• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.26 no.4
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• pp.181-192
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• 2023

Purpose: The development of assistive devices has allowed for the performance of capsule endoscopy in children. Anticipating the capsule's transit time could affect the efficacy of the investigation and potentially minimize the fasting period. This study determined the predictors of small bowel transit time for small-bowel capsule endoscopy in children and adolescents with inflammatory bowel disease. Methods: We retrospectively examined children and adolescents with inflammatory bowel disease who underwent capsule endoscopy by the age 18 at a Japanese tertiary care children's hospital. Small bowel transit time predictors were analyzed using multiple regression with explanatory variables. Results: Overall, 92 patients, aged 1-17 years, with inflammatory bowel disease (63 Crohn's disease and 29 ulcerative colitis cases) were examined for factors affecting small bowel transit time. In the simple regression analysis, diagnosis, age, height, weight, serum albumin, general anesthesia, and small intestine lesions were significantly associated with small bowel transit time. In the multiple regression analyses, serum albumin (partial regression coefficient: -58.9, p=0.008), general anesthesia (partial regression coefficient: 127, p<0.001), and small intestine lesions (partial regression coefficient: 30.1, p=0.037) showed significant associations with small bowel transit time. Conclusion: Hypoalbuminemia, the use of general anesthesia for endoscopic delivery of the capsule, and small intestine lesions appeared to be predictors of prolonged small bowel transit time in children and adolescents with inflammatory bowel disease. Expecting the finishing time may improve examination with a fasting period reduction, which benefits both patients and caregivers.

• YAKHAK HOEJI
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• v.59 no.2
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• pp.70-76
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• 2015

A Softgel is an oral dosage form for medicine similar to capsules and softgel dosage form offers several advantages over other oral dosage forms, such as delivering a liquid matrix designed to solubilize and improve the oral bioavailability of a poorly soluble compound as a unit dose solid dosage form, delivering low and ultra-low doses of a compound. This study aimed to qualify a proprietary vegetable soft capsule which contains modified starch and carrageenan as capsule shell components compare to the conventional gelatin softgel. Four kinds of samples were prepared with vegetable and gelatin capsule shell, respectively. Morphology of capsule shell, mechanical strength of capsule, and hygroscopic properties were studied for comparing the quality attributes of softgel. Short-term stability against heat and moisture was also investigated in this study. Vegetable capsule shell showed better mechanical strength, physical stability and disintegration time for temperature and humidity than those of conventional gelatin capsule shell with four different filling materials used frequently as soft capsule form. Conclusively, this vegetable capsule shell polymer system can replace easily gelatin-shell systems and additionally allows encapsulation of lipid fills at high temperatures that are semisolid or solid-like at room temperature.

• Journal of Yeungnam Medical Science
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• v.38 no.1
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• pp.19-26
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• 2021

Adhesive capsulitis of the shoulder joint is a common disease characterized by pain at the insertional area of the deltoid muscle and decreased range of motion. The pathophysiological process involves fibrous inflammation of the capsule and intraarticular adhesion of synovial folds leading to capsular thickening and contracture. Regarding the multidirectional limitation of motion, a limitation in external rotation is especially prominent, which is related to not only global fibrosis but also to a localized tightness of the anterior capsule. Ultrasound and magnetic resonance imaging studies can be applied to rule out other structural lesions in the diagnosis of adhesive capsulitis. Hydraulic distension of the shoulder joint capsule provides pain relief and an immediate improvement in range of motion by directly expanding the capsule along with the infusion of steroids. However, the optimal technique for hydraulic distension is still a matter of controversy, with regards to the infusion volume and rupture of the capsule. By monitoring the real-time pressure-volume profile during hydraulic distension, the largest possible fluid volume can be infused without rupturing the capsule. The improvement in clinical outcomes is shown to be greater in capsule-preserved hydraulic distension than in capsule-ruptured distension. Moreover, repeated distension is possible, which provides additional clinical improvement. Capsule-preserved hydraulic distension with maximal volume is suggested to be an efficacious treatment option for persistent adhesive capsulitis.

• Journal of Pharmaceutical Investigation
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• v.37 no.3
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• pp.197-203
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• 2007

A bioequivalence study of $Dilast^{TM}$ Capsule (Chong Kun Dang Pharma. Co., Ltd.) to $Ketas^{(R)}$ Capsule (Han Dok Pharma. Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty eight healthy male Korean volunteers received each medicine at the ibudilast dose of 20 mg in a $2{\times}2$ crossover study. There was one week wash-out period between the doses. Plasma concentrations of ibudilast were monitored by a liquid chromatography-tandem mass spectrometry (LC-MS/MS) for over a period of 36 hours after drug administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 36 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t\;and\;C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Dilast^{TM}$ $Capsule/Ketas^{(R)}$ Capsule were $log0.93{\sim}log1.06$ and $log0.93{\sim}log1.11$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80{\sim}log1.25$. Thus, our study demonstrated the bioequivalence of $Dilast^{TM}$ Capsule and $Ketas^{(R)}$ Capsule with respect to the rate and extent of absorption.

• Journal of Applied Reliability
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• v.18 no.3
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• pp.260-270
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• 2018

Purpose: The purpose of this study is to evaluate the life of the capsule, which is a core part of the heat storage cooling system. This paper will develop a life test mode that can reproduce environment conditions through the analysis of capsule shrinkage and expansion characteristics. Methods: In order to determine the life test mode of the capsule, this paper analyzed the case of field failures and analyzed the deformation characteristics according to the pressure fluctuation of the capsule. The method to find out whether the field failure and deformation analysis results are consistent is the testing with the construction of the repetition pressure test equipment and the thermal cycle test to reproduce the freezing and thawing characteristics. Results: In this study, failure mode analysis and analysis of freezing and thawing characteristics regarding to the capsule positions were completed. Based on this test & analysis results, this paper have been able to determine the main parameters for determining the life test mode, the freezing and thawing time. Conclusion: Determining the lifetime mode of the capsule can be used to improve the life and performance of the thermal storage system.

• International Journal of Air-Conditioning and Refrigeration
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• v.6
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• pp.113-123
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• 1998

The present study is to investigate the effect of experimental parameters on the heat transfer characteristics of a spherical capsule storage system using paraffins. N-Tetradecane and mixture of n-Tetradecane 40% and n-Hexadecane 60% were used as paraffins. Water with inorganic material was also tested for the comparison. The experimental parameters were varied for the Reynolds number from 8 to 16 and for the inlet temperature from -7 to 2$^{\circ}C$. Measured local temperatures of spherical capsules in the storage tank were utilized to calculate charging and discharging times, dimensionless thermal storage amount, and the average heat transfer coefficients in the tank. Local charging and discharging times in the storage tank were significantly different. The effect of inlet temperature on charging time was larger than that on discharging time, but the effect of Reynolds number on charging time was smaller than that on discharging time. Charging time of paraffins was faster by 11~72% than that of water with inorganic material, but little difference of discharging time was found among them. The effect of Reynolds number on the dimensionless thermal storage was less during charging process and more during discharging process than the effect of inlet temperature. The effect of the inlet temperature and the Reynolds number on the average heat transfer coefficient of the storage tank was stronger during discharging process than during charging process. The average heat transfer coefficients of the spherical capsule system using paraffins were larger by 40% than those using water.

• Progress in Medical Physics
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• v.19 no.2
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• pp.125-130
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• 2008

The object of this study is to measure the transit time and passage rate of capsule endoscopy (CE) in the gastrointestinal tract in medium sized beagle dogs ($7{\sim}13\;kg$). Animals were divided into four groups: only capsule (group 1, n=10), capsule+water (group 2, n=10), mettoclopramide+capsule (group 3, n=10), metoclopramide +capsule+water (group 4, n=10). The capsule transit times through the stomach and small bowel were evaluated by radiography findings. Gastric transit time (GTT), small intestinal transit time (SITT) and complete passage rate were measured in four groups. GTT's for each group were as follows; $45{\pm}20\;min$ (group 1), $117{\pm}35\;min$ (group 2), $150{\pm}40\;min$ (group 3), and $154{\pm}65\;min$ (group 4), while SITT's were $75{\pm}20\;min$ (group 1), $195{\pm}55\;min$ (group 2), $70{\pm}15\;min$ (group 3), and $76{\pm}15\;min$ (group 4). The complete passage rates were 20% (group 1), 40% (group 2), 20% (group 3), 50% (group 4). In all groups, if CE could pass through the pylorus, it passed all small intestinal tracts within 8 hours (battery life). Administration of water helped CE to pass pylori, except in case of metoclopramide administration. These results indicate that CE could be an useful tool for examining gastrointestinal diseases in the veterinary medicine.

• Journal of the Korea Society of Computer and Information
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• v.21 no.12
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• pp.125-130
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• 2016

Automatic quality inspection by computer vision can be applied and give a solution to the pharmaceutical industry field. Pharmaceutical capsule can be easily affected by flaws like dents, cracks, holes, etc. In order to solve the quality inspection problem, it is required computationally efficient image processing technique like thresholding, boundary edge detection and segmentation and some automated systems are available but they are very expensive to use. In this paper, we have developed a dented capsule image processing technique using edge-based image segmentation, TLS(Total Least Squares) curve fitting technique and adopted low cost camera module for capsule image capturing. We have tested and evaluated the accuracy, training and testing time of the classification recognition algorithms like PCA(Principal Component Analysis), ICA(Independent Component Analysis) and SVM(Support Vector Machine) to show the performance. With the result, PCA, ICA has low accuracy, but SVM has good accuracy to use for classifying the dented capsule.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.30 no.2
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• pp.313-318
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• 1997

Effects of the concentration of NaCl, the concentration and the molecular weight of chitosan on the permeability of capsule type fertilizer and herbicide were investigated. The encapsulating process was based on the electrostatic interaction between chitosan (a polycationic polymer) and sodium alginate (an anionic polysaccharide). Sodium alginate solution $(1\%)$ was dropped into chitosan solution $(1\%)$ in which various amounts of NaCl was added. The capsule strength was increased with the addition of NaCl and the maximum value of capsule strength was observed at 0.3M NaCl. Capsule type fertilizer and herbicide were immersed in deionized water to determine its permeability, and it was affected by the concentration of NaCl and chitosan, and the molecular weight of chitosan. As the concentration of NaCl in chitosan solution increased, permeability of the capsule increased and marked the maximum value of $ 88\%$(fertilizer), $87\%$ (herbicide) at 0.75M NaCl. As concentration of chitosan solution increased, permeability tended to decreased; it showed the maximum value of $90\%$ (fertilizer) and $90.3\%$ (herbicide) at $0.25\%$ chitosan and the minimum value of $83\%$ (fertilizer) and $82\%$ (herbicide) at $1\%$ chitosan. Permeability of fertilizer and herbicide also decreased, as the molecular weight of chitosan (material of capsule) was decreased; it was showed $86\%$ (fertilizer) and $83\%$ (herbicide) at M.W 330,000 (sonication time 0min) and $52\%$ (fertilizer) and $51\%$ (herbicide) at M.W 119,000 (sonication time 180 min). The chitosan-alginic acid capsule was manufactured (defined as prepared capsule), dried for 6 hrs and immersed in deionized water (defined as restored capsule) to examine restoration of capsule. Restoration of capsule was good, and capsule strength was slightly decreased form $20g/cm^2$ (prepared capsule) to $17g/cm^2$ (restored capsule)

• Journal of the Korean Institute of Landscape Architecture
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• v.22 no.3
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• pp.163-174
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• 1994

In November of 1994, The Seoul Metropolitan Government celebrates its sixth centennial anniversary of becoming the capital city of Korea. In celebration of this anniversary, the Government decided to construct a plaza and sought design proposals in March of 1994. The authors collaborated on a design for the Time Capsule Plaza Competition and won fourth place among twenty-six entries. In the authors' design, the traditional oriental concept of time resonates within the site through the shape of a clock, a unique planting style, and an "Ancestral Tomb" which has a time capsule inside. The plaza is meant to be a symbol of the passage of time, the cycles of nature, and the repetitive actions of man. As for the spatial composition of the plaza, in accordance with the traditional Korean way of spatial arrangement, the plaza is divided into three parts: entry, primary, and secondary spaces. In reality, the plaza is created with the primary goal of providing modern outdoor space for people to rest and gather through the creation of pleasant environments and the introduction of traditional Korean garden elements.