• 한국전문물리치료학회지
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• 제25권3호
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• pp.12-18
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• 2018

Background: Passive straight leg raising (PSLR) is the common clinical test to measure of hamstring muscle length. Hip flexion angle contributes to change the lumbopelvic rotation during PSLR. Pressure biofeedback unit (PBU) is commonly used to detect lumbopelvic movement during lower limb movements. Thus, there may be the relationship between pressure of PBU and lumbopelvic motion during PSLR. Objects: The objective of this study was to determine the relationship between pressure of PBU and lumbopelvic motion during PSLR. Methods: Thirty two subjects participated in this study. A three-dimensional motion analysis system were used to measure the lumbopelvic angle during PSLR, while recording the pressure of PBU according to angle of PSLR by 10 degree increments. Pearson product moment correlations and linear regression analysis were used to describe the relationship between variables. Results: The results showed that there was a significant relationship between the lumbopelvic and angle of PSLR (Pearson's r=.83, p<.05), between the pressure of PBU and angle of PSLR (Pearson's r=.75, p<.05), and between lumbopelvic motion and pressure of PUB (Pearson's r=.83, p<.05). Linear regression equation using lumbopevic angle as an independent factor was as follows: Pressure of PBU = 47.35 + (2.55 ${\times}$ angle of lumbopelvic motion) ($R^2=.69$, p<.05). Conclusion: Results of the present study indicate that pressure of PBU can be used to indirectly detect the amounts of lumbobevic motion during muscle length test or stretching of hamstring.

• Nutrition Research and Practice
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• 제3권2호
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• pp.156-161
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• 2009

Hyperglycemia in the diabetic state increases oxidative stress and antioxidant therapy can be strongly correlated with decreased risks for diabetic complications. The purpose of this study is to determine antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes. The antioxidant activity of garlic and aged black garlic was measured as the activity in scavenging free radicals by the trolox equivalent antioxidant capacity (TEAC) assay. Three week-old db/db mice were fed AIN-93G diet or diet containing 5% freeze-dried garlic or aged black garlic for 7 weeks after 1 week of adaptation. Hepatic levels of lipid peroxides and activities of antioxidant enzymes were measured. TEAC values of garlic and aged black garlic were $13.3{\pm}0.5$ and $59.2{\pm}0.8{\mu}mol/g$ wet weight, respectively. Consumption of aged black garlic significantly decreased hepatic thiobarbituric acid reactive substances (TBARS) level compared with the garlic group which showed lower TBARS level than control group (p<0.05). Activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of garlic and aged black garlic group were significantly elevated compared to the control group. Catalase (CAT) activity of aged black garlic group was increased compared with the control group. These results show that aged black garlic exerts stronger antioxidant activity than garlic in vitro and in vivo, suggesting garlic and aged black garlic, to a greater extent, could be useful in preventing diabetic complications.

• 대한수의학회지
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• 제44권1호
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• pp.89-98
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• 2004

This study was carried out to investigate the serotype, and antimicrobial susceptibility and analyze the plasmid profile for the 145 isolates of L. monocytogenes isolated from livestock products and these product processing plants in Gyeongnam, Korea. All of L. monocytogenes strains belonged to serotype 1/2b (57.9%), 1/2a (20.0%), 4b (11.4%), 1/2c, 3b, 4c (each 2.9%) and 4d (0.7%). Serotype 1/2b, 1/2a, 4b from each source were found predominantly. Serotype 1/2b was predominantly higher than other serotype, and there was no significant difference between serotypes isolated from livestock products and product processing plants. 4b was major serotype isolated from raw milk and pork, and serotypes isolated from beef, chickens and slaughterhouse were 1/2b and 1/2a. The susceptibility of 145 strains of L. monocytogenes to 14 antibiotics commonly used in veterinary and human therapy was determined by disk diffusion method. All of L. monocytogenes strains were susceptible to amikacin, ampicillin, cephalothin, chloramphenicol, gentamicin, kanamycin, neomycin and penicillin. L. monocytogenes strains had the highest resistance with colistin (100%), oxytetracycline (44.8%), tetracycline (43.4%) followed by erythromycin (2.8%), spectinomycin (1.4%) and streptomycin (0.7%). Tetracycline resistance, and serotype distribution of the isolates from sample sources were significantly different. Resistance to at least one antibiotic was observed in all of them and 7 different resistant profiles were recorded. The most common resistance pattern were CL-OTC-TC (colistin-oxytetracycline-tetracycline) (42.8%). Among all tested isolates, two different plasmid profiles were observed. Of the 97 examined strains, 14 (14.4%) contained either the 8 and 11 kb plasmid or the 11 kb.

• 대한지역사회작업치료학회지
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• 제10권1호
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• pp.17-30
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• 2020

목적 : 본 연구는 델파이 조사를 통해 국내 조현병 환자의 수단적 일상생활활동 훈련 중 식료품 쇼핑이라는 구체적인 수행 과제를 적용한 프로그램을 개발하기 위한 연구이다. 연구방법 : 델파이 1~3차 조사를 통해 최종 프로그램 항목 및 내용을 완성하는 단계로 2018년 8월부터 2019년 3월까지 진행되었다. 전문가 구성은 정신보건과 관련 있는 작업치료사 23명을 선정하였다. 개방형 문항으로 구성된 1차 설문으로부터 작성된 2차 설문지는 중요한 정도를 리커트 5점 척도를 이용하여 표시하도록 하였다. 3차 설문의 응답결과로 평균 및 표준편차, 내용타당도비율(Content Validity Ratio; CVR) 분석을 통해 전문가의 합의 수준을 다시 확인하였다. 결과 : 3차에 걸친 델파이 조사 결과 식료품 쇼핑의 견해, 물건 구매 전략, 필요한 기능, 구매 결정 방법에 대한 전문가의 지식과 경험에 의한 의견을 구하는 4개의 문항으로 1차 개방형 델파이 설문을 실시하여 4가지 영역에 24가지 항목을 선정하였다. 2차, 3차 델파이 설문을 거쳐 각 항목의 적합도 기준에 미달하거나 내용이 중복되는 4개의 항목을 삭제하고 최종적으로 20개의 항목을 추출하였다. 결론 : 만성조현병 환자들이 회복하고 사회의 일원으로 참여할 수 있도록 작업치료적 관점으로 식료품 쇼핑 기술에 전문가들의 합의를 도출하였다.

• 벤처창업연구
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• 제8권1호
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• pp.69-78
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• 2013

세계적인 월빙 및 웰니스 붐에 따른 건강 치유를 중시하는 라이프스타일의 정착과 21세기 최고의 유망 서비스산업으로 떠오르고 있는 의료관광 및 웰니스관광에 적극적으로 대응하기 위한 방안의 하나로 제주도의 향토자원을 활용한 스파산업 육성방향에 대하여 고찰하였다. 스파산업 육성에 활용할 수 있는 제주도의 향토자원은 자연환경, 광물자원, 수자원, 생물자원, 농산물, 민간요법의 6 종류의 자원인 것으로 파악되었다. 제주 향토자원을 활용 가능한 여러 가지 스파 트리트먼트 중에서도 제주를 상징할 수 있는 차별화된 스파 트리트먼트 즉, '제주 특화 스파 트리트먼트'로 개발이 가능한 것은 12가지로 판단되었다. 즉, 자연환경을 활용한 딸라소테라피, 광물자원을 활용한 스톤테라피 검은 모래찜질 화산회토를 이용한 온돌요법, 수자원을 활용한 탈라소테라피 음용요법 하이드로 테라피, 생물자원을 활용한 약초/한약재 찜질 삼림치유, 농산물을 활용한 스파퀴진, 민간요법을 활용한 얼굴미용 질병치유 및 건강증진 식이요법이다. 상기와 같은 12가지 스파 트리트먼트를 '제주 특화 스파 트리트먼트' 개발 활용하기 위해서는 향토자원의 물리화학적 특성에 관한 기초연구와 더불어 제품화 연구와 임상시험을 통화 효능연구가 선행되어야 한다. 또한, 개발된 스파 트리트먼트를 고객의 성향과 요구와 스파유형 등을 고려한 맞춤형 서비스 프로그램 개발과 표준화 및 매뉴얼화가 이루어져야 한다. 아울러, 제주 스파산업이 경쟁력 있는 산업으로 성장해 나가기 위해서는 제주특별자치도가 추진하고 있는 의료관광 및 웰니스관광과 연계와 더불어 창업 및 경영지원이 필요 할 것으로 판단된다.

• 한국산학기술학회논문지
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• 제18권8호
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• pp.88-98
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• 2017

본 연구는 최근 증가하고 있는 메디컬스킨케어에 맞추어 등장한 코스메슈티컬화장품을 사용하는 병원종사자의 제품선택이 마케팅커뮤니케이션에 미치는 영향에 대한 연구로 실시하였다. 코스메슈티컬화장품이 주로 사용, 판매되어지고 있는 병원의 병원종사자를 대상으로 코스메슈티컬화장품을 구매하는 소비자와의 불만에 대응하고 부정적 이슈의 영향을 최소화하여 소비자와의 우호적 관계를 강화할 수 있는 대안 마련에 필요한 자료를 얻는데 목적이 있다. 연구는 서울 경기 인천 지역의 병원(피부과, 성형외과, 여성의원, 기타병원)에서 코스메슈티컬화장품을 사용하는 병원종사자를 520명을 대상으로 설문조사를 실시되었다. 총 502부의 설문지가 최종분석에 사용되었으며, 데이터 분석은 Cronbach's ${\alpha}$, one-way ANOVA, 탐색적요인 분석 및 Duncan 테스트로 구성되었다. 또한 변수간의 상관관계를 조사하기 위해 상관분석을 수행하였고, 가설검정을 위해 회귀분석을 수행하였다. 본 연구의 결과로 코스메슈티컬화장품을 선택할 때 마케팅커뮤니케이션의 영향을 미친다는 것을 알 수 있으며 특히 제품의 가치, 품질, 가격 요인이 마케팅커뮤니케이션에 큰 영향을 미치는 것으로 보이고 있다. 즉, 제품의 가치 및 품질을 가장 중시함과 동시에 합리적인 가격을 원하는 것을 알 수 있다. 이를 고려하여 향후 코스메슈티컬화장품만의 차별화된 제품을 추구하고 트랜드의 변화양상에 맞추어 코스메슈티컬화장품의 잠재고객 확보 및 판매증대에 필요한 기초자료로 제공하고자 한다.

• 한국임상약학회지
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• 제3권2호
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• pp.175-185
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• 1993

The goal of this clerkship is to expose the student to basic skills needed fir a patient oriented pharmacist to assume an existing clinical role and participate in therapeutic decision making processes. As the pharmacy profession has moved from the traditional product orientation to a patient orientation, curricula within the college of pharmacy have evolved to include more experiential coursework to lister this patient orientation. This change has been supported by the philosophy of pharmaceutical care which encourages pharmacists to assume a patient advocacy role in optimizing a patient's drug therapy while minimizing the adverse effects of the medication. The role of experiential education, and especially the clerkship experience will be to hasten and enhance the development of this concept and philosophy for pharmacy students.

• Molecules and Cells
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• 제27권6호
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• pp.621-627
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• 2009

Spinocerebellar ataxia type 1 (SCA1) is an autosomal-dominant neurodegenerative disorder characterized by ataxia and progressive motor deterioration. SCA1 is associated with an elongated polyglutamine tract in ataxin-1, the SCA1 gene product. As summarized in this review, recent studies have clarified the molecular mechanisms of SCA1 pathogenesis and provided direction for future therapeutic approaches. The nucleus is the subcellular site where misfolded mutant ataxin-1 acts to cause SCA1 disease in the cerebellum. The role of these nuclear aggregates is the subject of intensive study. Additional proteins have been identified, whose conformational alterations occurring through interactions with the polyglutamine tract itself or non-polyglutamine regions in ataxin-1 are the cause of SCA-1 cytotoxicity. Therapeutic hope comes from the observations concerning the reduction of nuclear aggregation and alleviation of the pathogenic phenotype by the application of potent inhibitors and RNA interference.

• 통합자연과학논문집
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• 제8권4호
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• pp.267-272
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• 2015

Galactosemia is a potentially lethal disorder caused by the deficiency of the enzyme galactose-1-phosphate uridyltransferase (GALT) within the Leloir pathway. Galactokinase (GALK) is the enzyme in Leloir pathway which converts ${\alpha}$-D galactose to galactose 1-phosphate. The elevated level of galactose-1-phosphate, the product of GALK plays a major role in Galactosemia. Therefore the inhibition of GALK is a novel therapy for this disorder. Hence in the present study, we performed molecular docking of twenty inhibitors with different activity against galactokinase into the active site of galactokinase enzyme. The binding mode of these inhibitors was obtained using Surflex dock program interfaced in Sybyl-X2.0. The residues such as SER141, TYR109, ARG105, ARG228, TYR106, GLY346, GLY136, ASP86, ASP186 and SER142 found to interact with inhibitors.

• Natural Product Sciences
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• 제23권4호
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• pp.227-234
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• 2017

Moringa oleifera Lam (M. oleifera, Moringaceae) is a tree of the Moringaceae family that can reach a height of between 5 and 10 m. The current paper presents cytotoxic effect of M. oleifera fruits and its flavonoids 1 and 2. The viability of HCT116 human colon cancer cells were 38.5% reduced by $150{\mu}g/mL$ of ethanolic extracts in a concentration-dependent manner; in addition, we observed the apoptotic features of cell shrinkage and decreased cell size. Bcl-2 family proteins were regulated as determined by Western blotting analysis, suggesting that M. oleifera fruits and their flavonoids 1 and 2 induced apoptosis through an intrinsic pathway. Based on our findings, 70% ethanolic extracts of M. oleifera fruits and flavonoids 1 and 2 might be useful as cytotoxic agents in colorectal cancer therapy.