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A Thrombus Growth Model Based on Level Set Methods  

Ma, Chaoqing (Division of Computer Science and Engineering at Chonbuk National University)
Gwun, Oubong (Division of Computer Science and Engineering at Chonbuk National University)
Publication Information
Smart Media Journal / v.5, no.1, 2016 , pp. 137-142 More about this Journal
Abstract
In this paper, a multi-scale model is applied to the simulation of thrombus growth. This model includes macroscale model and microscale model. The former is used to model the plasma flow with Navier-Stokes equations, and the latter is used to model the platelets adhesion and aggregation, thrombus motion, and the surface expansion of thrombus. The force acting on platelets and thrombus from plasma is modeled by the drag force, and the forces from biochemical reactions are modeled by the adhesion force and the aggregation force. As more platelets are merged into the thrombus, the thrombus surface expands. We proposed a thrombus growth model for simulating the expansion of thrombus surface and tracking the surface by Level Set Methods. We implemented the computational model. The model performs well, and the experimental results show that the shape of thrombus in level set expansion form is similar with the thrombus in clinical test.
Keywords
thrombosis; computational model; Level Set Methods;
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