• BMB Reports
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• v.33 no.2
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• pp.184-187
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• 2000

Prostaglandin $E_2$ ($PGE_2$) plays an important role in the regulation of various gastric functions, and the growth-inhibitory activities on tumor cells are studied in vitro and in vivo. Although the mechanisms have attracted many researchers in the past decade, the molecular mechanisms of cell cycle arrest, or induction of apoptosis by $PGE_2$, is unclear. We investigated the effects of $PGE_2$ on the growth of the human gastric carcinoma cell line SNU1 and genes that are regulated by $PGE_2$ and isolated them using differential display RT-PCR (DD RT-PCR). FACS analysis suggested that SNU1 cells were arrested at the G1 phase by $PGE_2$ treatment. This growth inhibitory effect was in a time- and dose-dependent manner. Treatment of SNU1 cells with $10\;{\mu}g/ml$ $PGE_2$, followed by DD RT-PCR analysis, revealed differently expressed bands patterns from the control. Among the differently expressed clones, we found an unidentified cDNA clone (HGP-27) overexpressed in $PGE_2$-treated cells. The full-length cDNA of HGP-27 was isolated using RACE, which consisted of a 30-nt 5'-noncoding region, a 891-nt ORF encoding the 296 amino acid protein, and a 738-nt 3'-noncoding region including a poly(a) signal. This gene was localized on the short arm of chromosome number 11. Using the Motif Finder program, a myb-DNA binding repeat signature was detected on the ORF region. The COOH-terminal half was shown to have similarity with the $NH_3$-terminal domain of thioredoxin (Trx). This relation between HGP-27 and Trx implied a potential role for HGP-27 in modulating the DNA binding function of a transcription factor, myb.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.2 no.4
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• pp.531-538
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• 1998

In this paper the system performance degradation resulting from nonlinear transmitter power amplifier which is essential to increase the efficiency is analysed in a CDMA system. The power amplifier is modeled by its AM-AM, AM-PM characteristics. The effects of power amplifier's nonlinearity such as intersymbol interference, phase distonion on the RF system performance were visualized by examining the distorted time domain waveforms, signal vector constellation. And through the investigation of the power spectrum density of the transmitted signal, spectral regrowth or sideband regrowth which is result from amplitude distortion can be seen. All these characteristics result in BER performance degradation due to other user interferences and intersymbol interference. The analysis technique described here applies not only to power amplifier but also to any other nonlinear components such as mixers and switches. Also the effects of adjacent channel interference and supurious emission can be analysed between different systems.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.24 no.5
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• pp.558-565
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• 2013

In this paper, modeling and simulation for performance analysis of high resolution SAR system has been carried out in the time, frequency and numeric domain using ADS Ptolemy simulation tool of Agilent corporation. SAR system consists of antenna, controller and transceiver. Error parameters affecting SAR system performances have been defined, modeled and simulated such as phase noise of frequency synthesizer, amplitude and phase characteristic of TWTA, sampling frequency of waveform generator and I/Q imbalance. Finally, the development requirements of SAR system based on the impulse response function have been derived.

• Journal of The Institute of Information and Telecommunication Facilities Engineering
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• v.2 no.1
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• pp.52-62
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• 2003

In this paper, photonic bandgap(PBG) bandstop filters which are composed of periodically etched circles in the ground plane show good microwave characteristics with the harmonic suppression on stopband. The PBG structures were analyzed using a finite-difference time-domain(FDTD) simulation and experimental measurement. The FDTD technique is used because it can simulate arbitrary 3-D structures and provide broadband frequency response. The analysis results are presented it is the same that only one row of etched circles and 2-dimension three rows of etched circles. And we show the PBG resonator characteristics between etched circles using field pattern and frequency characteristics as functions of etched circle number n, etched circle radius r and period a.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2007.05a
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• pp.859-865
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• 2007

This paper presents a method to analyze the unbalance response of a high speed polygon mirror scanner motor supported by sintered bearing and flexible supporting structures by using the finite element method and the mode superposition method. The appropriate finite element equations for polygon mirror are described by rotating annular sector element using Kirchhoff plate theory and von Karman non-linear strain, and its rigid body motion is also considered. The rotating components except for the polygon mirror are modeled by Timoshenko beam element including the gyroscopic effect. The flexible supporting structures are modeled by using a 4-node tetrahedron element and 4-node shell element with rotational degrees of freedom. Finite element equations of each component of the polygon mirror scanner motor and the flexible supporting structures are consistently derived by satisfying the geometric compatibility in the internal boundary between each component. The rigid link constraints are also imposed at the interface area between sleeve and sintered bearing to describe the physical motion at this interface. A global matrix equation obtained by assembling the finite element equations of each substructure is transformed to a state-space matrix-vector equation, and both damped natural frequencies and modal damping ratios are calculated by solving the associated eigenvalue problem by using the restarted Arnoldi iteration method. Unbalance responses in time and frequency domain are performed by superposing the eigenvalues and eigenvectors from the free vibration analysis. The validity of the proposed method is verified by comparing the simulated unbalance response with the experimental results. This research also shows that the flexibility of supporting structures plays an important role in determining the unbalance response of the polygon mirror scanner motor.

• Journal of the Korean Society of Groundwater Environment
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• v.6 no.4
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• pp.188-193
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• 1999

Transport of pollutants in aquifer largely depends on groundwater flow which is governed by aquifer hydraulic parameters. Determination of these parameters and associated groundwater modeling become essential for adequate remediation of contaminate groundwater. The objective of this paper is to analyze groundwater flow and determine the optimum hydraulic parameters by performing groundwater modeling based on sensitivity analysis for unconfined sandy gavel aquifer constructed in a laboratory scale under various boundary condition. Results revealed that the simulated drawdown was lower than the observed drawdown irrespective of boundary conditions. and specific yield (S$_{y}$) had less effect on the grondwater flow than permeability (K) in the aquifer. Water balance analysis showed that the measured drawdown in neighboring observation wells during pumping was higher than either simulated or recovered water table. The indicated that a difference might exist in the water tables between aquifer and wells. The difference was investigated by time domain reflectometry (TDR) measurements on water contents in the region of water table and capillary fringe, and explained by a delayed response of water table during gravitational drainage as the water table was lowered as a result of pumping.g.

• Journal of Korea Water Resources Association
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• v.38 no.10 s.159
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• pp.851-859
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• 2005

Normalized cross-correlation (correlation coefficient) is a useful measure for pattern matching in PIV (Particle Image Velocimetry) analysis. Because it does not have a corresponding simple expression in frequency domain, several fast but inexact measures have been used. Among them, three measures of correlation for PIV analysis and the normalized cross-correlation were evaluated with a sample calculation. The test revealed that all other proposed correlation measures sometimes show inaccurate results, except the normalized cross-correlation. However, correlation coefficient method has a weakpoint that it requires so long time for calculation. To overcome this shortcoming, a fast and exact method for calculating normalized cross-correlation is suggested. It adopts Fast Fourier Transform (FFT) for calculation of covariance and the successive-summing method for the denominator of correlation coefficient. The new algorithm showed that it is really fast and exact in calculating correlation coefficient.

• Journal of the Korean Society for information Management
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• v.30 no.3
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• pp.71-87
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• 2013

In this study, we analyze the agenda setting and policy making process of the establishment of Gyeonggido Cyber Library, which has played an important role for development of public libraries in Gyeonggido since its launching, based on Kingdon's policy streams model. According to the model, policy formation is described as the result from the convergence of the three streams, such as problem, policy and politics streams. When these streams converge on a specific time point, a policy window is created so that the issues become policy agenda. At this moment, policy entrepreneurs propose their alternatives, which have been prepared already, and try to pass it through the window. We identify coupling of the streams in the policy window and the role of policy entrepreneurs in the process of agenda setting and selection of alternatives of Gyeonggido Cyber Library policy. Suggestions are provided based on the analysis for public policy formation in public libraries domain.

• Journal of Microbiology and Biotechnology
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• v.24 no.12
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• pp.1644-1653
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• 2014

Wuyiencin is produced by Streptomyces ahygroscopicus var. wuyiensis CK-15 and is widely used as an antifungal agent in agriculture. Analysis of wuyiencin biosynthetic gene clusters reveals wysR, a member of the LAL-family of transcriptional regulatory genes. WysR consists of an N-terminal PAS domain and a LuxR family C-terminal helix-turn-helix motif. However, the roles of wysR in wuyiencin biosynthesis are largely unknown. In this study, we showed that inactivation of wysR resulted in the complete loss of wuyiencin production, which could be restored by complementation with a single copy of wysR. Furthermore, we successfully increased wuyiencin production to a significantly higher level by overexpression of wysR in S. wuyiensis CK-15. Quantitative real-time RT-PCR analysis showed that WysR regulates wuyiencin biosynthesis by modulating other putative regulatory genes. Thus, WysR was identified as an activator of wuyiencin biosynthesis, and overexpression of wysR gene proved to be an effective strategy for improving wuyiencin production.

• The KIPS Transactions:PartB
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• v.11B no.7 s.96
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• pp.813-820
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• 2004

This paper proposes a digital image watermarking which is robust to geometric distortions using an independent component analysis(ICA) of fixed-point(FP) algorithm based on secant method. The FP algorithm of secant method is applied for better performance in a separation time and rate, and ICA is applied to reject the prior knowledges for original image, key, and watermark such as locations and size, etc. The proposed method embeds the watermark into the spatial domain of original image The proposed watermarking technique has been applied to lena, key, and two watermarks(text and Gaussian noise) respectively. The simulation results show that the proposed method has higher speed and better rate for extracting the original images than the FP algorithm of Newton method. And the proposed method has a watermarking which is robust to geometric distortions such as resizing, rotation, and cropping. Especially, the watermark of images with Gaussian noise has better extraction performance than the watermark with text since Gaussian noise has lower correlation coefficient than the text to the original and key images. The watermarking of ICA doesn't require the prior knowledge for the original images.