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Effects of Clematidis Radix Pharmacopuncture Injected at Sinsu ($BL_{23}$) on Neuropathic Pain in Rats (신유(腎兪)($BL_{23}$) 위령선약침이 백서(白鼠)의 L5 Spinal Nerve의 결찰로 유발된 신경병리성 동통에 미치는 영향)

  • Kim, Sung Phil;Choi, Sun Mi;Kim, Jeong Eun;Kim, Joo Hee;Shin, Kyung Min;Kim, Jae Hong
    • Journal of Acupuncture Research
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    • v.31 no.4
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    • pp.57-70
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    • 2014
  • Objectives : The purpose of this study is to examine if Clematidis Radix(CR) pharmacopuncture may be effective to the neuropathic pain(mechanical allodynia) in a rat model of neuropathic pain. Methods : To produce the model of neuropathic, L5 spinal nerve was ligated by 6-0 silk thread. After neuropathic surgery, the author examined if the animals exhibited the plantar withdrawal response of allodynia. The plantar withdrawal response was assessed by dynamic plantar aesthesiometer three days after the neuropathic surgery, CR pharmacopuncture was injected at $BL_{23}$ 1time/week for 6 weeks. After that, the author examined the plantar withdrawal response of rats' leg by dynamic plantar aesthesiometer. And also the author examined mGluR5, Bax, Bcl-2, Bax/Bcl-2 ratio in spinal cord, and c-Fos. Also the author observed the change of aspartate aminotransferase(AST), alanine aminotransferase(ALT) count in the blood serum of neuropathic rats. Results : 1. The withdrawal response of allodynia decreased in the PT3, PT4 group as compared with control group. 2. The mGluR5 increased in the PT1, PT2, PT3, and PT4 group. 3. The Bax and Bax/Bcl-2 ratio decreased in the PT4 group. 4. The c-Fos increased in the PT1 group, and decreased in the PT4 group. 5. The changes of AST in blood serum decreased in the every group excluded control group and the changes of ALT in blood serum isn't shown the signigicant change. Conclusions : These results are suggested that CR pharmacopuncture at BL23 decreased mechanical allodynia, can act on anti-apoptotic, neuroprotective effects and liver fuction in the model of neuropathic pain.

The comparison of torque values in two types of miniscrews placed in rabbits: tapered and cylindrical shapes - Preliminary study (토끼모델을 이용한 미니스크류 형상에 따른 토오크의 평가 - 원통형과 원추형 간의 비교)

  • Kim, Kyung-Ho;Chung, Choo-Ryung;Yoo, Hyun-Mi;Park, Dong-Sung;Jang, In-Sung;Kyung, Seung-Hyun
    • The korean journal of orthodontics
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    • v.41 no.4
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    • pp.280-287
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    • 2011
  • Objective: This study compared the stability of cylindrical miniscrews (Cy, 7 mm in length) with that of tapered miniscrews (Ta, 5 mm in length), using torque values to determine if the healing time before loading affects the stability of the miniscrew and if the insertion torque is associated with the removal torque measured after a few weeks of healing. Methods: Ta and Cy with different thread lengths were placed in the tibias of 12 female New Zealand white rabbits (body weight: 3.0 - 3.5 kg), and the maximum insertion torque values (ITV) were measured. No orthodontic forces were applied so as to allow us to determine the pure effects of the different shapes. After 3 different healing periods (2, 4, and 6 weeks), maximum removal torque values (RTV) were measured immediately before the rabbits were sacrificed. Results: No miniscrews were loosened. There were no significant differences in ITV or RTV between the Ta and Cy nor were there any significant differences in the ITV and RTV between the 3 groups, which had different healing periods. There was a correlation between the ITV and RTV. Conclusions: Shorter Ta showed similar stability as Cy, as determined by torque values. This result strongly suggests that the tapered shape is more advantageous than the cylindrical shape. The RTV did not increase significantly over time. It is recommended that a miniscrew be loaded immediately; waiting a few weeks before loading should be avoided. The correlation between the ITV and RTV suggests that the ITV can be used to estimate a screw's future stability.

Influence of Implant Designs on Initial Stability (임플란트의 형태가 초기 안정성에 미치는 영향)

  • Cho, Jae-Myoung;Kim, Chang-Seop;Yun, Mi-Jung;Jeong, Chang-Mo;Seo, Seung-U
    • Journal of Dental Rehabilitation and Applied Science
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    • v.26 no.1
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    • pp.47-57
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    • 2010
  • An undisturbed healing process without micromotion at the implant-bone interface is essential for achievement of osseointegration of dental implant. Therefore, initial stability was advocated as prerequisite for successful clinical outcome. Adequate bone quality and quantity were important to achieve initial stability and to prevent early failures. However there were few published data available regarding the effect of design change in implant geometry on initial stability of the implants. The purpose of the current study was to assess the initial stability of various designs of implants when placed into artificial bone materials of varying qualities and shapes of insertion holes. Within the scope of this study, the following results were drawn. Bone quality was major importance to achieve initial stability. Initial stability was higher on GS II which had additional design feature of double thread. With a tapered design of implant such as GS III showed a higher initial stability than straight one. An insertion hole with the similar shape of implant would lead to reduce a compression force on cortical bone and enhance a bone anchorage on cancellous bone.

The Effects of Gyejibokryeong-hwan (桂枝茯苓丸) for Wound Healing after Skin Suture (계지복령환(桂枝茯苓丸)이 피부봉합 후 상처 치유에 미치는 영향)

  • Jung, Hoon;Lee, Eun-Jung;Oh, Min-Seok
    • Journal of Korean Medicine Rehabilitation
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    • v.26 no.2
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    • pp.29-50
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    • 2016
  • Objectives There is few Korean medicinal studies about post-operation wound healing despite much effort for minimizing wound or post-op scar. The aim of this study is to evaluate the wound healing effect of Gyejibokryeong-hwan (Guizhifuling-wan, GBH) after skin suture. Methods < In vitro > We observed anti-oxidative and anti-inflammatory effect by using lipopolysaccharide (LPS)-treated RAW 264.7 cells. For anti-oxidation, we mesured the total amount of polyphenol, flavonoid, DPPH scavenging ability, ABTS scavenging ability and the value of ROS production, and for anti-inflammation, we mesured the amount of NO and pro-inflammatory cytokines ($TNF-{\alpha}$, $IL-1{\beta}$, IL-6). < In vivo > Thirty SD rats were divided into five equal groups (n=6, one normal, two controls and two experimentals). All groups except normal group were made a scar (around $1{\times}4cm^2$) in the back by the depth of the fascia and then sutured by a thread and needle. Normal group rats received no treatment at all. Control group rats were fed distilled water, and positive control group rats were percutaneously applied terramycin once in 2 days. GBH 200 group rats were orally medicated GBH 200 mg/kg, and GBH 400 group rats were orally medicated GBH 400 mg/kg per day for two weeks. We analyzed the blood samples (WBC, neutrophil, lymphocyte, monocyte, eosinophil), and the serums (TIMP-1, MMP-2, MMP-2. $PGE_2$, $TGF-{\beta}$, VEGF), and examined the wounded skin tissue histopathologically. Results < in vitro > 1. DPPH and ABTS scavenging activity was increased concentration-dependantly, and ROS production was significantly increased in GBH treated cells ($100{\mu}g/ml$). Therefore in this study, Gyejibokryeong-hwan appears to have the anti-oxidative. 2. NO production was significantly reduced in GBH treated cells ($100{\mu}g/ml$), and $IL-1{\beta}$ production was significantly reduced in GBH treated cells ($1{\mu}g/ml$). But, $TNF-{\alpha}$ and IL-6 did not show uneffective action. Therefore in this study, Gyejibokryeong-hwan did not show any significant effect on anti-inflammatory process. < in vivo > 1. Monocyte and neutrophil was significantly increased in GBH (200, 400) groups. WBC, lymphocyte and eosinophil did not show significant change. 2. TIMP-1, MMP-2, VEGF were significantly increased in GBH 400 group, $PGE_2$ was significantly reduced in GBH 400 group. $TGF-{\beta}$ was significantly increased in GBH (200, 400) groups, and MMP-9 was increased concentration-dependantly in GBH groups, but there was no significance. 3. In histopathological examinations, collagen was significantly increased and keratin was significantly decreased in GBH (200, 400) groups. Conclusions According to in vitro experiment, GBH appears to have the anti-oxidative effect and in vivo experiment, GBH stimulate the wound healing process hematologically and histopathologically. In conclusion, the results suggest that GBH promotes wound healing after skin suture.

Comparison of autogenous tooth bone graft and synthetic bone graft materials used for bone resorption around implants after crestal approach sinus lifting: a retrospective study

  • Kim, Young-Kyun;Lee, Junho;Yun, Ji-Young;Yun, Pil-Young;Um, In-Woong
    • Journal of Periodontal and Implant Science
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    • v.44 no.5
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    • pp.216-221
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    • 2014
  • Purpose: This retrospective study compares the amount of bone resorption around implants between an autogenous tooth bone graft (AutoBT) and a synthetic bone graft after a bone-added crestally approached sinus lift with simultaneous implant placements. Methods: In all, 37 patients participated in this study. Seventeen patients were grouped as group I and underwent an AutoBT-added sinus lift using the crestal approach. The remaining 20 patients were grouped as group II and underwent synthetic bone grafting. Both groups received the implant placements simultaneously. Of the 37 participating patients, only 22 patients were included in the final results: Eleven patients of group I and 11 patients of group II. Before the surgery, the distance from the alveolar crest to the sinus floor was measured using panoramic radiography. After the surgery, the distance was measured again from the neck of the implant thread to the most superior border of the added graft materials. Then, the amount of sinus lift was calculated by comparing the two panoramic radiographs. After a year, a panoramic radiograph was taken to calculate the resorption of the bone graft material from the radiograph that was taken after the surgery. The significance of the resorption amount between the two types of graft materials was statistically analyzed. Results: The bone height was increased to an average of 4.89 mm in group I and 6.22 mm in group II. The analysis of panoramic radiographs 1 year after the surgery showed an average bone resorption of 0.76 mm and 0.53 mm, respectively. However, the degree of lifting (P=0.460) and the amount of bone-grafted material resorption (P=0.570) showed no statistically significant difference. Conclusions: Based on this limited study, AutoBT can be considered a good alternative bone graft to a synthetic bone graft in a bone-added sinus lift, when extraction is necessary prior to the surgery.

Tile-level and Frame-level Parallel Encoding for HEVC (타일 및 프레임 수준의 HEVC 병렬 부호화)

  • Kim, Younhee;Seok, Jinwuk;Jung, Soon-heung;Kim, Huiyong;Choi, Jin Soo
    • Journal of Broadcast Engineering
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    • v.20 no.3
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    • pp.388-397
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    • 2015
  • High Efficiency Video Coding (HEVC)/H.265 is a new video coding standard which is known as high compression ratio compared to the previous standard, Advanced Video Coding (AVC)/H.264. Due to achievement of high efficiency, HEVC sacrifices the time complexity. To apply HEVC to the market applications, one of the key requirements is the fast encoding. To achieve the fast encoding, exploiting thread-level parallelism is widely chosen mechanism since multi-threading is commonly supported based on the multi-core computer architecture. In this paper, we implement both the Tile-level parallelism and the Frame-level parallelism for HEVC encoding on multi-core platform. Based on the implementation, we present two approaches in combining the Tile-level parallelism with Frame-level parallelism. The first approach creates the fixed number of tile per frame while the second approach creates the number of tile per frame adaptively according to the number of frame in parallel and the number of available worker threads. Experimental results show that both improves the parallel scalability compared to the one that use only tile-level parallelism and the second approach achieves good trade-off between parallel scalability and coding efficiency for both Full-HD (1080 x 1920) and 4K UHD (3840 x 2160) sequences.

The Genealogy of Trousers in the Eurasian Region (유라시아 지역 바지 구조의 계보)

  • 김문영;조우현
    • Journal of the Korean Society of Costume
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    • v.53 no.7
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    • pp.95-109
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    • 2003
  • The style of different styles of clothing have been developed by not only the natural environment and social effects. but also by various variables such as the peculiar cultures and religions of different ethnic groups. It is naturally accepted without question that the origin of trousers was derived from the Skytie race in the modern style of dress. And the style of those trousers has changed and developed throughout a long history in different environments and surroundings. As part of the research of the process in this styles of clothing, it is essential to know how the fabric of trousers has been developed and how the styles have been changed because of different weather conditions and different religions. Nowadays, Eurasian countries was scattered from western and eastern Asian countries to middle Asian countries such as Russia, Uzbekistan, Kazakistan, Turkey, Turkmenistan, Iran and China. These countries are located on the way to the Silk Road. They are fully developed in a cultural area among the different religions. In terms of cultural aspects within the different religions, men's trousers had developed the traditional style of this dress as one of the importnat items on the cultural basis. The ranges and types of these traditional trousers are divided by the regions, such as west and southern Asia, central Asia and China. Pakistan, Afghanistan, Iran, Iraq, Syria, Lebanon, Turkey. Jordan, Saudi Arabia, Kuwait and Israel was a part of the west and southern Asian countries which were located between western countries and eastern countries. This tribes wore Shalwar trousers which is a wide style of trousers. Shalwar in the western and eastern Asian region has a specific feature by the each nation but has the same distinctions such as by using very wide and loose style and tying a fine thread around the waist. Some central Asian countries consisted of part of China, Turkmenistan. the Republic of Tajikistan. the Republic of Kyrgyzstan and the Republic of Afganistan. These style of trousers are compound types which appeared with mixing Draperian Greek culture. So it can be inferred from this data that the horse-riding nomadic trousers which had been handed down from Skytie tribe through Persia. The style of the trousers in those regions has small pieces. The style of the trousers in China, which is located on the way to the far eastern countries, has developed new trousers put together two pieces of the textile. These widen trousers can be worn by using a sash belt. So we can find out that those trousers of countries which mentioned above have a common point and a rule.

Effects of Induced Microcurrent Shoes on Fatigue and Pain in Painful Foot to Patients with Plantar Fascitis (족저근막염 환자의 미세전류발생 신발 착용이 족부 근피로 및 통증 완화에 미치는 영향)

  • Park, Rae-Joon;Choi, Sang-Joon;Cheng, Goh Ah;Cho, Jeong-Sun;Lee, Yoon-Mi;Cho, Yong-Ho;Park, So-Hyun;Cho, Mi-Suk
    • The Journal of Korean Physical Therapy
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    • v.18 no.1
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    • pp.1-10
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    • 2006
  • Purpose: This study was to investigate how induced microcurrent shoes affect relief of feet pain, which often occurs to persons who are more than fifty years old and how they prevent fatigue of feet generated during everyday life. The subjects of this study were comprised af five males and five females, who agreed with this research and ate more than fifty years old. And they all have plantar faciitis and pain in their feet. Methods: Subjects ware the induced microcurrent shoes far more than 4 hours everyday during the test. When they wore those shoes, they also wore the specially produced shacks made of silver-mixed thread and they were asked to avoid serious exercise. Prior to starting test and after the test, assessments were carried out two times. In the examination before the test, general shoes were used and in examination after the test, induced microcurrent shoes used. Muscle fatigue was measured by electromyography(MP150, Biopac, USA). When the walking rate of subjects on a treadmill was increased from 2.Km/h to 3Km/h for 10 minutes, muscle activities of a lower leg were measured during the whale walking process by MP150 remote monitoring system(TEL 100C). And pain was measured by VAS. Results: The results are as follows. 1. Comparisons of VAS before and after experimentation showed that degree of pain was significantly decreased(p < .05). 2. Degree of fatigue of Tibialis anterior was significantly decreased after 6 weeks of treatment(p < .05). 3. Degree of fatigue of Soleus was slightly decreased after 6 weeks of treatment, but did not show significant difference (p > .05). Conclusion: The above results suggest that induced microcurrent shoes is helpful decreasing fatigue of feet and relief of feet pain.

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Retrospective Study of GS II Implant(Osstem) with an Internal Connection with Microthreads (Micro thread를 포함한 GSII RBM임플란트(Osstem)의 후향적 임상연구)

  • Chee, Young-Deok;Lee, Jae-Hwan;Oh, Sang-Chun
    • Journal of Dental Rehabilitation and Applied Science
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    • v.25 no.4
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    • pp.417-429
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    • 2009
  • Since the introduction of the concept of osseointegration in dental implants, high long-term success rates have been achieved and accepted as viable option for the treatment of fully and partially edentulous patients. Although the use of domestic implants have increased dramatically, there are few studies on domestic implants with clinical and objective long-term data. 96 endosseous implants placed in 31 patients at Wonkwang University Sanbon Dental Hospital were examined to determine the effect of various factors on implant survival rate and marginal bone loss, through clinical and radiographic results. The design of endosseous implant used to this study is straight with the microthread.(GS II RBM Fixture) 1. 3 fixtures were lost, resulting in 96.9% cumulative survival rate. 2. Survival rate in fifties was significantly lower (93.6%) and no significant difference in marginal bone loss was found according to gender. 3. Survival rates were 95.6% in the maxillary molar area and 97.3% in the mandible molar area. 4. No significant difference in survival rate was found according to presence of bone grafts, type of prostheses, implant position, and length and diameter of implant. 5. A factor influencing marginal bone loss was presence of type of prostheses, while facters such a length, diameter of fixture and bone grafts had no statistically significant effect on crestal bone loss. This study indicates the amount of marginal bone loss around implant has maintained a relative stable during follow-up periods.

A BIOLOGIC STUDY ON TOOTHASH - PLASTER OF PARIS MIXTURE WITH ABSORBABLE COLLAGEN MEMBRANE IN THE TREATMENT OF PERI-IMPLANT DEFECTS (임플란트 주위염 치료시 치아회분말과 치과용 연석고의 혼합 매식의 골재생 효과)

  • Choi, Hee-Yeon;Kim, Hak-Kyun;Kim, Su-Gwan;Moon, Seong-Yong;Kim, Sang-Yeol;Park, Kwang-Bum;Kim, Young-Min;Lim, Seong-Chul;Kim, Eun-Seok;Lee, Jeong-Hoon
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.30 no.2
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    • pp.142-149
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    • 2008
  • The purpose of this study was to evaluate histomorphometrically a toothash - plaster of Paris mixture associated with collagen membrane ($Bio-Gide^{(R)}$), regarding new bone formation in the peri-implantitis defects in dogs. Three mandibular molars were removed from 1-year-old mongrel dogs. After 2 months of healing, 2 titanium implants with sandblasted with large grit and acid etched (SLA) surface were installed in each side of the mandible. Experimental peri-implantitis was induced with ligatures after successful osseointegration. Ligatures were removed after identification of bone defect beneath the level of 5th thread of fixture on radiographic image. The mucoperiosteal flaps were elevated and the contaminated fixtures were treated with chlorhexidine and saline. The bone defects were assigned to one of the following treatments: no guided bone regeneration (GBR) procedure (group 1), GBR with Bio-$Oss^{(R)}$ and Bio-$Gide^{(R)}$ (group 2), or GBR with toothash - plaster of Paris mixture (TPM) and Bio-$Gide^{(R)}$ (group 3). The dogs were sacrificed after 8 or 16 months. The mean percentages of new bone formation within the limits of the 5 most coronal threads were $17.83{\pm}10.69$ (8 weeks) and $20.13{\pm}13.65$ (16 weeks) in group 1, $34.25{\pm}13.32$ (8 weeks) and $36.33{\pm}14.21$ (16 weeks) in group 2, and $46.33{\pm}18.39$ (8 weeks) and $48.00{\pm}17.78$ (16 weeks) in group 3, respectively. The present study confirmed statistically considerable new bone formation within the threads in group 3 compared with group 1 at 8 and 16 weeks (P<0.05). Although, data analysis did not reveal significant differences between group 2 and 3, the latter showed better results during the period of 8 or 16 weeks. Our findings support the effectiveness of TPM as a GBR material in the treatment of peri-implantitis bone defect.