• 대한한의학방제학회지
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• 제10권1호
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• pp.29-31
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• 2002

A therapeutic following confirming symptom(辨證施治) has a proper characteristic in oriental medicine, which can be grasped but by pathological body reflection not by histological or molecular level etiology. It is also able to be selected a prescription by means of clinical trials which promote human body's natural resurgent. Whereas, a therapeutic regimen prescription(定病傳方) has a merit in prescribing a disease to the point. which has been developed and established a therapy method naturally for thousands years. Then, which of the two is the better method in clinic? The answer is a co-exist of the two therapy methods in a matter of developing deciding therapeutic cooperation. To tie a knot, two methods need the opposite one.

• 대한방사선치료학회지
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• 제1권1호
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• pp.47-51
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• 1985

Authors describe some useful data when constructing tissue-equivalent compensators which would compensate tissue deficit in the treatment field of high energy electromagnetic radiation Tissue equivalent compensator is made of lucite. The ratio of compensator thickness to the thickness of tissue deficit depends on radiation energy, field size and the distance from the compensator to patient skin. When the compensator is separated from skin surface, the thickness ratio is always smaller than 1.0. This means that the larger the separation, the contribution to the total dose by means of scattered radiation from a tissue equivalent compensator is smaller. Authors propose that the thickness of lucite as tissue equivalent compensator is 0.57 times tissue deficit and the separation between compensator and skin is at least 15m for Co-60 gamma ray and 25cm for 10MV X-ray.

• 디지털융복합연구
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• 제13권10호
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• pp.437-444
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• 2015

디지털 시대에 현대인들은 종종 약함과 고립 그리고 두려움이라는 피할 수 없는 감정에 사로잡혀 우울과 좌절감을 경험하게 된다. 이러한 때, 시는 이런 문제를 극복할 수 있는 치유적 수단이 될 수 있다. 왜냐하면 시는 자아 발견의 기회를 주고 치유와 자아 통합이라는 촉매제가 되기 때문이다. 본 논문은 영시의 어떤 속성들이 치유의 통찰로 나아가게 하는지를 조명해 본다. 시가 다양한 인간의 감정들을 구현해서 카다르시스 즉 정서적 해방을 이끌고 있다는 점을 치유적 기능으로 연결한다. 시의 언어 또한 우리의 영혼과 마음을 치유한다는 점과 다양한 형태로 오는 시의 리듬과 형식 또한 시의 치유적 기능에 있어 중요한 요소들임을 살펴보게 될 것이다. 시의 이러한 속성들이 시가 궁극적으로 심리적 고통을 극복하게 하고 나아가 개인의 성장에 있어 중요한 수단이 될 수 있음을 확인하게 된다.

• 한국엔터테인먼트산업학회논문지
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• 제13권2호
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• pp.271-277
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• 2019

장애인을 위한 치료의 수단으로서 승마에 대한 관심이 높아지고 있는데 승마는 근육, 관절, 심폐 기능 등의 신체 조건을 향상시키고, 긴장을 완화시키며, 말과 같은 큰 동물을 통해 자신감을 키워주는 운동이다. 다양한 재활승마의 치료효과는 미국의 작업치료 및 물리치료협회 등을 포함한 많은 의학 전문가들에 의해 인정받고 있다. 반면 우리나라는 구체적인 질환별 치료적 효과나 임상적인 치료에 쓰기에 과학적 토대에 관한 연구는 아직 미비한 실정이다. 본 연구는 재활과 관련된 전문인력들의 재활승마에 대한 인식도를 조사함으로써 임상으로서의 가능성을 알아보고자 하였다. 재활승마에 대한 인지도와 사용경험은 전반적으로 낮았으나 효과성의 기대감이나 재활승마의 교육이 가정될 경우 활용하고자 하는 의사는 비교적 높았다. 이러한 결과를 토대로 향후 재활승마가 임상적 치료방법으로 인정될 가능성을 확인할 수 있다.

• Radiation Oncology Journal
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• 제36권3호
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• pp.172-181
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• 2018

Successful anticancer strategies require a differential response between tumor and normal tissue (i.e., a therapeutic ratio). In fact, improving the effectiveness of a cancer therapeutic is of no clinical value in the absence of a significant increase in the differential response between tumor and normal tissue. Although radiation dose escalation with the use of intensity modulated radiation therapy has permitted the maximum tolerable dose for most locally advanced cancers, improvements in tumor control without damaging normal adjacent tissues are needed. As a means of increasing the therapeutic ratio, several new approaches are under development. Drugs targeting signal transduction pathways in cancer progression and more recently, immunotherapeutics targeting specific immune cell subsets have entered the clinic with promising early results. Radiobiological research is underway to address pressing questions as to the dose per fraction, irradiated tumor volume and time sequence of the drug administration. To exploit these exciting novel strategies, a better understanding is needed of the cellular and molecular pathways responsible for both cancer and normal tissue and organ response, including the role of radiation-induced accelerated senescence. This review will highlight the current understanding of promising biologically targeted therapies to enhance the radiation therapeutic ratio.

• 기본간호학회지
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• 제26권3호
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• pp.166-175
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• 2019

Purpose: This study was done to investigate the degree of self-efficacy, transplant-related knowledge, and other factors affecting compliance with a therapeutic regimen for liver transplant recipients. Methods: Participants were 140 patients who had received a liver transplant at a tertiary hospital in Y City, Gyeongnam Province and made regular hospital visits as outpatients. A self-report questionnaire was used to collect the data and collection was done from December 4, 2017 to January 26, 2018. Data were analyzed using frequencies, percentages, means, and standard deviations, and t-test, ANOVA, Pearson's correlation coefficients. Multiple linear regression was performed using SPSS/WIN 21.0 program. Results: Participants scored $113.29{\pm}20.95$ (out of 150) on self-efficacy, $16.38{\pm}3.62$ (out of 18) on transplant-related knowledge, and $148.30{\pm}31.06$ (out of 200) on compliance with the therapeutic regimen. Analyzed of correlations among participant's self-efficacy, transplant-related knowledge, and compliance with the therapeutic regimen showed a significant positive correlation between self-efficacy and compliance with the therapeutic regimen (r=.64, p=.001), but no significant correlations were found between self-efficacy and transplant-related knowledge (r=-.01, p=.912) or between transplant-related knowledge and compliance with the therapeutic regimen (r=.06, p=.458). Multiple regression analysis showed that factors affecting compliance with the therapeutic regimen were state of re-transplantation (${\beta}=.17$, p=.016) and self-efficacy (${\beta}=.53$, p=.001). Conclusion: There is a need to apply a differentiated nursing intervention program considering the differences in patients' self-efficacy, transplant-related knowledge, and compliance with the therapeutic regimen.

• 대한방사성의약품학회지
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• 제8권2호
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• pp.139-150
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• 2022

Theranostics, a composite word of therapy and diagnosis, is known as personalized medicine and the concept of diagnosis and treatment at the same time. In nuclear medicine, it means performing both therapeutic and diagnostic radioisotope therapy using the same target molecule. The increased production and utilization of ⁶⁴Cu opens a new era of theranostics. The studies introduced here have shown that ⁶⁴CuCl₂ and various compounds or biomolecules labeled with ⁶⁴Cu are unique radiopharmaceuticals with physiological properties suitable for use as diagnostic and therapeutic agents. So far, these two abilities have been described only for radioactive iodine. Although ⁶⁴Cu has complex chemical properties compared to other PET radioisotopes such as ⁶⁸Ga, it has an appropriate half-life and enables high-quality PET images similar to ¹⁸F, which is an advantage in terms of diagnosis. In addition, since it also has therapeutic properties through the release of β^- particles and Auger electrons by electron capture, radiopharmaceuticals using ⁶⁴Cu stand for innovative radiopharmaceuticals for theranostic purposes. Therefore, based on the initial results obtained using ⁶⁴Cu as a therapeutic agent, it is expected that additional research on the application of ⁶⁴Cu will lead to a new era in the theranostics field.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권1호
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• pp.1-11
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• 2018

The emergence of mucosal healing as a treatment goal that could modify the natural course of Crohn's disease and the accumulating evidence showing that biologics are most effective in achieving mucosal healing, along with the success of early treatment regimens for rheumatoid arthritis, have led to the identification of early Crohn's disease and development of the concept of catching the therapeutic window during the early disease course. Thus, an increasing number of pediatric gastroenterologists are adopting an early biologic treatment strategy with or without an immunomodulator. Although early biologic treatment is effective, cost and overtreatment are issues that limit its early use. Currently, there are insufficient data on who will benefit most from early biologics, as well as on who will not need early or even any biologics. For now, top-down biologics should be considered for patients with currently known high-risk factors of poor outcomes. For other patients, close, objective monitoring and accelerating the step-up process by means of a treat-to-target approach seems the best way to catch the therapeutic window in early pediatric Crohn's disease. The individual benefits of immunomodulator addition during early biologic treatment should be weighed against its risks and decision on early combination treatment should be made after comprehensive discussion with each patient and guardian.

• BMB Reports
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• 제52권7호
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• pp.451-456
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• 2019

NDRG1 has been reported to exert pivotal roles in tumor progression and metastasis via Wnt/${\beta}$-catenin signaling pathway. However, little is known about the role of NDRG3 in hepatocarcinogenesis despite its classification in the same subfamily of NDRG1. The present study was aimed to characterize the expression pattern and understand the biological roles of NDRG3 in hepatocarcinogenesis, as a means to exploit its therapeutic potential. It was observed that NDRG3 was up-regulated in HCC tissues and higher NDRG3 expression was associated with significantly shorter overall survival. Furthermore, a lower level of NDRG3 exhibited marked positive correlation with metastasis-free survival. In vitro and in vivo experiments revealed that knock-down of NDRG3 inhibits HCC metastasis and angiogenesis. We further demonstrated that activation of WNT/${\beta}$-catenin signaling and enhanced CSC-like properties were responsible for NDRG3-mediated promoting effect on HCC. In conclusion, the principal findings demonstrated that high NDRG3 expression facilitates HCC metastasis via regulating the turnover of ${\beta}$-catenin, as well as provides a potential therapeutic target for future therapeutic interventions.

• 수면정신생리
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• 제8권2호
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• pp.90-97
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• 2001

The reason for exploring dreams is to understand the of patient's conflicts and unconscious motivation. Even if the therapeutic value of dreams is considerably faded these days, I can not deny that dreams are still very useful. From the beginning of human history, dreams have been an appealing subject for many people. In the past, dreams chiefly had the value of prophetic meaning, and in our tradition attention was paid to dreams in terms of good and bad dichotomy. Freud's discovery of the Unconscious and technical development of its exploration is reinforced by dream interpretation. In contemporary terms, although dreams are not the royal road to the Unconscious, they surely present a short-cut. I suggest that dreams as a treasure island of the Unconscious have a useful therapeutic value, and that stressing the importance of dreams is by no means anachronistic. I believe that practical sessions without dreams are like a river without bridges.