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Parasympathetic Modulation Plays a Key Role in Initiation of Paroxysmal Atrial Fibrillation

  • Lee, Won-Jae;Shin, Dong-Gu;Hong, Geu-Ru;Park, Jong-Sun;Kim, Young-Jo
    • Journal of Yeungnam Medical Science
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    • v.24 no.2
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    • pp.216-231
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    • 2007
  • Background : An acceleration or deceleration of the heart rate (HR), which reflects autonomic effects, is observed before the onset of paroxysmal atrial fibrillation (PAF). The purpose of this study was to assess the discrepancy in the autonomic interactions before the onset of PAF for different patterns of change in the HR. Materials and Methods : From 105 Holter tapes with the PAF recorded, 55 episodes (42 patients, 34 men, $58{\pm}12$ years) of PAF (>5 min), preceded by a sinus rhythm for more than 1 hour, were selected and submitted to time-domain and frequency-domain HR variability analyses. Fifty-five episodes were divided into 2 groups: group A PAF (n=30) with acceleration of the HR during the last 2 minutes before the PAF and group B (n=25) with deceleration of the HR. Results : A significant linear decrease in the mean R-R interval was observed in group A ($924{\pm}30$ to $835{\pm}28ms$, $P$=0.001) and an increase from $831{\pm}32$ to $866{\pm}31ms$ in group B PAF episodes ($P$=0.046). In the frequency-domain analyses, the LF/HF ratio exhibited a progressive linear increase before the PAF in group A ($P$=0.005). The HF normalized units (HFnu) and natural logarithm-transformed HF ($In$HF) values decreased from $30.8{\pm}4.0$ to $16.1{\pm}1.8$ ($P$=0.003) and $4.49{\pm}0.25$ to $4.07{\pm}0.22$ ($P$=0.001), respectively. Contrary to the results in group A, a significant increase in the HF components (HFnu and $In$HF) (from $22.6{\pm}3.2$ to $30.2{\pm}4.0$, $P$=0.005, and $4.27{\pm}0.27$ to 4.75 0.33, $P$=0.001, respectively) and a resultant decrease in the LF/HF ratio were observed in group B PAF episodes. No significant changes were observed in the LF components in either PAF group. Conclusion : Autonomic stimuli leading to an acceleration or deceleration of the HR before the onset of AF are due to parasympathetic modulation. Parasympathetic modulation plays a key role in the initiation of PAF.

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Effects of Condiments upon ${\alpha}-Amylase$ activity (조미료(調味料)가 ${\alpha}-amylase$활성(活性)에 미치는 영향(影響))

  • Suh, Myung-Jah
    • Journal of Nutrition and Health
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    • v.9 no.1
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    • pp.104-109
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    • 1976
  • Condiments such as welsh onion, garlic, ginger, black pepper, red pepper, japanese pepper, mustard, horse radish, monosodium glutamate and sugar were ground by a homogenizer, and 0%, 1%, 5%, and 10% of each of the ground condiments were put into 0.2% ${\alpha}-amylase$ solution for storage at the temperature of $15^{\circ}C$. ${\alpha}-amylase$ activity then was measured by the Wohlgemuth method at 48-hour interval, and the following results were obtained. 1) Among the condiments, black pepper and sugar checked the ${\alpha}-amylase$ activity most, about 80% in comparison with control. 2) Welsh onion, garlic, mustard, and ginger checked the ${\alpha}-amylase$ activity, about 50% in comparison with control, irrespective of the time stored. 3) The low concentration of red pepper, horse radish, japanese pepper and mono-sodium glutamate checked the ${\alpha}-amylase$ activity about 50%, while the high one did below 75% in comparison with control. To conclude: all the condiments used in the experiment checked ${\alpha}-amylase$ activity.

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Noise-robust electrocardiogram R-peak detection with adaptive filter and variable threshold (적응형 필터와 가변 임계값을 적용하여 잡음에 강인한 심전도 R-피크 검출)

  • Rahman, MD Saifur;Choi, Chul-Hyung;Kim, Si-Kyung;Park, In-Deok;Kim, Young-Pil
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.12
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    • pp.126-134
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    • 2017
  • There have been numerous studies on extracting the R-peak from electrocardiogram (ECG) signals. However, most of the detection methods are complicated to implement in a real-time portable electrocardiograph device and have the disadvantage of requiring a large amount of calculations. R-peak detection requires pre-processing and post-processing related to baseline drift and the removal of noise from the commercial power supply for ECG data. An adaptive filter technique is widely used for R-peak detection, but the R-peak value cannot be detected when the input is lower than a threshold value. Moreover, there is a problem in detecting the P-peak and T-peak values due to the derivation of an erroneous threshold value as a result of noise. We propose a robust R-peak detection algorithm with low complexity and simple computation to solve these problems. The proposed scheme removes the baseline drift in ECG signals using an adaptive filter to solve the problems involved in threshold extraction. We also propose a technique to extract the appropriate threshold value automatically using the minimum and maximum values of the filtered ECG signal. To detect the R-peak from the ECG signal, we propose a threshold neighborhood search technique. Through experiments, we confirmed the improvement of the R-peak detection accuracy of the proposed method and achieved a detection speed that is suitable for a mobile system by reducing the amount of calculation. The experimental results show that the heart rate detection accuracy and sensitivity were very high (about 100%).

Effects of Insoluble Dietary Fiber Supplementation on Performance and Nutrient Digestibility of Weanling Pigs (난용성 식이섬유의 첨가가 이유자돈의 생산성 및 영양소 소화율에 미치는 영향)

  • Han, Y.K.;Han, K.Y.;Lee, J.H.
    • Journal of Animal Science and Technology
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    • v.47 no.4
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    • pp.565-572
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    • 2005
  • An experiment was conducted to determine the effect of supplementation of insoluble dietary fiber (Vitacel®) on growth performance and nutrient digestibility in weanling pigs. A total of 96 pigs that averaged 6.49$\pm$0.52kg BW and 23$\pm$2.1d age were allocated in a randomized block design with two pigs per pen and 12 pens per treatment. Pigs and feeders were weighed 10-days interval for the 40-d trials to determine ADG, ADFI and feed:gain ratio(F:G). Pigs were fed one of four diets:1) Control diet (C) 2) C+0.3% insoluble dietary fiber(IDF) 3) C+0.6% IDF and 4) c+0.9% IDF. For the determination of fecal nutrients digestibility, pigs were fed diets(diet 2) with 1% Celite-545(Fluka) as a marker and feces were collected on $9^{th}$ day and $18^{th}$ day after feeding diet 2. During the whole experimental period, pigs fed diet with 0.3% IDF have significantly higher ADG than other dietary treatment groups(P<0.05). ADG of pigs fed diet with 0.6% IDF was higher than that of pigs fed control diet(P<0.05). However, there was no significant difference in ADG between control group and 0.9% IDF group(P>0.05). ADFI of pigs fed diet with 0.3% IDF was significantly higher than any other dietary treatment groups(P<0.05). There was no significant difference in ADFI among control group, 0.6% and 0.9% IDF supplementation groups (P>0.05). Digestibilities of organic matter, crude protein, crude fiber and energy were significantly higher in 0.3% IDF supplementation group than any other dietary groups. However, there was no difference in over all nutrient digestibilities between 0.6% and 0.9% IDF group. Feeding diets more than 0.6% IDF did not affect the rest of the nutrients digestibilities except for ADF digestibility compared to control diet. Dietary supplementation level of IDF showed a significant quadratic effect on performance improvement of piglets. This response of growth performance to IDF supplementation is, as expected, in agreement with that of nutrient digestibility. Our results showed that IDF supplementation to diet for weaned piglets might be beneficial in terms of growth and nutrient digestibility. However, there should be more study on the relationship between level of IDF supplementation and piglet response as well as the exact mode of action of IDF in weaned piglets.

The Residue Property of Fungicide Dimethomorph and Pyraclostrobin in Green Onion under Greenhouse Condition (시설재배 쪽파에서 살균제 Dimethomorph와 Pyraclostrobin의 잔류특성)

  • Park, Jong-Woo;Kim, Tae-Hwa;Chae, Seok;Sim, Jae-Ryoung;Bae, Byung-Jin;Lee, Hae-Kuen;Son, Kyeong-Ae;Im, Geon-Jae;Kim, Jin-Bae;Kim, Jang-Eok
    • The Korean Journal of Pesticide Science
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    • v.16 no.4
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    • pp.328-335
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    • 2012
  • In order to use in the classification of minor crop for the mutual application of safe use guideline, it was investigated the residue property of fungicide dimethomorph and pyraclostrobin in green onion, a stem-crop. After pesticides were applied 2 times with 1 week interval in that day of harvest, 3 days, 7 days, 10 days and 14 days before harvest, a green onion was harvested. The residue of dimethomorph in a green onion was 26.31 and 39.08 mg/kg in that day of harvest, however, in according to elapse time, it was reduced to 6.86 and 9.34 mg/kg in 14 days before harvest. In case of pyraclostrobin, it was also reduced from 13.46 and 39.08 mg/kg to 3.57 and 5.21 mg/kg. Based on the residue in that day of harvest, the deposit of spray solution in a green onion was calculated. The deposit of spray solution of dimethomorph was 274.35~345.84 mL/kg, in case of pyraclostrobin, it was calculated 213.65~343.33 mL/kg. When the amount of the deposit of both pesticides was compared in a green onion, it was so similar. On the other hand, it was estimated the predicted dissipation curve of pesticides in the green onion during cultivation. The half-life of dimethomorph was 6.95~7.45 days, in case of pyraclostrobin, 7.15~7.45 days. When both pesticides were compared with the residue property, the deposit of spray solution and half-life of dissipation were so similar.

Retrospective Analysis of Chemoradiotherapy for Limited-Stage Small-Cell Lung Cancer (제한병기 소세포암 환자의 항암화학방사선요법에 대한 후향적 분석)

  • Lee, Jong-Hoon;Kim, Sung-Hwan;Kim, Su-Zy;Lee, Joo-Hwan;Kim, Hoon-Kyo;Shim, Byoung-Yong
    • Radiation Oncology Journal
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    • v.27 no.3
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    • pp.133-139
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    • 2009
  • Purpose: This study was designed to analyze the outcome and toxicity of thoracic radiation therapy (TRT) and chemotherapy for patients who suffer with limited-stage small-cell lung cancer (LS-SCLC). Materials and Methods: We retrospectively studied 35 patients with LS-SCLC. TRT was administered once daily (1.8 to 2 Gy per fraction) and it was directed to the primary tumor for a total 50 to 66 Gy in 6 to 7 weeks. The patients received four cycles of etoposide plus cisplatin. TRT was begun on day 1 of the first cycle of chemotherapy in the concurrent arm and after the fourth cycle in the sequential arm. Results: The median progression-free survival time was 16.5 months (95% confidence interval [CI], 9.0 to 24.1 months) for the sequential arm, and 26.3 months (95% CI, 16.6 to 35.9 months) for the concurrent arm. The 2-year progression-free survival rate was 16.0 percent for the sequential arm and 50.0 percent for the concurrent arm (p=0.0950 by log-rank test). Leukopenia was more severe and more frequent in the concurrent arm than in the sequential arm. However, severe esophagitis was infrequent in both arms. The radiotherapy was interrupted more frequently in the concurrent arm than in the sequential arm due to hematologic toxicities (p=0.001). Conclusion: This study suggests that concurrent TRT with etoposide plus cisplatin is more effective for the treatment of LS-SCLC than sequential TRT. However, there is a significant increase in the risk of toxicities, and radiotherapy was frequently interrupted in the concurrent arm due to hematologic toxicities.

Long-Term Observation of Temperature in the Coastal Waters Adjacent to the Wolsung Nuclear Power Plant (월성 원자력 발전소 주변 해역의 장기간 수온관측)

  • Chung, Jong-Yul;Kang, Hyoun-Woo;Shin, Young-Jae;Kim, Kye-Young;Jun, Ho-Kyung
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.3 no.4
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    • pp.183-192
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    • 1998
  • The long-term observation of temperature in the coastal waters adjacent to the Wolsung Nuclear Power Plant has been carried out from November 10, 1996 to August 22, 1997, for approximately 280 days using a real-time temperature measurement buoy system. The sea-surface temperature was measured at every 10 minute using 10 buoys. The vertical structure of temperature was investigated near the outlet of the plant with two thermistor chains equipped with 10 sensors at 1 m interval The monthly averaged temperature was the lowest with spatial average of $12.8^{\circ}C$ in February and was the highest in August with spatial average of $19.6^{\circ}C$. The extremely low temperature was frequently observed between June and August, which seems to be the consequence of the intrusion of cold water near the southeastern coast of Korea. Distributions of the daily and hourly averaged temperature show that the highest temperature always occurred near the outlet of the plant and the warm-water patch moved along the north-south direction with the semidiurnal period. The semidiurnal fluctuation of temperature was also observed near the surface of the vertical profiles. The spectral analysis of temperature between February and April 1997 shows that the semidiurnal components prevailed near the outlet. It is likely that the semidiurnal components were due to the prevailing semidiurnal tide in this region. In August 1997, the diurnal components were dominant at the surface water of all stations except Station 12, which suggests that the warm water from the outlet of the plant has less effects in summer on the surrounding waters than the strong solar radiation.

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Studies on the Effect of the Thickness of Lining on Water Holding Capacity and Lield in Rice Patty with High Permeability (누수유에 있어서 밑다짐 두께의 차이가 보수력 및 수호량에 미치는 영향)

  • 이창구
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.11 no.1
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    • pp.1598-1603
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    • 1969
  • A field expeperiment has been conducted in order to explore possibilities of efficient and economical irrigation methods for the rice cultivation through which irrigation water may be saved and rice paddies may keep water for longer period of time, resulting in an increased yield of rice. Some of the major findings from the experimentation are summarized in the following. 1. There is slightly significant difference among experimental plots in the weight of rice straw. 2. The 9cm-lined plot proves to be the best in terms of the thickness. In this connection, however, it seems to by 3cm. 3. The wheat straw-lined plot is found superior in yield. However, this may be resulted in by the application of more fertilizer, and how long the plot could be durable may be problematic. Since every two or three years the straw-lining work has to be done, more labour may be required of the plot. 4. It would be inappropriate to expect any meaningful experimental results for the first year, since surface soil and deep soil are mixed up in the course of work. There is not observed any meaningful difference in the number of ears per stalk and in the number of grains per ear. However, in the lined plots, the number of tillers is slightly increased. 5. Irrigation has been applied by means of ordinary method after lining. When irrigation is applied at the interval of five to six days, irrigation water is saved by 44.9 per cent in the case of 9cm-lined plot, 39.7 per cent in the case of 6 cm-lined plot, and 36.3 percent in the case of 3 cm-lined plot. 6. An increased yields arenoted in the wheat straw-lined plot by 23.8 per cent, in the 9 cm-lined plot by 20.1 per cent, in the 3 cm-lined plot by 12 per cent. and in the case of vinyl-lined plot by 12.5 per cent. 7. The rate of maturity of grains is proved better, and the husking rate also found better(75%), that is, the quality of rice grains is improved.

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Analysis of 1,000 Cases of Abdominal Ultrasonography Performed by a Pediatrician (소아과 의사에 의해 시행된 복부 초음파 검사 1,000예에 대한 분석)

  • Bae, Sang-In;Park, Jae-Hong
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.10 no.1
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    • pp.28-35
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    • 2007
  • Purpose: The aim of this study was to evaluate the clinical usefulness of ultrasound examination of children performed by a pediatrician. Methods: One thousand children who presented with symptoms of a gastrointestinal disorder and underwent abdominal ultrasound evaluation in the Department of Pediatrics, between January 2003 and June 2006, were included in this study. We analyzed the patient's medical records and ultrasound results retrospectively. Results: Among the 1,000 patients, 58.4% were male and 41.6% were female. The mean age of the patients was $4.7{\pm}4.0$ years. The main reasons for ultrasound were abdominal pain (43.9%), vomiting (17.3%), elevated liver enzymes (11.8%), and jaundice (9.8%). Abnormal ultrasound findings were present in 57.9% of cases. The major abnormal findings were mesenteric lymphadenitis (29.2%), fatty liver (12.1%), hepatitis (6.4%), hepatosplenomegaly (6.2%), and acute appendicitis (4.8%). The time interval between the initial medical evaluation and the ultrasound evaluation was within 24 hours in most cases (78.5%). The main findings in children with abdominal pain were mesenteric lymphadenitis (32.6%), fatty liver (5.9%), intussusception (2.7%), and acute appendicitis (2.7%). The main findings in children with vomiting were mesenteric lymphadenitis (12.7%), hypertrophic pyloric stenosis (10.4%), and acute appendicitis (3.5%). The major ultrasound findings in children with urinary tract diseases were hydronephrosis (45.4%), urolithiasis (21.5%) and cystic renal disease (18.1%). Conclusion: Ultrasound examination played an important role as a non-invasive and prompt screening examination for detection of abdominal diseases. Ultrasound was an important tool for pediatricians to determine timely information for patient management.

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Hair Heavy Metal Contents in Mentally Retarded Children I - In Association with Lead - (정신지체아 두발 중 중금속 함량 I - 납과의 관련성 -)

  • Kim, Doo-Hie;Kim, Ock-Bae;Chang, Bong-Ki
    • Journal of Preventive Medicine and Public Health
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    • v.22 no.1 s.25
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    • pp.125-135
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    • 1989
  • This paper was carried out to study on correlation between mentally retardation and lead and zinc. The subjects were 297 mentally retarded children: 132 of Bomyung special school and Sunmyung, which were located in Taegu city of Korea. The former had their parents but the latter had not. The control group 63 children were randomly seleted from the Dong-in primary school near to Medical School of Kyungpook National University. Atomic absorption spectrophotometer, model IL-551 connected with CTF atomizer(IL. 655) was used for the analysis of lead and zinc. The mean value of lead in hair of mentally retarded children was $14.97{\pm}3.71ppm$ which is significantly higher than that of control group, $11.36{\pm}2.83ppm$. But the content of zinc was not significant in both groups. In the lead there was no significant correlation to age but significant negative correlation to IQ. Zinc showed significant correlation to age but not to IQ. Among the handicapped children, no signigicant correlation between orphan group and non orphan group. Handicaps of mentally-retarded children were speech impairment, emotional disturbance, double and triple handicaps, sensory impairment and abnormal dietary patterns. There were significantly higher contents of lead compared with normal group, except the latter two groups. The disease conditions of mentally retarded children were mongolism, autism, cerebral palsy, epilepsy and microcephaly. In comparing with mongolism, significant difference were existent only on the cerebral palsy and group of unknown etiology. We attempted to divide their past history into external etiology and internal etiology, but could not find significant difference. In view of the whole results, the relationship between mentally-retarded children and lead was presumed to be the early time exposure rather than long interval exposure during growth and the contact opportunity was considered important subject in maternal and child health care.

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