• 대한불안의학회지
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• 제15권1호
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• pp.1-12
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• 2019

Thought-action fusion (TAF) is a tendency to blindly assume causal relations between their thoughts and external reality. On the other hand, cognitive fusion (CF) is a tendency to take internal experiences, such as thoughts and feeling, literally rather than view them as random events. However, these two terms are often confusedly used and, in fact, have conceptual overlaps. Therefore, this study aimed to identify their distinctive features through a comprehensive review of the definition, origin, measurements and clinical implications especially on the understanding of obsessive-compulsive symptoms. The cognitive-behavioral concept of TAF is confined to erroneous and maladaptive beliefs about the connection between thoughts and behaviors. The CF is a broader construct that entails taking thoughts and feelings as facts and engaging or struggling with them such that the quality of life is lowered. They also have different theoretical backgrounds, developing processes and therapeutic approaches. From the perspective of the obsessive-compulsive disorder, both concepts have been studied as mid-structures for this illness. Recently, the effectiveness of psychological therapies related to these concepts such as defusion therapy has been tested. However, it is yet still in its infancy. In the future, complementary advances between the two concepts with studies on biological substrates is needed.

• Molecules and Cells
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• 제25권1호
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• pp.7-19
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• 2008

Complexins play a critical role in the control of fast synchronous neurotransmitter release. They operate by binding to trimeric SNARE complexes consisting of the vesicle protein Synaptobrevin and the plasma membrane proteins Syntaxin and SNAP-25, which are key executors of membrane fusion reactions. SNARE complex binding by Complexins is thought to stabilize and clamp the SNARE complex in a highly fusogenic state, thereby providing a pool of readily releasable synaptic vesicles that can be released quickly and synchronously in response to an action potential and the concomitant increase in intra-synaptic $Ca^{2+}$ levels. Genetic elimination of Complexins from mammalian neurons causes a strong reduction in evoked neurotransmitter release, and altered Complexin expression levels with consequent deficits in synaptic transmission were suggested to contribute to the etiology or pathogenesis of schizophrenia, Huntington's disease, depression, bipolar disorder, Parkinson's disease, Alzheimer's disease, traumatic brain injury, Wernicke's encephalopathy, and fetal alcohol syndrome. In the present review I provide a summary of available data on the role of altered Complexin expression in brain diseases. On aggregate, the available information indicates that altered Complexin expression levels are unlikely to have a causal role in the etiology of the disorders that they have been implicated in, but that they may contribute to the corresponding symptoms.

• 한국융합학회논문지
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• 제3권1호
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• pp.27-34
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• 2012

2011년 3월 11일 발생한 일본 후쿠시마 원전 사고 후 한국 대학생들의 방사선과 의료 방사선에 대한 생각을 파악하여 방사선에 대한 적절한 교육 방법과 국민들의 방사선 안전에 대한 올바른 대중 커뮤니케이션에 대해 모색하고자 전국 5개도(경기, 강원, 충청, 전라, 경상도)의 4년제 방사선학과가 설치된 대학교에서 790부 설문지를 수거한 후 분석하였다. 설문은 36문항으로 구성하였으며, '방사선이 위험하다'고 느끼는 중요 원인 중 하나는 '적은양의 방사선을 쪼여도 나중에 문제가 생길 수 있다'. ($3.28{\pm}1.05$)로 분석됐다. 방사선에 대한 관리에서는 개인보다는 정부가 나서야 된다는 응답자가 $3.87{\pm}0.89$으로 나타났다. '후쿠시마 원전 사고는 원자력 발전을 하지 말아야 한다는 쪽으로 나의 생각을 바꾸게 했다'라는 문항에는 $2.79{\pm}0.95$로 나타났다. '후쿠시마 원전사고 이후 의료 방사선에 대한 생각이 부정적으로 바뀌었다'라는 문항에는 전체적으로 $2.64{\pm}1.02$, 방사선학과 $2.31{\pm}1.00$, 치위생학과 $2.94{\pm}0.95$, 기타학과 $3.13{\pm}0.82$로 방사선과 관련된 교과목을 수강 경험이 없는 기타학과 학생일수록 부정적인 생각을 가지고 있는 것으로 나타났다. 또한 방사선에 관한 교육이 필요하다고 생각하는 사람이 82.28%로 나타났으며, 그 중 T.V나 인터넷이 가장 효율적인 교육 방법으로 나타났다.