• BMB Reports
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• v.57 no.5
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• pp.244-249
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• 2024

Many types of cancer are associated with excessive angiogenesis. Anti-angiogenic treatment is an effective strategy for treating solid cancers. This study aimed to demonstrate the inhibitory effects of (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP) in VEGFA-induced angiogenesis. The results indicated that MMPP effectively suppressed various angiogenic processes, such as cell migration, invasion, tube formation, and sprouting of new vessels in human umbilical vein endothelial cells (HUVECs) and mouse aortic ring. The inhibitory mechanism of MMPP on angiogenesis involves targeting VEGFR2. MMPP showed high binding affinity for the VEGFR2 ATP-binding domain. Additionally, MMPP improved VEGFR2 thermal stability and inhibited VEGFR2 kinase activity, suppressing the downstream VEGFR2/AKT/ERK pathway. MMPP attenuated the activation and nuclear translocation of NF-κB, and it downregulated NF-κB target genes such as VEGFA, VEGFR2, MMP2, and MMP9. Furthermore, conditioned medium from MMPP-treated breast cancer cells effectively inhibited angiogenesis in endothelial cells. These results suggested that MMPP had great promise as a novel VEGFR2 inhibitor with potent anti-angiogenic properties for cancer treatment via VEGFR2/AKT/ERK/NF-κB signaling pathway.

• Journal of the Korean Society of Combustion
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• v.12 no.1
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• pp.28-37
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• 2007

Numerical study is conducted to grasp the flame structure and NO emissions for a wide range of oxy-fuel combustion (covering from air blown combustion to pure oxygen combustion) and for various mole fractions of recirculated $CO_2$ in $CH4-O_2/N_2/CO_2$ counterflow diffusion flames. Special concern is given to the difference of the flame structure and NO emissions between air blown combustion and oxy-fuel combustion w/o recirculated $CO_2$ and is also focused on chemical effects of recirculated $CO_2$. Air blown combustion and oxy-fuel combustion w/o recirculated $CO_2$ are shown to be considerably different in the flame structure and NO emissions. Modified fuel oxidation reaction pathways in oxygen-enriched combustion are provided in detail compared to those in air blown combustion w/o recirculated $CO_2$. The formation and destruction of NO through Fenimore and thermal mechanisms are also compared for air blown combustion and oxyegn-enriched combustion w/o recirculated $CO_2$, and the role of the recirculated $CO_2$ and its chemical effects are discussed. Importantly contributing reaction steps to the formation and destruction of NO are also estimated in oxygen-enriched combustion in comparison to air blown combustion.

• Korean Journal of Acupuncture
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• v.19 no.2
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• pp.13-33
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• 2002

This study was examined for effects of acupuncture of Zusanli (ST36) on the facial thermography in health subjects. The volunteers who participating in this study had taken rest for 20 - 30 mins in room temperature (23-$25^{\circ}C$) before the examination and informed them what to prohibit smoking, drinking and administration of drug for the previous day. The thermography of face was taken using Infra-Red Imaging System (IR 2000, MEDI-CORE Co., Korea) by time interval of 15 minutes at 15 min before, just before and 15 min after, 30 min after and 45 min after acupuncture stimulation. Acupuncture was applied to the left ST36 for 30 mins. The results showed that acupuncture of ST36 significantly decreased the temperature of all the areas of facial surface comparing to those of control group. Also, it was observed that the quantities of thermal changes following acupuncture of ST36 been increased significantly at the A1, A4, A6, A7 and A9 ROIs (region of interest) comparing that of control group. Observed the thermography classified by ROI, it was clear the fact that acupuncture of ST36 could modulate the specific areas concerning to the facial pathway of Stomach Meridian, because the thermal responses following acupuncture of ST36 were specific at the A1, A2, A5 and A9 ROIs, relatively. These results suggest that acupuncture of ST36 may modulate thermal distributions and changes of facial areas concerned with Stomach Meridian.

• Polymer(Korea)
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• v.33 no.1
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• pp.1-6
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• 2009

We report the template-based synthesis of well-dispersed CdS nanoparticles (NPs) in the interior of poly (2-acetamidoacrylic acid) (PAAA) hydrogel as a novel type of nanocomposite without particle aggregation via ion exchange in a aqueous system. As revealed by the TEM image analysis, the mean crystallite diameter of CdS NPs embedded in hydrogel composite was 4.5 nm, and the composite did not suffer any observable change after 6 months. Desorption/decomposition of CdS/PAAA hydrogel composite was studied by evolved gas analysis-gas chromatography-mass spectrometry (EGA-GC-MS), and thermogravimetric analysis (TGA) methods. From the TGA data, the thermal stability of the composite system increased by ca. 100 $^\circ$C and the content of CdS NPs in a dry composite gel was over 70 wt%. In addition, the chemical pathway was proposed for the entire decomposition process.

• Molecules and Cells
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• v.27 no.4
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• pp.417-422
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• 2009

Lipoxygenase (LO) metabolites are generated in inflamed tissues. However, it is unclear whether the inhibition of the LO activity regulates the expression of c-Fos protein, a pain marker in the spinal cord. Here we used a carrageenan-induced inflammation model to examine the role of LO in the development of c-Fos expression. Intradermally injected carrageenan caused elevated number of cells exhibiting Fos-like immunoreactivity (Fos-LI) in the spinal dorsal horn, and decreased the thermal and mechanical threshold in Hargreaves and von Frey tests. Pretreatment with an inhibitor of phospholipase A2, that generates the LO substrate, prior to the carrageenan injection significantly reduced the number of Fos-(+) cells. A general LO inhibitor NDGA, a 5-LO inhibitor AA-861 and a 12-LO inhibitor baicalein also exhibited the similar effects. Moreover, the LO inhibitors suppressed carrageenan-induced thermal and mechanical hyperalgesic behaviors, which inidcates that the changes in Fos expression correlates with those in the nociceptive behaviors in the inflamed rats. LO products are endogenous TRPV1 activators and pretreatment with BCTC, a TRPV1 antagonist inhibited the thermal but not the mechanical hypersensitivity. Overall, our results from the Fos-LI and behavior tests suggest that LO products released from inflamed tissues contribute to nociception during carrageenan-induced inflammation, indicating that the LO pathway is a possible target for modulating inflammatory pain.

• Natural Product Sciences
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• v.20 no.2
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• pp.119-125
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• 2014

According to the results of my study on the chromatographic analysis of fresh ginseng (Panax ginseng C. A. Meyer) roots, most of the contents of protopanxadiol ginsenosides $Rb_1$, Rc, $Rb_2$, and Rd are derived from the corresponding malonyl ginsenosides in fresh ginseng by a heat process. Also, I confirmed that acetyl ginsenosides are naturally occurring constituents in fresh ginseng, not decarboxylates from malonyl ginsenosides. Seven neutral ginsenosides $Rg_1$, Re, Rf, Rc, $Rb_1$, $Rb_2$, and Rd were transformed to specific conversions in red ginseng preparation conditions. The conversion paths progress by three rules concluded from my study. These conversion rules are I: the ether bond is stable at positions 3 and 6 in the dammarane skeleton, II: the ether bond between sugars is stable in glycosides, and III: the ether bond to glycosides is unstable at position 20 in the dammarane skeleton.

• Journal of the Korean Chemical Society
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• v.68 no.2
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• pp.87-92
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• 2024

The commercialization of rechargeable metal-air batteries is extremely desirable but designing stable oxygen reduction reaction (ORR) catalysts with non-noble metal still has faced challenges to replace platinum-based catalysts. The nonnoble metal catalysts for ORR were prepared to improve the catalytic performance and stability by the thermal decomposition of ZIF-8 with optimum cobalt loading. The porous carbon was obtained by the calcination of ZIF-8 and different loading amounts of Co nanoparticles were anchored onto porous carbon forming a Co/PC catalyst. Co/PC composite shows a significant increase in the ORR value of current and stability (500 h) due to the good electronic conductive PCN support and optimum cobalt metal loading. The significantly improved catalytic performance is ascribed to the chemical structure, synergistic effects, porous carbon networks, and rich active sites. This method develops a new pathway for a highly active and advantageous catalyst for electrochemical devices.

• Journal of Ginseng Research
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• v.12 no.1
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• pp.1-10
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• 1988

Panax ginseng seedlings were grown at various temperature regimes from 15 to $30^{\circ}C$ for 19 days under dark and the linear relationship between various regrowth efficiencies and thermal stress indices, cumulative superoptimum temperatures corrected with factors. Gross growth efficiency(shoot weight l root weight loss) was 37.5 % at the optimum temperature $15^{\circ}C$/$15^{\circ}C$, and 12.3% at the highest temperature, $30^{\circ}C$/$30^{\circ}C$ while net growth efficiency (shoot weight + Sm)l(root loss-Rm), which corrected by maintenance respiration for shoot(Sm) and root(Rm) was 39.6% and 16.7 at optimum and highest temperature respectively. All growth efficiencies showed negative correlations (p = 0.001) with all thermal stress indices and negative(p = 0.001) with shoot growth(St). When growth temperature difference in a day was nil or above $15^{\circ}C$ growth efficiency decreased greatly. Thermal stress indices showed negative correlation with root dry matter loss(RDL) but positive with Rm. St showed positive correlation with RDL. Thermal stress appeared to inhibit substrate supply for shoot growth resulting in the extremely low growth efficiency comparing with other crops that seems to be main rate limiting factor of slow growth, Thus it is necessary that growth efficiency and thermal stress must be elucidated in terms of metabolic pathway.

• Korean Journal of Oriental Medicine
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• v.2 no.1
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• pp.514-550
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• 1996

There are many theory in acupuncture mechanism, so we must know the detail contents. and then we can use the acupuncture as we know. the follow article will be helpful in this part. 1. Spinal cord are role in intermediate part in somatosensorypathway also in acupuncture stumulating tract 2. Acute pain pathway started in laminae I, V of gray colmn, next are the spinothalamic tract(trigeminal spinothalamic tract in above neck part) and then go to the specific thalamic nucleus. but chronic pain in laminae II, III, VI, VII, next are spinoreticular tract(trigeminal spinoreticular tract in the neck part) and finally to the nonspecific thalamic nucleus. 3. Thalamus is very important area in somatosensory stimuation including acupuncture stumulating sensory also as a pain control center. but except this, there are Hypothalamus, Limbic system Cerebral cortex and Cerebellum as intermediator. as we Know hypothalamus is related to the emotional analgesic system with a limbic system. 4. A ${\delta$ fiber has relationship in Acute, sharp and initial pain, contrary this C fiber is related with Chronic, dull and last pain. 5. In Acupuncture mechanism of pain analgesia, there are two theory, one is gate control theory as large fiber another is stimuation produced analgesia as small diameter fier. 6. In DNIC, the stimulation sources are mechanical, thermal, heating, pain and acupuncture stimulation etc. we call these as a Heterotopic Noxious Stimulation. 7. In DNIC, SRD(Subnucleus reticularis dorsalis)is core nucleus in pain imtermediated analgesic mechanism. 8. Takeshige insisted nonacupuncture point dependent analgesic mechanism and acupuncture point dependent analgesic mechanism. and protested that Stimulation acupuncture piing evoke blocking nomacupuncture point analgesic pathway.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.601-610
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• 2003

Biotin is a water-soluble vitamin used as a skin conditioning agent and promotes the formation of intercellular lipid layers through increased lipid synthesis, which improves the skin's natural barrier function. The anti-inflammatory effects of biotin have been investigated using in vitro assay models, such as MTT assay, measurements of concentrations of nitric oxide(NO), prostaglandin E2(PGE$_2$), and inhibition rate of 5-lipoxygenase(5-LOX). In comparison with biotin, other plant extracts were tested at the same time which were kudzu vine extract, sage extract, paeonia extract, and dipotassium glycyrrhetinate. Nitric oxide is a signal molecule with functions such as neurotransmission, local vascular relaxation, and anti-inflammation in many physiological and pathological processes. NO can cause apoptosis and necrosis of target cells such as keratinocytes and is generated from L-arginine by nitric oxide synthase (NOS). Prostanoids, including prostaglandins and thromboxanes, are generated by the phospholipase $A_2$/cyclooxygenase(COX) pathway, and leukotrienes are generated by the 5-lipoxygenase pathway from arachidonic acid. Prostaglandin E2 recently have been shown to be beneficial in the resolution of tissue injury and inflammation, also has been implicated as an immunosuppressive agent and plasma levels of PGE$_2$ are elevated in patients sustaining thermal injury. Lipoxygenase metabolites from arachidonic acid have been implicated in inflammation, anti-inflammatory activity of the raw materials was evaluated in vitro by the offered inhibition of lipoxygenase.