• Title/Summary/Keyword: Therapeutic ratio

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An Experimental Study on the Effects of Hyperthermia and Irradiation on the Rat's Kidney (방사선조사와 온열요법이 백서신에 미치는 조직 변화에 관한 실험적 연구)

  • Yoo, Myung-Hee;Lee, Kyung-Ja;Rhee, Chung-Sik
    • Radiation Oncology Journal
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    • v.7 no.2
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    • pp.157-169
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    • 1989
  • Radiological and clinical evidences indicate that hyperthermia combined with irradiation produce a significant improvement in therapeutic effect of cancer The experiences obtained from 90 rats' kidney A single dose of irradiation ranged from 6Gy, 8Gy and 10Gy was delivered on the rat's kidney. The combined therapy group had the same irradiation after hyperthermia at $42\~44^{\circ}C$ for 30 minutes. Microscopic examination and calculation of thermal enhancement ratio were carried out, and the results were as follows: 1. In the group of hyperthermia alone, there were moderate glomerular congestion and mild tubular degeneration on light microscopic examination. 2. In the group of irradiation alone, tubular degeneration was noted in 6Gy irradiation and its severity was increased along with radiation dose. 3. In the group of hyperthermia combined with irradiation, tubular degeneration and necrosis were appeared in 6Gy and 10Gy irradiation, respectively. 4. On electron microscopic examination, proximal convoluted tubular and glomerular changes in irradiation group were similar to that of combined with hyperthermia, and its severity was increased along with observation periods. 5. Thermal enhancement ratio (TER) was 1.0 after evaluation of histipathologic changes in rat's kidney, with combination therapy.

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Frontal Alpha Asymmetry, Heart Rate Variability, and Positive Resources in Bereaved Family Members with Suicidal Ideation after the Sewol Ferry Disaster

  • Jang, Kuk-In;Lee, Sangmin;Lee, Seung-Hwan;Chae, Jeong-Ho
    • Psychiatry investigation
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    • v.15 no.12
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    • pp.1168-1173
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    • 2018
  • Objective After the Sewol ferry disaster, bereavement with suicidal ideation was a critical mental health problem that was accompanied by various neuropsychological symptoms. This study examined the frontal alpha asymmetry (FAA), heart rate variability (HRV), and several psychological symptoms in bereaved family members (BFM) after the Sewol ferry disaster. Methods Eighty-three BFM after the Sewol ferry disaster were recruited. We assessed FAA, HRV, and psychological symptoms, including depression, post-traumatic stress, post-traumatic growth factor, anxiety, grief, and positive resources, between BFM with the presence and absence of current suicidal ideation. Results Compared to BFM without suicidal ideation, BFM with suicidal ideation showed a higher FAA with right dominance. Significant differences in psychological symptoms were observed between the groups. In BFM with suicidal ideation, the low: high frequency (LF:HF) ratio correlated with social resources and support. Conclusion The FAA and LF:HF ratio may be biomarkers that represent the pathological conditions of BFM with suicidal ideation. If researched further, they may shed light on the interaction between bereavement with suicidal ideation and social resources for therapeutic intervention.

The clinical observation of patient with Headache Treated by Trigger point acupuncture therapy (발통점(發通點)을 이용(利用)한 두통(頭痛) 치험례(治驗例) 보고(報告))

  • Lee Seung-Yeon;Kim Jang-Hyun
    • The Journal of Pediatrics of Korean Medicine
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    • v.12 no.1
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    • pp.133-143
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    • 1998
  • Myofascial pain syndrome is one of the pain syndrome resulted from myofascia which covered muscles and clinically characteristic feature by sensitive trigger point in skeletal muscles and referred pain reactivated by stimulating each trigger point. The origin of headache are local lesion such as head, chest, abdominal organ, systemic lesion with fever or in toxic state. the other factors are consciousness, personality, anxiety, depression, which cause muscle strain in physiological environment. The Oriental Medical therapy for headache has herb medication and acupuncture. especially acupuncture therapy has not only classical systemic acupuncture(體鍼) but also neo-acupuncture(新鍼) such as commonly using auricular acupuncture(耳鍼) and manual acupuncture (手鍼), recently trigger point acupuncture is used. The author analyzed 27 cases of patient with headache treated by trigger point acupuncture therapy in Dong-yu Oriental Medical Hospital from March 1st 1997 to February 28th 1998. The following results were obtained. 1. The sex ratio of the female was 59.26%(16 cases) and male was 40.74%(11 cases), the ratio of high school student was 62.96%(17cases) as first. 2. The headache duration ratio of 2-3 years was 37.04%(10 cases) as first, 1-2 years was 25.93%(7 cases) as second. 3. The portion ratio of whole headache was 33.33%(9 cases) as first, lateral headache was 29.63%(8 cases) as second 4. The combined symptoms ratio of anorexia was 40.74%(11 cases) as first, fatigue was 33.33%(9 cases) as second, neck stiffness and dizziness was each 25.93%(7 cases) as third. 5. The therapeutic duration ratio of below 1 week was 29.63%(8 cases) as first, 2-3 weeks was 22.22%(6 cases) as second, 1-2 weeks and 3-4 weeks was each 18.52%(5 cases) as third. 6. The ratio of family history was 11 cases(40.74%). mother with headache was 6 cases, father was 3 cases, and brothers & sisters was 2 cases. 7. The herb medication ratio of Chungsanggyuntongtang(淸上?痛湯) was 37.04%(10 cases), Kamiondamtang(加味溫膽湯) was 22.22%(6 cases), Hyangsapyunguisan(香砂平胃散) was 18.25%(5 cases) etc. 8. The remedial effect ratio of good was 25.93%(7 cases), fair was 48.15%(13 cases), not improved was 7.41%(2 cases), side effect was 3.70%(1 cases), and unknown was 14.81%(4 cases).

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Clinical Experience of Atelectasis (무기폐의 임상적 고찰)

  • 류삼열
    • Journal of Chest Surgery
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    • v.24 no.11
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    • pp.1098-1106
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    • 1991
  • Atelectasis may be defined as collapse of the lung due to absence of air within the alveoli. It may involve anatomic segments, lobes, or whole lungs but also may be a diffuse miliary process, as in the adult respiratory distress syndrome. The key to treatment are the anticipation and prevention of atelectasis in various clinical situations, the recognition and treatment of underlying disease, and the prompt initiation of vigorous treatment once atelectasis is found. Repeated assessment by physical examination is necessary to determine the presence of atelectasis and its response to treatment. During the period of January, 1981 to October, 1990, 100 patients with atelectasis were treated in the department of Thoracic and Cardiovascular Surgery, Pusan National University Hospital. There were 70 males and 30 females ranging from 3 days to 79 years of age. The occurrence ratio of right to left side was 2.1 : 1. The underlying pathologic lesions of atelectasis were pneumonia with effusion(28), lung ca.(24), pulmonary tuberculosis(24), and chronic empyema(9), The treatment procedure for atelectasis were closed thoracostomy in 26 cases, ressection in 21 cases, therapeutic bronchoscopy in 14 cases and etc.

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Intra Operative Radiation Therapy (IORT) (위암환자의 수술중 전자선을 이용한 방사선 치료방법에 대한 고찰)

  • Kim, Dong-Wook;Suh, Myong-Won
    • The Journal of Korean Society for Radiation Therapy
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    • v.2 no.1
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    • pp.75-80
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    • 1987
  • Intraoperative Radiation therapy (IORT) is a cancer treatment modality in which resectable masses or organs are removed surgically and residual cancer calls are sterilized by irradiation with a single massive dose during while patient is still anesthetized. Because it is possible that the turner mass can be visualized directly at the time of surgical exploration, tumor volume can be determined more precisely and at the same tin e sensitive adjacent structures can be pulled aside from the irradiation. With these theoretical advantages as compare to conventional external irradiation, IORT can improve the therapeutic ratio of tumor control to normal tissue injury. Yonsei cancer center initiated a pilot study of multidisciplinary IORT program in february of 1986 for the fist attempt in Korea. IORT Was performed in 7 patients with stomach cancer by using existing NELAC-1018 Linear Accelerator treatment room as a surgical suite. IOTR team included department of surgery, Department of Anethesiology, Department of Clinical pathology, operating room nursing personal and Department of radiation oncology.

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The Effect of Electrical Stimulation and Therapeutic Exercise on Muscular Strength in Knee Extensor Muscles (전기 자극과 치료적 운동에 의한 슬관절 신전근의 근력 증가 효과)

  • Park Rae-Joon;Kang Hwa-Soon
    • The Journal of Korean Physical Therapy
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    • v.10 no.2
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    • pp.33-40
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    • 1998
  • This study was carried out to investigate the muscle strength of quadriceps muscles by means of isokinetic test. The experimental objects were devided into electrically stimulated, isotonic and isometric groups and trained for 4weeks. The results were as follows : 1. the values of total work, peak torque, average power and the ratio of peak torque between flexors and extensors revealed singnificant statistically in three experimental groups(p<0.05). 2. The endurance was increased slightly in electrically stimulated group, but decreased in isotonic and isometric group, 3. The value of post training on all items did not reveal significant statistically in three experimental groups(P>0.05). 4. The electrically stimulated groups effected on increasing of muscle strength as isotonic and isometric exercises.

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The Phsical therapeutic Approache of Low Back Pain On the Study of Cause and Phscal Examination (요통의 물리치료적 접근 -원인과 물리적진단 중심으로-)

  • Park Youn-Ki;Park Ji-whan
    • The Journal of Korean Physical Therapy
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    • v.3 no.1
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    • pp.221-227
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    • 1991
  • Regardless of the age, Low back pains are appeared to the highest occurrence ratio and every one meet with the disease once at least through life. In order to treat a pain, therefore, it make a accurated treatment program by the accurated a cause and evaluation and can expected to effects of treatment. In order to do the perfected physical therapy, futhermore, it is nessessary more systematic studies not a cause and physical diagnosis but pathological aspects.

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Clinical Evaluation of Spontaneous Pneumothorax A Review of 165 cases (자연기흉의 임상적 고찰: 165례)

  • 성후식
    • Journal of Chest Surgery
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    • v.18 no.4
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    • pp.582-588
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    • 1985
  • We have observed 165 cases of spontaneous pneumothorax from Aug. 1978 to May. 1985 at the department of Thoracic and Cardiovascular Surgery, School of Medicine, Keimyung University. The ratio of male to female cases were 8.2:1 in male predominance, and the incidence was highest in the adolescence between 21 to 30 year of age. There were 85 patients of primary spontaneous pneumothorax and 80 patients of secondary spontaneous pneumothorax. The etiologic factors of secondary spontaneous pneumothorax were tuberculous origin in 50 cases, chronic bronchitis with emphysematous bullae or blebs in 17 cases, asthma in 10 cases and lung cancer in 3 cases. Closed thoracotomy was performed for reexpansion of collapsed lung in 153 cases, bed rest in 3 cases, needle aspiration in 5 cases and open thoracotomy in 14 cases. Closed thoracotomy was the main therapeutic approach of choice in the great majority of spontaneous pneumothorax with recurrence rate of 21.6%. However, open thoracotomy was undertaken in patients with continuous air leakage, recurrent episodes, bilateral pneumothorax and large visible apical blebs or bullae.

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Clinical Study of Patients with Hoarseness in According to Causes and Therapies (애성환자에 있어서 원인 및 치료에 따른 고찰)

  • 안철민;권기환;박효진;이용배
    • Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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    • v.6 no.1
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    • pp.16-21
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    • 1995
  • Clinical study was performed on 128 cases who complained of hoarsseness in according to causes therapies. which causes were newly known and advanced treatment methods were developed. The following results were obtained : 1) Among 128 cases, male was 45.3%, and female 54.7%, so sex ratio was 1:1.2. 2) The highest incidence of age causing hoarseness in order of frequency were 4th decade 30.5%, 5th decade 26.6% and 6th decade 24.8%. 3)The underlying diseases causing hoarsensess in oder of frequency were functional dysphonia 26.5%, laryngeal nodule 17.7% and chroic laryngitis 16.3%. 4) In view of the occupation. sterss group was 84.1% and non-stress group 15.9%. 5) The highest incidence of associated diseases in order of frequency were gastro intestinal diseases 29.7%, hypertension 9.4% and pulmonary tuberculosis 2.3%. 6) Vocal hygiene and voice therapy are the most needful therapeutic modalities.

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Effects of Chicory Extract on the Serum Glucose and Lipid Metabolism in Strptozoticin-induced Diabetic Rats (치커리추출액이 Streptozotocin 유발 당뇨쥐의 혈당과 지질대사에 미치는 영향)

  • 이정선
    • Journal of Nutrition and Health
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    • v.30 no.7
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    • pp.781-788
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    • 1997
  • This present study was undertaken to evaluate the effects of 5 % chicory extract on serum glucose and lipid metabolism in diabetic rats treated with streptozotocin (STZ). The experimental subjects were divided into 4 groups. : No-fiber , cellulose, insulin, and chicorygroup. The animals were fed ad libitum each of the experimental diets for 4 weeks. The food intake and food efficiency ratio in chicory group was significantly higher than in no-fiber, cellulose, and inulin groups. The reduction of body weight was also significantly lower. The wet weights of cecum and cecal contents were significantly increased in rat fed chicory extract. Total glycated hemoglobin was significantly decreased by chicory extract feeding whereas serum total cholesterol . LDL-choelsterol, and HDL-choelsterol levels were significantly increased. But there were no differences between HDL-choesterol/total cholesterol ratios, LDL-cholesterol/HDL-cholesterol ratios, and atherogenic index. After 10 -hour fast, the levels of hepatic triglyceride and phospholipid were significantly higher in the chicory group than any in other groups. These results indicated that chicory extract is an effective therapeutic regimen for control of metabolic deragements in diabetics.

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