• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10917-10922
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• 2015

Background: This study was conducted to determine DEPDC1 expression in hepatocelluar carcinomas (HCCs) and to reveal its potential role in diagnosis and prognosis of affected patients. Materials and Methods: DEPDC1 expression at the mRNA level was detected by quantitative real-time PCR (qRT-PCR) in 205 cases of HCC and paired adjacent normal liver tissues, and by semi-quantitative RT-PCR in 20 cases. Survival curves were obtained by using Kaplan-Meier method and Log-rank test. Independent predictors associated with regard to disease free survival (DFS) and overall survival (OS) were identified using the Cox proportional hazard model. Results: High DEPDC1 mRNA levels were detected in 144 out of 205 cases (70.24%) of HCC, significantly associated with clinicopathological parameters, including tumor size (${\geq}4cm$), alpha-fetoprotein (${\geq}100ng/ml$), B-C of BCLC stage and recurrence. Kaplan-Meier survival analysis revealed that HCC patients with high DEPDC1 expression had poor OS and DFS. Multivariate analysis demonstrated that high DEPDC1 expression was an independent predictor for OS (HR=1.651; 95% 95%CI, 1.041-2.617; p=0.033) and DFS (HR=1.583; 95%CI, 1.01-2.483; p=0.045). Conclusions: Our results indicate DEPDC1 might be a novel diagnostic marker and an independent prognostic predictor for HCC patients.

• International Journal of Fluid Machinery and Systems
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• v.2 no.4
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• pp.392-399
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• 2009

The paper concerns the description of the step by step development process of the new fixed blade runner called "Mixer" suitable for the uprating of the Francis turbines units installed at the older low head hydropower plants. In the paper the details of hydraulic and mechanical design are presented. Since the rotational speed of the new runner is significantly higher then the rotational speed of the original Francis one, the direct coupling of the turbine to the generator can be applied. The maximum efficiency at prescribed operational point was reached by the geometry optimization of two most important components. In the first step the optimization of the draft tube geometry was carried out. The condition for the draft tube geometry optimization was to design the new geometry of the draft tube within the original bad draft tube shape without any extensive civil works. The runner blade geometry optimization was carried out on the runner coupled with the draft tube domain. The blade geometry of the runner was optimized using automatic direct search optimization procedure. The method used for the objective function minimum search is a kind of the Nelder-Mead simplex method. The objective function concerns efficiency, required net head and cavitation features. After successful hydraulic design the modal and stress analysis was carried out on the prototype scale runner. The static pressure distribution from flow simulation was used as a load condition. The modal analysis in air and in water was carried out and the results were compared. The final runner was manufactured in model scale and it is going to be tested in hydraulic laboratory. Since the turbine with the fixed blade runner does not allow double regulation like in case of full Kaplan turbine, it can be profitably used mainly at power plants with smaller changes of operational conditions or in case with more units installed. The advantages are simple manufacturing, installation and therefore lower expenses and short delivery time for turbine uprating.

• Journal of the Korean Society for Nondestructive Testing
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• v.24 no.6
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• pp.559-565
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• 2004

Two different methods were used for the scattering analysis of side-drilled holes(SDH). The scattering models include an explicit model based on the Kirchhoff approximation and the solution of the exact separation of variables. The far-field scattering amplitude was calculated and their time-domain results were compared for the case of shear vertical wave. The exact solution predicts the existence of the creeping wave. The Kirchhoff approximation agreed to the exact solution, except the case of the creeping wave. Two measurement models were introduced to predict the response from the SDHs for the case of immersion, pulse-echo testing. The received voltage was calculated for the case of the shear vertical waves with the incident angle of $45^{\circ}$ to the SDH with the diameter of 1mm, and compared with the experimental results.

• Journal of Biomedical Engineering Research
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• v.25 no.5
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• pp.377-382
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• 2004

In the present study, thirteen healthy volunteers performed lumbar extension exercises at 48$^{\circ}$/s, loaded by 40, 50, 60kg(about 44, 55, 66％ of maximum voluntary contraction). During the whole period of exercises, electromyographic(EMG) signal was measured in the erector spinae muscle in order to determine muscle fatigue. Using the wavelet transform, EMG signal was separated by various frequency ranges in the time-frequency domain, and muscle fatigue was analyzed, comparing with the results based on the median frequency(MDF). MDF shifted toward the lower frequency ranges with the muscle fatigue, showing a single characteristic frequency. On the other hand, wavelet transform of EMG signals resulted in increased power amplitude in lower frequency ranges(0-125Hz), and decreased power amplitude in higher frequency ranges(375-468Hz). This study reveals that the muscle fatigue during dynamic movement is explained better by wavelet analysis.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.9A
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• pp.719-726
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• 2009

CR systems performs spectrum sensing operation to detect the appearance of primary users. However, since it is not feasible to do spectrum sensing and data transmission simultaneously, they typically operate alternatively in a time domain. There have been an effort(8) to investigate the optimal spectrum sensing duration for maximum throughput for the scheme with cooperative spectrum sensing. This is based on an assumption that the communication channels between each secondary user and the fusion center are ideal and does not consider the effects of transmission error. Motivated by this, we here model the channels as binary symmetric channels and examined its effect on the maximum throughput and the associated optimal sensing duration. Analysis shows that the performance degradation due to the transmission error is smaller for the case of using the AND fusion rule than for the OR fusion rule.

• Nuclear Engineering and Technology
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• v.46 no.5
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• pp.633-640
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• 2014

In this research, the surface roughness affecting the pressure drop in a pipe used as the steam generator of a PWR was studied. Based on the CFD (Computational Fluid Dynamics) technique using a commercial code named ANSYS-FLUENT, a straight pipe was modeled to obtain the Darcy frictional coefficient, changed with a range of various surface roughness ratios as well as Reynolds numbers. The result is validated by the comparison with a Moody chart to set the appropriate size of grids at the wall for the correct consideration of surface roughness. The pressure drop in a full-scale U-shaped pipe is measured with the same code, correlated with the surface roughness ratio. In the next stage, we studied a reduced scale model of a U-shaped heat pipe with experiment and analysis of the investigation into fluid-structure interaction (FSI). The material of the pipe was cut from the real heat pipe of a material named Inconel 690 alloy, now used in steam generators. The accelerations at the fixed stations on the outer surface of the pipe model are measured in the series of time history, and Fourier transformed to the frequency domain. The natural frequency of three leading modes were traced from the FFT data, and compared with the result of a numerical analysis for unsteady, incompressible flow. The corresponding mode shapes and maximum displacement are obtained numerically from the FSI simulation with the coupling of the commercial codes, ANSYS-FLUENT and TRANSIENT_STRUCTURAL. The primary frequencies for the model system consist of three parts: structural vibration, BPF(blade pass frequency) of pump, and fluid-structure interaction.

• Fisheries and Aquatic Sciences
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• v.21 no.3
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• pp.5.1-5.8
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• 2018

Stimulator of interferon gene (STING) is induced by various inflammatory agents, such as lipopolysaccharide and microbial pathogens, including virus and bacteria. In this study, we obtained a full-length cDNA of a STING homolog from olive flounder using rapid amplification of cDNA ends PCR technique. The full-length cDNA of Paralichthys olivaceus STING (PoSTING) was 1442 bp in length and contained a 1209-bp open reading frame that translated into 402 amino acids. The theoretical molecular mass of the predicted protein sequence was 45.09 kDa. In the PoSTING protein, three transmembrane domains and the STING superfamily domain were identified as characteristic features. Quantitative real-time PCR revealed that PoSTING expressed in all the tissues analyzed, but showed the highest level in the spleen. Temporal expression analysis examined the significantly upregulated expression of PoSTING mRNA after viral hemorrhagic septicemia virus (VHSV) stimulation. In contrast, no significant changes in the PoSTING expression were detected in Edwardsiella tarda-challenged group compared to the un-injected control. The expression of P. olivaceus type I interferon (PoIFN-I) was also highly upregulated upon VHSV challenge. These results suggest that STING might be involved in the essential immune defense against viral infection together with the activation of IFN-I in olive flounder.

• Journal of Korea Water Resources Association
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• v.49 no.9
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• pp.773-787
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• 2016

A coupled river-overland hydrodynamic model was applied to estimate flood risk by a scenario-based approach. The study area is Seongseo Industrial Complex in Daegu which is located near Nakdong river and Geumho river. Inundation depth and velocity at each time were calculated by applying a coupled 1D/2D hydrodynamic model to the target area of interest. The 2D inundation analysis for river and overland domain was performed with the scenario-based approach that there are levee overflow against 100/200 year high quantile (97.5%) design flood and levee break against 100/200 year normal quantile (50%) design flood. The level of flood risk was displayed for resident/industrial area using information about maximum depth and velocity of each node computed from the 2D inundation map. The research outcome would be very useful in establishing specified emergency action plans (EAP) in case of levee break and overflowing resulting from a flood.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.73-76
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• 2008

The damage of earthquakes have to achieve by probabilistic evaluation because of uncertainty of earthquake. Fragility analysis is a useful tool for predicting the probability of damage induced by the probable earthquake. This paper presents the probability of damage as a function of peak ground acceleration and estimates the probability of five damage levels for the pier of prestressed concrete (PSC) bridge subjected to given ground acceleration. At each 100 artificial earthquake motions were generated in terms of soil conditions, and nonlinear time domain analyses were performed for the damage states of the pier of PSC bridge structures. These damage states are described by displacement ductility result from seismic performance based on existing research results. Using the damage states and ground motion parameters, five fragility curves for the pier of PSC bridges with five types of dominant frequencies were constructed assuming a log-nomal distribution. It was found that there was a significant effect on the fragility curves due to the dominant frequencies.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.27 no.2
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• pp.101-107
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• 2016

This paper presents the characteristics of a double-cone broadband antenna with compact and three-dimensional structure that can be used in UWB system. The theoretical analysis is conducted using a finite difference time domain(FDTD) method. The parameters are the radius, a height of broadband double-cone antennas with shorting plate, and the number of plates on a ground plane. This paper examines influence of structural parameters on return loss. The results show that a condition for an optimum structure of broadband double-cone antennas with shorting plate exists. It also shows that the broadband double-cone antennas with shorting plate have radiation patterns similar to those of a dipole antenna. To verify the theoretical analysis, computed results are compared to experimental results.