displacement decreased significantly. The comparison between the FE models and centrifuge test results showed good agreement. This indicated that renovation was technically feasible, and it could be considered to study further by testbed before applying in practice.

• Archives of Plastic Surgery
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• v.49 no.1
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• pp.61-69
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• 2022

Background Single free flaps are a commonly used reconstructive method for multiple soft tissue defects in digits. We analyzed the flap size, division timing, and degree of necrosis in cases with various types of flap division. Methods We conducted a retrospective review of the medical charts of patients who had undergone single free flap reconstruction for multiple soft tissue defects across their digits from 2011 to 2020. The flap types included were the lateral arm free flap, venous forearm free flap, thenar free flap, hypothenar free flap, anterolateral thigh free flap, medial plantar free flap, and second toe pulp free flap. Flap size, anastomosed vessels, division timing, and occurrence of flap necrosis were retrospectively investigated and then analyzed using the t-test. Results In total, 75 patients were included in the analysis. The success rate of the free flaps was 97.3%. All flaps were successfully divided after at least 17 days, with a mean of 47.17 days (range, 17-243 days) for large flaps and 42.81 days (range, 20-130 days) for the medium and small flaps (P=0.596). The mean area of flap necrosis was 2.38% in the large flaps and 2.58% in the medium and small flaps (P=0.935). Severe necrosis of the divided flap developed in two patients who had undergone flap division at week 6 and week 34. Conclusions In cases where blood flow to the flap has been stable for more than 3 weeks, flap division can be safely attempted regardless of the flap size.

• Journal of the Korean Orthopaedic Association
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• v.56 no.2
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• pp.168-172
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• 2021

Acquired digital fibrokeratoma is very a rare, benign, fibrous, and hyperkeratotic skin tumor that develops most frequently on the finger or toe. The tumor usually occurs in adults as a solitary, dome-shaped lesion. Sometimes, it appears as a rudimentary supernumerary digit and may be misdiagnosed as an accessory nail (double nail) or verruca vulgaris. The pathophysiology of an acquired digital fibrokeratoma is unknown. On the other hand, trauma has often been proposed as a predisposing factor for an acquired type of digital fibrokeratoma. This paper reports a case of trauma-related acquired digital fibrokeratoma presenting as a supernumerary digit and nail in a 36-year-old male. This case is presented with a 0.5 cm×0.4 cm×1.3 cm sized, firm, hyperkeratotic, protruding mass over the left second finger nail.

• The Journal of Engineering Geology
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• v.33 no.1
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• pp.201-211
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• 2023

This study investigated the damage range of the debris flow to predict the amount of collapsed soil in a landslide event. The height of the collapsed slope and the distance traveled by the collapsed soil were used to predict the total trajectory distance using a random walk model. Debris flow trajectory probabilities were calculated through 10,000 Monte Carlo simulations and were used to calculate the damage range as measured from the landslide scar to its toe. Compiled information on debris flows that occurred in the Cheonwangbong area of Mt. Jirisan was used to test the accuracy of the proposed random walk model in estimating the damage range of debris flow. Results of the comparison reveal that the proposed model shows reasonable accuracy in estimating the damage range of debris flow and that using 10 m × 10 m cells allows the damage range to be reproduced with satisfactory precision.

• Journal of the Korean Society of Physical Medicine
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• v.18 no.1
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• pp.1-8
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• 2023

PURPOSE: This study analyzed how proprioceptive neuromuscular facilitation (PNF) combined with auricular acupuncture affected the activation of the leg muscles of stroke patients and measured the effects of this combination to provide clinical data. METHODS: The subjects were divided randomly into experimental group I, which received PNF combined with auricular acupuncture, and experimental group II, which received PNF alone. Each group had ten members. A 30-minute intervention was performed four days a week for six weeks. Before the six weeks of intervention, pre-tests were conducted to measure muscle activation in the legs. After six weeks, post-tests were also conducted to measure muscle activation in the legs. RESULTS: Experimental group I showed a statistically significant difference in muscle rectus femoris, muscle biceps femoris, muscle tibialis anterior, and muscle soleus. Experimental group II also showed a statistically significant difference in the muscle rectus femoris, muscle biceps femoris, muscle tibialis anterior, and muscle soleus (p < .05). In a between-group comparison of the changes, a statistically significant difference was observed between the two groups in terms of muscle rectus femoris, muscle biceps femoris, muscle tibialis anterior, and muscle soleus (p < .05). CONCLUSION: Intervention in experimental group I increased the activation of the leg muscles more effectively because auricular acupuncture was applied to various spots on the ear corresponding to the spleen, liver, kidney, pelvis, knee, ankle, and toe. Auricular acupuncture is expected to be used more widely in the future because it is a safe way of stimulating muscle activation.

• The Journal of Korean Physical Therapy
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• v.35 no.2
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• pp.48-52
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• 2023

Purpose: This study was undertaken to determine whether the position of cane use affects the distribution of weight-bearing on both feet of children with hemiplegic cerebral palsy in a standing posture. Methods: Twenty participants with cerebral palsy were recruited as volunteers for this study. Using the Zebris FDM-System, weight-bearing distribution according to the method of using a cane was measured under three conditions in randomized order: (1) standing unaided (no cane); (2) standing with the affected side using the cane; and (3) standing with the non-affected side using the cane. The cane was matched by measuring length-from-floor to the greater trochanter of the subject, and was placed 15 cm outward from the little toe on the supporting side. Results: Evaluating the method of using a cane under the three conditions, we determined that pressure of the foot on the affected side was higher in the order: standing with affected side using cane > standing unaided (no cane) > standing with non-affected side using cane (p<0.05). In the post-hoc analysis, a significant difference was observed between (i) standing unaided (no cane) and standing with the affected side using cane, and (ii) standing with affected side using cane and standing with non-affected side using cane (p<0.05). Conclusion: This study suggests that induced weight-bearing methods using a cane on the affected side could increase the weight-bearing capacity on the affected side in children with spastic hemiplegic cerebral palsy, which will have a positive effect on reducing asymmetry weight support.

• Proceedings of the Korean Society of Developmental Biology Conference
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• 2003.10a
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• pp.85-85
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• 2003

Human lactoferrin (hLF) is an 80 kDa iron-binding glycoprotein that is expressed in high concentration in milk and in lesser amount in the secondary or specific granules of neutrophils and in plasma, LF is classically considered to be related to the binding, transport, and storage of iron. The transgenic mice carrying the human hLF gene in conjunction with the bovine $\beta$-casein promoter produced the human hLF in their milk during lactation. To screen transgenic mice, PCR was carried out using chromosomal DNA extracted from tail or toe tissues. In this study, stability of germ line transmission and expression of hLF were monitored up to generation Fl7 of a transgenic line. When female mouse of generation F9 was crossbred with normal male, generation F9 to Fl7 mice showed similar transmission rates ($66.0 \pm 12.57%, 42.0 \pm 14.98%, 72.2 \pm 25.45%, 50.0 \pm 16.70%, 65.7 \pm 6.45%, 48.6 \pm 14.65%, 54 1 \pm 18 11%, 57.8 \pm 16.16% and 48.6 \pm 20.66$, respectively), implying that the hLF gene can be transmitted stably up to long term generation in the transgenic mice For ELISA analysis, hLF expression levels were determined with an hLF ELISA kit in accordance with the supplier's protocol. Expression levels of human hLF from milk of generation F9 to Fl3 mice were $ 3.2 \pm 0.69 mg/ml, 3.1 \pm 0.81 mg/ml, 4.6 \pm 1.38 mg/ml, 3.1 \pm 0.42 mg/ml, and 4.5 \pm 1,48 mg/ml$, respectively. These expression levels were lower than that of founder (6.6 mg/$m\ell$) mouse. We concluded that transgenic mice faithfully passed the transgene on their progeny and successively secreted target proteins into their milk through several generations.

• Journal of Microbiology and Biotechnology
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• v.33 no.3
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• pp.339-347
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• 2023

Transforming growth factor-β is a key factor in regulating adhesion formation during tendon healing. We investigated the effectiveness of SMAD family members, SMAD7 and SMAD3, in the TGF-β/Smad signaling during flexor tendon repair. Mouse flexor toe deep tendon rupture anastomosis models were made. On days 3, 7, 14, 21, and 28, the expressions of smad7 and smad3 in flexor tendon tissues were detected by RT-qPCR and western blot. Furthermore, postoperative intraperitoneal injections of SMAD7 agonists or SMAD3 antagonists were given. The degree of tendon healing was evaluated by adhesion testing and biomechanical experiments. Hematoxylin and eosin (HE) staining was used to observe the pathological changes. Immunohistochemistry was used to evaluate the expressions of collagen III, SMAD3, and SMAD7. The mRNA levels of matrix metalloproteinases, Mmp2 and Mmp9, and scleraxis (SCX) in flexor tendon tissue were detected by RT-qPCR. Smad3 expression increased and Smad7 expression decreased in flexor tendon tissue after injury. In addition, the SMAD7 agonist blocked SMAD3 phosphorylation. SMAD7 agonist and SMAD3 antagonist both improved adhesion formation during flexor tendon healing, and decreased the expressions of collagen III, Mmp9, and SCX, while increasing Mmp2 expression. This study provides a possible theoretical basis for the SMAD7-SMAD3 signal cascade during flexor tendon adhesion healing.

• Journal of the Korean Geotechnical Society
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• v.25 no.8
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• pp.77-93
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• 2009

The load distribution and deformation of rock socketed drilled shafts subjected to axial loads were evaluated by a load transfer approach. The emphasis was laid on quantifying the end bearing load transfer characteristics of rock socketed drilled shafts based on 3D Finite Difference (FD) analysis performed under varying rock strength and rock mass conditions. From the results of FD analysis, it was found that the ultimate unit toe resistance ($q_{max}$) was influenced by both rock strength and rock mass conditions, while the initial tangent of end bearing load transfer curve ($G_{ini}$) was only dependent on rock strength. End bearing load transfer function of drilled shafts socketed in rock was proposed based on the FD analysis and the field loading tests which were performed on weathered rock in South Korea. Through the comparison with the results of the field loading tests, it is found that the load transfer curve by the present study is in good agreement with the general trend observed by field loading tests, and thus represents a significant improvement in the prediction of load transfer behavior of drilled shaft.