• 대한치과보철학회지
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• 제55권4호
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• pp.389-393
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• 2017

목적: 본 연구의 목적은 탄성력이 높게 개발된 레진의 굽힘 강도를 평가하고, resin wire splint (RWS)와 유연성을 비교 평가하는 것이다. 재료 및 방법: 세가지 레진 G-aenial flo (GA, GC), Superbond (SB, Sun medical), G-fix (GF, GC)의 세 점 굽힘 강도는 ISO4049/2000에 따라 진행하였다. GA, SB, GF를 이용한 세개의 RS군과 GA와 교정용 016" SS wire를 이용한 RWS군간의 치아 동요도 비교는 영구치 모형을 이용하였다. 상악좌측중절치에 3도의 동요를 부여하고, 치아의 수평적인 동요도를 splint 전후에 각 3회씩 periotest vale로 평가하였다. Splint 전후 periotest value는 splinting 효과로 환산하여 평가하였다. 통계적인 평가는 one-way ANOVA와 turkey HDS test를 이용하였다(${\alpha}=.05$). 결과: SB와 GF가 GA에 비해 낮은 굴곡강도를 보였으나, 세가지 RS군은 RWS에 비해 높은 splinting 효과를 나타내었다 (P < .05). 결론: 제한된 본 연구에서 사용된 재료와 상관없이 RS는 RWS에 비해 높은 견고성을 보였으며, 이는 탈구치아 치료를 위한 flexible splint에 부적합한 것으로 보인다.

• 농업과학연구
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• 제40권2호
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• pp.155-162
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• 2013

Genome-wide association study was performed on data from 266 Hanwoo steers derived from 66 sire using bovine 10K mapping chip in Hanwoo (Korean Cattle). SNPs were excluded from the analysis if they failed in over 5% of the genotypes, had median GC scores below 0.6, had GC scores under 0.6 in less than 90% of the samples, deviated in heterozygosity more than 3 standard deviations from the other SNPs and were out of Hardy-Weinberg equilibrium for a cutoff p-value of $1^{-15}$. Unmapped and SNPs on sex chromosomes were also excluded. A total of 4,522 SNPs were included in the analysis. To test an association between SNP and QTL, GWAS for five genetic mode (additive, dominant, overdominant, recessive and codominant) was implemented in this study. Three SNPs (rs29018694, ss46526851 and rs29018222) at a threshold p< $1.11{\times}10^{-5}$ were detected on BTA12 and BTA21 for dressing percentages in codominant and recessive genetic mode. The G allele for rs29018694 has 4.9% higher dressing percentage than A allele, while the T allele for ss46526851 has 2.57 % higher dressing percentage than C allele. Therefore, rs29018694 SNP showed a bigger effect than the other two SNPs (ss46526851 and rs29018222) in this study. In conclusion, this study identifies three loci with moderate effects and many loci with infinitesimally small effect across genome in Hanwoo.

• 생명과학회지
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• 제31권6호
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• pp.568-573
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• 2021

본 연구는 전장 유전체 연관성 분석(genome-wide association study, GWAS)을 통해 ERp29의 mRNA 발현과 관련된 유전좌위(expression quantitative trait loci, eQTL)을 식별하는 것을 목표로 하였다. 대상 유전자는 ERp29이다. ERp29는 소포체(ER)의 lumen에 단백질의 folding & assembly 기능을 가진 분자 chaperone 단백질로서 소포체 스트레스에 의해 발현량이 증가하며, 분비 단백질의 생합성에 관여한다. 최근 연구 결과 발암과 연관성이 알려지면서 주목을 받고 있다. 총 373명의 유럽인의 genome을 대상으로 GWAS 분석 결과, ERp29 유전자 발현은 정소와 뇌에서 강하게 발현하는 long noncoding RNA (LncRNA) LOC105372577과 관계가 있었다. 즉, 3개의 eQTL: rs6138266 (p<4.172e10-9), rs62193420 (p<1.173e10-8), rs6138267 (p<2.041e10-8)와 연관성이 깊은 것으로 밝혀졌다. ERp29의 발현과 연관이 있는 것으로 확인된 3개의 eQTL을 사용한 transcriptome-wide association study (TWAS) 결과 osteosarcoma amplified 9 (OS9) 발현과 유의한 연관성을 보이며 OS9 유전자의 up-stream에 upstream of transcription factor 1 (USF1)이 결합할 수 있는 것을 알았다.

• 농업과학연구
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• 제38권1호
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• pp.153-162
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• 2011

This study analyzed the spatio-temporal change detection of land-use and urbanization in Yongin and Anseong regions, Kyunggi Province, using three Landsat-5 TM images for 1990, 1996, and 2000. Remote sensing (RS) and geographic information system (GIS) techniques were used for image classification and result analysis. Six land-use types were classified using supervised maximum likelihood classification. In the two study areas, the land-use changed significantly, especially the decrease of arable land and forest and increase of built-up area. Spatially, the urban expansion of Yongin region showed a spreading trend mainly along the national road and expressways. But in Anseong region the expansion showed 'urban sprawl phenomenon' with irregular shape like starfish. Temporally, the urban expansion showed disparity - the growth rates of urbanized area rose from the period 1990-1996 to 1996-2000 in both study areas. The increased built-up areas were converted mainly from paddy, dry vegetation, and forest.

• 대한물리의학회지
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• 제5권4호
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• pp.543-549
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• 2010

Purpose : The study was designed to investigate the changes of plantar foot pressure by different loads during walking in flatfoot. Methods : Fifteen subjects with flatfoot were recruited along with their written informed consent. They were asked to walk on plate at a self-selected and comfortable speed with loads of 0, 5, 10, and 15kg. Three walking trials were obtained and then averaged for data analysis. Foot pressure were measured from RS-Scan system (RS-Scan system, RS scan Ltd., German) and contact area, maximum force were analyzed. Results : There were significant increases on midfoot and decreases on forefoot in contact area. And there were significant increases in maximum force of foot pressure of 2nd metatarsal bone and midfoot. Conclusion : These findings revealed that flatfoot increases risk factors of metatarsal bone with different loads. Therefore, patients of flatfoot must be careful during walking with loads or activities of daily living.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 춘계학술대회 논문집
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• pp.232-235
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• 2006

해저 해빈모래가 다량 유실되어 이 지역의 장기관리를 위해 침식구간에 대한 지속적인 모니터링 작업이 필요하다. 그러나 각 구청은 지형변화 분석 작업 없이, 양빈작업에 급급하고 있어 장기효과가 나타나지 않고 있다. 그러므로 본 연구는 수심측량 및 GPS 측량을 통해 해저 해빈지대의 정확한 공간자료를 구축, RS GIS 기법을 도입하여 지형변화를 정량 정성적으로 탐지 분석하였다. 연구 결과, 해운대 해저지형은 과도한 도시개발과 하천복개공사로 지난 25년간, 평균수심 0.40m, 수표면적 $11,028m^2$, 수중체적 $2,207,884m^3$ 가량 침식되었다. 해빈지형은 지난 5년간, 평균고도 0.27m, 총면적 $6,501m^2$, 총체적 $25,667m^3$ 가량 퇴적되었다. 이의 원인은 지오그리드의 설치로 해빈모래가 서측까지 도달하지 못하고, 계절영향으로 사료된다. 본 연구는 해저 해빈지형의 정확한 측량작업으로 해안 및 지형변화에 관한 모니터링 작업을 실시하여 연안침식 현황을 분석하고, 양빈작업 및 안전한 해양레저 활동, 해수욕장 관리에 필요한 정보를 제공할 수 있을 것으로 판단된다.

• Asian-Australasian Journal of Animal Sciences
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• 제8권5호
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• pp.443-447
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• 1995

Fifteen Karan-Swiss male calves of 9-12 months of age were divided into three groups of five each in a randomised block design. Animals in group I were fed wheat straw ad lib. and concentrate mixture according to their requirements, while in group II and III the animals were fed with 1/3 of the required concentrate mixture replaced by UMM licks 'Ex' and 'F', respectively. The DMI (kg/day as well as per 100 kg b.wt.) were similar (p > 0.05) among different groups of animals, however, the digestibility of DM as well as OM enhanced from $52.85{\pm}1.48$ to $58.36{\pm}1.89$ and $55.33{\pm}1.48$ to $60.12{\pm}1.75$, respectively. Growth rates of the calves were $533.8{\pm}27.25$, $532.3{\pm}42.24$ and $538.4{\pm}18.68$ g/d in groups I, II and ill (p > 0.05), respectively. Body composition and N balances of the animals were not affected by supplementation of UMM licks, however, protein retention efficiency was higher in group III ($82.57{\pm}2.54$) though nonsignificant. Feed cost/day was reduced from Rs. 7.92 (group I) to Rs. 4.62 (group II) and Rs. 3.44 (group III). Hence, partial replacement of concentrates by UMM licks reduced the cost of feeding of growing calves by 41.7 to 56.6% without affecting the growth performance.

• Genomics & Informatics
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• 제9권2호
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• pp.64-68
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• 2011

Monomelic amyotrophy (MA), also known as Hirayama disease, occurs mainly in young men and manifests as weakness and wasting of the muscles of the distal upper limbs. Here, we sought to identify a genetic basis for MA. Given the predominance of MA in males, we focused on candidate neurological disease genes located on the X chromosome, selecting two X-linked candidate genes, androgen receptor (AR ) and ubiquitin-like modifier activating enzyme 1 (UBA1). Screening for genetic variants using patients' genomic DNA revealed three known genetic variants in the coding region of the AR gene: one nonsynonymous single-nucleotide polymorphism (SNP; rs78686797) encoding Leu57Gln, and two variants of polymorphic trinucleotide repeat segments that encode polyglutamine (CAG repeat; rs5902610) and polyglycine (GGC repeat; rs3138869) tracts. Notably, the Leu57Gln polymorphism was found in two patients with MA from 24 MA patients, whereas no variants were found in 142 healthy male controls. However, the numbers of CAG and GGC repeats in the AR gene were within the normal range. These data suggest that the Leu57Gln polymorphism encoded by the X-linked AR gene may contribute to the development of MA.

• 대한의생명과학회지
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• 제26권1호
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• pp.42-46
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• 2020

Tuberculosis (TB) remains a major health problem worldwide. TB depends not only on the characteristics of the Mycobacterium tuberculosis (MTB) but also on the genetic susceptibility of infected patients. Recent studies have suggested that FOXO3 play an important role in the human immune associated disorder, such as TB. It was previously reported that FOXO3 genetic variants associated with a risk of TB in Chinese population. In this study, we confirm whether the genetic polymorphism of the FOXO3 gene, which was previously in Chinese, is reproduced in Korean population. Of the 154 SNPs were extracted from the FOXO3 gene, reproducibility analysis of the four SNPs performed in the previous study showed that there was a statistically significant correlation in the three SNPs (rs4946935, rs1536057, rs3800228). This study suggests that polymorphism of the FOXO3 gene in Koreans may affect the onset of tuberculosis and could be used to treat and prevent tuberculosis.

• 대한임베디드공학회논문지
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• 제10권5호
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• pp.281-296
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• 2015

This paper describes a novel disaster evacuation system using embedded systems such as smart devices for crisis and emergency management. In indoor environments deployed with the Bluetooth Low Energy(BLE) beacons, smart devices detect their indoor positions from beacon messages and interact with Map Server(MS) and Route Server(RS) in the Internet over the LTE and/or Wi-Fi functions. The MS and RS generate an optimal path to the nearest emergency exit based on a novel graph generation method for less route computation, called the Disaster Evacuation Graph(DEG), for each smart device. The DEG also enables efficient processing of some constraints in the computation of route, such as load balancing in situation of different capacities of paths or exits. All data interfaces among three system components, the MS, RS, smart devices, have been defined for modular implementation of our disaster evacuation system. Our experimental system has been deployed and tested in our building thoroughly and gives a good evidence that the modular design of the system and a novel approach to compute emergency route based on the DEG is competitive and viable.