• 대한한의학회지
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• 제26권4호
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• pp.122-129
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• 2005

Objectives: Graves' disease is the most common cause of hyperthyroidism, and its pathogenesis includes thyroid specific autoimmunity. Anti-thyroid drugs are widely used for regulating the thyroid function. However, in spite of long-term therapy with anti-thyroid drugs, about 40$\sim$$70\%$ of the treated patients have a relapse, and some suffer adverse effects. In this study, to evaluate the clinical efficacy of Ahnjeonbaekho-tang(AJBHT) on Graves' disease patients, we performed the clinical study prospectively. Methods: Through the thyroid function test(TFT) of 54 patients diagnosed as Graves' disease in other hospitals, 21 patients were assigned into the study. After the withdrawal of anti-thyroid drugs, AJBHT was administerd to patients for 2 months. At the same time, TFT, TSH binding inhibiting immunoglobulin(TEII) level and visual analogue scales (VAS) about fatigue and palpitation were measured before and after administration. Thirteen patients have completed the entire follow-up of this study over two months. Results: Serum levels of T3 and FT4 were significantly improved by AJBHT(T3: 298.85$\pm$79.60 ng/dl 181.15$\pm$33.92 ng/dl p<0.0001, FT4: 2.78$\pm$1.06 ng/dl$\rightarrow$1.78$\pm$0.83 ng/dl p<0.05). However, there were no significant changes in TSH and TBII values. And the VAS scores of fatigue and palpitation also were significantly improved(5.80$\pm$3.01$\rightarrow$3.60$\pm$2.63, p<0.05; 6.19$\pm$2.09$\rightarrow$3.60$\pm$2.46, p<0.01). Patients' age was related to the post-treatment FT4 values(p<0.05). Conclusions: From these results, we suggest that AJBHT is effective on the TFT and the symptoms of Graves' disease, and is a safe alternative drug for Graves' disease patients.

• 대한핵의학회지
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• 제21권2호
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• pp.151-154
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• 1987

Total 114 patients were studied prospectively with radioiodine uptake (RAIU) and $^{99m}TcO_4^-$ thyroid scan to design a very simple, rapid and inexpensive method measuring the thyroid uptake on thyroid scan. After the RAIU was obtained at 24 hours after P.O. of $^{131}I$, Thyroid scan was performed at 20 minutes after LV. of $^{99m}TcO_4^-$ and the bilateral salivary glands were included in the scan field. Pinhole collimated and computer assisted gamma camera was used. Three regions of interest were set on each salivary gland and on the thyroid by automatic edge detection method. Mean counts per pixel were calculated for each ROI and the salivary-thyroid ratio (STR) was defined as; $$STR(%)=\frac{Mean\;counts\;per\;pixel\;of\;salivary\;glands\;(KC)}{Mean\;counts\;per\;pixel\;of\;thyroid\;gland\;(KC)}\times100$$ 114 cases consisted of 41 normal, 55 hyperthyroid and 18 hypothyroid patients and correlation between the STR and the RAID were evaluated in total and each group. The STR and the RAID showed reverse linear regression in 114 cases (r= -0.8, P=0) and closer correlation was shown in hyperthyroid group (r= -0_9, p=0). Mean STR in normal group was 47.6%. In predicting the RAID by STR, sensitivity and specificity were 88.3% and 64.9% in 114 cases and 95.3% and 83.3% in hyperthyroid group. It is recommended that the STR be used in place of the RAID giving same information at saving time, money and radiation exposure.

• Journal of Preventive Medicine and Public Health
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• 제54권1호
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• pp.37-45
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• 2021

Objectives: Bisphenol A (BPA) is used in the electrical, mechanical, medical, and food industries. Previous studies have suggested that BPA is an endocrine disruptor. Regulation of BPA has led to increased use of bisphenol F (BPF) and bisphenol S (BPS). However, few studies have investigated the associations of BPF and BPS with thyroid dysfunction in children. Our study investigated the associations of prenatal BPA and early childhood BPA, BPF, and BPS exposure with thyroid function in 6-year-old children. Methods: Prenatal BPA concentrations were measured during the second trimester of pregnancy in an established prospective birth cohort. We measured urinary BPA, BPF, and BPS concentrations and thyroid hormone levels (thyroid-stimulating hormone, total T3, and free T4) in 6-year-old children (n=574). We examined the associations between urinary bisphenol concentrations and percentage change of thyroid hormone concentrations using multivariate linear regression. We also compared thyroid hormone levels by dividing the cohort according to BPA, BPF, and BPS concentrations. Results: The associations between prenatal BPA and total T3 levels were statistically significant in all models, except for girls when using a crude model. The associations between urinary BPA and BPS concentrations and levels of all thyroid hormones were not statistically significant. However, we observed that lower free T4 levels (-1.94%; 95% confidence interval, -3.82 to -0.03) were associated with higher urinary BPF concentrations in girls only. Conclusions: Our findings identified significant associations between prenatal BPA exposure and total T3 levels in all children and between BPF exposure and free T4 levels in girls only.

• 대한임상검사과학회지
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• 제54권1호
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• pp.28-37
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• 2022

임신은 갑상선 기능 검사의 중요한 해석을 필요로 하며 임신 중 갑상선 기능 이상과 외부 바이러스성 감염 인자들의 항체의 존재는 태아 및 산모의 건강에 영향을 미치기에 임신에서 갑상선 기능의 선별적 평가가 요구된다. 본 연구에서는 임신기간 동안 정상 산모들의 선택적 산전 감염인자 검사 항목 중에서 갑상선 관련 인자와 바이러스성 감염 인자의 임신시기별 상호 연관성을 알아보고자 하는 후향적 단편 실태조사이다. 분석한 결과를 살펴보면, T3는 나이가 증가함에 따라 감소하고, 특히 HCV가 양성인 그룹에서 양의 유의성을 보였다(P<0.01). 또한 HIV가 음성이지만 임계치에 근접하거나 쌍둥이 임산부에서는 FT4가 유의한 증가를 나타냈다(P<0.05). TSH는 30대 연령에서 높게 분포하였으며, 다른 바이러스성 감염인자와는 통계적 유의성이 나타나지 않았다. 또한, TSH의 결과 값을 삼분위로 나누어 분석한 결과, FT4와 T3은 양의 상관성을 보였으나 TSH와는 음의 상관성을 보였다(P<0.05). 따라서 본 연구를 통해서 임신 중 산전검사인 갑상선 검사와 바이러스성 감염인자의 검사를 통한 임신 중 평가는 임신 경과시간, 감염인자의 노출상태 및 정량적 수치의 상태를 반영하여 이루어져야 할 것이며, 갑상선 관련 내분비 인자에 대한 산전검사의 유용성에 대한 평가의 보완이 이루어져야 할 것으로 사료된다.

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2004년도 International Conference Current Challenges and Advances in Environmental Health
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• pp.86-87
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• 2004

• Journal of Chest Surgery
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• 제27권7호
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• pp.571-575
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• 1994

The hemodynamic effects of thyroid hormone are well established, and this hormone affects myocardial contractility, heart rate, and myocardial oxygen consumption. But the role of cardiopulmonary bypass on the thyroid function is not yet fully understood. We have studied twelve patients [male and female patients were equal in number] who were performed open heart surgery under cardiopulmonary bypass. The results are followed. 1] The serum level of T3 began to fall after cardiopulmonary bypass and sustained significantly till 24 hours after operation[p<0.05] 2] The concentrations of T4, Free T4, and TSH were slightly decreased after cardiopulmonary bypass but was maintained within normal range. 3] This above findings are similar to the "sick sinus syndrome" that is seen in severely ill patient. 4] We can propose that T3 would be effective in postoperative low cardiac output syndrome. syndrome.

• 수면정신생리
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• 제2권1호
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• pp.65-72
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• 1995

The author compared indices of thyroid function in 76 patients with panic attack and 80 control subjects. And SCL-90-R was performed to evaluate the relationship between the psychiatric symptoms and thyroid indices in the patients with panic attack The results were as follows: 1). No siginificant differences in T3, T4 or TSH were found between the two groups. But T3 level was significantly lower in male panic patients than male controls(p<0.005). 2) The T3 level was significantly lower in male panic patients who had higher depression socre than average in SCL-90-R(p<0.025). 3) The TSH level was significantly lower in patients with higher anxiety(p<0.001) and phobia(p<0.05) score and in female panic patients(p<0.001) with higher anxiety and phobia score than average in SCL-90-R. 4) The phobic symptom(p<0.001) was siginificantly higher and the T3 level(p<0.005) was lower in the male than the female patients with panic attack.

• 대한한방내과학회지
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• 제42권5호
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• pp.746-759
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• 2021

Objectives: This study assessed the effect of a combination of Korean medicine and immunotherapy on three papillary thyroid cancer patients following thyroidectomy. Methods: The three patients who underwent thyroidectomy received Korean medical treatments, including acupuncture, moxibustion, pharmacopuncture, and immunotherapy. To evaluate the patients, symptoms were measured using the Numerical Rating Scale (NRS) and Karnofsky Performance Status Scale (KPS). Blood tests, including thyroid function tests, were conducted during treatment. Results: After treatment, postoperative pain and general weakness were gradually alleviated. Conclusions: These cases provide evidence that treatment with a combination of Korean medicine and immunotherapy can have substantial benefits for postoperative complications following thyroidectomy.

• Journal of Yeungnam Medical Science
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• 제34권1호
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• pp.69-74
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• 2017

Background: Chronic kidney disease is considered a risk factor for thyroid nodules as well as thyroid dysfunction such as hypothyroidism. Among patients on hemodialysis, we assessed the size of thyroid nodule and goiter at baseline and 1 year later with ultrasonography. Methods: We prospectively selected 47 patients with hemodialysis at January 2012 and reviewed their medical records. We checked goiter and thyroid nodules at January 2012 and December 2012. Results: In the hemodialysis patients (n=47), 24 patients (51.1%) had thyroid nodules and 33 patients (70.2%) had goiter at baseline. Parathyroid hormone (PTH) was higher in patients with thyroid nodules ($204.4{\pm}102.9$ vs. $129.9{\pm}93.6pg/mL$, p=0.01). Thyroid ultrasonography was conducted in 29 patients after 1 year. The thickness of the thyroid isthmus increased ($2.8{\pm}1.6$ vs. $3.2{\pm}1.9mm$, p=0.003), but the number of nodules did not change ($1.2{\pm}1.9$ vs. $1.4{\pm}2.0$, p=0.109). PTH was associated with the enlargement of thyroid nodules significantly through logistic regression analysis. Conclusion: Thyroid goiter and nodules in hemodialysis patients were more prevalent than in the general population. PTH influenced the production of thyroid nodules in hemodialysis patients. Regular examination with thyroid ultrasonography and thyroid function test should be considered in hemodialysis patients.

• 대한방사선기술학회지:방사선기술과학
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• 제30권3호
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• pp.237-243
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• 2007

방사성의약품을 이용한 핵의학적 영상기록에 있어 장기가 함유하고 있는 정보량을 최대한 묘출시켜 양질의 진단정보를 제공해야 한다는 것은 매우 중요하다. 그것을 위한 기술적인 문제를 비롯하여 장비성능의 유지관리에 많은 노력을 기울이고 있으며, 다양한 종류로 상업화되어 이용되고 있는 우수한 phantom들이 사용되고 있다. 본 연구에서 인체의 연부조직과 매우 흡사한 물리적 조건을 가지고 있으며 구입하기 쉬운 Paraffin을 이용하여 기존에 사용되고 있는 acryl thyroid phantom과 동일하게 paraffin phantom을 제작하였으며, 판매되고 있는 acryl thyroid phantom에서 측정할 수 있는 것 보다 더 높은 분해능을 측정할 수 있도록 작은 3mm와 6mm 직경의 cold area를 삽입한 paraffin thyroid phantom을 수작업으로 제작하였다. 방사성의약품 $^{99m}TcO_4$를 이용하고 pinhole collimator를 이용하여 상업화되어 사용되고 있는 acryl thyroid phantom과 본 연구를 위하여 제작한 paraffin thyroid phantom의 특성을 비교 분석한 결과 paraffin을 이용한 phantom도 상업화되어 사용 중인 acryl thyroid phantom과 동일한 물리적 특성을 유지하고, 오히려 분해능이 높은 부분을 측정할 수 있고 연부조직의 특성을 연구할 수 있는 등가물질로서 구입하기 쉽고 제작이 수월한 장점을 비롯하여 경제성이 있음을 증명하는 계기가 되었다.