• Korean Journal of Veterinary Research
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• v.54 no.3
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• pp.165-169
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• 2014

The present study compared leptin, adiponectin, and thyroid hormone concentrations in normal and obese dogs, and evaluated the association between leptin and adiponectin concentrations and thyroid function. The serum leptin, adiponectin, thyroid-stimulating hormone (TSH), total thyroxine (tT4), free thyroxine (fT4), triiodothyronine (T3), and cortisol concentrations were measured in 18 normal dogs (body condition score [BCS]: 4-5/9) and 16 obese dogs (BCS: 8-9/9). Leptin and T3 concentrations were higher in the obese group than the normal weight group (p < 0.01 and p < 0.05, respectively). In both groups, the T3 and leptin concentrations were correlated (r = 0.370, p < 0.05), as were the TSH and fT4 and adiponectin concentrations (r = -0.373, p < 0.05 and r = 0.369, p < 0.05, respectively). In the normal weight group, the TSH and fT4 concentrations were correlated with the adiponectin concentrations (r = -0.528, p < 0.05 and r = 0.482, p < 0.05, respectively). The results of the present study suggest that leptin and T3 concentrations are significantly higher in obese dogs than normal weight dogs, and the serum T3 and leptin concentrations are positively correlated.

• The Korean Journal of Nuclear Medicine
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• v.15 no.2
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• pp.43-51
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• 1981

In an attempt to evaluate the diagnostic significance of the serum thyroxine binding globulin (TBG) in various thyroid disease states, the authors measured serum $T_3$ uptake, $T_3$, total $T_4\;free\;T_4$, TSH and TBG by radioimmunoassay technique, and calculated the free $T_4$ index$(FT_4I)$ and $T_4/TBG$ ratio in 10 cases of normal subjects, 11 cases of hypothyroidism, 62 cases of euthyroidism and 37 cases of hyperthyroidism. The data were analysed in the aspects of diagnostic significance in each thyroid disease state, and the results were as follows; 1. In 10 cases of normal subjects, serum TBG was $17.4\sim26.8{\mu}g/ml$, $FT_4I$ was $5.1\sim9.7$, and $T_4/TBG$ ratio was $21.9\sim49.9(Mean{\pm}S.D.)$. 2. In 62 cases of euthyroidism with diffuse and nodular goiter, $FT_4I$ was $7.26{\pm}1.82,\;T_4/TBG$ ratio was $31.47{\pm}10.42$, and there were no significant difference from those of normal subjects (p>0.5). 3. In 11 cases of hypothyroidism, the $FT_4I$ was $3.13{\pm}2.15,\;T_4/TBG$ ratio was $11.3{\pm}5.31$, significantly lower than normal controls (p<0.01). 4. In 37 cases of hyperthyroidism, the $FT_4I$ was $30.0{\pm}12.0,\;T_4/TBG$ ratio was $121.4{\pm}62.2$, significantly higher than normal controls (p<0.01). 5. There were significant correlations between the $FT_4I$ and $T_4/TBG$ ratio, total $T_4\;and\;T_4/TBG$ ratio, in each thyroid function states. 6. The $FT_4I$ showed 100% of diagnostic value in hyperthyroidism, 89.2% in euthyroidism, and 80% in hypothyroidism group. The $T_4/TBG$ ratio showed 100% of diagnostic value in hyperthyroidism and hypothyroidism, and 80.6% in euthyroidism group. The above results suggest that $T_4/TBG$ ratio and $FT_4I$ showed same diagnostic value in hyperthyroidism group, but $T_4/TBG$ showed higher diagnostic significance than $FT_4I$ in hypothyroidism.

• The Korean Journal of Nuclear Medicine
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• v.9 no.2
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• pp.13-22
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• 1975

The purpose of the present study is to evaluate the diagnostic value of the ETR test as compared to other thyroid function tests in normal persons, patients with thyroid disorders and patients with alterations of thyroxine-binding proteins. The ETR values were obtained from 35 cases as normal control, 63 hyperthyroid patients, 56 euthyroid patients, 23 hypothyroid patients, 10 pregnant women, 5 women taking oral contraceptive medication, 8 liver cirrhosis patients and 4 nephrotic syndrome patients. The results obtained were as follows. 1. The mean value of ETR obtained from the normal controls was $0.99{\pm}0.06$. 2. The mean ETR values of various thyroid states were $1.25{\pm}0.16$ in hyperthyroidism, $0.99{\pm}0.08$ in euthyroidism and $0.82{\pm}0.05$ in hypothyroidism and significant difference was found between these groups. 3. Seven out of 63 hyperthyroid patients(11.1%) and 2 out of 23 hypothyroid patients(8.7%) had ETR values within normal range and among the 56 euthyroid patients 6(10.7%) had ETR values outside normal range, so the diagnostic compatibility of ETR was 89.4% in thyroid diseases. 4. Even though the ETR value was well correlated with $^{131}I$-thyroid uptake rate, serum $T_3$ resin uptake rate and serum $T_4$, a high positive correlation was found (r=0.79) between ETR and $T_7$. 5. The mean ETR values from patients with alteration in TBG binding capacity were $0.99{\pm}0.05$ in pregnant women, $0.98{\pm}0.04$ in women with oral contraceptive medication, $1.04{\pm}0.09$ in liver cirrhosis patients and $0.94{\pm}0.02$ in nephrotic syndrome patients and most of them (85.2%) had ETR values within normal range. Our results, therefore, suggests that the ETR estimation does offer the simplest and most reliable single procedure for the screening and diagnosis of various thyroid diseases as a indirect indicator of serum-free thyroxine concentration without essential influence of changes in the thyroxine-binding proteins in serum.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.3
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• pp.354-357
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• 1999

Hypothyroidism was induced in three age groups (8 months, 1 year and 2 years) of Black Bengal goats by administering thiourea subcutaneously for 30 days. From fourth day onwards the animals were observed to be in hypothyroid state. For 8 months age group, a control group of similar age was taken. For the 1 year and 2 years age groups there was no control group but the values obtained on the pre-treatment day were considered as control values. For confirming the establishment of hypothyroidism, peripheral plasma triiodothyronine $(T_3)$ and thyroxine $(T_4)$ were estimated in all the animals before and during the treatment period by radioimunoassay. In the thiourea treated 8 months age group the $T_3$ and $T_4$ levels were significantly (p<0.001) lower than those in the control group during the treatment period. In all the thiourea treated groups the $T_3$ and $T_4$ levels observed during the treatment period were significantly (p<0.01) lower than the pre-treatment levels. A nonsignificant loss in the body weight was observed in all the thiourea treated groups whereas there was a significant growth in the control group of animals. The study indicates that hypothyroidism has a negative effect on growth in goats.

• Journal of radiological science and technology
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• v.11 no.1
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• pp.25-31
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• 1988

Studies on the clinical significance with Amerlex $FT_{4}$ RIA kit observing the determination of $FT_{4}$ were investigated using a tracer as $^{125}I-T_{4}$ derivative which is not almostly bound to thyroxine binding globulin, etc. The results are followed; 1. $FT_{4}$ value($1,55{\pm}0.38ng/100ml$) of normal group was not accorded that of hyperthyroidism with Amerlex $FT_{4}$ RIA kit, and was higher than that of hypothyroidism. 2. $FT_{4}$ value was lower level in chronic-kidney disfunction syndrome whereas, it was normal in a cancer patient, a woman in pregnancy and a patient in TBG disfunction. 3. The value of this method is a good corelationship at that of equilibrium dialysis method. (r=0.931) 4. $FT_{4}$ value by this kit was linear relationship to those of the other kit (Gamma Coat and Liquisol), and the normal value of each methods was also similar. As mentioned above, this method is more simple and rapid, compared to the other method. Therefore, it was thought that this method is a very useful clinically.

• Korean Journal of Animal Reproduction
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• v.16 no.4
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• pp.377-385
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• 1993

This study was taken to examine correlationships between ehdocrine changes such as estradiol-17$\beta$, progesterone, T4 and T3 and serum components concentrations of female Oreochromis niloticus living in 0$\textperthousand$, 10$\textperthousand$, 20$\textperthousand$, and 30$\textperthousand$ salt concentrations, respectively. The results obtained in these experiments were summarized as follows. Correlation coefficients of serum albumin and thyroxine were ＋0.907 and ＋0.611 in 10$\textperthousand$ and 20$\textperthousand$, respectively. In 30$\textperthousand$ salinity, serum BUN and other 3 kinds of hormones showed all negative correlation coefficients. Correlation coefficients of serum estradiol-17$\beta$ with calcium and cholesterol in 20$\beta$ were ＋0.624, ＋0.733, respectively. Correlation coefficient between serum triglycerides and thyroxine in 30$\beta$ was ＋0.989.

• Asian-Australasian Journal of Animal Sciences
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• v.7 no.2
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• pp.239-248
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• 1994

To study the relationship between certain hormones and metabolites and between hormones and milk yield during different stage of lactation, six lactating Karan Swiss cows and six Murrah buffaloes were maintained. Growth hormone, insulin, $T_3$, $T_4$, glucose, BHBA, NEFA and milk yield were studied. Highly negative relationship of growth hormone with insulin and triiodothyronine in cows and marginally negative in buffaloes suggest that insulin and triiodothyronine aid in the process of partitioning of nutrients towards milk production through reducing the demands of nutrients by peripheral tissue. The significant and negative correlation of growth hormone with dry matter intake in both the species suggest that the availability of nutrients from the digestive tract play a role in the regulation of growth hormone secretion. Positive relationship of growth hormone with non esterified fatty acids in both the species suggest that high growth hormone levels may result in fat mobilization and thereby increase the availability of energy precursors for milk synthesis. Insulin was negatively correlated with milk yield and lactose content and positively with milk fat and protein but the degree of relationship varied. In both the species the relationship between triiodothyronine and milk yield was negative and between thyroxine and milk yield was positive. However, it was significant only in cows and not in buffaloes. Thyroxine was positively correlated with beta-hydroxybutyrate and non-esterified fatty acids with milk yield in both the species.

• The Korean journal of sports medicine
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• v.36 no.4
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• pp.214-220
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• 2018

Purpose: The purpose of this research is to study changes in pituitary hormone in anterior lobe and thyroid hormone before, after, and during recovery time in severe 100 km ultramarathon. Methods: Healthy middle-aged runners (age, $52.0{\pm}4.8$ years) participated in the test. Grade exercise test is done, and then blood is taken from those participants before and after completing 100 km ultramarathon at the intervals of 24 hours (1 day), 72 hours (3 days), and 120 hours (5 days) to analyze their luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), and free thyroxine (Free T4). Results: For LH, it decreased more significantly at 100 km than pre-race. However, after 1 day result increased more than that of 100 km. At 3 days, it was significantly higher than pre-race and 100 km, recovering at 5 days. In terms of FSH, it decreased at 100 km, 1 day, and 3 days more than pre-race but recovered at 5 days. TSH was higher at 1 day and 5 days compared to pre-race. T3 was only higher at 100 km than pre-race. T4 was higher till 5 days at 100 km than pre-race. Free T4 increased more significantly at 100 km than pre-race. Conclusion: In terms of severe long distance running, LH and FSH which belong to hormone from anterior lobe as well as T3, T4, and Free T4 which belong to thyroid hormone showed their variation within the standard range. However, TSH showed abnormal increase from enhanced concentration of blood after marathon becoming hyper-activation even during the recovery period.

• Clinical and Experimental Pediatrics
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• v.48 no.11
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• pp.1252-1255
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• 2005

Abnormalities in the levels of thyroxine-binding globulin (TBG) are not associated with clinical disease and they do not require treatment. Congenital TBG deficiency is inherited in an X-linked manner. To date, some complete and partial TBG variants and one polymorphism have been identified by analysis of the TBG gene. Two male neonates were referred to us because of their low $T_4$ levels that were noted on the neonatal screening test. They showed normal levels of free $T_4$ and TSH. Their serum TBG was not detectable and those values of their parents were within the normal ranges. The genomic DNA was extracted from their white blood cells and the four coding exons of the TBG gene were amplified by using polymerase chain reaction. Sequencing of the four coding regions and all the intron/exon junctions revealed a single nucleotide deletion of the first base of the codon 352 of the mature protein in both of the neonates. This mutation resulted in a frameshift and a premature stop codon (TGA) 374. Their mothers were shown to be heterozygotes. We detected a single nucleotide deletion resulting in a frameshift in two male Korean neonates who had complete TBG deficiency.

• KOREAN ASSOCIATION OF OCCUPATIONAL HEALTH NURSES
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• v.18 no.2
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• pp.17-24
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• 2011

갑상선 호르몬은 2가지 형태, 즉 L-thyroxine(tetraiodothyronine, T4)과 L-triiodothyronine(T3)으로서 갑상선(thyroid gland)에서 합성된다. 요오드는 갑상선 호르몬의 핵심요소이며 음식물에 포함된 요오드는 섭취 후 소장에서 흡수되어 혈류를 통해 갑상선으로 운반되고, 갑상선에서 농축, 산화되어 thyroglobulin이라는 단백질의 구성 아미노산 중 tyrosine에 삽입됨으로써 T4와 T3를 생성하게 된다. 갑상선 호르몬의 합성에는 요오드 이외에도 셀레니움이 필수적이다. 요오드와 셀레니움은 미량원소로서 부족하면, 갑상선 호르몬 결핍 또는 갑상선 비대를 초래할 수 있다.