• Journal of Nutrition and Health
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• v.6 no.4
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• pp.55-60
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• 1973

To determine the effects of condiments upon Proteinase Activity, condiments such as welsh onion, garlic, ginger, black pepper, red pepper, mi-won (glutamic acid natrium), sugar, mustard and horse-radish were ground by a homogenizer, and each of them was dosed by 0%, 1%, 5% and 10% into Pancreatin Solution of 0.2% for storage at the temperature of 15 degrees Cels. The Enzyme Solution thus obtained then was measured at a certain interval of time by the Fuld Gross Method, and the following results were obtained. 1) The condiments that kept Proteinase Action of Pancreatin checked below 75% were mustard, horse-radish, red pepper and welsh onion. The centrol power of welsh onion, in particular, became stronger as storage time became longer. 2) The condiments that kept Proteinase Action of Pancreatin checked below 50% were sugar, black pepper and ginger. 3) Mi-won and garlic showed a strong checking powor over Proteinase Action at an early stage of storage, but as time passed, their control power gradually diminished to naught. In short, it may be concluded that ail of the condiments used in this experiment demonstrated their checking power over Proteinase Action.

• Korean Journal of Environment and Ecology
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• v.28 no.4
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• pp.404-410
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• 2014

In this study, we conducted an analysis of the drumming bioacoustics of three woodpeckers typical to South Korea. The targeted species were, from largest to smallest in size, the Black Woodpecker(Dryocopus martius), the Great Spotted Woodpecker(Dendrocopos major) and the Japanese Pygmy Woodpecker(Dendrocopos Kizuki). The drumming sounds of these three species of woodpeckers were recorded and analyzed. Sound recordings were taken in the Guryongsa Valley, Chiaksan National Park and on the campus of Sangji University, Wonju City, South Korea. Drumming recordings were obtained in the following manner. As researchers walked along trails in the investigation areas, when woodpecker drumming sounds were indicated, positive identification of the species was made using binoculars then the recording of the drumming sound was started. The average time per drumming, in seconds, was Black Woodpecker(D. martius) 1.614 seconds, Great Spotted Woodpecker(D. major) 0.683 seconds and Japanese Pygmy woodpecker(D. Kizuki) 0.200 seconds. The average number of strikes for each drumming was Black Woodpecker(D. martius) 31.2 times, Great Spotted Woodpecker(D. major) 14.9 times and Japanese Pygmy Woodpecker(D. Kizuki) 6.7 times. The strike speed, in strikes/sec, for each species was the Black Woodpecker(D. martius)19.3strikes/sec, the Great Spotted Woodpecker(D. major) 21.8strikes/sec and Japanese Pygmy Woodpecker(D. Kizuki)33.3strikes/sec. The frequency of drumming, in Hertz, was Black Woodpecker(D. martius) 776.9Hz, Great Spotted Woodpecker (D. major) 1,213.8Hz and Japanese Pygmy Woodpecker(D. Kizuki) 826.0Hz. In interpreting this data, Analysis of Variance (ANOVA) was used and it was determined that there was a significant statistical difference between species in drumming duration, time and interval of striking. The findings support that the bigger the biomass of the woodpecker, the longer the drumming duration and striking time. However, the smaller the size of the woodpecker, the faster the strike speed. A correlation between body type size and drumming characteristics was clearly identified. As for strike frequency, measured in Hertz, the medium sized Great Spotted Woodpecker's (D. major) frequency was high whereas the Black Woodpecker(D. martius) and Japanese Pygmy Woodpecker's(D. Kizuki) frequency was similar. A clear trend in reference to body size on this measure does not exist.

• Korean Journal of Agricultural Science
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• v.8 no.1
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• pp.90-96
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• 1981

To design more efficient agricultural machinery, the accurately measuring system among many other factors is essential. A light-beam oscillographic recorder is generally used in measuring dynamic strain but it is not compatible with the extremely high speed measuring system such as 1,000 m/s, also is susceptable to damage due to vibration while using the system in field. The recorder used light sensitive paper for strip chart recording. The reading and analysis of data from the strip charts is very cumbersome, errorneous and time consuming. A microcomputer was interfaced with A/D converter, microcomputer program was developed for measuring, system calibration was done and the strain generated from a cantilever beam vibrator was measured. The results are summarized as follows. 1. Microcomputer program was developed to perform strain measuring of agricultural machine elements and could be controled freely the measuring intervals, no. of channels and no. of data. The maximum measuring speed was $62{\mu}s$. 2. Calibration the system was performed with triangle wave generated from a function generator and checked by an oscilloscope. The sampled data were processed using HP 3000 minicomputer of Chungnam National University computer center the graphical results were triangle same as input wave and so the system have been out of phase distorsion and amplitude distorsion. 3. The strain generated from a cantilever beam vibrator which has free vibration period of 0.019 second were measured by the system controlled to have l.0 ms of time interval and its computer output showing vibration curve which is well filted to theoretical value. 4. Using microcomputer on measuring the strain of agricultural machine elements could not only save analyzing time and recording papers but also get excellent adaptation to field experiment, especially in measurement requiring high speed and good precision.

• Sleep Medicine and Psychophysiology
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• v.19 no.1
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• pp.27-34
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• 2012

Objectives: The analysis of heart rate variability (HRV) is a useful non-invasive tool to investigate the autonomic nerve function. Previous studies on the relationship between HRV and depression have been reported controversial results. Similarly, the correlation between the serum lipids and depression is debatable. The purpose of this study is to examine the relationship between heart rate variability, lipid profile and depression. Methods: A total of 42 patients with major depressive disorder (MDD) and 32 age and sex-matched normal subjects who had no previous history of major medical and mental illnesses were recruited for this study. A structured-interview was used to assess the general characteristics and psychiatric illness. HRV measures were assessed by time-domain and frequency-domain analyses. Psychological symptoms were measured using the Hamilton rating scale for anxiety (HAM-A), Hamilton rating scale for depression (HAM-D). In addition, the evaluation for lipid profile was performed by blood test. Results: In serum lipid profile test, MDD group showed higher cholesterol ($197.68{\pm}42.94$ mg/dL vs. $176.85{\pm}34.68$ mg/dL, p=0.044), TG ($139.45{\pm}92.54$ mg/dL vs. $91.4{\pm}65.68$ mg/dL, p=0.018), LDL ($130.03{\pm}33.18$ vs. $106.62{\pm}27.08$, p=0.004) level than normal control group. In HRV time domain analyses, the standard deviation of the NN interval (SDNN) was decreased in MDD group than normal control group, but was not significant ($32.82{\pm}14.33$ ms vs. $40.36{\pm}21.40$ms, p=0.078). ApEn (Approximate Entrophy) was significantly increased in MDD group than normal control group ($1.13{\pm}0.11$ vs. $0.91{\pm}0.18$, p<0.001). ApEn was correlated with LDL level (r=0.277, p=0.028), HAM-D scores (r=0.534, p<0.001) and HAM-A scores (r=0.470, p<0.001). Conclusions: MDD patients showed increased ApEn, one of the HRV measurement. And this ApEn was correlated with LDL, HAM-D and HAM-A scores. In this study, the analysis of ApEn would be a useful test of MDD.

• The Journal of Korean Academy of Prosthodontics
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• v.52 no.2
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• pp.105-112
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• 2014

Purpose: The aim of present investigation was to find out the influence of several times iatrogenic mobilization in the initial stage of implant installation on bone-implant osteointegration. Materials and methods: The experimental implants (3.75 mm in diameter, 8.0 mm in length) were made of commercially pure (Grade IV) titanium, and were treated with RBM ($MegaGen^{(R)}$: Ca-P) on lower 4.0 mm part. Only lower part of implant was inserted to bone and the implants were nonsubmerged. The 130 implants (two in each tibia) were inserted into the monocortical tibias of 33 rabbits which each weighed more than 3.5 kg (Female, New Zealand White). According to the removal torque interval, the groups were divided into 13 groups, group I (1 day), group II (1 day + 2 days), group III (1 day + 2 days + 3 days), group IV (1 day + 2 days + 3 days + 4 days), group V (2 days), group VI (2 days + 4 days), group VII (2 days + 4 days + 6 days), group VIII (2 days + 4 days + 6 days + 8 days), group IX (4 days), group X (4 days + 7 days), group XI (4 days + 7 days + 10 days), group XII (4 days + 7 days + 10 days + 14 days) and control group. In the control group, the removal torque was measured at 8 weeks with a digital torque gauge (Mark-10, USA). In the experimental groups, the removal torque was given once, twice, three times or four times by experiment design before the final removal torque and the value was measured each time. The implants were then screwed back to their original positions. All the experimental groups were given a final healing time of 8 weeks after placement, in which values were compared with the control groups and the 1st, 2nd, 3rd or 4th removal torque values in each experimental group. Results: In comparison of the final removal torque tests among experimental groups, the removal torque value of experimental groups except group XII were not statistically different that of control group. And the values of group I and II were significantly higher than the values of group VI, VIII, X, XI, and XII. In addition, the values of group III, IV, and V were significantly higher than group XI and XII. In comparison of the removal torque in the each experimental group, the final removal torque were significantly higher in all groups except group VIII, X, XI, and XII. Conclusion: If sufficient healing time was allowed, a few mobilization of fixture at the very early stage after the implant placement in the rabbits didn't interrupt the final bone to implant osseointegration.

• Journal of Magnetics
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• v.20 no.4
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• pp.381-386
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• 2015

The purpose of this study is to improve diagnostic efficiency of clinical study by setting up guidelines for more precise examination with a comparative analysis of signal intensity and image distortion depending on the location of X axial of object when performing magnetic resonance diffusion weighted imaging (MR DWI) examination. We arranged the self-produced phantom with a 45 mm of interval from the core of 44 regent bottles that have a 16 mm of external diameter and 55 mm of height, and were placed in 4 rows and 11 columns in an acrylic box. We also filled up water and margarine to portrait the fat. We used 3T Skyra and 18 Channel Body array coil. We also obtained the coronal image with the direction of RL (right to left) by using scan slice thinkness 3 mm, slice gap: 0mm, field of view (FOV): $450{\times}450mm^2$, repetition time (TR): 5000 ms, echo time (TE): 73/118 ms, Matrix: $126{\times}126$, slice number: 15, scan time: 9 min 45sec, number of excitations (NEX): 3, phase encoding as a diffusion-weighted imaging parameter. In order to scan, we set b-value to $0s/mm^2$, $400s/mm^2$, and $1,400s/mm^2$, and obtained T2 fat saturation image. Then we did a comparative analysis on the differences between image distortion and signal intensity depending on the location of X axial based on iso-center of patient's table. We used "Image J" as a comparative analysis programme, and used SPSS v18.0 as a statistic programme. There was not much difference between image distortion and signal intensity on fat and water from T2 fat saturation image. But, the average value depends on the location of X axial was statistically significant (p < 0.05). From DWI image, when b-value was 0 and 400, there was no significant difference up to $2^{nd}$ columns right to left from the core of patient's table, however, there was a decline in signal intensity and image distortion from the $3^{rd}$ columns and they started to decrease rapidly at the $4^{th}$ columns. When b-value was 1,400, there was not much difference between the $1^{st}$ row right to left from the core of patient's table, however, image distortion started to appear from the $2^{nd}$ columns with no change in signal intensity, the signal was getting decreased from the $3^{rd}$ columns, and both signal intensity and image distortion started to get decreased rapidly. At this moment, the reagent bottles from outside out of 11 reagent bottles were not verified from the image, and only 9 reagent bottles were verified. However, it was not possible to verify anything from the $5^{th}$ columns. But, the average value depends on the location of X axial was statistically significant. On T2 FS image, there was a significant decline in image distortion and signal intensity over 180mm from the core of patient's table. On diffusion-weighted image, there was a significant decline in image distortion and signal intensity over 90 mm, and they became unverifiable over 180 mm. Therefore, we should make an image that has a diagnostic value from examinations that are hard to locate patient's position.

• Tuberculosis and Respiratory Diseases
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• v.66 no.4
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• pp.280-287
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• 2009

Background: The epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), became an attractive therapeutic option for advanced non-small-cell lung cancer (NSCLC). Several studies suggested that there might be some different efficacy or response predictors between gefitinib and erlotinib. We compared the efficacy and toxicity of gefitinib and erlotinib in Korean patients with advanced NSCLC and evaluated specific predictors of response for both gefitinib and erlotinib. Methods: We collected the clinical information on patients with advanced NSCLC, who were treated with gefitinib or erlotinib at the Ewha Womans University Hospital, between July 2003 and February 2009. Median survival times were calculated using the Kaplan-Meier method. Results: Eighty-six patients (52 gefitinib vs. 34 erlotinib) were enrolled. Patient median age was 64 years; 53 (62%) subjects were male. Out of the 86 patients treated, 83 received response evaluation. Of the 83 patients, 35 achieved a response and 12 experienced stable disease while 36 experienced progressive disease, resulting in a response rate of 42% and a disease control rate of 57%. After a median follow-up of 502 days, the median progression-free and overall survival time was 129 and 259 days, respectively. Comparing patients by treatment (gefitinib vs erlotinib), there were no significant differences in the overall response rate (44% vs. 39%, p=0.678), median survival time (301 days vs. 202 days, p=0.151), or time to progression (136 days vs. 92 days, p=0.672). Both EGFR-TKIs showed similar toxicity. In a multivariate analysis using Cox regression model, adenocarcinoma was an independent predictor of survival (p=0.006; hazard ratio [HR], 0.487; 95% confidence interval [CI], 0.292-0.811). Analyses of subgroups did not show any difference in response predictors between gefitinib and erlotinib. Conclusion: Comparing gefitinib to erlotinib, there were no differences in the response rate, overall survival, progression-free survival, or toxicity. No specific predictor of response to each EGFR-TKI was identified.

• The Korean Journal of Pesticide Science
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• v.16 no.2
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• pp.98-108
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• 2012

In order to use in the classification of minor crop for the mutual application of safe use guideline, it was investigated the residue property of fungicide boscalid and fludioxonil at the same time harvest leafy-vegetables, such as spinach, ulgaribaechu, vitaminchae and cheongkyungchae. After pesticides were applied 2 times with 1 week interval in that day of harvest, 2 days, 5 days and 7 days before harvest, vegetables were harvested, and the residue of pesticides was investigated. Base on the residue in that day of harvest, the deposit of spray solution in vegetables was calculated. The deposit of spray solution of boscalid was 253.9 mL/kg in spinach, 83.0 mL/kg in ulgaribaechu, 97.8 mL/kg in vitaminchae, and 88.3 mL/kg in cheongkyungchae, respectively. In case of fludioxonil, it was calculated 157.6 mL/kg in spinach, 67.6 mL/kg in ulgaribaechu, 64.8 mL/kg in vitaminchae, and 66.6 mL/kg in cheongkyungchae, respectively. When the amount of the deposit of both pesticides was compared in leafy-vegetables, it was the highest in the spinach. On the other hand, it was estimated the predicted dissipation curve of pesticides in leafy-vegetables during cultivation. The half-life of boscalid was 5.9 days in spinach, 7.4 days in ulgaribaechu, 4.6 days in vitaminchae, and 4.3 days in cheongkyungchae, respectively. Also, it was estimated half-life in fludioxonil, it was 3.0 days in spinach, 4.0 days in ulgaribaechu, 3.2 days in vitaminchae, and 3.5 days in cheongkyungchae, respectively. The half-life was the longest in the ulgaribaechu. When both pesticides were compared with the residue property, the deposit of spray solution and half-life of dissipation of boscalid were more than those of fludioxonil.

• Radiation Oncology Journal
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• v.11 no.1
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• pp.51-58
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• 1993

We tried to establish the theoretical basis of clinical use of combined modality of hyperthermia and radiation therapy. For this purpose, we made an in vitro experiment in order to get the synergistic and/or additive effects on the cell killing of hyperthermia combined with radiation therapy by using the microwave-hyperthermia machine already installed at our department. In our experiment, we use two human cell lines: MKN-45 (adenocarcinoma of stomach) and K-562 (leukemia cell lines). In cases of combined treatments of hyperthermia and gamma-irradiation, the therapeutic effect was the highest in the simultaneous trial. Hyperthermia after gamma irradiation showed slightly higher therapeutic effect than that before irradiation without significant difference, but its effect was the same in the interval of 6 hours between hyperthermia and irradiation. The higher temperature and the longer treatment time were applied, the higher therapeutic effects were observed. We could observe the thermoresistance by time elapse at $43^{\circ}C$. When hyperthermia was done for 30 minutes at the same temperature, thermal enhancement ratio (TER) at DO. 01 (dose required surviving fraction of 0.01) were $2.5{\pm}0.08,\;3.75{\pm}0.18$, and $5.0{\pm}0.15\;at\;436{\circ}C,\;44^{\circ}C,\;and\;45^{\circ}C$ respectively in K-562 leukemia cell lines. Our experimental data showed that more cell killing effect can be obtained in the leukemia cell lines, although they usually are known to be radiosensitive, when treated with combined hyperthermia and radiation therapy. Furthermore, our data show that leukemia cell lines may have various intrinsic radiosensitivity, especially in vitro experiments. The magnitude of cell killing effect, however, will be less than that of MKN-45.

• Magazine of the Korean Society of Agricultural Engineers
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• v.19 no.1
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• pp.4323-4337
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• 1977

The study was to estimate the effect of the rise of water temperature in the warm water pool and to make contribution to the establishment of reducing to a damage of cool water as well as to the planning for warm water pool. This observation was performed in Wudu warm water pool located at Wudu-Dong of Chuncheon for two years from 1975 to 1976. The results were showed as follows; 1. The daily variation of water temperature was the least for inset (No.1; 0.6$^{\circ}C$) the second for middle overflow (No2: 3$^{\circ}C$, No.3; 2.3$^{\circ}C$) and another for outflet (No.4; 3.6$^{\circ}C$, No.5; 3.8$^{\circ}C$) And the highest reaching time of water temperature in each block was later about 1 hour than the time at which air temperature happend in the daytime. So, the variation of water temperature was sensitive to the variation of air temperature 2. The monthly variation of water temperature at each measuring point was plotted to be increased with increase in air temperature till August (Mean monthly rising degree; No.1; 1.15$^{\circ}C$, No.2; 1.7$^{\circ}C$, No.3; 1.73$^{\circ}C$, No.4; 2.08$^{\circ}C$, No.5; 2.0$^{\circ}C$), and expressed gradually descended influence upon water temperature after August. 3. The mean temperature of inflow folwed in warm Water pool was 7.5∼12.5$^{\circ}C$, and outflow temperature was described as 13.4∼22.5$^{\circ}C$ to be climbed. And So, the rising interval of water temperature was shown as 6.7∼10.4$^{\circ}C$. 4. The correlation between the rising of water temperature and the weather condition was found out highly significant. As the result, their correlation coefficents of water temperature depending on mean air temperature, ground temperature, wind velocity and relative humidity were to be 0.93, 0.90, - 0.83 and 0.71 respectively. But there was no confrimation of the correlation on the clouds, sunlight time, volume of evaporation, and heat capacity of horizontal place. 5. The water temperature of balance during the period of rice growing in Chuncheon district was shown as table 10, and the mean of whole period was calculated as about 23.7$^{\circ}C$. 6. The observed value of the outflow temperature passed through the warm water pool was higher than that of computed, the mean difference between two value was marked as 1.15$^{\circ}C$ for blockl, 1.18$^{\circ}C$ for block2, and 0.47$^{\circ}C$ for block3, respectivly. Therefore, the ratio on the rising degree between the observed and computed were shown as 53%, 44%, and 18%, mean 38% through each block warm water pool (referring item $\circled9$ of table 11,12, and 13). Accordingly, formula (4) in order to fit for each block warm water pool was transfromed as follow; {{{{ { theta }_{w } - { theta }_{ 0} =[1-exp LEFT { { 1-(1+2 varphi )} over {cp } CDOT { A} over { q} RIGHT } ] TIMES ( { theta }_{w } - { theta }_{ 0}) TIMES C }}}} Here, correction coefficinent was computed 1.38, and being substituted 1.38 for C in preceding formula, the expected water temperature will be calculated to be able to irrigate the rice paddy. As the result, we can apply the coefficient in order to plan and to construct a new warm water pool.