• 대한두경부종양학회:학술대회논문집
• /
• 1989.11a
• /
• pp.18.1-18.1
• /
• 1989

• Radiation Oncology Journal
• /
• v.31 no.1
• /
• pp.48-54
• /
• 2013

Castleman's disease or angiofollicular lymph node hyperplasia is a rare lymphoproliferative disorder. Complete surgical resection was recommended in unicentric Castleman's disease. Radiotherapy was considered alternative therapeutic option. However, there have been consistent favorable responses to radiotherapy. We also experienced two cases of uncentric Castleman's disease salvaged successfully with radiotherapy. This paper described these cases and reviewed the literature about Castleman's disease treated with radiotherapy. Reviewed cases showed that radiotherapy is a successful treatment option in unicentric Castleman's disease. Furthermore, our report confirms the radiotherapy role in uncentric Castleman's disease.

• The Korean Journal of Pain
• /
• v.34 no.4
• /
• pp.427-436
• /
• 2021

Background: Pharmacological and non-pharmacological therapies have been used to treat patients with chemotherapy-induced peripheral neuropathy (CIPN). However, the effect of therapies in cancer patients has yet to be investigated comprehensively. We hypothesized that cyclic thermal therapy would improve blood flow and microcirculation and improve the symptoms driven by CIPN. Methods: The criteria of assessment were blood volume in region of interest (ROI) in the images, and European Organization for Research and Treatment of Cancer-Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy 20 questionnaire scores. The blood volume was quantified by using red blood cell (RBC) scintigraphy. All patients were treated 10 times during 10 days. The thermal stimulations, between 15° and 41°, were repeatedly delivered to the patient's hands. Results: The total score of the questionnaires, the score of questions related to the upper limbs, the score of questions closely related to the upper limbs, and the score excluding the upper limbs questions was decreased. The blood volume was decreased, and the variance of blood volume was decreased. During cooling stimulation, the blood volume was decreased, and its variance was decreased. During warming stimulation, the blood volume was decreased, and its variance was decreased. Conclusions: We suggest that cyclic thermal therapy is useful to alleviate CIPN symptoms by blood circulation improvement. RBC scintigraphy can provide the quantitative information on blood volume under certain conditions such as stress, as well as rest, in peripheral tissue.

• Journal of the Korean Society of Radiology
• /
• v.10 no.6
• /
• pp.469-476
• /
• 2016

In this study, evaluated absorbed dose of moving target using PLD according to prescribed dose and therapeutic technique. First, result of MCNPX when target was deviated from exposure field was reduced dose in proportion to distance. According to prescribed dose, absorbed dose of 3D CRT was better than IMRT in low dose and IMRT was more better in high dose. Absorbed dose of 3D CRT was highest according to therapeutic technique. Therefore, 3D CRT was technique of irradiated highest dose to moving target. But, considered protective effect of normal tissue and patient condition that therapeutic technique was selected to maximized treatment efficiency.

• Radiation Oncology Journal
• /
• v.8 no.2
• /
• pp.255-260
• /
• 1990

From April 1985 to September 1989, 26 patients with stage I and II non-Hodgkin's lymphoma of unfavorable histology localized in head and neck region were treated with combined modality (combination chemotherapy plus radiotherapy) at the Department of Therapeutic Radiology in Kyungpook National University Hospital. Of the 26 patients, 23 showed complete response and 3 partial response. Between these two groups there were no statistical differences according to the variables. Three-year survival and disease-free survival rate were $62.4{\%}$ and $65.2{\%}$, respectively. Unilateral involvement of neck node (p<0.05), radiation dose over 5000 cGy (p<0.01), and 6 or more cycles chemotherapy (p=0.06) had a favorable effect on 3-year survival rate. There were 8 recurrences including 3 partial responders, 1 local failure, 1 distant failure, 1 contiguous failure, and 2 simultaneous local and distant failure. It could be suggested that combined modality treatment might be necessary for the treatment of stage I and II Non-Hodgkin's lymphoma of unfavorable histology.

• Radiation Oncology Journal
• /
• v.13 no.2
• /
• pp.199-203
• /
• 1995

Purpose: To evaluate the dose under lung block as a function of depth and the effectiveness of a block as a function of block width. Materials and Methods : Field size of mantle field was $22.8{\times}32.4cm^2.$ Dose distribution of the mantle field was measured with two dimensional water phantom system. To analyze the effectiveness of the lung block. central axis plane, 5cm off-axis plane, and 10cm off-axis plane were studied. Results: The dose under the lung block was recorded with maximum at the depth between 5cm and 10cm. In the central axis plane, dosimetric block width was $10-15\%$ less than physical block width. In the 5cm off-axis plane, dosimetric block width was $4-9\%$ less than physical block width. In the 10cm off-axis plane, dosimetric block width was $2\%$ less than physical block width. Conclusion: Depth dependence of the dose under the lung block was founded. Also, block width dependence of the lung block was founded. To induce the accurate relation between the physical block width and the 'effective' block width, it needs more detailed understanding of the variables involved.

• Radiation Oncology Journal
• /
• v.7 no.1
• /
• pp.113-121
• /
• 1989

The inclusion of air filled cavities in treatment fields creates a potential dosimetric problem due to the rebuildup phenomenon near the air-tissue interface using a simulated phantom, such as air gap, air cylinder, and air cavity, the amount of rebuldup along the various field sizes and air cavity dimensions was measured. The results are as follows. 1. As the field size becomes larger in comparison with the cavity size, or as the cavity size gets bigger when the field size is equal to the cavity size, rebuildup decreases. 2. When the distance between the phantom surface and the air cavity is less than 1.5cm, there is prominent rebuildup. And when the distance is more than 1.5cm, rebuildup is relatively constant, 3. The change according to the depth of the cavity is affected by the field size and the cavity size, rebuildup usually increases when the depth of the cavity increases. 4. It is suggested that tissue equivalent material should be applied on the skin to make tissue thickness over the air cavity more than 1.5cm and that the field size should include the air cavity with at least 1cm margin.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.20
• /
• pp.8793-8796
• /
• 2014

Objective: To explore the influence of serum vascular endothelial growth factor (VEGF) level on therapeutic outcome and diagnosis/prognostic value in patients with cervical cancer. Materials and Methods: A total of 37 patients diagnosed with cervical cancer by biopsy were selected and treated with concurrent chemoradiotherapy. Double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) was adopted before treatment to assess VEGF levels, and its relationships with clinicopathological features and short-term therapeutic effects were analyzed. Results: The median VEGF level in 37 patients before treatment was 647.15 (393.35~1125.16) pg/mL. Serum VEGF levels in patients aged <50 years, in International Federation of Gynecology and Obstetrics (FIGO) stage IIIa~IVa, with lymph node metastasis and tumor size >4 cm were significantly increased (P<0.05). The complete remission (CR) rate was 48.7% (18/37), partial remission (PR) rate was 35.1% (13/37), stable disease (SD) rate was 13.5% (5/37) and progressive disease (PD) rate was 2.70% (1/37), so the objective remission rate (ORR) after treatment was 83.8% (31/37). Logistic regression analysis showed that tumor size and serum VEGF level before treatment were independent risk factors affecting the therapeutic outcome, and the higher the level of serum VEGF, the worse the prognosis when tumor size>4 cm. Some 56.8% of patients manifested with myelosuppression, 37.8% with leucopenia, 24.3% with thrombocytopenia, 5.41% with diarrhea, 46.0% with nausea and vomiting, 21.6% with hair loss and 8.11% with hepatic and renal injury during the treatment. Conclusions: Serum VEGF level may reflect the degree of malignancy of cervical cancer and predict therapeutic effect, which is of great importance to cancer diagnosis and prognosis.

• Radiation Oncology Journal
• /
• v.8 no.1
• /
• pp.29-34
• /
• 1990

Total of 154 patients of pathologically proven and previously untreated nasopharyngeal carcinoma who were treated in the Department of Therapeutic Radiology, Korea Cancer Center Hospital during the period from 1964 to 1984 were analyzed. Minimal follow-up period of survivors was 3 years. Thirteen percent of the patients had $T_4$ primary lesions and $65\%$ had stage IV disease. Total radiation dose to the primary site was $1550\~1750$ ret in 82 and above 1750 ret in 72 patients. Local control was obtained in $79\%$ of patients. Significant prognostic factors for the survival were tumor dose (above vs. below 1750 ret), age (below vs. above 30 years), stage (AJCC I-III vs. IV), T stage ($T_1\;vs.\;T_2-4$), and N stage (NO vs. $N^+$).

• Radiation Oncology Journal
• /
• v.5 no.2
• /
• pp.75-82
• /
• 1987

For evaluation of biological effect of $p^+(50.5MeV)$ Be neutron beam produced by Korea Cancer Center Hospital (KCCH) cyclotron the RBE had been measured in experimental tumor Walker 256 carcinosarcoma as well as normal tissue, mouse intestine and bone marrow, in single and fractionated irradiation. As pilot study, the RBE had been measured for the mouse jejunal crypt cells in single whole body irradiation of which the result was 2.8. The obtained RBE values of TCD 50 of Walker 256 tumor, bone marrow and intestine En single irraiation were 1.9, 1.9 and 1.5 respectively. In fractionated irradiation, the RBE value of tumor Walker 256 was decreased as increasing of fraction number and increased as increaing of fraction size.