• Journal of Pharmaceutical Investigation
• /
• v.37 no.1
• /
• pp.57-62
• /
• 2007

The purpose of the present study was to evaluate the bioequivalence of two donepezil tablets, $Aricept^{TM}$ tablet (Dae Woong Pharm. Co., Ltd., Korea, reference drug) and $Donpezil^{TM}$ tablet (Dong Wha Pharm. Ind. Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four healthy male Korean volunteers received one tablet containing donepezil hydorchloride 10 mg in a $2{\times}2$ crossover study. There was a three-week washout period between the doses. Plasma concentrations of donepezil were monitored by an LC-MS/MS far over a period of 240 hr after the administration. $AUC_t$, (the area under the plasma concentration-time curve from time zero to 240 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$)were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$, No significant sequence effects were found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ and $C_{max}$ were log 0.95${\sim}$log 1.03 and log 0.94${\sim}$log 1.08, respectively. These values were within the acceptable bioequivalence intervals of log 0.80${\sim}$log 1.25. Taken together, our study demonstrated the bioequivalence of $Aricept^{TM}$ and $Donpezil^{TM}$ with respect to the rate and extent of absorption.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.1 no.2
• /
• pp.145-158
• /
• 1997

Method for synchronizing multimedia data is needed to support continuous transmission of multimedia data through a network in a bounded time and it also required for supporting continuous presentation of multimedia data with the required norminal playout rate in distributed network environments. This paper describes a new synchronization method for supporting delay-sensitive multimedia Presentation without degration of Quality of services of multimedia application. It mainly aims to support both intermedia and intermedia synchronization by absorbing network variations which may cause skew or jitter. In order to remove asynchonization problems, we make use of logical time system, dynamic buffer control method, and adjusting synchronization intervals based on the quality of services of a multimedia. It might be more suitable for working on distribute[1 multimedia systems where the network delay variation is changed from time to time and no global clock is supported. And it also can effectively reduce the amount of buffer requirements needed for transfering multimedia data between source and destination system by adjusting synchronization intervals with acceptable packet delay limits and packet loss rates.

• Journal of Pharmaceutical Investigation
• /
• v.34 no.4
• /
• pp.311-317
• /
• 2004

A bioequivalence study of $Gomcillin^{TM}$ capsules (DAEWOONG Pharmaceutical Co., Korea) to $Famoxin^{TM}$ capsules (Dong Wha Pharm. Ind. Co., Korea) was conducted according to the guideline of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the amoxicillin dose of 500 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of amoxicillin were monitored by a high-performance liquid chromatography for over a period of 8 hours after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 8 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Gomcillin^{TM}/Famoxin^{TM}$ were $log0.91\;{\sim}\;log1.03$ and $;log0.93\;{\sim}\;log1.10$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80\;{\sim}\;log1.25$. Thus, our study demonstrated the bioequivalence of $Gomcillin^{TM}$ and $Famoxin^{TM}$ with respect to the rate and extent of absorption.

• Restorative Dentistry and Endodontics
• /
• v.38 no.3
• /
• pp.128-133
• /
• 2013

Objectives: This study was performed to evaluate the effect of blood contamination on the compressive strength (CS) of Root MTA (RMTA) modified with Calcium chloride ($CaCl_2$) and Disodium hydrogen phosphate ($Na_2HPO_4$) as setting accelerators over time. Materials and Methods: A total of 110 cylindrical specimens of RMTA were divided into 6 experimental groups as follows: Group1, RMTA; Group 2, RMTA modified with $CaCl_2$ (RMTA-C); Group 3, RMTA modified with $Na_2HPO_4$ (RMTA-N); Group 4, RMTA contaminated with blood; Group 5, RMTA-C contaminated with blood; Group 6, RMTA-N contaminated with blood. The CS of specimens in all groups was evaluated after 3 hr, 24 hr, and 1 wk. In the modified groups (groups 2, 3, 5, and 6) the CS of five specimens per group was also evaluated after 1 hr. Results: Blood contamination significantly reduced the CS of all materials at all time intervals (p < 0.05). After 3 hr, the CS of specimens in the RMTA groups (with and without blood contamination) was significantly lower than those in the RMTA-C and RMTA-N groups (p < 0.05). The CS values were not significantly different at the other time intervals. In all groups, the CS of specimens significantly increased over time (p < 0.05). Conclusions: Blood contamination decreased the CS of both original and accelerated RMTA.

• Journal of Broadcast Engineering
• /
• v.24 no.4
• /
• pp.553-563
• /
• 2019

As the number of videos uploaded on live streaming platforms rapidly increases, the demand for providing highlight videos is increasing to promote viewer experiences. In this paper, we present novel methods for predicting highlights using chat logs and audio data in videos. The proposed models employ bi-directional LSTMs to understand the contextual flow of a video. We also propose to use the features over various time-intervals to understand the mid-to-long term flows. The proposed Our methods are demonstrated on e-Sports and baseball videos collected from personal broadcasting platforms such as Twitch and Kakao TV. The results show that the information from multiple time-intervals is useful in predicting video highlights.

• Archives of Plastic Surgery
• /
• v.46 no.5
• /
• pp.405-413
• /
• 2019

Background Face transplantation has naturally evolved from reconstructive procedures. However, few institutions perform face transplantations, because it is time-consuming and it is necessary to justify non-vital organ transplantation. We investigated the process of organ donation from brain-dead patients and the possibility of incorporating face transplantation into the donation process. Methods A retrospective review was performed of 1,074 brain-dead patients from January 2015 to December 2016 in Korea. We analyzed the time intervals from admission to brain death decisions (first, second, and final), the causes of brain death, and the state of the transplanted organs. Results The patient base (n=1,074) was composed of 747 males and 327 females. The average period between admission to the first brain death decision was 8.5 days (${\pm}15.3$). The average time intervals between the first brain death decision and medical confirmation using electroencephalography and between the first brain death decision and the final determination of brain death were 16 hours 58 minutes (${\pm}14hours$ 50 minutes) and 22 hours 57 minutes (${\pm}16hours$ 16 minutes), respectively. The most common cause of brain death was cerebral hemorrhage/stroke (42.3%), followed by hypoxia (30.1%), and head trauma (25.2%). Conclusions When face transplantation is performed, the transplantation team has 22 hours 57 minutes on average to prepare after the first brain death decision. The cause of brain death was head trauma in approximately one-fourth of cases. Although head trauma does not always imply facial trauma, surgeons should be aware that the facial tissue may be compromised in such cases.

• International Journal of Computer Science & Network Security
• /
• v.22 no.10
• /
• pp.113-130
• /
• 2022

Sophisticated automation-based electronics world, more electrical and electronic devices are being used by people from different regions across the universe. Different manufacturers and vendors develop and market a wide variety of power generation and utilization devices under different operating parameters and conditions. People use a variety of appliances which use electrical energy as power source. These appliances or gadgets utilize the generated energy in different ratios. Night time the utilization will be less when compared with day time utilization of power. In industrial areas especially mechanical industries or Heavy machinery usage regions power utilization will be a diverse at different time intervals and it vary dynamically. This always causes a fluctuation in the grid lines because of the random and intermittent use of these apparatus while the power generating apparatus is made to operate to provide a steady output. Hence it necessitates designing and developing a method to optimize the power generated and the power utilized. Lot of methodologies has been proposed in the recent years for effective optimization and economical load dispatch. One such technique based on intelligent and evolutionary based is Black Widow Optimization BWO. To enhance the optimization level BWO is hybridized. In this research BWO based optimize the load for multi area is proposed to optimize the cost function. A three type of system was compared for economic loads of 16, 40, and 120 units. In this research work, BWO is used to improve the convergence rate and is proven statistically best in comparison to other algorithms such as HSLSO, CGBABC, SFS, ISFS. Also, BWO algorithm best optimize the cost parameter so that dynamically the load and the cost can be controlled simultaneously and hence effectively the generated power is maximum utilized at different time intervals with different load capacity in different regions of utilization.

• Korean Journal of Medicinal Crop Science
• /
• v.5 no.4
• /
• pp.318-324
• /
• 1997

When Bupleurum falcatum field was irrigated three times with 20mm at intervals of 10days after sowing, establishment was inproved (64%) and root yield increased to 58kg/10a. And in early growing stage, 30mm irrigation six times at intervals of 10days increased the number of harvested plants per square meter and resulted in yield increase by 26% over yield from natural plot. 20mm irrigation in sowing time at intervals of 10days and 30mm irrigation in early growing stage at intervals of 10days kept adequate soil moisture content (soil moisture tension: $0.39{\sim}0.49bar)$ and resulted in better establishment, growth and yield of Buleurum falcatum.

• Asian-Australasian Journal of Animal Sciences
• /
• v.9 no.4
• /
• pp.371-374
• /
• 1996

Experiments were conducted to determine the effect of time intervals between collecting and use of cattle faeces as a source of micro-organisms in in vitro digestibility assays of forages. The results suggested that temperature conservation capacity by faeces depended on the size of the sample. There was no significant difference(p>0.05) between the first (T1 or 08:30 h) and second using time (T2 or 10:30 h). In vitro organic matter digestibility was significantly lower when faeces was used 5 h (T3 or 13:30 h) after collection. However, the organic matter digestibility determined at the second using time (T2) and third using time (T3) were highly correlated ($R^2=0.99$) with the first using time. It was concluded that faeces can be used as a source of microorganisms for in vitro digestibility assays of forages even 5 h after being voided.

• Proceedings of the KIEE Conference
• /
• 2001.11c
• /
• pp.149-151
• /
• 2001

In real-time control system, it is essential to confirm the timing behavior of all tasks because these tasks of real-time controller have to finish their processes within the specified time intervals called a deadline. In order to satisfy this objective, the timing analysis of a real-time system such as a schedulability test must be performed during the system design phase. This paper presents a Matlab toolbox for simulation of real-time control system based on OSEK-OS, which is one of the most widely adopted real-time operating systems in automotive industry. The toolbox allows the user to explore the timely behavior of control algorithms, and to study the interaction between the object of the OSEK-OS, such as task, scheduler and resource etc.