• Geomechanics and Engineering
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• v.30 no.6
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• pp.579-586
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• 2022

Pile-supported structures are installed on saturated sloping grounds, where the ground stiffness may decrease due to liquefaction during earthquakes. Thus, it is important to consider saturated sloping ground and pile interactions. In this study, we conduct a centrifuge test of a pile-supported structure, and analyze the p-y_p loops, p-y_p loops provide the correlation between the lateral pile deflection (y_p) and lateral soil resistance (p). In the dry sand model (UV67), the p-y_p loops stiffness increased as ground depth increased, and the p-y_p loops stiffness was larger by approximately three times when the pile moved to the upslope direction, compared with when it moved to the downslope direction. In contrast, no significant difference was observed in the stiffness with the ground depth and pile moving direction in the saturated sand model (SV69). Furthermore, we identify the unstable zone based on the result of the lateral soil resistance (p). In the case of the SV69 model, the maximum depth of the unstable zone is five times larger than that of the dry sand model, and it was found that the saturated sand model was affected significantly by kinematic forces due to slope failure.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4315-4320
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• 2012

Background: The P53 tumor suppressor gene plays a pivotal role in maintaining cellular homeostasis by preventing the propagation of genome mutations. P53 in its transcriptionally active form is capable of activating distinct target genes that contribute to either apoptosis or growth arrest, like P21. However, the MDM2 gene is a major negative regulator of P53. Single nucleotide polymorphisms (SNP) in codon Arg72Pro of P53 results in impairment of the tumor suppressor activity of the gene. A similar effect is caused by a SNP in codon 31 of P21. In contrast, a SNP in position 309 of MDM2 results in increased expression due to substitution of thymine by guanine. All three polymorphisms have been associated with increased risk of tumorigenesis. Aim of the study: We aimed to study the prevalence of SNPs in the P53 pathway involving the three genes, P53, P21 and MDM2, among acute myeloid leukemia (AML) patients and to compare it to apparently normal healthy controls for assessment of impact on risk. Results: We found that the P21 ser31arg heterozygous polymorphism increases the risk of AML (P value=0.017, OR=2.946, 95% CI=1.216-7.134). Although the MDM2 309G allele was itself without affect, it showed a synergistic effect with P21 ser/arg polymorphism (P value=0.003, OR=6.807, 95% CI=1.909-24.629). However, the MDM2 309T allele abolish risk effect of the P21 polymorphic allele (P value=0.71). There is no significant association of P53 arg72pro polymorphism on the risk of AML. Conclusion: We suggest that SNPs in the P53 pathway, especially the P21 ser31arg polymorphism and combined polymorphisms especially the P21/MDM2 might be genetic susceptibility factors in the pathogenesis of AML.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.8
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• pp.1571-1579
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• 2009

This paper proposes a P2P(Peer-to-Peer) streaming protocol which allows various QoS(Qualify of Service) requirements of video streaming to be supported for various personal IPTV applications in ubiquitous Internet environments. The proposed P2P streaming protocol takes fairly short startup delay, guarantees end-to-end delay bound and bandwidth requirements, and supports reliability level of video streaming for an IPTV application. The QoS-based P2P streaming protocol can properly use not only the advantages of scalability, availability, and ubiquity of P2P streaming but also complement its disadvantages of performance and reliability so that various types of personal IPTV applications can be properly implemented in the existing broadband Internet environments.

• Journal of information and communication convergence engineering
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• v.8 no.2
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• pp.234-237
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• 2010

P300 component of the event-related potential(ERP) has been studied for theoretical, empirical, and clinical applications. Nowadays the 1-, 2-, and 3-stimulus oddball paradigms are used for eliciting P300 component of EEG in the auditory stimulus experiments. In this paper, we used a method to add one more stimulus to the 3-stimulus auditory paradigm. The adding stimulus has not the same volume but the same tone of the target stimulus. The 4-stimulus oddball paradigm to use two targets is used to elicit the P300 event-related potentials. In 4-stimulus oddball paradigm, an infrequent non-target (p=0.10) is presented in addition to two infrequent targets (p=0.10) and a frequent standard (p=0.70). Two target stimuli elicited a P300 component with a parietal maximum distribution. The amplitude of the P300 in target 2 was larger than that in target 1 and the latency of the P300 in target 2 was longer than that in target 1. The P300 component due to target 2 stimuli was larger than that due to target 1 stimuli. The experimental results approve that the 4-stimulus oddball paradigm can elicit P300 component clearly. The results are compared with the results of the traditional oddball paradigm.

• Natural Product Sciences
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• v.20 no.1
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• pp.1-6
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• 2014

P-glycoprotein (P-gp) is a permeability glycoprotein also known as multidrug resistance protein 1 (MDR1). P-gp is an ATP-binding cassette (ABC) transporter that pumps various types of drugs out of cells. These transporters reduce the intracellular concentrations of drugs and disturb drug absorption. The Caco-2 cell permeability assay system is an effective in vitro system that predicts the intestinal absorption of drugs and the functions of enzymes and transporters. Rhodamine-123 (R-123) and digoxin are well-known P-gp substrates that have been used to determine the function of P-gp. Efflux of P-gp substrates by P-gp has been routinely evaluated. To date, a number of herbal medicines have been tested with Caco-2 cell permeability assay system to assess bioavailability. There are growing efforts to find phytochemicals that potentially regulate P-gp function. The Caco-2 cell permeability assay system is a primary strategy to search for candidates of P-gp inhibitors. In this mini review, we have summarized the P-gp modulation by herbal extracts, decoctions or single components from natural products using Caco-2 cell permeability assays. Many natural products are known to regulate P-gp and herbal medicines could be used in combination with conventional drugs to enhance bioavailability.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.10 no.3
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• pp.421-429
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• 2006

Recently, DHT-based Structured P2P System have a attention to scalability and providing efficient lookup by routing. Retrieving content of DHT-based P2P require knowledge of the exact identifier of sharing file. But user may wish to search for sharing file using descriptive keyword or content. To resolve the problem, this paper propose Extended-CAN mechanism to support keyword search. We defined content-based keyword and identifier of sharing file, and PLS extended to KID and CKD for keyword, common keyword processing. As a result, Extended-CAN mechanism provide efficient keyword search for DHT-based Structured P2P System.

• 한국해양학회지
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• v.1 no.1_2
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• pp.1-6
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• 1966

A latitudinal, differential pH distribution is observed in the Northeastern Pacific Ocean with a pH range of 8.15 at high latitude (42 N) to 8.29 at low latitude (23 N). These pH values are generally greater than the calculated equilibrium pH with respect to atmospheric carbon dioxide. If we assume that the calculated equilibrium pH values ae valid, then the surface waters are undersaturated with respect to the atmospheric carbon dioxide during April to June 1966. A high surface pH value of about 8.26 was observed immediately south of the SubarcticBoundary zone near 170 W. This value differs from the equilibration pH by as much as 0.1 unit.

• Journal of Communications and Networks
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• v.10 no.4
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• pp.422-429
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• 2008

Mobile peer-to-peer (P2P) systems have recently got in the limelight of the research community that is striving to build efficient and effective mobile content addressable networks. Along this line of research, we propose a new peer-to-peer file sharing protocol suited to mobile ad hoc networks (MANET). The main ingredients of our protocol are network coding and mobility assisted data propagation, i.e., single-hop communication. We argue that network coding in combination with single-hop communication allows P2P file sharing systems in MANET to operate in a more efficient manner and helps the systems to deal with typical MANET issues such as dynamic topology and intermittent connectivity as well as various other issues that have been disregarded in previous MANET P2P researches such as addressing, node/user density, non-cooperativeness, and unreliable channel. Via simulation, we show that our P2P protocol based on network coding and single-hop communication allows shorter file downloading delays compared to an existing MANET P2P protocol.

• Journal of Nutrition and Health
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• v.39 no.4
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• pp.392-402
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• 2006

The purpose of this study was to compare the eating habit, food intake frequency and preferred food and taste of juvenile delinquents (100 numbers) and male high school students (100 numbers), using questionnaires from August to October 2004. 1) It was shown that the juvenile delinquents took more unbalanced diet (p<0.05), smoking (p<0.001) and drinking (p<0.001) than general students, while general students had more eating between meals (p<0.01). 2) The intake of food was a significant difference in white rices (p<0.01), bibimbab (p<0.001), kimbab (p<0.001), fried rice (p<0.001), ramen (p<0.001), jajangmyun (p<0.001), jambong (p<0.001), hamburger (p<0.001), pizza (p<0.001) and breads (p<0.05). The juvenile delinquents took more major food than that of general students in all the items except for white rice. It was observed, then, that the juvenile delinquents showed more intake of such subsidiary foods as bulgoki (p<0.001), roasted thin pork chops (p<0.001), grilled pork belly (p<0.001), pork cutlet (p<0.01), sweet and sour pork (p<0.001), chicken with ginseng (p<0.001), fried chicken (p<0.001), kimchi pot stew (p<0.01) and zucchini (p<0.05) than general students, with general students taking more kimchi (p<0.01) and fried or boiled soybean curd (p<0.01). The intake of dessert was a significant difference in yogurt (p<0.01), orange juice (p<0.001), cola (p<0.001), soft drinks (p<0.001), ion drinks (p<0.001), coffee (p<0.001), apple (p<0.01), banana (p<0.001), orange (p<0.001), cake (p<0.001), hot dog (p<0.001), ddokbokgi (p<0.01), mandu (p<0.001), fried fish paste (p<0.05), steamed korean sausage (p<0.001), fried foods (p<0.05), hem & sausage (p<0.001), cheese (p<0.001), ice-cream (p<0.001), candy (p<0.01), chocolate (p<0.001), mayonnaise (p<0.05), jam (p<0.01) and butter & margarine (p<0.01). Then, the juvenile delinquents were shown to entirely have more intake of all the desserts than those of general students. 3) Regarding preference of foods, it was shown that the juvenile delinquents preferred cereals (p<0.05), grilled pork belly (p<0.001), chicken with ginseng (p<0.01), anchovies and small fish (p<0.05), chicken with ginseng (p<0.05), seasoned spinach (p<0.001), seasoned zucchini (p<0.001), milk (p<0.05), coffee (p<0.001) and butter & margarine (p<0.05) while general students did egg (p<0.01), soybean sprout soup (p<0.001), boiled or fried potato (p<0.05), seasoned soybean sprout (p<0.05), boiled or fried soybean curd (p<0.01), fried foods (p<0.01) and snack (p<0.05). For their preference of tastes, hot taste (p<0.01) was higher in the juvenile delinquents. 4) Under general environments there was a change of the difference in their behaviour of pork cutlet (p<0.01) intake in accordance with other family and of milk (p<0.001) and butter & margarine (p<0.05) preference in accordance with growth in a big city between the two groups.

• Journal of Environmental Health Sciences
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• v.3 no.1
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• pp.1-3
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• 1976

The authors studied the viability and pH of Lactobacillus casei which was isolated from the Yakult in terms of its storage temperature time(days). The following results have been obtained: (1) The viability test to Lactobacillus casei under storage in 4$\circ$C temperature condition in 35 days, has shown that the original population of $4.0\times 10^8$ organisms was decreased to $0.1\times 10^8$, under storage in 10$\circ$C temperature the organisms to $0.08\times 10^8$, in room temperature the organisms to $0.009\times 10^8$, and in 35$\circ$C temperature the organisms to $0.0009\times 10^8$. The correlation coefficient of storage period (days) and number of bacterial viability were significant as r=0.956(p<0.01) in 4$\circ$C, r=-0.999 (p<0.01) in 100C, r=0.975(p<0.01) in room temperature and r=-0.923(p<0.01) in 35$\circ$C. (2) The pH test to Lactobacillus casei unde.r storage in 4$\circ$C temperature condition for 35 days has shown that the original pH of 3.54 were acidified to 3.35, under storage in 10$\circ$C temperature the pH were acidified to 3.20, in room temperature the pH were acidified to 3.15, and in 35$\circ$C temperature the pH were acidified to 3.0. The correlation coefficient of variation of pH between storage period (days) and temperature were significant as r=-0.972(p<0.01) in 4$\circ$C, r=-0.922 (p<0.01) in 10$\circ$C, r=-0.963 (p<0.01) in room temperature and r=-0.953 in 35$\circ$C.