• 스마트미디어저널
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• 제5권1호
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• pp.137-142
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• 2016

In this paper, a multi-scale model is applied to the simulation of thrombus growth. This model includes macroscale model and microscale model. The former is used to model the plasma flow with Navier-Stokes equations, and the latter is used to model the platelets adhesion and aggregation, thrombus motion, and the surface expansion of thrombus. The force acting on platelets and thrombus from plasma is modeled by the drag force, and the forces from biochemical reactions are modeled by the adhesion force and the aggregation force. As more platelets are merged into the thrombus, the thrombus surface expands. We proposed a thrombus growth model for simulating the expansion of thrombus surface and tracking the surface by Level Set Methods. We implemented the computational model. The model performs well, and the experimental results show that the shape of thrombus in level set expansion form is similar with the thrombus in clinical test.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2003년도 The Fifth Asian Computational Fluid Dynamics Conference
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• pp.147-149
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• 2003

Using computational fluid dynamics with the fluid-structure interaction, structural effects of intra-luminal thrombus were determined in thrombosed axisymmetric abdominal aorta aneurysm (AAA) models under pulsatile flow. Four different models, varying dilatations of the aneurysm and Young's moduli of intra-luminal thrombus, were defmed. Compared with unthrombosed AAA models, both von Mises stress and radial displacements in the aneurysm wall significantly decreased. Stiffer intra-luminal thrombus reduced von Mises stress in the aneUtysm wall. The present study supported that intra-luminal thrombus might reduce wall stress in the aneurysm.

• Journal of Chest Surgery
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• 제46권6호
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• pp.464-466
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• 2013

Floating thrombi in the aortic arch are very rare and an unusual source of systemic embolism. Herein, a case of a 3-cm thrombus in the aortic arch is reported. It was a floating, highly mobile thrombus attached to the lesser curvature of the aortic arch. The patients had a hypercoagulable disorder induced by protein C and S deficiency. The thrombus was operatively removed with a favorable outcome.

• Journal of Chest Surgery
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• 제33권2호
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• pp.190-192
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• 2000

A 53-year-old male patient who had suffered from acute myocardial infarction before a week was admitted due to postinfarction angina A mobile pedunculated left ventricular thrombus of 2.0-cm diameter which was overlooked in cardiac catheterization and ventriculographic study was diagnosed with transthoracic two-dimensional echocardiography. There was no exact clinical finding of left ventricular aneurysm and the thrombus was placed in the akinetic and hypokinetic apical portion. For preventing systemic embolism that was removed through a left ventriculotomy just prior to coronary artery bypass grafting.

• 한국임상수의학회지
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• 제34권6호
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• pp.478-480
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• 2017

A Cocker spaniel (7-year-old, female) was presented with one week of anorexia, halitosis, oral ulcer, intermittent vomiting, acute weight loss and 3-day history of oliguria. The patient was diagnosed with acute on chronic kidney disease and pancreatitis. Hemodialysis was continued three times a week (total 7 sessions) with improved clinical signs and kidney panel, but presented with another episode of abdominal distention, respiratory distress, and large bowel diarrhea. Echocardiography revealed nearly totally occlusive thrombus in the cranial vena cava, as well as a right atrial mass of approximately $2cm{\times}1cm$. The patient was treated with catheter removal, thrombolysis and anticoagulation therapy with recombinant tissue plasminogen activator. During anticoagulation therapy, size of atrial thrombus was not changed and heart function was not improved after treatment. Since clinical signs were deteriorated, the patient was euthanized by owner's request. Catheter-related giant thrombus in right atrium is a rare complication and treatment guideline for atrial thrombus does not exist. This case is first report of hemodialysis catheter-induced thrombus in Korea.

• 한국임상수의학회지
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• 제34권3호
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• pp.213-217
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• 2017

A 1-year and 8-month-old male, thoroughbred horse showed fever ($39.8^{\circ}C$), cardiac murmur, tachycardia up to 80 beats/min, anorexia, depression and lameness for about 2 months. The dead horse was referred to pathology laboratory at the College of Veterinary Medicine in Jeju National University. At necropsy, Severe protruding multiple rough cauliflower-like yellowish red nodules ranged $5{\sim}6{\times}2{\sim}3cm$ in size were attached on the mitral valve of the left heart. A yellowish red long stick-shaped thrombus $15{\times}3.5{\times}1.5cm$ in size was also present inside the right ventricle. Multifocal infarcts were scattered in the myocardium and renal cortex. Histopathologic examination revealed that morphologic diagnosis were vegetative endocarditis, thrombus in right ventricle, infarcts in myocardium and kidney, pulmonary congestion and edema, and splenic congestion. The isolated bacteria from vegetative lesions and thrombus were confirmed as Escherichia (E.) coli based on the bacterial culture and VITEK 2 system. Based on the gross and histopathologic features, and bacterial test, this case was diagnosed as vegetative endocarditis with thrombus formation associated by E. coli in a thoroughbred horse.

• Clinical and Experimental Pediatrics
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• 제50권6호
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• pp.588-591
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• 2007

좌심실 혈전은 전벽 심근 경색이나 심한 심첨부 심벽 운동 이상에 의해 주로 발생하며, 매우 드물게 급성 심근염에 합병되어 나타날 수 있다. 급성 심근염에 의한 혈전 형성은 심내막 손상 및 혈액의 울혈과 관계가 있는 것으로 생각되고 있다. 좌심실 혈전이 유동적이고 유경성일 경우, 전신 색전증의 위험이 증가하는 것으로 알려져 있다. 혈전이 무경성이고 유동성이 없는 경우에는 항응고 치료 요법을 고려할 수 있지만, 유경성의 과유동성 혈전이어서 전신 색전증의 가능성이 높거나 이미 전신 색전증이 발생한 경우에는 색전증의 재발을 막기 위해서 신속한 수술적 혈전 제거술이 필요하다. 저자들은 급성 심근염에 의해 생긴 좌심실 혈전을 수술적 치료로 제거하였기에 보고하고자 한다.

• Journal of Yeungnam Medical Science
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• 제27권2호
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• pp.133-138
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• 2010

Apical hypertrophic cardiomyopathy is rare disease and a variant of hypertrophic cardiomyopathy with prevalence of 1 in 500 in the general population. Apical hypertrophic cardiomyopathy with apical aneurysm and intramural thrombus is extremely rare. We report a case of apical hypertrophic cardiomyopathy progressing to left ventricular apical aneurysm with intramural thrombus diagnosed by contrast echocardiography.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1993년도 추계학술대회
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• pp.110-113
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• 1993

An in vitro experiment under laminar non-pulsatile blood flow and an acute canine ex vivo femoral A-V series shunt experiment were undertaken to investigate the effectiveness of saline perfusion through pores of porous tubes to prevent formation of mural thrombus. PS/SBR porous tubes were used for the in vitro experiment. Commercially obtained ePTFE porous tubes were etched by sodium naphthalenide, and the etched tubes were used for the ex vivo experiment. According to the results of the in vitro experiment, mural thrombus on the surface of the porous tribe could be prevented by the saline perfusion. Adhered blood cells decreased semi-logarithmically with increased perfusion rate (up to $0.022\;ml/min-cm^2$) of isotonic saline solution. According to results of the ex vivo experiment, mural thrombus decreased with increased perfusion rate (upto $0.060\;ml/min-cm^2$).

• 대한의용생체공학회:의공학회지
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• 제23권4호
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• pp.295-300
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• 2002

국부적 저산소증(localized hypoxia)은 산소공급의 저하로 인하여 조직세포를 파괴하고 관강압력에 대한 동맥류 벽의 저항을 현저하게 감소시킨다고 보고되고 있다. 본 연구에서는 동맥류 파열의 원인이 되는 저산소증의 기전을 이해하기 위하여 혈전의 두께에 따라 세 가지의 축대칭 동맥류 모델을 구성하여 동맥류 내 혈전을 통한 정상 층류유동 (steady laminar flow)에서의 산소전달현상(O$_2$transport phenomenon)을 유체-고체 열전달 현상과의 유사성을 이용하고 Fick의 법칙을 적용하여 해석하였다. 전산해석을 통해서 혈전이 형성된 혈관에서 산소농도는 혈관 벽에서 가장 낮게 나타났으며 혈전의 크기가 증가할수록 저산소농도(low $O_2$concentration) 영역이 혈관 벽 가까이 넓게 분포되어 저산소증의 가능성이 증가됨을 알 수 있었다 본 연구를 통해서 동맥류 내의 혈전은 구조와 크기에 따라 산소의 흐름에 주요한 영향을 미침을 확인할 수 있었다.