• 대한한의학회지
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• 제22권1호
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• pp.22-32
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• 2001

This study was conducted to investigate the antitoxic effects of Houttuynia cordata THUNB with chloroform and ethyl acetate fractions. The results were as follows: 1. Detoxication effects of chloroform and ethyl acetate fractions of Houttuynia cordata THUNB were increased in proportion to the dosages. Detoxication effects of ethyl acetate fraction of Houttuynia cordata THUNB were higher than chloroform fraction of Houttuynia cordata THUNB's results and detoxication effects in the kidneys were higher than results for the liver. 2. Metallothionein concentrations in the liver were higher than concentrations in the kidneys, and ethyl acetate fraction of Houttuynia cordata THUNB was higher than chloroform fraction of Houttuynia cordata THUNB in induction of metallothionein. 3. After the administration of chloroform and ethyl acetate fractions of Houttuynia cordata THUNB, body weights increased in proportion to chloroform and ethyl acetate fraction s dosage of Houttuynia cordata THUNB but changes of body weight dminished after 3 weeks. From the above results, this study suggests that chloroform and ethyl acetate fraction of Houttuynia cordata THUNB increased metallothionein induction to cadmium intoxication in rat s kidney and liver and decreased the toxicity of cadmium in rats.

• 운동영양학회지
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• 제13권1호
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• pp.59-67
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• 2009

Houttuynia Cordata Thunb, well known as "E-Sung Cho" in Korea, has been used for the treatment of herpes simplex, chronic sinusitis and nasal polyps. Recently, some studies reported the antileukemic activity, anticancer activity, adjuvanticity, and antioxidant action of Houttuynia Cordata Thunb. In the present study, the anti-obesity activity of Houttuynia Cordata Thunb was investigated. Middle-aged women were examined over a period of 8 weeks (n=30). Participants were divided into four group: Houttuynia Cordata Thunb Exercise (HCE, n=7), Placebo Exercise (PE, n=8), Houttuynia Cordata Thunb Non Exercise (HCNE, n=8), and Placebo Non Exercise (PNE, n=7). Participants in Houttuynia Cordata Thunb groups were received 4.5 g Houttuynia Cordata Thunb and in placebo groups were received same dose of placebo thrice daily with meals. The result after 8 weeks demonstrated that HCE significant decreased visceral fat than PNE. Our present study provides the evidence that Houttuynia Cordata Thunb intake and exercise performance may reduce visceral fat and further studies with larger numbers of subjects are warranted to conclusively demonstrate effectiveness.

• 한국식품조리과학회지
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• 제24권1호
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• pp.23-30
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• 2008

Sulgidduk samples made with additions of 2, 4, 6, 8, and 10% Houttuynia cordata Thunb. powder, and a control were examined for quality characteristics such as moisture content, water activity, color, gelatinization properties, textural characteristics, and sensory qualities in order to determine the optimal ratio of Houttuynia cordata Thunb. powder in the formulation. The moisture contents among the samples ranged from 41.98% to 44.97%, and increased as the content of Houttuynia cordata Thunb. powder increased. The water activities of the samples were not significantly different. As the Houttuynia cordata Thunb. powder content increased, the redness and yellowness of the samples also increased, but lightness decreased. For the gelatinization properties, the additions of Houttuynia cordata Thunb. powder caused decreases in peak viscosity (P) and holding strength viscosity (H). Furthermore, final viscosity (F), setback, and time to peak viscosity decreased with increasing Houttuynia cordata Thunb. powder content; however, breakdown and temperature to peak viscosity were not significantly different among the samples. Hardness and gumminess decreased with increasing Houttuynia cordata Thunb. powder content, and adhesiveness, cohesiveness, chewiness, and resilience also tended to decrease; however, springiness was not significantly different among the samples. In the consumer acceptance test, as the content of Houttuynia cordata Thunb. powder increased, the scores of all evaluated characteristics decreased; while the characteristic intensity ratings showed the reverse effect, and the 2 and 4% Houttuynia cordata Thunb. powder samples obtained fairly good scores. In conclusion, the results indicate that adding $2{\sim}4%$ Houttuynia cordata Thunb. powder to Sulgidduk is optimal, providing good physiological properties and reasonably high overall consumer acceptability.

• 한국응용과학기술학회지
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• 제25권3호
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• pp.269-274
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• 2008

Anti-microbiological effects of xanthorrhizol, ie., extract from curcuma xanthorrhiza and extract from houttuynia cordata Thunb. against influenza virus and E. coli O157 were tested. From the influenza experiments, the effects were shown above 93 % in case of houttuynia cordata Thunb. extract, however, the effects was not shown in case of xanthorrhizol. The effects were sustained in mixtures of houttuynia cordata Thunb. and curcuma xanthorrhiza extracts. We also tested the anti-microbiological effects of hand sanitizer containing houttuynia cordata Thunb. and xanthorrhizol. The effect of hand sanitizer containing 2,000 ppm of xanthorrhizol and 500 ppm of houttuynia cordata Thunb. extract was better than that of commercialized foreign product.

• 한국약용작물학회지
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• 제14권6호
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• pp.347-353
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• 2006

This study was conducted to evaluate the vegetation structure and ordination of the Peucedanum japonicum Thunb. community by the Phytosociological method, floristic composition table on east coast of South Korea. The vegetation of Peucedanum japonicum Thunb. community was classified into 2 communities such as the Aster Spathulifolius community and the calystegia soldanella-Artemisia princeps community. Vegetation of the Peucedanum japonicum Thunb. community with the Aster spathulifolius community was shown southward, whereas vegetation of Peucedanum japonicum Thunb. community with the calystegia soldanella-Artemisia princeps community was shown northward from the base line of Pohang at North latitude of 36" 05'. Accordingly, the Peucedanum japonicum Thunb. community was grown commonly with the Aster spathulifolius community southward of the base line of Pohang, whereas it was grown commonly with the calystegia soldanella-Artemisia princeps community northward on the east coast. All environmental conditions of habitat taken together, the optimum habitat of Peucedanum japonicum Thunb. was at Ulsan geographically and the middle region of sea cliff topography, and was suitable for alkali. sandyloam.

• 동국한의학연구소논문집
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• 제7권2호
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• pp.155-162
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• 1999

귀전우(Euonymus alatus Sieb.)가 간암, 식도암, 위암, 자궁암등의 각종 암을 치료하는 방법으로 민방에서 많이 사용하고 있다. 실제 Euonymus alatus(Thumb.) Sieb의 추출물중 Eupolyphaga simensis(ES)는 HDL-C/TC ratio와 LCATactivity를 증진시킨다. Human hepatoblastoma 세포인 Hep3B 세포의 성장억제를 유도하는 factor로는 TGF-${\beta}$, Insulin 등으로 알려져 있다. 따라서 귀전우는 간에 있어 당 대사에 관여하는 plasma HDL3-C level은 낮게 유지함으로써 간에서 지방간 이행을 억제 하여 간에서의 암 발생을 억제하는 효과를 보인다. 실험에서 귀전우가 자궁암세포보다도 간암세포에 보다 높은 세포독성을 보임으로써 여러종류의 암에 모두 적용하기는 어렵다고 보여진다. 또한 귀전우가 바이러스에 의해 유도되는 간암과 hepatocellular Carcinoma 세포에서 효과가 있는지와 HCC에서 세포의 증식억제효과를 어떤 경로를 통해 이루어지는지 계속적으로 연구가 수행되어져야 될 것이다.

• 대한본초학회지
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• 제21권3호
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• pp.7-19
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• 2006

Objectives : Propolis and Hovenia dulcis Thunb. has been used as treatment of diseases in the Korean medicine. In this study, we investigated that the hepatoprotective effects of Propolis oral administration according to mixture with Hovenia dulcis Thunb. on ${\gamma}-GTP$, GOT, GPT, Total bilirubin, LDH, ALP, Total cholesterol, Triglyceride, SOD, activity of catalase and Glutathione Peroxidase in galactosamine (GalN)-induced liver in rats. Methods : The animals were divided into 5 groups. Control, the liver injury-induced and not treated group. Pro1, liver injury and administrated propolis. Pro2, liver injury and administrated propolis capsule. Pro3, liver injury and administrated mixture of propolis capsule with Hovenia dulcis Thunb. Pro4, liver injury and administrated mixture of Propolis capsule with Hovenia dulcis Thunb. and Artemisia capillaris Thunb.. Animals were treated by Oral administration of Propolis, Hovenia dulcis Thunb., and Artemisia capillaris Thunb. mixture ltime 2 days for 14 days. Results : The Pro1 group was significantly increased on ${\gamma}-GTP$ and activity of Glutathione peroxidase but decreased on GOT in serum as compared with the control group. The Pro2 group was significantly increased on WBC, RBC, Hct, HGB in serum and activity of CuZnSOD as compared with the control group. The Pro 3 group was decreased on Total bilirubin, increased on LDH, WBC, RBC, Hct and HGB in serum as compared with the control group. The Pro 4 group was decreased on GOT in serum as compared with the control group. Conclusion : By evaluating the liver function and lipid metabolism, Pro3 had a hepatoprotective effect on the prevention of hepatotoxity.

• 한국식품영양학회지
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• 제34권5호
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• pp.526-536
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• 2021

This study was conducted to investigate the anti-obesity effect of Discorea Japonica Thunb. fermented with Monascus After inducing obesity by feeding hight fat diet (diet induced obesity model: DIO) for four weeks, each 8 rats were assigned to normal (Nor), high fat diet (HF), high fat diet containing orlistat (PC), high fat diet containing different concentration of Discorea Japonica Thunb. fermented with Monascus (UPDM_L, UPDM_H) and Discorea Japonica Thunb. (UPD) extract. Although the UPD, UPDM_L (ultrafine pulverized Discorea Japonica Thunb. fermented with Monascus: 400 mg/kg) and UPDM_H (DIO oral administration ultrafine pulverized Discorea Japonica Thunb. fermented with Monascus: 800 mg/kg) showed weight gain inhibition effects, the results of poor obesity inhibition rather than PC were confirmed. However, it showed a more effective weight loss effect in UPDM_H than UPD, and significantly reduced the weight of epididymal fat and subcutaneous fat. Furthermore, the possibility of anti-obesity effects of Discorea Japonica Thunb. fermented with Monascus can be confirmed by observing the effects of reducing serum total cholesterol, triglyceride and LDL concentrations, reducing ALT and AST levels, and inhibiting fat build-up in liver tissue. It is believed that Discorea Japonica Thunb. fermented with Monascus can be expected to utilize as a functional material that is important to improve anti-obesity and metabolic syndrome.

• Journal of Nutrition and Health
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• 제33권2호
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• pp.115-123
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• 2000

This study evaluates the effect of Dioscorea japonica Thunb subfractions on hyperglycemia and the composition of energy metabolites in diabetic rats. Diabetes emllitus was induced in male Sprague-Dawley rats by an injection of streptozotocin(STZ) dissolved in a citrate buffer into the tail vein at a dose of 45㎎/㎏ of body weight. Diabetic rats were assigned to 6 groups; STZ-control, subfraction A, B , C, D and E groups. All groups were fed an AIN-76 diet. The second butanol fraction of Dioscorea administered orally with carboxymethyl cellucose for 10 days after the STZ injection Body weight gain, diet intake and organ weights were monitored Levels of hematocrit, blood glucose, liver and muscle glycogen were measured. Levels of cholesterol, triglycerides and free fatty acids were also assayed. Body weight losses were observed by subfraction A group. Liver and kidney weights were not affected in any of the subgractioned groups. The decrease of blood glucose in daibetic rats which were fed Dioscorea japonica Thunb was significantly greater than the dicrease of blood glucose in the STZ-control group. cholesterol plasma level was not influenced in any subfraction of Dioscorea japonica Thunb. Liver triglyceride levels were significantly lowered in subfraction A compared with the STZ-control group. This study's results suggest that oral administration of subfraction C of Dioscorea japonica Thunb frction is capabl of reducing blood glucose, plasma triglyceride and free fatty acid levels, and therefore Dioscorea japonica Thunb may contain antihyperglycemic compounds.

• 한국식품영양과학회지
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• 제40권10호
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• pp.1391-1396
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• 2011

어성초(H. cordata Thunb) 건조 분말(0.05 g)을 10 mL의 증류수와 함께 스테인리스 용기에 넣고 밀봉한 후 여러 온도(50, 100, 200, $300^{\circ}C$)에서 10, 30, 60분간 추출하였다. 추출온도와 시간은 어성초 추출물의 중요 성분, 항산화 활성, acetylcholinesterase 저해 활성에 크게 영향을 미쳤다. $300^{\circ}C$에서 30분간 처리한 어성초 추출물에서 가장 높은 페놀 함량($33.34{\pm}0.96\;{\mu}g$ gallic acid equivalents/mL), quercetin 함량($15.75{\pm}0.20\;{\mu}g/mL$), DPPH 라디칼 소거능($44.07{\pm}2.65%$), acetylcholinesterase 저해 활성($36.53{\pm}1.14%$)이 나타났다. 플라보노이드 함량은 $100^{\circ}C$ 10분 추출물에서 $2.55{\mu}g$ quercetin equivalents/mL로 가장 높게 측정되었다. $100^{\circ}C$ 이상의 고온에서 밀폐된 증류수는 높은 압력에서 아임계수 형태로 존재하는데 이러한 아임계수는 고품질의 어성초 추출물을 제조하는데 매우 유용하였다.