• Korean Journal of Veterinary Research
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• v.54 no.3
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• pp.189-192
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• 2014

This study evaluated the antibacterial effects of a mixture of Sophorae radix and Glycyrrhiza uralensis Fischer (1 : 1) ethanol extracts (SGE) on mice infected with Streptococcus (S.) pyogenes. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration of SGE necessary for antibacterial effects against S. pyogenes were $20{\mu}g/mL$. Based on the time-kill curves for S. pyogenes, SGE was effective at $4{\times}$ MIC after 16 h. On Day 12 after challenge, the survival rate of mice treated with 2.0 mg/kg SGE was 60%. In conclusion, SGE had potent in vitro and in vivo antibacterial activities against S. pyogenes.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.27 no.2
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• pp.125-131
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• 1991

Electrolyte matrix fabrication process can be classifed as hot pressing, tape casting, callendering, electrophoretic deposition. however, these have limits in practice. Hot pressing is cumbersome method, because of careful heating and cooling. Furthermore, the perfected tile is so fragile that it is difficult to fit in a cell. Therefore this method is not adequate for mass production of the electrolyte matrix. Using electrophoretic deposition method, a very thin matrix can be made, but many attempts of the electrolyte embeding were found to be failure. Tape casting and callendering methods are employed in most of the matrix fabrication for the present. But these methods require lots of water as a solvent, so that coating of the LiAlO sub(2) with electrolyte is difficult. Recently, hot roll milling method has been developed and the perfected matrix was proved to be free from crack. The method, however, needs a roller to make a matrix and a perfected matrix is carefully striped off from the cooled roller. Therefore, this method requires a long time due to the cooling process. The author proposes a cold rolling process. On this method, heated slurry of the LiAlO sub(2) mixed with binder, is rolled with a cold roller. The heated slurry dose not adhere to the roller, since contacted hot slurry is rapidly solidified. Therefore fabrication speed is increased, without getting rid of merits of the hot rolling process.

• Archives of Pharmacal Research
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• v.28 no.5
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• pp.557-560
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• 2005

Resveratrol, a phenolic antioxidant found in grapes, has been known to mediate various biological activities on the human body. In the present study, we tested the antifungal a ctivity of resveratrol against human pathogenic fungi before carrying out further studies to elucidate the antifungal mechanism(s) of resveratrol. Resveratrol displayed potent antifungal activity against human pathogenic fungi at concentration levels of 10-20 ${\mu}g$/mL. Furthermore, time-kill curve exhibited fungicidal effect of resveratrol on C. albicans, but the compound had no hemolytic activity against human erythrocytes. The destruction of C. albicans cells by resveratrol was confirmed by scanning electron microscopy. These results suggest that resveratrol could be employed as a therapeutic agent to treat fungal infections of humans.

• Advances in Traditional Medicine
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• v.3 no.3
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• pp.151-156
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• 2003

The leaves of Mirabilis jalapa L contains protein fraction presumed ribosome-inactivating protein (RIP). RIP is a group of protein that has RNA N-glycosidase activity that is capable to inhibit protein synthesis. Protein fraction of the plant was shown to be cytotoxic on HeLa cell-line, however, the mechanism by which the protein kill the cells is not identified yet, whether trough apoptosis, necrosis, or other mechanism. This research aim to study the mechanism of cell death caused by the protein fraction isolated from the leaves of this plant on HeLa and Raji cell-line, as representative of different kind of cancer cells. Results showed that protein fraction isolated from the leaves of Mirabilis jalapa L was more cytotoxic to HeLa cell-line (LC50: 0.65 mg/ml) than to Raji cell-line (1.815 mg/ml) on 48 hours incubation time. Moreover, it was demonstrated that the death of HeLa cells caused by the protein fraction was due to induction of apoptosis, while on Raji cell-line was due to non-apoptosis way, presumably via necrosis.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2004.05a
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• pp.43-48
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• 2004

A pilot-scale system of 20t/h for the treatment of ship's ballast water and the setup of dissolved hydroxyl radical was introduced in this paper. With this experimental system, the kill efficiencies of bacteria, mono-algae, protozoan reach 100% within 2.67s when dissolved OHㆍconcentration is 0.6mg/L. At the same time, the effect of hydroxyl radicals on the photosynthesis pigments of phytoplankton was done. The results indicate that the contents of chi-a, chl-b, chl-c and carotenoid are decreased to 35~64% within 8.0s further to the lowest limit of test after 5 minutes. When dissolved OHㆍratio concentration is 0.68mg/L, the attenuation efficiencies of photosynthesis pigment are 100%. Therefore the invasive marine species can be killed in the process of the inputting and discharge ship's ballast water.

• Microbiology and Biotechnology Letters
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• v.48 no.4
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• pp.429-438
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• 2020

The emergence of multi-drug resistant, pathogenic methicillin-resistant Staphylococcus aureus (MRSA) is a threat to global health and has created a need for novel functional therapeutic agents. In this study, we evaluated the underlying mechanisms of the anti-MRSA effect of an azaphilone pigment, sclerotiorin (SCL) from Penicillium sclerotiorum. The antimicrobial activity of SCL was evaluated using agar disc diffusion, broth microdilution, time-kill assays and biophysical studies. SCL exhibits selective activity against Gram positive bacteria including MRSA (range, MIC = 128-1028 ㎍/ml) and exhibited rapid bactericidal action against MRSA with a > 4 log reduction in colony forming units within three hours of administration. Biophysical studies, using fluorescent probes and laser or electron microscopy, demonstrated a SCL dose-dependent alternation in membrane potential (62.6 ± 5.0.4% inhibition) and integrity (> 95 ± 2.3%), and the release of UV260 absorbing materials within 60 min (up to 3.2 fold increase, p < 0.01) of exposure. Further, SCL localized to the cytoplasm and hydrolyzed plasmid DNA. While in vitro checkerboard studies revealed that SCL potentiated the antimicrobial activity of topical antimicrobials such as polymixin, neomycin, and bacitracin (Fractional Inhibitory Concentration Index range, 0.26-0.37). Taken together these results suggest that SCL targets the membrane and DNA of MRSA to facilitate its anti-MRSA antimicrobial effect.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.38 no.3
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• pp.108-116
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• 2015

A missile defense system is composed of radars detecting incoming missiles aiming at defense assets, command control units making the decisions on weapon target assignment, and artillery batteries firing of defensive weapons to the incoming missiles. Although, the technology behind the development of radars and weapons is very important, effective assignment of the weapons against missile threats is much more crucial. When incoming missile targets toward valuable assets in the defense area are detected, the asset-based weapon target assignment model addresses the issue of weapon assignment to these missiles so as to maximize the total value of surviving assets threatened by them. In this paper, we present a model for an asset-based weapon assignment problem with shoot-look-shoot engagement policy and fixed set-up time between each anti-missile launch from each defense unit. Then, we show detailed linear approximation process for nonlinear portions of the model and propose final linear approximation model. After that, the proposed model is applied to several ballistic missile defense scenarios. In each defense scenario, the number of incoming missiles, the speed and the position of each missile, the number of defense artillery battery, the number of anti-missile in each artillery battery, single shot kill probability of each weapon to each target, value of assets, the air defense coverage are given. After running lpSolveAPI package of R language with the given data in each scenario in a personal computer, we summarize its weapon target assignment results specified with launch order time for each artillery battery. We also show computer processing time to get the result for each scenario.

• Journal of the Korean Society for Library and Information Science
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• v.51 no.3
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• pp.45-64
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• 2017

The purpose of this study is to understand the direction of the community reading campaign in the U.S.A. known as 'One Book, One City' reflected in the books selected for this campaign for the past 20 years in terms of their classification numbers, subject headings, publication dates, and genres. Analyzed are the author and state lists of 'One Book, One City' Reading Promotions Projects available from the website of the LC (Library of Congress) Center for the Books, and bibliographic records of 735 books selected in only one 'One Book' program, accessed from LC OPAC. Major findings include continuing influences of the all-time favorite 'One Book' selections, including To Kill a Mockingbird and the extension of their span of life through The Big Read, preference for the recent publications, importance of P (Literatures and Languages) Class (530 titles, 72.1%) and PS(American Literatures) subclass (307 titles, 57.9%) in the LC Classification Scheme, distribution of books in 43 genres, including domestic fiction, historical fiction, and psychological fiction, etc., the use of 535 unique LC subject headings and much interests in "City and town life" (10 titles) and "World War, 1939-1945" (8 titles), and prominence of subject groups which begin with "African American..." and "Woman..." out of 96 groups of subject headings. It is found that the subjects and focus of the selected books expand from integration, understanding, integrity to human rights, environment, peace, etc. The limitations of this study is that the influence of the selected books and the changes in communities are not properly analyed.

• Korean journal of applied entomology
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• v.59 no.1
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• pp.5-13
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• 2020

Cockroaches are a not only nuisance insects but also have medical importance as they mechanically propagate various pathogens. To date, baits have been widely suggested for use in cockroach control. In this study, we investigated the insecticidal effects of three Korean baits-Korea Combat Ultra Slim (K-CUS), Korea Combat Power (K-CP), and Korea Zaps Dual Bait (K-ZDB)-and three US baits-US Combat Source Kill Max (US-CSKM), US Hot Shot MaxAttrax Roach Bait (US-HSM), and US Raid Double Control Small Roach Bait (US-RDC)-on the German cockroach (Blattella germanica). Among the six baits, three (K-CUS, K-CP, and US-CSKM), the main active ingredients of fipronil, showed rapid and strong insecticidal efficacy. In addition, we compared the persistence of the insecticidal effects of K-CUS and K-CP 6 months and 12 months after initial opening. Insecticidal effects of both baits decreased over time, but the mortality rates of cockroaches exposed to 6-month- and 12-month-aged baits were over 90%, suggesting that these baits can maintain their insecticidal effect for at least one year after indoor installation.

• Convergence Security Journal
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• v.22 no.3
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• pp.25-32
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• 2022

Recently, the image processing industry has been activated as deep learning-based technology is introduced in the image recognition and detection field. With the development of deep learning technology, learning model vulnerabilities for adversarial attacks continue to be reported. However, studies on countermeasures against poisoning attacks that inject malicious data during learning are insufficient. The conventional countermeasure against poisoning attacks has a limitation in that it is necessary to perform a separate detection and removal operation by examining the training data each time. Therefore, in this paper, we propose a technique for reducing the attack success rate by applying modifications to the training data and inference data without a separate detection and removal process for the poison data. The One-shot kill poison attack, a clean label poison attack proposed in previous studies, was used as an attack model. The attack performance was confirmed by dividing it into a general attacker and an intelligent attacker according to the attacker's attack strategy. According to the experimental results, when the proposed defense mechanism is applied, the attack success rate can be reduced by up to 65% compared to the conventional method.